A. Boué, A. Boué, M. Rozet, A. Boué, M. Reboul, A. Boué, M. Forkhammer, Mm. Marcel De Serres, A. Plantigrades, M. Scherubel, A. Boué, A. M. Boué, Colonel Ch. Silvertop, A. Boué, M. Rozet, F. G. Levrault,
... Pour Le Géologue, Animaux Invertébrés.— Mollusques Premier Genre Helice (Helix), Bulletin Bibliographique Les Ouvrages Suivans Viennent De ...
1831 - Gale Group | NCCO-STM 1of2
Doris M. Cheng, Lou‐Sing Kan, Denise Fréchet, Paul O. P. Ts’o, Seiichi Uesugi, Toshio Shida, Morio Ikehara,
Abstract Two short DNA helices, d ‐(CpGpCpG) 2 and d ‐(CpGpCpGpCpG) 2 , in dilute salt solutions have been studied thoroughly by 1 H‐ and 31 ... the nonexchangeable proton resonances of these two short helices have been assigned by the “incremental method,” “sequential ... the sugar conformational analyses indicate that these CG helices are in the B‐form in dilute salt ... NHN hydrogen‐bonded resonances of these two helices are based on their thermal stability. The through‐ ... protons and the NHN protons in the helices were calculated and compared with the experimental values. ...
Tópico(s): Advanced biosensing and bioanalysis techniques
1984 - Wiley | Biopolymers
George Némethy, Harold A. Scheraga,
... packing of two identical collagenlike poly(tripeptide) triple helices in order to determine the energetics of favorable ... function of composition and chain length. The triple helices considered were [CH 3 CO‐(Gly‐Pro‐Pro) ... 0 of the axes of the two triple helices. For short triple helices ( n t = 3 or 4), many low‐energy ... of Ω 0 , can occur. When the triple helices are longer ( n t = 5), the only low‐ ... arrangements of two poly(Gly‐Pro‐Pro) triple helices are those with a nearly parallel orientation of ... preferred antiparallel arrangement of a pair of α‐helices. Since the preference for a parallel arrangement of ...
Tópico(s): Proteoglycans and glycosaminoglycans research
1984 - Wiley | Biopolymers
Mirjam Gerritsen, Kuo‐Chen Chou, George Némethy, Harold A. Scheraga,
... favorable packing arrangements within a group of α‐helices. The influence of side chains and of the number of interacting α‐helices on the mode of packing was analyzed. In ... the packing energy of a pair of α‐helices [Chou, K.‐C., Némethy, G. & Scheraga, H. A. ( ... been extended to treat the interactions among several helices. Also, new algorithms allow the matching of standard ... complexes and the analysis of interrelations between several helices. As a specific test case, the packing of three neighboring α‐helices, viz., the A, G, and H helices of ...
Tópico(s): Enzyme Structure and Function
1985 - Wiley | Biopolymers
V E Reyes, L. Phillips, Robert E. Humphreys, R A Lew,
... which, when coiled as alpha or 3(10) helices, had one axial, hydrophobic strip and otherwise variably ... proteins. A derivative of this algorithm (the structural helices algorithm (SHA] was tested for the prediction of helices in crystallographically defined proteins. For the SHA, eight ... and C-terminal Gly in the stability of helices. In analyses of 35 crystallographically defined proteins with known alpha and 3(10) helices, the predictions with the SHA overlapped (had overlap ... equal to 0.5) with 34% of known helices, touched (had overlap indices 0.5 greater than ...
Tópico(s): Protein Structure and Dynamics
1989 - Elsevier BV | Journal of Biological Chemistry
David J. Barlow, Janet M. Thornton,
... report we describe a general survey of all helices found in 57 of the known protein crystal ... together with a detailed analysis of 48 α-helices found in 16 of the structures that are determined to high resolution. The survey of all helices reveals a total of 291 α-helices, 71 310-helices and no examples of π-helices. The conformations of the observed helices are significantly different from the “ideal” linear structures. ... φ, ψ angles for the α- and 310-helices found in proteins are, respectively, (−62 °, −41 °) and (− ...
