Produção Nacional
Revisado por pares
Patrícia Mendonça Pauletti, Helder Lopes Teles, Dulce Helena Siqueira Silva, Ângela R. Araújo, Vanderlan da Silva Bolzani,
The Styracaceae contains 11 genera and approximately 160 species consisting of small trees and shrubs, mostly native to tropical and subtropical regions. This family is well-known by the genus Styrax, which is notorious due to the production of resinous material, a pathological product, harvested by making incisions into the tree’s bark. The gum is used in perfumes, as antiseptic, expectorant, incense, and fumigating material. This paper reviews the phytochemical and biological studies carried out ...
Tópico(s): Phytochemistry and Biological Activities
2006 - Springer Science+Business Media | Revista Brasileira de Farmacognosia
Produção Nacional
Revisado por pares
Helder Lopes Teles, Renata Sordi, Geraldo Humberto Silva, Ian Castro‐Gamboa, Vanderlan da Silva Bolzani, Ludwig H. Pfenning, Lucas M. Abreu, Claudio M. Costa‐Neto, Maria Cláudia Marx Young, Ângela R. Araújo,
Tópico(s): Mycotoxins in Agriculture and Food
2006 - Elsevier BV | Phytochemistry
Produção Nacional
Revisado por pares
Geraldo Humberto Silva, Helder Lopes Teles, Lisinéia Maria Zanardi, Maria Cláudia Marx Young, Marcos N. Eberlin, Renato Moreira Hadad, Ludwig H. Pfenning, Claudio M. Costa‐Neto, Ian Castro‐Gamboa, Vanderlan da Silva Bolzani, Ângela R. Araújo,
Five cadinane sesquiterpenes derivatives were isolated by bioassay-guided fractionation from Phomopis cassiae, an endophytic fungus isolated from Cassia spectabilis. The structures of the two diastereoisomeric 3,9,12-trihydroxycalamenenes (1, 2); 3,12-dihydroxycalamenene (3); 3,12-dihydroxycadalene (4) and 3,11,12-trihydroxycadalene (5) were established on the basis of analyses of 1D and 2D NMR and HRTOFMS experiments. Antifungal activity of the isolates was evaluated against Cladosporium sphaerospermum ...
Tópico(s): Plant biochemistry and biosynthesis
2006 - Elsevier BV | Phytochemistry
Produção Nacional
Revisado por pares
Maysa L. Inácio, Geraldo Humberto Silva, Helder Lopes Teles, Henrique C. Trevisan, Alberto José Cavalheiro, Vanderlan da Silva Bolzani, Maria Cláudia Marx Young, Ludwig H. Pfenning, Ângela R. Araújo,
Tópico(s): Traditional and Medicinal Uses of Annonaceae
2006 - Elsevier BV | Biochemical Systematics and Ecology
Idalina Machado, Joana Graça, Hélder Lopes, Susana Patrícia Lopes, Maria Olívia Pereira,
This work aims at characterizing endoscope biofilm-isolated (PAI) and reference strain P. aeruginosa (PA) adhesion, biofilm formation and sensitivity to antibiotics. The recovery ability of the biofilm-growing bacteria subjected to intermittent antibiotic pressure (ciprofloxacin (CIP) and gentamicin (GM)), as well as the development of resistance towards antibiotics and benzalkonium chloride (BC), were also determined. The capacity of both strains to develop biofilms was greatly impaired in the presence ...
Tópico(s): Cystic Fibrosis Research Advances
2012 - Hindawi Publishing Corporation | ISRN Biotechnology
Produção Nacional
Revisado por pares
Renata Colombo, Andrea N. L. Batista, Helder Lopes Teles, Geraldo Humberto Silva, Giovani C. C. Bomfim, Rosilene Cristina Rossetto Burgos, Alberto José Cavalheiro, Vanderlan da Silva Bolzani, Dulce Helena Siqueira Silva, Clícia R. Pelícia, Fabiana M. Guimarães, Maria Célia H. Heimberg,
Abstract Phyllanthus niruri L., commonly known in Brazil as ‘quebra‐pedra’, has long been used in the treatment of diverse diseases and especially urolithiasis. The therapeutic effects of P. niruri are attributed to various compounds present in the plant, including the hydrolysable tannin corilagin. In the present study, high‐performance liquid chromatography (HPLC‐/PAD) profiles of leaves and commercial extracts of P. niruri were examined and three compounds, found to be present in all of the samples ...
