A. Boué, A. Boué, M. Rozet, A. Boué, M. Reboul, A. Boué, M. Forkhammer, Mm. Marcel De Serres, A. Plantigrades, M. Scherubel, A. Boué, A. M. Boué, Colonel Ch. Silvertop, A. Boué, M. Rozet, F. G. Levrault,
... Pour Le Géologue, Animaux Invertébrés.— Mollusques Premier Genre Helice (Helix), Bulletin Bibliographique Les Ouvrages Suivans Viennent De ...
1831 - Gale Group | NCCO-STM 1of2
Nannan Zhang, Jin Jei Wu, Siping Zhang, Maoran Yuan, Hang Xu, Jie Li, Ping Zhang, Mingzhu Wang, Megan L. Kempher, Xuanyu Tao, Liqun Zhang, Honghua Ge, Yong‐Xing He,
... homodimer with each subunit consisting of a DBD (helices α1-α3) and an LBD (helices α4-α9). The DBD of PhlH contains a canonical DNA-binding helix-turn-helix motif (helices α2 and α3) with the α3 helix recognizing ... dimerization through the α6 helix and α8-α9 helices, which form a 4-helix bundle in the ... TtgR. Notably, the distance between the DNA recognition helices (α3, residues 54–57) is ∼46 Å, which ... a long interior tunnel-like cavity, surrounded by helices α4, α5, α6, α7, and α8, in a ... and F173 in the α4, α7, and α8 helices from one protomer and F178′, L186′, V190′ in ...
Tópico(s): Plant tissue culture and regeneration
2022 - Elsevier BV | Journal of Biological Chemistry
Yue Ren, Yang Li, Yaojie Wang, Tianlei Wen, Xuhang Lu, Shenghai Chang, Xing Zhang, Yuequan Shen, Xue Yang,
... heptamers with ordered or flexible long C-terminal helices at resolutions of 3.2 Å and 2. ... rerio CALHM1 octamer with flexible long C-terminal helices at a resolution of 3.5 Å. Structural ... heptamers with ordered or flexible long C-terminal helices at resolutions of 3.2 Å and 2. ... rerio CALHM1 octamer with flexible long C-terminal helices at a resolution of 3.5 Å. Structural ... analysis showed that they all have four transmembrane helices (TMs) in the monomer that form an oligomer ... suggested that interactions between the long C-terminal helices (LCHs) and the TM4-LCH linker may determine ...
Tópico(s): Advanced Memory and Neural Computing
2022 - Elsevier BV | Journal of Biological Chemistry
Denise Mehner-Breitfeld, Michael T. Ringel, Daniel Alexander Tichy, Laura Josefine Endter, Kai Steffen Stroh, Heinrich Lünsdorf, Herre Jelger Risselada, Thomas Brüser,
... a hydrophobic mismatch with the membrane, as the helices comprise only 12 consecutive hydrophobic residues; however, the ... function and assembly. We found the WT length helices functioned best, but some variation was clearly tolerated. ... membrane and—together with laterally-aligned tilted amphipathic helices—generated a deep V-shaped membrane groove. We ... a hydrophobic mismatch with the membrane, as the helices comprise only 12 consecutive hydrophobic residues; however, the ... function and assembly. We found the WT length helices functioned best, but some variation was clearly tolerated. ...
Tópico(s): RNA and protein synthesis mechanisms
2022 - Elsevier BV | Journal of Biological Chemistry
Anna-Katharina Pfitzner, Joachim Moser von Filseck, Aurélien Roux,
... they form a four-helix bundle; the longer helices, α1 and α2, form a hairpin, with the shorter helices, α3 and α4, packed against the hairpin, as ... Google Scholar] (Figure 1A ). In their open state, helices α2 and α3 merge into a single helix ... mediates the assembly and architecture of ESCRT-III helices.Cell. 2012; 151: 356-371Abstract Full Text Full ... vivo, including rings, flat spirals, open and closed helices, as well as cones. Most intriguingly, different ESCRT- ... mediates the assembly and architecture of ESCRT-III helices.Cell. 2012; 151: 356-371Abstract Full Text Full ...