Tópico(s): Glycosylation and Glycoproteins Research
1988 - Elsevier BV | Journal of Molecular Biology
Shin‐ichi Terawaki, Ken Kitano, Tomoyuki Mori, Yan Zhai, Yoshiki Higuchi, Norimichi Itoh, Takashi Watanabe, Kozo Kaibuchi, Toshio Hakoshima,
... an antiparallel coiled coil with two long α-helices (α2 and α3) and a C-terminal Ex ... forming a small globular domain comprising three α-helices (α4–α6) (Figures 2C and 3). The PH ... residue linker (residues 626–629). Two long α-helices, α2 and α3, of the CC domain form extended antiparallel CC helices that are stabilized by being N-terminally capped ... by regular non-polar interactions between two intertwined helices. Ex subdomain is folded into a novel small- ... with the groove formed by α4 and α5 helices (Supplementary Figure S5A). In addition to non-polar ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2009 - Springer Nature | The EMBO Journal
Harri Lempiäinen, Thanos D. Halazonetis,
... of selected PIKKs to the C-terminal α-helices of the PI3K catalytic subunits p110α and p110γ. The boundaries of helices αK11, αK12 and αK13 of p110γ are shown ... shows a domain consisting entirely of four α-helices (Choi et al, 1996). In mTOR, this part ... further predicts that the majority of these α-helices adopt a tertiary structure similar to that of ... S. cerevisiae Tor1 (PDB file 1w1n) and of helices αK12 and αK13 of the PI3K catalytic subunit ... ATP, from the p110γ structure, is coloured orange. Helices αK11 and αK12 of p110α are coloured purple ...
Tópico(s): PI3K/AKT/mTOR signaling in cancer
2009 - Springer Nature | The EMBO Journal
Christian Neufeld, Fabian V. Filipp, Bernd Simon, Alexander Neuhaus, Nicole Schüller, Christine David, Hamed Kooshapur, Tobias Madl, Ralf Erdmann, Wolfgang Schliebs, Matthias Wilmanns, Michael Sattler,
... a three-helical fold. Pex5 and Pex19 ligand helices bind competitively to the same surface in Pex14( ... both peptides bind to an overlapping site involving helices α1 and α2 and the connecting linker (Figure ... calculated) is shown. Secondary structure elements in Pex14 (helices α1, α2, α3 and the helical linker connecting ... figure Download PowerPoint Pex14(N) comprises three α-helices, forming a three-helical bundle. Helices α1 and α2 are in an anti-parallel ... forms a scaffold diagonal across the pair of helices α1 and α2. A short helical turn is ...
Tópico(s): Insect Resistance and Genetics
2009 - Springer Nature | The EMBO Journal
Alessandro Alaimo, Juan Camilo Gómez-Posada, Paloma Aivar, Ainhoa Etxeberría, José A. Rodrı́guez-Alfaro, Pilar Areso, Álvaro Villarroel,
... binding to the C-terminal A and B helices. Here we show that the L339R mutation in ... membrane. We used glutathione S-transferase fused to helices A and B to examine the impact of ... binding to the C-terminal A and B helices. Here we show that the L339R mutation in ... membrane. We used glutathione S-transferase fused to helices A and B to examine the impact of ... Text PDF PubMed Scopus (163) Google Scholar), and helices A and B constitute the binding site for ... studied in vitro using GST fusion proteins containing helices A and B of KCNQ2 (GST-Q2AB; FIGURE ...
Tópico(s): Neuroscience and Neuropharmacology Research
2009 - Elsevier BV | Journal of Biological Chemistry
Kasuen Mauldin, Vincent Raussens, Trudy M. Forte, Robert O. Ryan,
... a model wherein apoA-V(1–146) α-helices circumscribe the perimeter of a disk-shaped bilayer. ... a model wherein apoA-V(1–146) α-helices circumscribe the perimeter of a disk-shaped bilayer. ... an up-and-down series of amphipathic α-helices wherein the hydrophobic face of each helical segment ... same time, the polar face of the amphipathic helices is directed toward the exterior of the bundle. ... promotes interaction between the hydrophobic faces of amphipathic helices and the lipid surface. Essentially, lipid binding of ...