Tópico(s): Ethnobotanical and Medicinal Plants Studies
2009 - Wiley | Biomedical Chromatography
Produção Nacional
Helder Lopes Vasconcelos, Eric Guibal, Rogério Laus, Luciano Vitali, Valfredo T. Fávere,
Chitosan microspheres cross-linked with glutaraldehyde and containing the reactive dye Orange 16 (RO 16) as a chelating agent were obtained by spray drying technique. These microspheres (CHS-RO 16) were characterized by FTIR, TGA, DSC, SEM and EDX analyses, and tested for metal adsorption. The new adsorbent was used in batch experiments to evaluate the adsorption of Cu(II) and Cd(II) ions in single and binary metal solutions. In single metal solutions, the maximum adsorption capacity for Cu(II), obtained ...
Tópico(s): Extraction and Separation Processes
2008 - Elsevier BV | Materials Science and Engineering C
Albertino Damasceno, Joana Gomes, Ana Azevedo, Carla Carrilho, Vitória Lobo, Hélder Lopes, Tavares Madede, Pius Pravinrai, Carla Silva‐Matos, Sulemane Jalla, Simon Stewart, Nuno Lunet,
Already a major cause of death and disability in high-income countries, the burden of stroke in sub-Saharan Africa is also expected to be high. However, specific stroke data are scarce from resource-poor countries. We studied the incidence, characteristics, and short-term consequences of hospitalizations for stroke in Maputo, Mozambique.Over 12 months, comprehensive data from all local patients admitted to any hospital in Maputo with a new stroke event were prospectively captured according to the ...
Tópico(s): Global Public Health Policies and Epidemiology
2010 - Lippincott Williams & Wilkins | Stroke
Produção Nacional
Geraldo Humberto Silva, Camila Martins de Oliveira, Helder Lopes Teles, Patrícia Mendonça Pauletti, Ian Castro‐Gamboa, Dulce Helena Siqueira Silva, Vanderlan da Silva Bolzani, Maria Cláudia Marx Young, Claudio M. Costa‐Neto, Ludwig H. Pfenning, Roberto G. S. Berlinck, Ângela R. Araújo,
Tópico(s): Fungal Biology and Applications
2010 - Elsevier BV | Phytochemistry Letters
Produção Nacional
Revisado por pares
Geraldo Humberto Silva, Camila Martins de Oliveira, Helder Lopes Teles, Vanderlan da Silva Bolzani, Ângela R. Araújo, Ludwig H. Pfenning, Maria Cláudia Marx Young, Claudio M. Costa‐Neto, Renato Haddad, Marcos N. Eberlin,
AN ENDOPHYTIC FUNGUS FROM Piper aduncum.A chemical study on the EtOAc extract produced by Xylaria sp., an endophytic fungus from Piper aduncum, resulted in the isolation of a new cytochalasin 1, along with five known 19,20-epoxycytochalasin D (2), C (3), N (4), Q (5), and R (6).The 1-6 were evaluated against the fungi C. cladosporioides and C. sphaerospermum and only 5 showed weak activity.The cytotoxicity in vitro against HeLA and CHO cells lines were investigated and the cytochalasins 2-4, and 6 showed ...
