Yupanqui Caldas, Héctor Giral, Michael A. Cortázar, Eileen Sutherland, Kayo Okamura, Judith Blaine, Vı́ctor Sorribas, Hermann Koepsell, Moshe Levi,
Cholesterol is pumped out of the cells in different tissues, including the vasculature, intestine, liver, and kidney, by the ATP-binding cassette transporters. Ligands that activate the liver X receptor (LXR) modulate this efflux. Here we determined the effects of LXR agonists on the regulation of phosphate transporters. Phosphate homeostasis is regulated by the coordinated action of the intestinal and renal sodium–phosphate (NaPi) transporters, and the loss of this regulation causes hyperphosphatemia. ...
Tópico(s): Peroxisome Proliferator-Activated Receptors
2011 - Elsevier BV | Kidney International
Héctor Giral, Yupanqui Caldas, Eileen Sutherland, Paul Wilson, Sophia Y. Breusegem, Nicholas P. Barry, Judith Blaine, Tao Jiang, Xiaoxin X. Wang, Moshe Levi,
Hyperphosphatemia associated with chronic kidney disease is one of the factors that can promote vascular calcification, and intestinal P(i) absorption is one of the pharmacological targets that prevents it. The type II Na-P(i) cotransporter NaPi-2b is the major transporter that mediates P(i) reabsorption in the intestine. The potential role and regulation of other Na-P(i) transporters remain unknown. We have identified expression of the type III Na-P(i) cotransporter PiT-1 in the apical membrane ...
Tópico(s): Potassium and Related Disorders
2009 - American Physical Society | AJP Renal Physiology
Ichiro Kaneko, Hiroko Segawa, Junya Furutani, Shoji Kuwahara, Fumito Aranami, Etsuyo Hanabusa, Rieko Tominaga, Héctor Giral, Yupanqui Caldas, Moshe Levi, Shigeaki Kato, Ken–ichi Miyamoto,
Tópico(s): Vitamin D Research Studies
2010 - Springer Science+Business Media | Pflügers Archiv - European Journal of Physiology
Evgenia Dobrinskikh, Héctor Giral, Yupanqui Caldas, Moshe Levi, R. Brian Doctor,
Serum phosphate levels are acutely impacted by the abundance of sodium-phosphate cotransporter IIa (NaPiIIa) in the apical membrane of renal proximal tubule cells. PSD-95/Disks Large/Zonula Occludens (PDZ) domain-containing proteins bind NaPiIIa and likely contribute to the delivery, retention, recovery, and trafficking of NaPiIIa. Shank2 is a distinctive PDZ domain protein that binds NaPiIIa. Its role in regulating NaPiIIa activity, distribution, and abundance is unknown. In the present in vivo study, ...
Tópico(s): Ion Transport and Channel Regulation
2010 - American Physical Society | AJP Cell Physiology
Luca Lanzanò, Tim C. Lei, Kayo Okamura, Héctor Giral, Yupanqui Caldas, Omid Masihzadeh, Enrico Gratton, Moshe Levi, Judith Blaine,
The kidney is a key regulator of phosphate homeostasis. There are two predominant renal sodium phosphate cotransporters, NaPi2a and NaPi2c. Both are regulated by parathyroid hormone (PTH), which decreases the abundance of the NaPi cotransporters in the apical membrane of renal proximal tubule cells. The time course of PTH-induced removal of the two cotransporters from the apical membrane, however, is markedly different for NaPi2a compared with NaPi2c. In animals and in cell culture, PTH treatment ...
Tópico(s): Erythrocyte Function and Pathophysiology
2011 - American Physical Society | AJP Cell Physiology
Yves Sabbagh, Héctor Giral, Yupanqui Caldas, Moshe Levi, Susan C. Schiavi,
Phosphate is absorbed in the small intestine by a minimum of 2 distinct mechanisms: paracellular phosphate transport which is dependent on passive diffusion, and active transport which occurs through the sodium-dependent phosphate cotransporters. Despite evidence emerging for other ions, regulation of the phosphate-specific paracellular pathways remains largely unexplored. In contrast, there is a growing body of evidence that active transport through the sodium-dependent phosphate cotransporter, ...
