Khondaker Miraz Rahman, Higia Vassoler, C. James, David E. Thurston,
The pyrrolobenzodiazepines (PBDs) are covalent DNA minor-groove binding agents with a reported preference for binding to 5′-Pu-G-Pu sequences with their A rings oriented toward the 3′-end of the covalently modified DNA strand. Using HPLC/MS methodology and a range of designed hairpin-forming 17-mer oligonucleotides, the kinetics of reaction of a bis-pyrrole PBD conjugate (GWL-78, 2) has been evaluated with eight isomeric oligonucleotides, each containing a single PBD binding site in one of two locations. ...
Tópico(s): Cancer Treatment and Pharmacology
2010 - American Chemical Society | ACS Medicinal Chemistry Letters
Kilmara Higia Gomes Carvalho, Aluizio G. Brasi, Paulo E. Cabral Filho, Denise P. L. A. Tenório, Ana C. A. de Siqueira, Elisa Soares Leite, Adriana Fontes, Beate S. Santos,
We present here a new and alternative method that uses a Fluorescence Plate Reader in a different approach, not to study protein-protein interactions, but to evaluate the efficiency of the protein bioconjugation to quantum dots (QDs). The method is based on the QDs' native fluorescence and was successfully tested by employing two different QDs-proteins conjugation methodologies, one by promoting covalent binding and other by inducing adsorption processes. For testing, we used bioconjugates between ...
Tópico(s): Glycosylation and Glycoproteins Research
2014 - American Scientific Publishers | Journal of Nanoscience and Nanotechnology
Yibby Forero Torres, Marisol Galindo Borda, Gabriel Ramı́rez,
... en donde se preguntaron temas relacionados con condiciones higiénico-sanitarias y listas de chequeo en el ...
Tópico(s): Food Safety and Hygiene
2017 - | Revista chilena de nutrición
Felícia Marie Knaul, Patricia García, Mary Gospodarowicz, Beverley M. Essue, Naomi Lee, Richard Horton,
... non-profit organisation, from Merck Sharp & Dohme, Roche, Higia, Novartis, and Pfizer; grants to the Mexican Health ...
Tópico(s): Global Health and Surgery
2021 - Elsevier BV | The Lancet
N. García Fernández, Stella Cabral de Bejarano, Gladys Estigarribia, Analía Ortiz, Patricia Ríos,
... corte transversal cuyo objetivo fue evaluar las condiciones higiénico-sanitarias de los servicios de alimentación de ... indicaciones de inocuidad (clave 5). Se encontraron deficiencias higiénico-sanitarias en los servicios de alimentación probablemente ...
Tópico(s): Food Safety and Hygiene
2018 - Universidad Nacional de Asunción | Memorias del Instituto de Investigaciones en Ciencias de la Salud
... y relevantes de las inquietudes médicas e higiénicas, en la transformación de la enfermedad como ... hizo indispensable instruir a la familia en saberes higiénicos que actuarán mediante prácticas racionales ...
Tópico(s): Public Health and Social Inequalities
2019 - Pontifical Catholic University of Chile | Historia
David E. Thurston, Higia Vassoler, Paul J. Jackson, C. James, Khondaker Miraz Rahman,
Pyrrolobenzodiazepine (PBD) monomer GWL-78 reacts faster with DNA hairpins containing a hexaethylene glycol (HEG) loop compared to hairpins containing a TTT loop due to the greater structural flexibility of the HEG.
Tópico(s): HIV/AIDS drug development and treatment
2015 - Royal Society of Chemistry | Organic & Biomolecular Chemistry
Dael Abigail Romero, Cecilia González, Yvalena Guillén, Laura Aria, Teresa Meza, Alejandra Rojas, Belén Infanzón, María Eugenia Acosta,
... odds ratio) para establecer asociación entre las variables higiénicas, alimenticias y de conocimiento con la toxoplasmosis. ...