Tópico(s): Peroxisome Proliferator-Activated Receptors
2009 - Elsevier BV | Journal of Biological Chemistry
Ricky C. Cheng, Denis B. Tikhonov, Boris S. Zhorov,
... group is stabilized at the focus of P-helices; and (iv) the nitrile group binds to a ... group is stabilized at the focus of P-helices; and (iv) the nitrile group binds to a ... domain of LTCC includes the pore-lining inner helices S6, the outer helices S5, and the P-loops from all four ... III and IV. In particular, residues in transmembrane helices IIIS5, IIIS6, and IVS6 and P-loops of ... by nucleophilic C-terminal ends of the pore helices. In the DHP-LTCC models (20Tikhonov D.B. ... and S6s from the four repeats. The P-helices and ascending limbs (positions p47–p57) were modeled ...
Tópico(s): Neuroscience and Neuropharmacology Research
2009 - Elsevier BV | Journal of Biological Chemistry
Sonia Martinez‐Caballero, Laurent M. Dejean, Michael Kinnally, Kyoung Joon Oh, Carmen A. Mannella, Kathleen W. Kinnally,
... model. Assuming the staves are two transmembrane α-helices in Bax and Bak, mature MAC pores would ... model. Assuming the staves are two transmembrane α-helices in Bax and Bak, mature MAC pores would ... Bak have multiple putative transmembrane domains; the amphipathic helices 5 and 6 of Bax are predicted to ... 2103Crossref PubMed Scopus (321) Google Scholar). Bax lacking helices 5 and 6 does not translocate to mitochondria ... structural similarities between Bax and Bak, the same helices may be important in formation of the MAC ...
Tópico(s): ATP Synthase and ATPases Research
2009 - Elsevier BV | Journal of Biological Chemistry
Voula Kanelis, Rhea P. Hudson, Patrick H. Thibodeau, Philip Thomas, Julie D. Forman‐Kay,
... MSD. Intracellular domains (ICDs) extend beyond the transmembrane helices to link the MSDs with the NBDs. The ... terminal to the NBDs that extend the transmembrane helices into the cytoplasm. Connecting these long α-helical ... the ICDs are short helical elements or coupling helices (Supplementary Figure 1a). Coupling helices 1 and 3 are located between the second and third transmembrane helices in MSD1 and MSD2, respectively. Coupling helices 2 and 4 are between the fourth and ... subdomain and is composed of two short α-helices separated by a disordered linker, most of which ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2009 - Springer Nature | The EMBO Journal
Vesselin Z. Miloushev, Joshua A. Levine, Mark A. Arbing, J.F. Hunt, Geoffrey S. Pitt, Arthur G. Palmer,
... Glu-1868 and is composed of four α-helices separated by two short anti-parallel β-strands; ... the helix II-III interhelical segment or in helices III and IV of the NaV1.2 (1777- ... Glu-1868 and is composed of four α-helices separated by two short anti-parallel β-strands; ... the helix II-III interhelical segment or in helices III and IV of the NaV1.2 (1777- ... in Table 1. The structure contains four α-helices and two short anti-parallel β-strands, consistent ... 116) Google Scholar). Comparison of interhelical angles of helices I and II of NaV1.2 CTD and ...
Tópico(s): Neuroscience and Neuropharmacology Research
2009 - Elsevier BV | Journal of Biological Chemistry
Jingzhi Li, Xinguo Qian, Junbin Hu, Bingdong Sha,
... terminal targeting sequences that form the short amphipathic helices (2.Gray M.W. Burger G. Lang B. ... of the Tom71 monomer consists of 28 α-helices (A0–A27) and no β-strands (Fig. 1, ... b). The electron densities for the loops between helices A1 and A2, A7 and A8, and A22 and A23 are missing. A majority of the helices of Tom71 form 11 TPR motifs (TPR1–TPR11). ... the Tom71 structure. The N-terminal domain covers helices A0–A7 (TPR1–TPR3), and the C-terminal domain includes helices A8–A27 (TPR4–TPR11). The N-terminal domain ...
Tópico(s): Protein Structure and Dynamics
2009 - Elsevier BV | Journal of Biological Chemistry
James R. Whittle, Thomas Schwartz,
... a tripartite fold back structure of ∼28 α-helices, distinct from the regular α-solenoid domains found ... helical blocks. A rigid block of four α-helices, residues 934–1008, forms an interface bundle that ... which are essentially all α-helical. Connections between helices were mostly visible, allowing tracing of the molecule ... chain topology and variation in the length of helices allowed us to assign each modeled helix unambiguously ... irregular α-helical stack composed of 26 α-helices and overall dimensions of 12 × 4 × 4 nm ( ...