Tópico(s): Magnesium in Health and Disease
2011 - Elsevier BV | Advances in Chronic Kidney Disease
Héctor Giral, Luca Lanzanò, Yupanqui Caldas, Judith Blaine, Jill W. Verlander, Tim C. Lei, Enrico Gratton, Moshe Levi,
The sodium-dependent phosphate (Na/P(i)) transporters NaPi-2a and NaPi-2c play a major role in the renal reabsorption of P(i). The functional need for several transporters accomplishing the same role is still not clear. However, the fact that these transporters show differential regulation under dietary and hormonal stimuli suggests different roles in P(i) reabsorption. The pathways controlling this differential regulation are still unknown, but one of the candidates involved is the NHERF family ...
Tópico(s): Ion Transport and Channel Regulation
2011 - Elsevier BV | Journal of Biological Chemistry
Yupanqui Caldas, Héctor Giral, Vı́ctor Sorribas, Moshe Levi,
New pharmaceutical research approaches are focusing on trying to alleviate the perturbed phosphate (Pi) homeostasis associated with the onset of chronic kidney disease; this includes activation of some of the nuclear receptors. We have recently reported the down regulation of the intestinal and renal sodium-phosphate (NaPi) cotransporters by the liver X receptor (LXR) agonists, and the consequent decrease of the serum Pi levels. In this review, we describe our current knowledge of the different proteins ...
Tópico(s): Parathyroid Disorders and Treatments
2013 - Karger Publishers | Contributions to nephrology
Judith Blaine, Luca Lanzanò, Héctor Giral, Yupanqui Caldas, Moshe Levi, Enrico Gratton, Radu Moldovan, Tim C. Lei,
Although in vivo and cell culture studies have provided useful information about the regulation of the sodium phosphate (NaPi) cotransporters, such studies are unable to provide information at the molecular level about interactions between proteins. The NaPi proteins are found within both intestinal and renal brush border microvilli, and previous work has shown that these microvilli contain scaffolding proteins (PDZ proteins) and myosin motors. The recent development of several advanced imaging techniques ...
Tópico(s): Magnesium in Health and Disease
2011 - Elsevier BV | Advances in Chronic Kidney Disease
Judith Blaine, Kayo Okamura, Héctor Giral, Sophia Y. Breusegem, Yupanqui Caldas, Andrew C. Millard, Nicholas P. Barry, Moshe Levi,
Parathyroid hormone (PTH) plays a critical role in the regulation of renal phosphorous homeostasis by altering the levels of the sodium-phosphate cotransporter NaPi2a in the brush border membrane (BBM) of renal proximal tubular cells. While details of the molecular events of PTH-induced internalization of NaPi2a are emerging, the precise events governing NaPi2a removal from brush border microvilli in response to PTH remain to be fully determined. Here we use a novel application of total internal reflection ...
Tópico(s): Erythrocyte Function and Pathophysiology
2009 - American Physical Society | AJP Cell Physiology
Héctor Giral, DeeAnn Cranston, Luca Lanzanò, Yupanqui Caldas, Eileen Sutherland, Joanna Rachelson, Evgenia Dobrinskikh, Edward J. Weinman, R. Brian Doctor, Enrico Gratton, Moshe Levi,
P(i) uptake in the small intestine occurs predominantly through the NaPi-2b (SLC34a2) co-transporter. NaPi-2b is regulated by changes in dietary P(i) but the mechanisms underlying this regulation are largely undetermined. Sequence analyses show NaPi-2b has a PDZ binding motif at its C terminus. Immunofluorescence imaging shows NaPi-2b and two PDZ domain containing proteins, NHERF1 and PDZK1, are expressed in the apical microvillar domain of rat small intestine enterocytes. Co-immunoprecipitation ...
Tópico(s): Ion Transport and Channel Regulation
2012 - Elsevier BV | Journal of Biological Chemistry
... in dietary potassium deficiencySophia Y. Breusegem, Hideaki Takahashi, Hector Giral-Arnal, Xiaoxin Wang, Tao Jiang, Jill W. Verlander, Paul Wilson, Shinobu Miyazaki-Anzai, Eileen Sutherland, Yupanqui Caldas, Judith T. Blaine, Hiroko Segawa, Ken-ichi ...