Tópico(s): Phytochemical compounds biological activities
2010 - Brazilian Chemical Society | Química Nova
Produção Nacional
Revisado por pares
Rogério Laus, Reginaldo Geremias, Helder Lopes Vasconcelos, Mauro C. M. Laranjeira, Valfredo T. Fávere,
Effluents from coal mining operations are not only highly acid but also depict elevated concentrations of metals which may contaminate the environment. Due to the polybasic characteristic of chitosan, this biopolymer is capable of both neutralizing and removing iron, aluminum and copper ions from such effluents. The present study aimed at evaluating the use of chitosan microspheres for their importance in continuous systems. The microspheres were prepared by the phase inversion method. Their average ...
Tópico(s): Extraction and Separation Processes
2007 - Elsevier BV | Journal of Hazardous Materials
Produção Nacional
Revisado por pares
Helder Lopes Vasconcelos, Tiago P. Camargo, Norberto S. Gonçalves, Ademir Neves, Mauro C. M. Laranjeira, Valfredo T. Fávere,
Tópico(s): Adsorption and biosorption for pollutant removal
2007 - Elsevier BV | Reactive and Functional Polymers
Produção Nacional
Revisado por pares
Helder Lopes Vasconcelos, Valfredo T. Fávere, Norberto S. Gonçalves, Mauro C. M. Laranjeira,
This study aimed at immobilizing Reactive Blue 2 (RB 2) dye in chitosan microspheres through nucleophilic substitution reaction. The adsorbent chemical modification was confirmed by Raman spectroscopy and thermogravimetric analysis. This adsorption study was carried out with Cu(II) and Ni(II) ions and indicated a pH dependence, while the maximum adsorption occurred around pH 7.0 and 8.5, respectively. The pseudo second-order kinetic model resulted in the best fit with experimental data obtained from ...
Tópico(s): Electrochemical Analysis and Applications
2007 - Elsevier BV | Reactive and Functional Polymers
Helder Lopes Ferreira, A. Costescu, A. L’Abbate, P. Minnebo, Gianluca Fulli,
The unbundling of the electricity power system will play a key role on the deployment of distributed generation (DG) in European distribution systems evolving towards Smart Grids. The present paper firstly reviews the relevant European Union (EU) regulatory framework: specific attention is paid to the concept of unbundling of power distribution sector in Europe. Afterwards, the focus is on the current state of penetration of DG technologies in the EU Member States and the corresponding interrelations ...
Tópico(s): Renewable energy and sustainable power systems
2011 - Elsevier BV | Energy Policy
Produção Nacional
Revisado por pares
Mariana Carrara Cafêu, Geraldo Humberto Silva, Helder Lopes Teles, Vanderlan da Silva Bolzani, Ângela R. Araújo, Maria Cláudia Marx Young, Ludwig H. Pfenning,
ANTIFUNGAL COMPOUNDS OF Xylaria sp., AN ENDOPHYTIC FUNGUS ISOLATED FROM Palicourea marcgravii (RUBIACEAE).Five compounds, 2-hexyl-3-methyl-butanodioic acid (1), cytochalasin D (2), 7-dechlorogriseofulvin (3), cytochalasin B (4) and griseofulvin (5), have been isolated from the endophytic fungus Xylaria sp., and their structures were elucidated on the basis of spectroscopic data.In the bioautography assay against Cladosporium cladosporioides and Cladosporium sphaerospermum, compounds 1 and 2 were found ...
Tópico(s): Mycorrhizal Fungi and Plant Interactions
2005 - Brazilian Chemical Society | Química Nova
Produção Nacional
Revisado por pares
Helder Lopes Teles, Geraldo Humberto Silva, Ian Castro‐Gamboa, Vanderlan da Silva Bolzani, José Odair Pereira, Claudio M. Costa‐Neto, Renato Haddad, Marcos N. Eberlin, Maria Cláudia Marx Young, Ângela R. Araújo,
An isolate of Curvularia sp. was obtained from the leaves of Ocotea corymbosa, a native plant of the Brazilian Cerrado. The ethyl acetate extract from culture of this fungus afforded two benzopyran derivatives: (2′S)-2-(propan-2′-ol)-5-hydroxy-benzopyran-4-one (2) and 2,3-dihydro-2-methyl-benzopyran-4,5-diol (4); and two known benzopyrans: 2-methyl-5-methoxy-benzopyran-4-one (1) and (2R)-2,3-dihydro-2-methyl-5-methoxy-benzopyran-4-one (3). The structures of 2 and 4 were established on the basis of comprehensive ...