Tópico(s): RNA modifications and cancer
2009 - Elsevier BV | Journal of Biological Chemistry
Hans Henrik Gad, Christoffer Dellgren, Ole J. Hamming, Susanne Vends, Søren R. Paludan, Rune Hartmann,
... Elements A and C–F are all α-helices, whereas element B generally is flexible and adopts a number of structures. Helices A, C, D, and F form a four- ... structure in the crystal structure of IFN-λ3. Helices A, C, D, and F constitute the typical ... that is known to form intertwined dimers, where helices E and F from one molecule pack with helices A, B, C, and D from another molecule ... with an artificial IL-10 molecule composed of helices A, B, C, and D from one molecule (residues 12–117) and the intertwined helices E and F from another molecule (residues 118– ...
Tópico(s): Immune Cell Function and Interaction
2009 - Elsevier BV | Journal of Biological Chemistry
Several types of lipid-associating helices exist: transmembrane helices such as in receptor proteins, pore-forming helices in ion channel proteins, fusion-inducing peptides in viral proteins, and amphipathic helices such as in plasma apolipoproteins. In order to propose a classification of these helices according to their molecular properties, we introduce the ... segments. The calculation of this parameter for alpha-helices enables the visualization of the hydrophobic and hydrophilic ... used this parameter to differentiate between pore-forming helices with a hydrophobic envelope larger than the hydrophilic ...
Tópico(s): Protein Structure and Dynamics
1991 - Elsevier BV | Journal of Biological Chemistry
Laura Chan, Michael Zuker, Ann B. Jacobson,
... tables to identify and sort common base paired helices that are located in identical positions in more ... information on the total number of base paired helices that are conserved between related sequences and provides detailed information about common helices that have a minimum of one or more ... and type of complementary segments (potential base paired helices) that can be found in common among related ... one another were analyzed, significant numbers of potential helices with two or more independent base changes were ...
Tópico(s): Fractal and DNA sequence analysis
1991 - Oxford University Press | Nucleic Acids Research
Rochelle R. Torgerson, R A Lew, V E Reyes, Larry W. Hardy, Robert E. Humphreys,
... this hypothesis, we fitted sequences of 247 a-helices of 55 proteins to the circular (infinite) template ... structures in 87% of four-or five-turn helices compared.We determined the longitudinal quadrant distributions of ... in the template-fitted, sheet projections of a-helices with respect to the best longitudinal, hydrophobic strip ... the N and C termini, interiors, and entire helices.Amino acids Leu, Ile, Val, and Phe were ... other amino acids and for termini of the helices were also found.a-Helices in proteins are ...
Tópico(s): Amino Acid Enzymes and Metabolism
1991 - Elsevier BV | Journal of Biological Chemistry
Mary E. Karpen, Pieter L. De Haseth, Kenneth Neet,
... dihedral angles. Several clusters, derived from 3(10)-helices and multiple-turn conformations, had strong amino acid sequence patterns not evident among alpha-helices. Aspartate occurred over twice as frequently in the N-cap position of 3(10)-helices as in the N-cap position of alpha-helices. Unlike alpha-helices, 3(10)-helices had few C-termini ending in a left- ... of hydrophobic residues among 3(10)- and alpha-helices were also apparent, producing amphipathic 3(10)-helices. Local interactions that stabilize 3(10)-helices can ...
Tópico(s): RNA and protein synthesis mechanisms
1992 - Wiley | Protein Science
K.L. Kavanagh, Mario Klimacek, Bernd Nidetzky, David K. Wilson,
... N-terminal domain (domain 1) includes 9 α-helices, 14 β-strands, and 3 310-helices (Fig. 2). The largest β-sheet is a ... domain (domain 2). Domain 2 contains 11 α-helices, 2 310-helices, and a small β-hairpin. The most important ... domains are loop regions on domain 1 and helices α10 and α15 in domain 2. In addition, ... are also labeled sequentially as A–F. α-Helices arecolored green and numbered 1–20.View Large ... 133 has a water-mediated interaction. Eleven α-helices and a small β-hairpin make up the ... divided into two subdomains. Residues 289–375 compose helices α10-α14, forming domain 2A, an antiparallel three- ...