Tópico(s): Extraction and Separation Processes
2021 - Elsevier BV | Trends in Cell Biology
Yuxia Zhang, Satoshi Watanabe, Akihisa Tsutsumi, Hiroshi Kadokura, Masahide Kikkawa, Kenji Inaba,
... The A, N, and P domains and transmembrane helices (TM1−TM11) are colored yellow, magenta, cyan, and ... are colored yellow, magenta, and cyan, respectively. TM helices are colored wheat. TM1 in these two structures ... E1·2Ca2+ state, all cytosolic domains and TM helices, including TM11 and the luminal extension tail (LE), ... all Cα atoms (Fig 2A). Meanwhile, the TM helices undergo small positional shifts between the open and ... TM10. Thus, the positions and orientations of TM helices seem to be stabilized by bound Ca2+. However, ...
Tópico(s): Calcium signaling and nucleotide metabolism
2021 - Springer Nature | The EMBO Journal
D. Prakash, Matthew Dwyer, Marcos Martínez Argudo, Mengistie L. Debasu, Hassan Dibaji, M. G. Lagally, Daniel W. van der Weide, Francesca Cavallo,
... conductive nanomembranes. Our work coordinates simulations of cold helices (i.e., helices with no electron beam) and hot helices (i.e., helices that interact with an electron beam). The theoretical ... interaction devices based on self-assembled and electroplated helices will potentially provide gain-bandwidth products higher than ... Informed by the simulation results, we fabricate prototype helices for operation as slow-wave structures at THz frequencies, using metal nanomembranes. Single and intertwined double helices, as well as helices with one or two ...
Tópico(s): Photonic and Optical Devices
2020 - American Chemical Society | ACS Nano
Marius Stopp, Philipp Aloysius Steinmetz, Christopher Schubert, Christian Griesinger, Dirk Schneider, Gottfried Unden,
... DcuS of Escherichia coli is anchored by TM helices TM1 and TM2 in the membrane. Signal transmission ... DcuS of Escherichia coli is anchored by TM helices TM1 and TM2 in the membrane. Signal transmission ... diverse mechanisms, including piston-type movement of TM helices, scissor-like kinking with structural rearrangement, rotation of the TM helices, or a combination of these, has been obtained ( ... a TM domain composed of the antiparallel transmembrane helices TM1 and TM2, and a cytoplasmic PASC and ... Scopus (29) Google Scholar), and the two α-helices TM1 and TM2 of the DcuS monomer are ...
Tópico(s): Photosynthetic Processes and Mechanisms
2020 - Elsevier BV | Journal of Biological Chemistry
Hector Flores‐Romero, Uris Ros, Ana J. García‐Sáez,
... on both sides by pairs of amphipathic α-helices. This peculiar folding is strikingly similar to the ... concentration. In this model, the central hairpin of helices α5 and α6 lies on the membrane surface ... acyl chains are shown in red and protein helices by dark cylinders (top). The corresponding normalized electron ... represented with nine cylinders corresponding to its nine helices. BH3 domain and C-terminal/tail anchoring domain ... white (1ʹ–9ʹ). The relative orientation of the helices α9 remains unresolved. (C) BAX oligomers are organized ...
Tópico(s): Toxoplasma gondii Research Studies
2020 - Springer Nature | The EMBO Journal
Yihu Yang, Xiaoran Roger Liu, Zev J. Greenberg, Fengbo Zhou, Peng He, Lingling Fan, Shixuan Liu, Guomin Shen, Takeshi Egawa, Michael L. Gross, Laura G. Schuettpelz, Weikai Li,
... al, 2017). Among the proteins with four transmembrane helices (TM), tetraspanins are distinguished by the unequal size ... CD81 adopts a mushroom-like structure with five helices (named A to E); the A and E helices form the mushroom “stalk”, and B and variable ... fold with a head and stalk. The stalk helices connect to TM3 and TM4 through two hinges. ... in the EC2 groove (electrostatic surface) formed by helices A and B. Interactions stabilizing the EC1-EC2 ... show that CD53 lacks the C and D helices found in CD81. The red box indicates the ...
Tópico(s): RNA Interference and Gene Delivery
2020 - Springer Nature | The EMBO Journal
Jan Ludwiczak, Aleksander Winski, Antônio Marinho da Silva Neto, Krzysztof Szczepaniak, Vikram Alva, Stanisław Dunin-Horkawicz,
Abstract Canonical π-helices are short, relatively unstable secondary structure elements found in proteins. They comprise seven or more residues and are present ... ion-binding sites. Given their similarity to α-helices, the prediction of π-helices is a challenging task and none of the ... a neural network-based tool for predicting π-helices in protein sequences. By performing a rigorous benchmark we show that PiPred can detect π-helices with a per-residue precision of 48% and sensitivity of 46%. Interestingly, some of the α-helices mispredicted by PiPred as π-helices exhibit a ...