Tópico(s): Plant tissue culture and regeneration
2005 - Elsevier BV | Phytochemistry
Produção Nacional
Revisado por pares
Geraldo Humberto Silva, Helder Lopes Teles, Henrique C. Trevisan, Vanderlan da Silva Bolzani, Maria Cláudia Marx Young, Ludwig H. Pfenning, Marcos N. Eberlin, Renato Haddad, Claudio M. Costa‐Neto, Ângela R. Araújo,
Two new metabolites, ethyl 2,4-dihydroxy-5,6-dimethylbenzoate (1) and phomopsilactone (2) were isolated from Phomopsis cassiae, an endophytic fungus in Cassia spectabilis. Their structures were elucidated by 1D and 2D NMR, MS and IR spectral data. Compounds 1 and 2 displayed strong antifungal activity against the phytopatogenic fungi Cladosporium cladosporioides and C. sphaerospermum, as well as cytotoxicity against human cervical tumor cell line (HeLa), in in vitro assays.
Tópico(s): Phytochemistry and Biological Activities
2005 - Brazilian Chemical Society | Journal of the Brazilian Chemical Society
Produção Nacional
Revisado por pares
Helder Lopes Teles, Jefferson P. Hemerly, Patrícia M. Pauletti, J. R. C. Pandolfi, Ângela R. Araújo, Sandro Roberto Valentini, Maria Cláudia Marx Young, Vanderlan da Silva Bolzani, Dulce Helena Siqueira Silva,
An ethanolic extract from the stems of Styrax camporum Pohl (Styracaceae), a plant traditionally used for gastrointestinal diseases, was fractionated and subjected to flash chromatography and afforded two benzofuran lignans, egonol and homoegonol, and one furofuran lignan, (+/-)syringaresinol, which were identified by spectral data interpretation. Their cytotoxic activities against Hep-2 (larynx epidermoid carcinoma), HeLa (human cervix carcinoma) and C6 (rat glioma) cell lines were evaluated using the MTT ( ...
Tópico(s): Biological Activity of Diterpenoids and Biflavonoids
2005 - Taylor & Francis | Natural Product Research
Nancy L. Wengenack, Hélder Lopes, Matthew J. Kennedy, Pedro Tavares, Alice S. Pereira, Isabel Moura, José J. G. Moura, Frank Rusnak,
Mycobacterium tuberculosis KatG is a multifunctional heme enzyme responsible for activation of the antibiotic isoniazid. A KatG(S315T) point mutation is found in >50% of isoniazid-resistant clinical isolates. Since isoniazid activation is thought to involve an oxidation reaction, the redox potential of KatG was determined using cyclic voltammetry, square wave voltammetry, and spectroelectrochemical titrations. Isoniazid activation may proceed via a cytochrome P450-like mechanism. Therefore, the possibility ...
Tópico(s): Drug Transport and Resistance Mechanisms
2000 - American Chemical Society | Biochemistry
Joana Gomes, Albertino Damasceno, Carla Carrilho, Vitória Lobo, Hélder Lopes, Tavares Madede, Pius Pravinrai, Carla Silva‐Matos, Domingos Diogo, Ana Azevedo, Nuno Lunet,
The effect of ambient temperature as a stroke trigger is likely to differ by type of stroke and to depend on non-transient exposures that influence the risk of this outcome. We aimed to quantify the association between ambient temperature variation and stroke, according to clinical characteristics of the events, and other risk factors for stroke. We conducted a case-crossover study based on a 1-year registry of the hospital admissions due to newly occurring ischemic and hemorrhagic stroke events ...