Tópico(s): Medical Imaging and Pathology Studies
2008 - American Physical Society | AJP Renal Physiology
Sophia Y. Breusegem, Hideaki Takahashi, Hector Giral‐Arnal, Xiaoxin Wang, Tao Jiang, Jill W. Verlander, Paul Wilson, Shinobu Miyazaki‐Anzai, Eileen Sutherland, Yupanqui Caldas, Judith Blaine, Hiroko Segawa, Ken–ichi Miyamoto, Nicholas P. Barry, Moshe Levi,
Dietary potassium (K) deficiency is accompanied by phosphaturia and decreased renal brush border membrane (BBM) vesicle sodium (Na)-dependent phosphate (P i ) transport activity. Our laboratory previously showed that K deficiency in rats leads to increased abundance in the proximal tubule BBM of the apical Na-P i cotransporter NaPi-IIa, but that the activity, diffusion, and clustering of NaPi-IIa could be modulated by the altered lipid composition of the K-deficient BBM (Zajicek HK, Wang H, Puttaparthi ...
Tópico(s): Magnesium in Health and Disease
2009 - American Physical Society | AJP Renal Physiology
Tomás Caycho‐Rodríguez, Daniel E. Yupanqui-Lorenzo, Héctor Sánchez Carlessi, Carlos Reyes Romero, Patricia Matos Ramírez, Carlos Carbajal-León, Lindsey W. Vilca, Pablo D. Valencia, José Ventura‐León, Mario Reyes-Bossio, Mariel Delgado-Campusano, Miguel Gallegos, Rodrigo Moreta‐Herrera, Diana Ximena Puerta-Cortés, Andrés Camargo, Júlio Torales, Daniela Ferrufino-Borja, Águeda Muñoz del Carpio Toia, Marion K. Schulmeyer, Jesús Ayala-Colqui, Nicol A. Barria‐Asenjo, Luis Hualparuca‐Olivera, Iván Barrios,
Tópico(s): COVID-19 and Mental Health
2025 - Drustvo Psihologa Srbije | Psihologija
Yupanqui Caldas, Héctor Giral, Eileen Sutherland, Vı́ctor Sorribas, Judith Blaine, Kayo Okamura, Moshe Levi,
The Liver X Receptor (LXR) agonists have shown to modulate the lipid composition of different tissues including the vascular tissue and kidney. Since dyslipidemia has been associated with chronic kidney disease (CKD) and hyperphosphatemia is a consequence of CKD, we used both an in vitro and in vivo system to study the effect of the LXR agonists on renal NaPi cotransport protein regulation given their important role in maintaining Pi homeostasis. C57BL/6 mice fed chronically with either of the LXR ...
Tópico(s): Ion Transport and Channel Regulation
2010 - Wiley | The FASEB Journal
Luca Lanzanò, Yupanqui Caldas, Héctor Giral, Michelle A. Digman, Moshe Levi, Enrico Gratton,
Intestinal phosphate (Pi) uptake is one of the key mechanisms of systemic Pi homeostasis. Modulation of intestinal Pi transport has been recently recognized as an important target in prevention of hyperphosphatemia and the associated cardiovascular complications in Chronic Kidney Disease. Intestinal Pi absorption is mainly mediated by the type IIb sodium-phosphate co-transporter NaPi2b which is expressed in the intestinal apical microvilli. Recent evidences show that agonists of the LXR nuclear hormone ...
Tópico(s): Biomedical Research and Pathophysiology
2012 - Elsevier BV | Biophysical Journal
Luca Lanzanò, Yupanqui Caldas, Héctor Giral, Michelle A. Digman, Moshe Levi, Enrico Gratton,
Intestinal phosphate (Pi) uptake is a key mechanism in systemic Pi homeostasis. Modulation of intestinal Pi transport has been recently recognized as an important target in prevention of hyperphosphatemia and the associated cardiovascular complications in Chronic Kidney Disease. Intestinal Pi absorption is mainly mediated by the sodium‐phosphate co‐transporter NaPi2b expressed in the intestinal apical microvilli. Recent evidences show that agonists of the LXR nuclear hormone receptor inhibit intestinal ...
Tópico(s): Magnesium in Health and Disease
2012 - Wiley | The FASEB Journal
Héctor Giral, Yupanqui Caldas, Luca Lanzanò, Enrico Gratton, Eileen Sutherland, Judith Blaine, Kayo Okamura, Jill W. Verlander, Moshe Levi,
The Na‐dependent phosphate (NaPi) transporters NaPi‐2a and NaPi‐2c play a major role in the renal reabsorption of Pi and maintenance of Pi homeostasis. The transporters show differential regulation under dietary and hormonal stimuli suggesting different regulatory pathways controlling the endocytosis, stability, or functionality of the transporters. The scaffolding NHERF family of PDZ proteins has been involved in the regulation of NaPi‐2a and NaPi‐2c. We propose that differences in the molecular ...