Tópico(s): RNA and protein synthesis mechanisms
2019 - Nature Portfolio | Scientific Reports
Chuan‐Zhi Liu, Satish Koppireddi, Hui Wang, Dan‐Wei Zhang, Zhan‐Ting Li,
... foldamers to achieve new supramolecular double and quadruple helices in the solid state. Three compounds, which bear ... to form one‐component supramolecular P and M helices, which stack to afford supramolecular double‐stranded helices. One of the double helices can dimerize to form a G‐quadruplex‐like ... to form two‐component supramolecular P and M helices, with one turn consisting of four (2+2) ... of the pyridine‐bearing molecules in two P helices and two M helices stack alternatingly to form another supramolecular quadruple helix. ...
Tópico(s): Supramolecular Chemistry and Complexes
2018 - Wiley | Angewandte Chemie International Edition
Chuan‐Zhi Liu, Satish Koppireddi, Hui Wang, Dan‐Wei Zhang, Zhan‐Ting Li,
... foldamers to achieve new supramolecular double and quadruple helices in the solid state. Three compounds, which bear ... to form one‐component supramolecular P and M helices, which stack to afford supramolecular double‐stranded helices. One of the double helices can dimerize to form a G‐quadruplex‐like ... to form two‐component supramolecular P and M helices, with one turn consisting of four (2+2) ... of the pyridine‐bearing molecules in two P helices and two M helices stack alternatingly to form another supramolecular quadruple helix. ...
Tópico(s): Supramolecular Chemistry and Complexes
2018 - Wiley | Angewandte Chemie
Alexander McPherson, Steven B. Larson,
... the four crystals. In two monoclinic crystals, two helices closely engage one another in an antiparallel fashion. ... the four crystals. In two monoclinic crystals, two helices closely engage one another in an antiparallel fashion. ... hinge sequence near the center, allowed the two helices to form an intramolecular, antiparallel duplex (3Rozek A. ... some others, implied that the arrangements of antiparallel helices likely existed in solution, and in our crystals, ... entire length. With that realization, when polyalanine α-helices were properly placed, amino acid side chains appropriate ...
Tópico(s): Protein Structure and Dynamics
2018 - Elsevier BV | Journal of Lipid Research
David C. Hooper, Andrew G. Mark, Christian Kuppe, Joel T. Collins, Peer Fischer, Ventsislav K. Valev,
... 28, 29 oligomers,30, 31 gyroids,32 and helices.33-36 Of all these examples, the latter ( ... the evaporation process in order to fabricate the helices by shadow growth. Figure 1a shows the dimensions ... can be attributed to the end of the helices, which all have identical orientation in our sample. ... is associated with the quasihexagonal array of the helices on the sample surface. The polarization–anisotropy maps ... wave plate rotation angle for the right-handed helices (in red) and the left-handed helices (in ...
Tópico(s): Quantum Mechanics and Non-Hermitian Physics
2017 - | Advanced Materials
Abiola M. Pollard, Victor Sourjik,
... of only a fluorescent protein and the TM helices of Tar to demonstrate that interactions between the lipid bilayer and transmembrane (TM) helices of Escherichia coli chemoreceptors alone are sufficient to ... on the sequence or length of the TM helices, implying that certain conformations of these helices facilitate clustering, whereas others do not. Notably, observed ... that being more than just membrane anchors, TM helices could play an important role in the clustering ... of only a fluorescent protein and the TM helices of Tar to demonstrate that interactions between the ...
Tópico(s): Escherichia coli research studies
2017 - Elsevier BV | Journal of Biological Chemistry
Tarun Narwani, Pierrick Craveur, Nicolas K. Shinada, Hubert Santuz, Joseph Rebehmed, Catherine Etchebest, B De,
... in crystals as (i) rigid macromolecules (ii) with helices, sheets and coils. However, both definitions are partial ... points, we analyzed and quantified the stability of helices by considering α-helices as well as 310- and π-helices. Molecular dynamic (MD) simulations were performed on a ... quantification showed the percentage of rigid and flexible helices that underlie unexpected behaviors. Only 76.4% of the residues associated with α-helices retain the conformation, while this tendency drops to 40.5% for 310-helices and is never observed for π-helices. α- ...