Tópico(s): Thermoregulation and physiological responses
2014 - Elsevier BV | Clinical Neurology and Neurosurgery
Joana Gomes, Albertino Damasceno, Carla Carrilho, Vitória Lobo, Hélder Lopes, Tavares Madede, Pius Pravinrai, Carla Silva‐Matos, Domingos Diogo, Ana Azevedo, Nuno Lunet,
The burden of stroke is increasing in developing countries that struggle to manage it efficiently. We identified determinants of early case-fatality among stroke patients in Maputo, Mozambique, to assess the impact of in-hospital complications. Patients admitted to any hospital in Maputo with a new stroke event were prospectively registered ( n = 651) according to the World Health Organization's STEPwise approach, in 2005–2006. We assessed the determinants of in-hospital and 28-day fatality, independently ...
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
2013 - SAGE Publishing | International Journal of Stroke
Joana Gomes, Albertino Damasceno, Carla Carrilho, Vitória Lobo, Hélder Lopes, Tavares Madede, Pius Pravinrai, Carla Silva‐Matos, Domingos Diogo, Ana Azevedo, Nuno Lunet,
Background Identifying locale-specific patterns regarding the variation in stroke incidence throughout the year and with atmospheric temperature may be useful to the organization of stroke care, especially in low-resource settings. Goal We aimed to describe the variation in the incidence of stroke hospitalizations across seasons and with short-term temperature variation, in Maputo, Mozambique. Methods Between August 1, 2005, and July 31, 2006, we identified 651 stroke events in Maputo dwellers, according ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2013 - Elsevier BV | Journal of Stroke and Cerebrovascular Diseases
Helder Lopes Ferreira, Raquel Garde, Gianluca Fulli, W.L. Kling, João Peças Lopes,
In the current situation with the unprecedented deployment of clean technologies for electricity generation, it is natural to expect that storage will play an important role in electricity networks. This paper provides a qualitative methodology to select the appropriate technology or mix of technologies for different applications. The multiple comparisons according to different characteristics distinguish this paper from others about energy storage systems. Firstly, the different technologies available ...
Tópico(s): Hybrid Renewable Energy Systems
2013 - Elsevier BV | Energy
Michael Preziosi, Tomás F. Zimba, Kristen Lee, Manuel Tomás, Suraida Kinlin, Clotilde Nhatave-Paiva, Rosa Bene, Tania Paunde, Hélder Lopes, Stephen Kalkhoff, Vishnu Prathap, Kevan Akrami, Emília Virginia Noormahomed, Robert T. Schooley, Eliah Aronoff‐Spencer,
Background. Bacteraemia is a common cause of fever among patients presenting to hospitals in sub-Saharan Africa. The worldwide rise of antibiotic resistance makes empirical therapy increasingly difficult, especially in resource-limited settings. Objectives. To describe the incidence of bacteraemia in febrile adults presenting to Maputo Central Hospital (MCH), an urban referral hospital in the capital of Mozambique, and characterise the causative organisms and antibiotic susceptibilities. We aimed ...
Tópico(s): Antibiotic Resistance in Bacteria
2015 - Health and Medical Publishing Group | South African Medical Journal
Over the last 15 years, several genome-scale metabolic models (GSMMs) were developed for different yeast species, aiding both the elucidation of new biological processes and the shift toward a bio-based economy, through the design of in silico inspired cell factories. Here, an historical perspective of the GSMMs built over time for several yeast species is presented and the main inheritance patterns among the metabolic reconstructions are highlighted. We additionally provide a critical perspective ...