Tópico(s): Biomedical Research and Pathophysiology
2010 - Wiley | The FASEB Journal
Kayo Okamura, Héctor Giral, Yupanqui Caldas, Eileen Sutherland, Andrew C. Millard, Moshe Levi, Judith Blaine,
Parathyroid hormone (PTH) is a critical regulator of renal phosphate (Pi) homeostasis. In the kidney Pi reabsorption is regulated by the sodium phosphate cotransporters NaPi2a and NaPi2c. It has previously been shown that PTH‐induced removal of NaPi2c from the renal proximal tubule brush border membrane (BBM) is approximately 3 times slower than that of NaPi2a. The reason for this is unknown. Using a novel application of total internal reflection fluorescence microscopy (TIR‐FM) to the apical membrane ...
Tópico(s): Renal and related cancers
2010 - Wiley | The FASEB Journal
Héctor Giral, Yupanqui Caldas, Luca Lanzanò, Enrico Gratton, Moshe Levi,
NHERF- 1 Modulates Intestinal NaPi transporter NaPi-2b expression in Apical Microvilli. H. Giral 1 , Y. Caldas 1 , L. Lanzano 2 , E. Gratton 2 , M. Levi 1 ; 1 University of Colorado Denver, Aurora, CO, 2 University of California Irvine, CA The regulation of phosphate (Pi) homeostasis is maintained by the coordinated function of the renal and intestinal phosphate transporters. Several PDZ (PSD-95/discs large/ZO-1 homologous) domain proteins, including NHERF‐1, PDZK1, ShanK2, and PIST play an important role in ...
Tópico(s): Magnesium in Health and Disease
2011 - American Society for Cell Biology | Molecular Biology of the Cell
Sabina Jeleń, Héctor Giral, Yupanqui Caldas, Eileen Sutherland, Moshe Levi,
Renal Pi reabsorption has been considered the main mechanism controlling Pi homeostasis. However, recently small intestine Pi absorption has emerged as a putative pharmacological target for the control of hyperphosphatemia, especially important in the setting of chronic kidney disease. We have recently reported that activation of Liver X Receptor (LXR) with LXR agonists leads to a decreased serum Pi concentration and increased urinary Pi excretion. In parallel, these changes were associated with ...
Tópico(s): Biomedical Research and Pathophysiology
2013 - Wiley | The FASEB Journal
Zien Zhou, Meg Jardine, Qiang Li, Brendon L. Neuen, Christopher P. Cannon, Dick de Zeeuw, Robert Edwards, Adeera Levin, Kenneth W. Mahaffey, Vlado Perkovic, Bruce Neal, Richard I. Lindley, Rodolfo Andrés Ahuad Guerrero, Diego Aizenberg, Juan Pablo Albisu, Andres Alvarisqueta, Ines Bartolacci, Mario Alberto Berli, Anselmo P. Bordonava, Pedro Calella, Maria Cecilia Cantero, Luis Cartasegna, Esteban Cercos, Gabriela Cecilia Coloma, Hugo Colombo, Victor Commendatore, Jesus Cuadrado, Carlos Alberto Cuneo, Ana María Cusumano, Walter Douthat, Ricardo D. Dran, Eduardo Farias, María Florencia Fernández, Hernan Finkelstein, Guillermo Fragale, Jose Osvaldo Fretes, Néstor H. García, Anibal Gastaldi, Elizabeth Gelersztein, Jorge Archibaldo Glenny, Joaquin Pablo Gonzalez, Patricia del Carmen Gonzalez Colaso, Claudia Goycoa, Gustavo Greloni, Adrián Guinsburg, Sonia Hermida, Luis I. Juncos, Maria Isabel Klyver, Florencia Kraft, Fernando Krynski, Paulina Virginia Lanchiotti, Ricardo Alfonso Leon de la Fuente, Nora Marchetta, Pablo G. Mele, Silvia Nicolai, P. Novoa, Silvia Ines Orio, Fabián Otreras, Alejandra Oviedo, Pablo Raffaele, Jorge