Tópico(s): Protein Structure and Dynamics
2002 - Elsevier BV | Journal of Biological Chemistry
Christoph von Ballmoos, Yvonne Appoldt, Josef Brunner, T. Granier, Andrea Vasella, Peter Dimroth,
... accord with models in which the C-terminal helices of the c-subunits are on the outside ... tightly associated inner ring comprising the N-terminal helices is surrounded by an outer ring comprising the C-terminal helices. The outer helices are positioned within the grooves formed by the inner ring of helices leaving enough space between them to form access ... channel formed between an inner and two outer helices of the c11-ring after the rotor has ... accord with models in which the C-terminal helices of the c-subunits are on the outside ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2002 - Elsevier BV | Journal of Biological Chemistry
Hing C. Wong, Gaohua Liu, Yongmei Zhang, Charles O. Rock, Jie Zheng,
... structure is well defined and consists of four helices arranged in a right-handed bundle held together ... structure is well defined and consists of four helices arranged in a right-handed bundle held together ... Scopus (200) Google Scholar). An extended loop connects helices I and II; α helix III is short ... is located in the long loop between two helices. The solution structure was of high precision. The ... and structurally undefined carboxyl terminus. The four α-helices in the structure of AcpM comprise a “right- ...
Tópico(s): Bacteriophages and microbial interactions
2002 - Elsevier BV | Journal of Biological Chemistry
Andreas K. J. Veenendaal, Chris van der Does, Arnold J. M. Driessen,
... been built in which the positions of the helices that form the central core of the bacterial ... been built in which the positions of the helices that form the central core of the bacterial ... of the contacts suggests the presence of α-helices as the secondary structure of the investigated transmembrane ... TMS 3 of SecE were constructed as α-helices with the HyperChem (Hypercube Inc.) software, exported in ... TMS 3 of SecE, which are depicted as helices. Cysteine-substituted residues involved in SecY-SecE cross- ...
Tópico(s): Escherichia coli research studies
2002 - Elsevier BV | Journal of Biological Chemistry
Michael Godsey, Ekaterina E. Heldwein, Richard G. Brennan,
... 10418Google Scholar). The protein consists of seven α helices, six of which comprise two three-helix bundles ... adjacent major grooves, and because the two "recognition helices" have different amino acid sequences each makes a ... bend the DNA. Bending occurs because the recognition helices of MarA are separated by only 27 Å, ... an α/β protein composed of 6 α helices and 3 β strands (25Alekshun M.N. Levy ... in their dimer conformations. The major groove binding helices (the "recognition" helices) are separated by 33.3 ...
Tópico(s): Bacterial Genetics and Biotechnology
2002 - Elsevier BV | Journal of Biological Chemistry
Daniel A. Lafontaine, D. Norman, David M.J. Lilley,
... shape of the 3–4–5 junction (relating helices III–V) by electrophoresis and FRET. Estimation of the dihedral angle between helices II and V electrophoretically has allowed us to ... the substrate is docked into a cleft between helices II and VI, with its loop making a ... including a long-range loop–loop interaction between helices I and V (Rastogi et al., 1996). It ... a proposed tertiary interaction between the loops of helices I and V (Rastogi et al., 1996). (B) ... ion-induced folding into a structure in which helices III and VI are co-axially stacked, and ...
Tópico(s): RNA modifications and cancer
2002 - Springer Nature | The EMBO Journal
Dharmaraj Samuel, Yaw‐Jen Liu, Chao‐Sheng Cheng, Ping‐Chiang Lyu,
... a triangular hydrophobic cavity formed by three prominent helices. The four disulfide bonds required for stabilization of ... a triangular hydrophobic cavity formed by three prominent helices. The four disulfide bonds required for stabilization of ... stabilized by four disulfide bonds. The prominent four helices of nsLTP1 are packed against a flexible C- ... predominantly α-helical protein consisting of three prominent helices within the N-terminal 40 amino acids. The ... a stereo representation in Fig. 3 A. Three helices of rice nsLTP2 positioned at Cys3–Ala16, Thr22– ...
Tópico(s): GABA and Rice Research
2002 - Elsevier BV | Journal of Biological Chemistry