Tópico(s): Influenza Virus Research Studies
2017 - Universidad Nacional de Asunción | Memorias del Instituto de Investigaciones en Ciencias de la Salud
... sólidos son materiales de desecho que debemos manejar higiénica y adecuadamente dentro de la vivienda, y ... sólidos son materiales de desecho que debemos manejar higiénica y adecuadamente dentro de la vivienda, y ...
Tópico(s): Business, Innovation, and Economy
2022 - | UNESUM - Ciencias Revista Científica Multidisciplinaria
Produção Nacional
Revisado por pares
Azemar dos Santos Soares Júnior,
... da Educação -, e, no livro didático - A fada Higia -, possibilitaram entender o modelo de corpo que o ...
Tópico(s): History of Education Research in Brazil
2019 - Associação Sul-Rio-Grandense de Pesquisadores em História da Educação (ASPHE) | História da Educação
Produção Nacional
Clóvis Silveira, Fabrício Herpich, Anita Raquel da Silva, Liane Margarida Rockenbach Tarouco,
... campo conceitual. Implementou-se a agente conversacional, denominada HÍGIA, que oferece serviços de informação com vistas a ...
Tópico(s): Misinformation and Its Impacts
2023 - National Pedagogic University | Tecné Episteme y Didaxis TED
Tópico(s): Dental Trauma and Treatments
1974 - School of Dental Medicine, University of Zagreb | Acta Stomatologica Croatica
Tópico(s): Pediatric health and respiratory diseases
1974 - School of Dental Medicine, University of Zagreb | Acta Stomatologica Croatica
Estefanía M. Cáffaro-Tommasiello, María E. Latorre, Rosana Cepeda, Lorena Garitta, Miriam Sosa, Peter P. Purslow,
... puntos más importantes son la calidad sensorial, higiénico-sanitaria, disponibilidad de productos y tendencia de ...
Tópico(s): Food Safety and Hygiene
2018 - University of Tarapacá | Idesia
Mary Gospodarowicz, David A. Jaffray, Felícia Marie Knaul,
... Merck KGaA and EMD Serono, and grants from Higia, Fundacion Axa, Pfizer, Roche, and Novartis, outside the ... Merck KGaA and EMD Serono, and grants from Higia, Fundacion Axa, Pfizer, Roche, and Novartis, outside the ...
Tópico(s): Global Cancer Incidence and Screening
2020 - Elsevier BV | The Lancet Oncology
Produção Nacional
Revisado por pares
Luana P. Barreto, Francisco Mendes Neto, Marina Paiva, Raí E.T. de Freitas, Sandra R. Rocha, Bruno S. Monteiro,
... insecurity. To address this need, the mobile application Higia Way was developed, providing content on prenatal care, ... pregnant women's adherence. The study demonstrated that Higia Way offers reliable and relevant information and functionalities ...
Tópico(s): Infant Development and Preterm Care
2024 - Elsevier BV | Procedia Computer Science
... and Yuval Shany, ‘Zchuyot Hevratiot—Ra'ayon She-higia Zmano’ (Social Rights—An Idea Whose Time has ...
Tópico(s): Judicial and Constitutional Studies
2008 - Taylor & Francis | Israel Affairs
Yolanda Gil García, Salud Gallardo Martín, María Sánchez Gallardo,
... las divinidades salutiferas como Asclepio y su hija Higia (Salud), que «curaban al paciente en la ilusion ...
Tópico(s): Medicine, History, and Philosophy
2011 - | Más dermatología
José Luis Ponce Marco, Beatriz Boscá, Marina Branco Lopes Côrte Real, María Dolores San Martín, María Dessire Valls, M. Dolores Guerrero, R. M. Zaragoza,
... de Urgencias y de la base de datos HIGIA del hospital. Se analizan los casos de forma ...