Hector Resk, Lucas Rista, Nelson Papini, Jorgelina Sala, Juan Carlos Santos, Lilia Beatriz Schiavi, Horacio Sessa, Tomas Smith Casabella, María Rosa Ulla, María Valdez, Augusto Vallejos, Adriana Villarino, Virginia Esther Visco, Alfredo Wassermann, Cesar Javier Zaidman, N. Wah Cheung, Carolyn Droste, I. W. Fraser, David W. Johnson, Peak Mann Mah, Kathy Nicholls, David Packham, Joseph Proietto, A. J. Roberts, Simon D. Roger, Venessa Tsang, Roberto Abrão Raduan, Fernando Augusto Alves da Costa, Celso Amodeo, Luiz Alberto Andreotti Turatti, Rachel Bregman, Fernanda Cristina Camelo Sanches, Luís Henrique Santos Canani, Antônio Roberto Chacra, João Borges, Sérgio Vencio, Roberto Jorge da Silva Franco, Domingos O. d’Avila, Evandro de Souza Portes, Pedro de Souza, Luciane Mônica Deboni, Fadlo Fraige Filho, Bruno Geloneze Neto, Marcus Vinícius Peinado Gomes, Suely Keiko Kohara, Elizete Keitel, José Francisco Kerr Saraiva, Hugo Roberto Kurtz Lisbôa, Fabiana Loss de Carvalho Contieri, Rosângela Milagres, Renan Magalhães Montenegro, Claudia Moreira de Brito, Miguel Nasser Hissa, Ângela Regina Nazario Sabbag, Irene de Lourdes Noronha, Daniel Panarotto, Roberto Pecoits–Filho, Márcio Antônio Pereira, Wladmir Faustino Saporito, Antônio Scafuto Scotton, Tiago Schuch, Roberto Simões de Almeida, Cássio Slompo Ramos, João Soares Felício, Fernando Saldanha Thomé, Jean Carlo Tibes Hachmann, Sérgio Yamada, C Y Hayashida, Tarissa Beatrice Zanata Petry, Maria Teresa Zanella, Viktoria Andreeva, Angelina Angelova, Stefan Dimitrov, Veselka Genadieva, Gabriela Genova-Hristova, Kiril Hristozov, Zdravko Kamenov, Atanas Koundurdjiev, L Lozanov, Viktor Margaritov, Boyan Nonchev, Rangel Rangelov, Alexander Shinkov, Margarita Temelkova, Ekaterina Velichkova, Andrian Yakov, Naresh Aggarwal, Ronnie Aronson, Harpreet S. Bajaj, David Z.I. Cherney, Guy Chouinard, James Conway, Serge Cournoyer, Gerald DaRoza, Sacha De Serres, François Dubé, Ronald Goldenberg, Anil Gupta, Milan Gupta, Sam Henein, Hasnain Khandwala, Lawrence A. Leiter, François Madore, Alan W. McMahon, Norman Muirhead, Vincent Pichette, Rémi Rabasa‐Lhoret, Andrew Steele, Navdeep Tangri, Ali Torshizi, Vincent Woo, Nadia Zalunardo, María Alicia Fernández Montenegro, Juan Gonzalo Godoy Jorquera, Marcelo Medina Fariña, Victor Saavedra Gajardo, Margarita Véjar, Nan Chen, Qinkai Chen, Shenglian Gan, Yaozhong Kong, Detian Li, Wenge Li, Xuemei Li, Hongli Lin, Jian Liu, Weiping Lu, Mao Hong, Yan Ren, Weihong Song, Jiao Sun, Lin Sun, Ping Tu, Guixia Wang, Jinkui Yang, Aiping Yin, Xueqing Yu, Ming‐Hui Zhao, Hongguang Zheng, J.L. Mendoza, Édgar Arcos, Jorge Avendaño, Jorge Ernesto Andres Diaz Ruiz, Luis Hernando Garcia Ortiz, Alexander Lebrato González, Eric Hernandez Triana, Juan Diego Higuera, Natalia Malaver, Dora I. Molina, Ricardo Rosero, Monica Alexandra Terront Lozano, Luis Alfonso Valderrama Cometa, Álex Valenzuela, Ruben Dario Vargas Alonso, Iván Villegas, Hernan Yupanqui, Dagmar Bartášková, P. Bartoň, Jana Bělobrádková, Lenka Dohnalová, Tomas Drasnar, Richard Ferkl, Katarina Halčiaková, Vera Klokocnikova, Richard Kovar, Jiří Laštůvka, Martin Lukáč, Satu Sinikka Pešičková, Karel Peterka, Jiri Pumprla, Ivan Rychlík, F Saudek, Vladimı́r Tesař, Martin Vališ, Pavel Weiner, Stanislav