Tópico(s): Lipid metabolism and biosynthesis
2017 - University of Belgrade, University of Novi Sad | Archives of Biological Sciences
Massoud Saidijam, Sonia Azizpour, Simon G. Patching,
... numbers, lengths and amino acid compositions of transmembrane helices in 235 high-resolution structures of integral membrane proteins. The properties of 1551 transmembrane helices in the structures were compared with those obtained ... the 81 (5.2%) missing or additional transmembrane helices in the prediction results were identified. Main reasons for missing transmembrane helices were mis-identification of N-terminal signal peptides, ... or charged residues in the middle of transmembrane helices and transmembrane helices with unusual amino acid composition. ...
Tópico(s): Protein Structure and Dynamics
2017 - Taylor & Francis | Journal of Biomolecular Structure and Dynamics
D. A. Tikhonov, D. A. Tikhonov,
... angles in pairs of consecutive and connected α-helices in spatial structures of proteins is presented. A ... of protein structural organization. All pairs of connected helices were divided into three subsets according to the criterion of crossing of projections of the helices on parallel planes, which pass through the axes of the helices. It is shown that the distribution of all ... helical pairs consisting of α- and 3 10 -helices, and most pairs with the crossing projections of helices are helical pairs formed by two α-helices. ...
Tópico(s): Machine Learning in Bioinformatics
2017 - | Mathematical Biology and Bioinformatics
Elias G. Carayannis, David F. J. Campbell,
Alors que pour le modèle de la triple hélice, l’existence d’une démocratie n’est pas ( ... de connaissance et pour l’innovation, la quadruple hélice est plus explicite à ce sujet. La manière ... de système d’innovation basé sur la quadruple hélice sans démocratie ou un environnement démocratique. Les attributs et les éléments suivants définissent la quatrième hélice de la quadruple hélice : « des citoyens influencés par les médias et la ... l’innovation basée sur l’art ». La quatrième hélice de la quadruple hélice représente la perspective d’ ...
Tópico(s): Intellectual Capital and Performance Analysis
2017 - De Boeck | Innovations
PolyProline-II (PPII) helices are defined as a continuous stretch of a protein chain in which the constituent residues have backbone torsion angle ( ... structures, with their number exceeding that of π-helices, though it is considerably less than that of α-helices and β-strands. A relatively new procedure, ASSP, ... secondary structures using Cα trace identifies 3597 PPII-helices in 3582 protein chains, solved at resolution ⩽2. ... advantage of this significantly expanded database of PPII-helices, we have analyzed their structural and functional roles ...
Tópico(s): biodegradable polymer synthesis and properties
2016 - Elsevier BV | Journal of Structural Biology
Zhi Zhang, Sabareesh Subramaniam, Justin Kale, Chenyi Liao, Bo Huang, Hetal Brahmbhatt, Samson G.F. Condon, Suzanne M. Lapolla, Franklin A. Hays, Jingzhen Ding, Feng He, Xuejun C. Zhang, Jianing Li, Alessandro Senes, David W. Andrews, Jialing Lin,
... the remaining interface with α2, α3, and α4 helices was rearranged. Another dimer interface was formed inside the MOM by two intersected or parallel α9 helices. Combinations of these interfaces generated oligomers in the ... dimerization-mediated expansion. Bax protein oligomerization initiates with helices α2-α5 forming a BH3-in-groove dimer ... rearranged after α5 insertion into the membrane. α9 helices from neighboring Bax molecules form another dimer interface ... et al, 2006). The activated Bax partially embeds helices α5, α6, and α9 into the MOM as ...
Tópico(s): Mitochondrial Function and Pathology
2015 - Springer Nature | The EMBO Journal
... a C(α) trace has identified 659 π-helices in 3582 protein chains, solved at high resolution. ... advantage of this significantly expanded database of π-helices, we have analysed the functional and structural roles of π-helices and determined the position-wise amino acid propensity within and around them. These helices range from 5 to 18 residues in length ... total of 546 (~ 83%) out of 659 π-helices occur in conjunction with α-helices, with 101 π-helices being interspersed between two α-helices. The majority ...
Tópico(s): RNA and protein synthesis mechanisms
2015 - Wiley | FEBS Journal
Minttu T. Virkki, Christoph Peters, Daniel Nilsson, Therese Sörensen, Susana Cristóbal, Björn Wallner, Arne Elofsson,
The translocon recognizes transmembrane helices with sufficient level of hydrophobicity and inserts them into the membrane. However, sometimes less hydrophobic helices are also recognized. Positive inside rule, orientational preferences of and specific interactions with neighboring helices have been shown to aid in the recognition of these helices, at least in artificial systems. To better understand how the translocon inserts marginally hydrophobic helices, we studied three naturally occurring marginally hydrophobic helices, ...