Tópico(s): Fungal and yeast genetics research
2017 - Oxford University Press | FEMS Yeast Research
Produção Nacional
Revisado por pares
Geraldo Humberto Silva, Maria Luiza Zeraik, Camila Martins de Oliveira, Helder Lopes Teles, Henrique C. Trevisan, Ludwig H. Pfenning, Camila P. Nicolli, Maria Cláudia Marx Young, Yvonne Primerano Mascarenhas, Lucas M. Abreu, Amanda Correia Saraiva, Alexandra Ivo de Medeiros, Vanderlan da Silva Bolzani, Ângela R. Araújo,
Three new isoaigialones, A, B, and C (1–3), along with aigialone (4), were isolated from the crude EtOAc extract of a Phaeoacremonium sp., an endophytic fungus obtained from the leaves of Senna spectabilis. The structures of these compounds were elucidated based on the analysis of spectroscopic data. Compounds 2 and 4 were active against the phytopathogenic fungi Cladosporium cladosporioides and C. sphaerospermum. This is the first report of metabolites produced by an Phaeoacremonium sp., associated ...
Tópico(s): Plant biochemistry and biosynthesis
2017 - American Chemical Society | Journal of Natural Products
Produção Nacional
Juliana R. Gubiani, Michele C.S. Oliveira, Ricardo A.R. Neponuceno, Maria José de Camargo, Walmir Silva Garcez, Andressa R. Biz, Marcos Antônio Soares, Ângela R. Araújo, Vanderlan da Silva Bolzani, Helen Cristina Fávero Lisboa, Paulo Teixeira de Sousa, Leonardo Gomes de Vasconcelos, Tereza Auxiliadora Nascimento Ribeiro, Juliana Magalhães de Oliveira, Thais Petrochelli Banzato, Carolina A. de Lima, Giovanna Barbarini Longato, João M. Batista, Roberto G. S. Berlinck, Helder Lopes Teles,
Prenyl indole alkaloids constitute a diverse class of natural products with complex chemical structures and potent biological activities. Investigation of the growth medium EtOAc extract produced by the endophytic fungus Aspergillus terreus P63 collected from roots of the grass Axonopus leptostachyus, yielded the prenylated indole alkaloid, giluterrin, bearing an unprecedented carbon skeleton. The structure of giluterrin was established by analysis of spectroscopic data and HRMS. The absolute configuration ...
Tópico(s): Plant chemical constituents analysis
2019 - Elsevier BV | Phytochemistry Letters
Élvio Rúbio Gouveia, Andreas Ihle, Bruna R. Gouveia, Ana Rodrigues, Adilson Marques, Duarte Freitas, Matthias Kliegel, Ana Luísa Correia, Ricardo Alves, Hélder Lopes,
This study investigated the relation between students' attitude toward physical education (PE) and its correlates by simultaneously considering age, sex, enjoying physical activity (PA), self-perceived physically active lifestyle (PAL), self-perception of physical competence, PA, and cardiovascular fitness (CF). This cross-sectional study included 235 students (M = 15.2 ± 2.5 years). All correlates of students' attitude toward PE were assessed via questionnaires. CF was assessed by via Fitnessgram. Pearson ...
Tópico(s): Physical Education and Pedagogy
2019 - Sagamore-Venture Publishing | The Physical Educator
F. Santos, Honorato Sousa, Élvio Rúbio Gouveia, Hélder Lopes, Miguel Peralta, João Martins, Eugenia Murawska‐Ciałowicz, Grzegorz Żurek, Adilson Marques,
Objective This study aimed to systematically review and analyse intervention programs in a school context centred on the family, focused on increasing youths' physical activity. Data source The research was carried out in the PubMed, Scopus and Web of Science databases. Study inclusion criteria Studies were included if participants were children or adolescents, focusing on school-based intervention studies with parental involvement and physical activity, sedentary behaviour or physical fitness outcomes. ...
Tópico(s): Health and Lifestyle Studies
2022 - SAGE Publishing | American Journal of Health Promotion
Cíntia França, Élvio Rúbio Gouveia, Romualdo Caldeira, Adilson Marques, João Martins, Hélder Lopes, Ricardo Henriques, Andreas Ihle,
This study aimed to examine the associations between lower-body explosive strength (squat jump-SJ, and countermovement jump-CMJ), speed (10- and 35-m linear sprints), and agility (
Tópico(s): Sports injuries and prevention
2022 - Multidisciplinary Digital Publishing Institute | International Journal of Environmental Research and Public Health