Zemek, É. Alamartine, Sophie Borot, Bertrand Cariou, Bertrand Dussol, Jean‐Pierre Fauvel, Pierre Gourdy, Alexandre Klein, Yannick Le Meur, A. Penfornis, Ronan Roussel, Pierre‐Jean Saulnier, Éric Thervet, Philippe Zaoui, Volker Burst, Markus Faghih, Grit Faulmann, Hermann Haller, Reinhold Jerwan‐Keim, Stephan Maxeiner, Björn Paschen, Georg Plassmann, Ludger Rose, Ronaldo Arturo Gonzalez Orellana, Franklin Paul Haase, Juan Pablo Moreira Diaz, Luis Alberto Ramirez Roca, Jose Antonio Sánchez Arenales, José Vicente Sanchez Polo, Erick Turcios Juarez, Gyongyi Csecsei, Botond Csiky, P. Dános, L. Deák, Mihaly Dudas, Eleonóra Harcsa, Katalin Keltai, Sandor Keresztesi, Krisztián Kis, L. Könyves, Lajos Major, Margit Miléder, Marta Molnar, János Mucsi, Tamás Oroszlán, Ivan Ory, György Paragh, Eva Péterfai, Gizella Petró, Katalin Révész, Robert Takacs, Sandor Vangel, Szilárd Vasas, Marianna Zsom, Abraham Oomman, Sree Bhushan Raju, Deepak Dewan, M. Edwin Fernando, Natarajan Gopalakrishnan, Noble Gracious, Hansraj Alva,
Chronic kidney disease with reduced estimated glomerular filtration rate or elevated albuminuria increases risk for ischemic and hemorrhagic stroke. This study assessed the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on stroke and atrial fibrillation/flutter (AF/AFL) from CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation) and a meta-analysis of large cardiovascular outcome trials (CVOTs) of SGLT2i in type 2 diabetes mellitus.CREDENCE ...
Lippincott Williams & Wilkins
Tae Won Yi, Brendan Smyth, Gian Luca Di Tanna, Clare Arnott, Kathryn Cardoza, Amy Kang, Carol A. Pollock, Rajiv Agarwal, George L. Bakris, David M. Charytan, Dick de Zeeuw, Hiddo J.L. Heerspink, Bruce Neal, David C. Wheeler, Christopher P. Cannon, Hong Zhang, Bernard Zinman, Vlado Perkovic, Adeera Levin, Kenneth W. Mahaffey, Meg Jardine, Vlado Perkovic, Kenneth W. Mahaffey, Rajiv Agarwal, George L. Bakris, Barry M. Brenner, Christopher P. Cannon, David M. Charytan, Dick de Zeeuw, Tom Greene, Meg Jardine, Hiddo J.L. Heerspink, Adeera Levin, Gary Meininger, Bruce Neal, Carol A. Pollock, David C. Wheeler, Hong Zhang, Bernard Zinman, Meg Jardine, Hiddo J.L. Heerspink, David M. Charytan, Nicole Li, Inna Kolesnyk, Diego Aizenberg, Roberto Pecoits–Filho, Adeera Levin, David Z.I. Cherney, Gregorio T. Obrador, Glenn M. Chertow, Tara I. Chang, Carmel M. Hawley, Linong Ji, Hong Zhang, Takashi Wada, Vivekanand Jha, Soo Kun Lim, Mary Anne Lim-Abrahan, Florence Santos, Dong-Wan Chae, Shang‐Jyh Hwang, Evgueniy Vazelov, Ivan Rychlík, Samy Hadjadj, Vera Krane, László Rosivall, Luca De Nicola, Alexander Dreval, Michał Nowicki, Adalbert Schiller, Larry A. Distiller, José Luis Górriz, Mykola Kolesnyk, David, Caroline P. D. Wheeler, Rodolfo Andrés Ahuad Guerrero, Diego Aizenberg, Juan Pablo Albisu, Andres Alvarisqueta, Ines Bartolacci, Mario Alberto Berli, Anselmo P. Bordonava, Pedro Calella, Maria Cecilia Cantero, Luis Cartasegna, Esteban Cercos, Gabriela Cecilia Coloma, Hugo Colombo, Victor Commendatore, Jesus Cuadrado, Carlos Alberto Cuneo, Ana María Cusumano, Walter Douthat, Ricardo D. Dran, Eduardo Farias, María Florencia Fernández, Hernan Finkelstein, Guillermo Fragale, Jose Osvaldo Fretes, Néstor H. García, Anibal Gastaldi, Elizabeth Gelersztein, Jorge Archibaldo