Tópico(s): Pharmaceutical Practices and Patient Outcomes
2004 - Centro de Investigaciones y Publicaciones Farmaceuticas | Pharmacy Practice
Produção Nacional
Eliana Auxiliadora Magalhães Costa, Ezinete de Oliveira Dórea, Márcia Angélica Alves, Fátima Nery, Hígia Schettini, Marilene Belmonte, Valdiva Santana, Gracimara Jesus Santos, Lorena Pastor,
Objective: To analyze the technical conditions for reprocessing of medical products, in the light of service quality and sanitary safety among the users of reprocessed items. Methods: The study presents an evaluation based on multiple case studies collected in the reprocessing facilities of ten public hospitals in the State of Bahia, Brazil. The analysis is referred to five independent variables that influence conditions for reprocessing of medical products. Each of these five variables was considered ...
Tópico(s): Healthcare and Environmental Waste Management
2015 - | Revista Sobecc
Cárdenas Veliz, Jemina Elizabeth,
... calidad, como papel billetes, paA±ales, servilletas papel higiA©nico, filtros para maquinaria, textiles para hospitales (mandiles, ...
Tópico(s): Silkworms and Sericulture Research
2016 - Servicios Academicos Intercontinentales | OBSERVATÓRIO DE LA ECONOMÍA LATINOAMERICANA
Fabiola Villa Sánchez, Karla Carmen Miranda Ramos,
... aA±adidos los malos hAibitos dietA©ticos e higiA©nicos hacen que sean mayores estos casos. En ...
Tópico(s): Public Health and Environmental Issues
2017 - Servicios Academicos Intercontinentales | Revista Caribeña de Ciencias Sociales
Rafaella Dias Gonçalves, Jamille Dias Gonçalves,
... operations, like "Operation Asclepio and Operation Chalice of Higia".
Tópico(s): Public Health in Brazil
2019 - | Revista de Propriedade Intelectual- Direito Constitucional e Contemporâneo
Daniela Marino, Rocío González, Ofelia C. Flores, Ana Avendaño,
... lineamientos nacionales e internacionales relacionados con la calidad: higiénica y sanitaria, bromatológica y sensorial. Se diseñ ...
Tópico(s): Health and Lifestyle Studies
2019 - | Revista chilena de nutrición
Lilian Aguilera Céspedes, Osvaldo Oduardo Zamora, Ledianis Villalón Quintana,
... alcohol y cigarros, asA como los inadecuados hAibitos higiA©nicos entre otros; planteAindose como problema social: Â? ...
Tópico(s): Health and Lifestyle Studies
2019 - Servicios Academicos Intercontinentales | Revista Caribeña de Ciencias Sociales
Ma. Angélica Michea, Pablo Dittus, Miguel Fernández, Patricio Neira,
... utico consideró la fase sistémica, la fase higiénica con el tratamiento periodontal no quirúrgico para ...
Tópico(s): Oral microbiology and periodontitis research
2020 - | International journal of interdisciplinary dentistry
Carlos Enrique Martínez Alberto, Ángel Moisés Reyes Abreu, Silvia Murat Ruiz, Agustín Reyes Afonso, Adrián Gaona Fernández, Natalia Dóniz Ruiz, Armando Aguirre-Jaíme,
... automanejo de la medicación y los hábitos higiénico-dietéticos como herramienta fundamental para el ...
Tópico(s): Health and Lifestyle Studies
2020 - Ene | Ene
... televisión contribuyó decisivamente a mejorar los hábitos higiénicos de la población, fortalecida por el pá ...
Tópico(s): Zoonotic diseases and public health
2023 - SciELO | Revista chilena de infectología
Produção Nacional
Iraci De Souza João-Roland, Maria Elizete Kunkel, Daniel A. J. Roland,
... de caso único foi conduzido com o Projeto Hígia. Por meio de entrevistas, análise de reportagens e ...
Tópico(s): Social and Economic Solidarity
2023 - Fundação para Pesquisa e Desenvolvimento da Administração, Contabilidade e Economia (Fundace) | Revista de Administração Contabilidade e Economia da Fundace
Andrés Kalawski, Daniel Party, Cristián Opazo,
... vida queer en un estado con afán higiénico de modernidad. Su revisión abre nuevas posibilidades ...
Tópico(s): Cultural and Social Studies in Latin America
2021 - University of Chile | Revista chilena de literatura