Tópico(s): Cellular transport and secretion
2014 - Elsevier BV | Journal of Molecular Biology
Avradip Chatterjee, Silva Zakian, Xiaowen Hu, Martin R. Singleton,
... structural elements of the A. gossypii Wapl domain. Helices are numbered, and position of the canonical HEAT ... The fold is defined by 20 consecutive α-helices and may be divided into 3 subdomains (Figure ... 4-helix bundle capped by two anti-parallel helices at the extreme C-terminal. Three-dimensional homology ... and 3 were identified. The topology of the helices in these domains is the same as in ... K113 in ScSmc3. WIS2 constitutes two short α-helices and connecting loops that lie over the ATP- ... Smc3 projecting into the hydrophobic cavity formed by helices α16, α17, α19, and α20 (Figure 5C; Supplementary ...
Tópico(s): Photosynthetic Processes and Mechanisms
2013 - Springer Nature | The EMBO Journal
Alexey Slobozhanyuk, Mikhail Lapine, David A. Powell, Ilya V. Shadrivov, Yuri S. Kivshar, Ross C. McPhedran, Pavel A. Belov,
... of a novel metamaterial based on flexible metallic helices is reported. The helices undergo compression under the influence of incident radiation, ... achieve this goal, we use compact multi-turn helices made of thin copper wire with closely spaced ... temperature annealing increases the mechanical stability of the helices and minimizes thermal effects, while the large number ... of precise analytical description. But for multi-turn helices, we may expect a more efficient current-induced ... value. For the experiment we have used 16 helices with practically identical resonant frequencies, and we arranged ...
Tópico(s): Antenna Design and Analysis
2013 - | Advanced Materials
Caroline Koshy, Eva S. Schweikhard, Rebecca M. Gärtner, Camilo Pérez, Özkan Yıldız, Christine Ziegler,
... movement along the midsection of mainly two transmembrane helices from each inverted repeat, TM1′ (The numbering of the BetP TM helices was adapted to the LeuT numbering for better ... Resolved lipids are shown in trimeric context with helices of each chain involved in conformational changes highlighted. Lipids are closely associated with loops connecting helices involved in functional movement. Inset shows distinct elements ... the alternating access mechanism for substrate translocation. Bundle helices are in red, scaffold helices in blue and ...
Tópico(s): Peroxisome Proliferator-Activated Receptors
2013 - Springer Nature | The EMBO Journal
Ryohei Ishii, Kazunobu Isogaya, Azusa Seto, Daizo Koinuma, Yuji Watanabe, Fumio Arisaka, So-ichi Yaguchi, Hiroaki Ikushima, Naoshi Dohmae, Kohei Miyazono, Keiji Miyazawa, Ryuichiro Ishitani, Osamu Nureki,
... with the other HLH proteins and consists of helices α5 and α6, which correspond to the first and second α-helices, respectively, of the canonical HLH motif and are ... short loop L5. The N-bundle consists of helices α1 to α4 and forms extensive hydrophobic interactions ... region (Figure 2A). The C-bundle consists of helices α7 to α10 and forms extensive hydrophobic interactions ... species. These interactions anchor the N termini of helices α4 and α8, thereby stabilizing the V-shaped ... the conserved hydrophobic residues on the amphiphilic α-helices, H1 and H2 (Longo et al, 2008; Figure ...
Tópico(s): RNA modifications and cancer
2012 - Springer Nature | The EMBO Journal
Nicolae Solcan, Jane Kwok, P. W. Fowler, Alexander D. Cameron, David Drew, So Iwata, Simon Newstead,
... contain 12, but sometimes 14, trans-membrane (TM) helices. Crystal structures from several MFS transporters reveal a ... I). PepTSt adopts the canonical MFS fold with helices H1–H6 forming the N-terminal bundle and helices H7–H12 the C-terminal bundle and represents ... is tightly sealed, through the close packing of helices H1 and H2 against H7 and H8 forming ... two 6-TM bundles, PepTSt contains two other helices, HA and HB, which are inserted within the intracellular loop connecting helices H6 and H7 and pack to one side ...
Tópico(s): Amino Acid Enzymes and Metabolism
2012 - Springer Nature | The EMBO Journal