Glenny, Joaquin Pablo Gonzalez, Patricia del Carmen Gonzalez Colaso, Claudia Goycoa, Gustavo Greloni, Adrián Guinsburg, Sonia Hermida, Luis I. Juncos, Maria Isabel Klyver, Florencia Kraft, Fernando Krynski, Paulina Virginia Lanchiotti, Ricardo Alfonso Leon de la Fuente, Nora Marchetta, Pablo G. Mele, Silvia Nicolai, P. Novoa, Silvia Ines Orio, Fabián Otreras, Alejandra Oviedo, Pablo Raffaele, Jorge Hector Resk, Lucas Rista, Nelson Papini, Jorgelina Sala, Juan Carlos Santos, Lilia Beatriz Schiavi, Horacio Sessa, Tomas Smith Casabella, María Rosa Ulla, María Valdez, Augusto Vallejos, Adriana Villarino, Virginia Esther Visco, Alfredo Wassermann, Cesar Javier Zaidman, N. Wah Cheung, Carolyn Droste, I. W. Fraser, David Johnson, Peak Mann Mah, Kathy Nicholls, David Packham, Joseph Proietto, A. J. Roberts, Simon D. Roger, Venessa Tsang, Roberto Abrão Raduan, Fernando Augusto Alves da Costa, Celso Amodeo, Luiz Alberto Andreotti Turatti, Rachel Bregman, Fernanda Cristina Camelo Sanches, Luís Henrique Santos Canani, Antônio Roberto Chacra, João Borges, Sérgio Vencio, Roberto Jorge da Silva Franco, Domingos O. d’Avila, Evandro de Souza Portes, Pedro de Souza, Luciane Mônica Deboni, Fadlo Fraige Filho, Bruno Geloneze Neto, Marcus Vinícius Peinado Gomes, Suely Keiko Kohara, Elizete Keitel, José Francisco Kerr Saraiva, Hugo Roberto Kurtz Lisbôa, Fabiana Loss de Carvalho Contieri, Rosângela Milagres, Renan Magalhães Montenegro, Claudia Moreira de Brito, Miguel Nasser Hissa, Ângela Regina Nazario Sabbag, Irene L. Noronha, Daniel Panarotto, Roberto Pecoits–Filho, Márcio Antônio Pereira, Wladmir Faustino Saporito, Antônio Scafuto Scotton, Tiago Schuch, Roberto Simões de Almeida, Cássio Slompo Ramos, João Soares Felício, Fernando Saldanha Thomé, Jean Carlo Tibes Hachmann, Sérgio Yamada, C Y Hayashida, Tarissa Beatrice Zanata Petry, Maria Teresa Zanella, Viktoria Andreeva, Angelina Angelova, Stefan Dimitrov, Veselka Genadieva, Gabriela Genova-Hristova, Kiril Hristozov, Zdravko Kamenov, Atanas Koundurdjiev, L Lozanov, Viktor Margaritov, Boyan Nonchev, Rangel Rangelov, Alexander Shinkov, Margarita Temelkova, Ekaterina Velichkova, Andrian Yakov, Naresh Aggarwal, Ronnie Aronson, Harpreet S. Bajaj, David Z.I. Cherney, Guy Chouinard, James Conway, Serge Cournoyer, Gerald DaRoza, Sacha De Serres, François Dubé, Ronald Goldenberg, Anil Gupta, Milan Gupta, Sam Henein, Hasnain Khandwala, Lawrence A. Leiter, Adeera Levin, François Madore, Alan W. McMahon, Norman Muirhead, Vincent Pichette, Rémi Rabasa‐Lhoret, Andrew Steele, Navdeep Tangri, Ali Torshizi, Vincent Woo, Nadia Zalunardo, María Alicia Fernández Montenegro, Juan Gonzalo Godoy Jorquera, Marcelo Medina Fariña, Victor Saavedra Gajardo, Margarita Véjar, Nan Chen, Qinkai Chen, Shenglian Gan, Yaozhong Kong, Detian Li, Wenge Li, Xuemei Li, Hongli Lin, Jian Liu, Weiping Lu, Mao Hong, Yan Ren, Weihong Song, Jiao Sun, Lin Sun, Ping Tu, Guixia Wang, Jinkui Yang, Aiping Yin, Xueqing Yu, Ming‐Hui Zhao, Hongguang Zheng, J.L. Mendoza, Édgar Arcos, Jorge Avendaño, Jorge Ernesto Andres Diaz Ruiz, Luis Hernando Garcia Ortiz, Alexander Lebrato González, Eric Hernandez Triana, Juan Diego Higuera, Natalia Malaver, Dora I. Molina, Ricardo Rosero, Monica Alexandra Terront Lozano, Luis Alfonso Valderrama Cometa, Álex Valenzuela, Ruben Dario Vargas Alonso, Iván Villegas, Hernan Yupanqui, Dagmar Bartášková, P. Bartoň, Jana Bělobrádková, Lenka Dohnalová, Tomas Drasnar, Richard Ferkl, Katarina Halčiaková, Vera Klokocnikova, Richard Kovar, Jiří Laštůvka, Martin Lukáč, Satu Sinikka Pešičková, Karel Peterka, Jiri Pumprla, Ivan Rychlík, F Saudek,
It is unclear whether the effect of canagliflozin on adverse kidney and cardiovascular events in those with diabetic kidney disease varies by age and sex. We assessed the effects of canagliflozin among age group categories and between sexes in the Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) study.Secondary analysis of a randomized controlled trial.Participants in the CREDENCE trial.Participants were randomly assigned to receive canagliflozin ...
Elsevier BV
Eduardo Cabrera, Héctor O. Ventura, A. Yupanqui, V. Ccahuana, H. Oslin,
Among mandibular tumors ameloblastoma is a common disease in maxillofacial surgery in Peru, it is described as a local growth, aggressive and invasive with considerable potential for recurrence, so that clinical integration, imaging and histopathologic directs us to establish a diagnose to determine treatment. With knowledge of maxillofacial surgical techniques, we used a partial mandibulectomy with immediate reconstruction based on a free autologous bone graft followed by rehabilitation with osseointegrated ...
Tópico(s): Periodontal Regeneration and Treatments
2011 - Elsevier BV | International Journal of Oral and Maxillofacial Surgery
Segundo Eloy Tuesta Bardalez, Héctor Villegas Chávez, Orlando Roberto Yupanqui Linares,
Objetivo: Determinar la relación entre los beneficios tributarios del sector agrario y el desarrollo económico-social peruano. Método: El estudio se basó en el método analítico y sintético de las relaciones de las variables cuantitativas investigadas bajo un diseño no experimental, utilizando como técnicas el análisis documental y el modelo estadístico de la correlación canónica, considerando la información pública en un periodo transversal (2005-2019). Resultados: El indicador de Hotellings evidencia ...
Tópico(s): Business, Innovation, and Economy
2021 - National University of San Marcos | Quipukamayoc
Hector Giral‐Arnal, Paul Wilson, Eileen Sutherland, Sophia Y. Breusegem, Yupanqui Caldas, Nicholas P. Barry, Tao Jiang, Xiaoxin Wang, Moshe Levi,
Elevated serum phosphate (Pi) remains a clinical challenge in patients with chronic kidney disease. However, Pi absorption mechanism in the small intestine is not fully understood. NaPi‐2b was identified as the main transporter responsible for intestinal Pi absorption. In mice NaPi‐2b expression concentrates mainly in the ileum. In contrast, rat NaPi‐2b mRNA and protein is expressed in jejunum and duodenum with negligible amounts in ileum, a pattern similar to humans. We report expression of another ...
Tópico(s): Potassium and Related Disorders
2009 - Wiley | The FASEB Journal
... MIGUEL, MARTÍNEZ SAUL, RÚA CATALINA, OLARTE CARLOS MARIO, YUPANQUI HERNÁN, ROSERO OSCAR, FLÓREZ SANDRA) E-8 IMPACTO ... DEBUT DE HIPOTIROIDISMO (OSORIO CORREA CINDY VERÓNICA, HERNÁNDEZ HÉCTOR, OCAMPO JOSE MAURICIO) E-24 CARCINOMA SUPRARRENAL CON ...
Tópico(s): Medical research and treatments
2019 - | Acta Médica Colombiana