Directory of Open Access Journals (DOAJ)
Mary Fulton, John Huxley, Malcolm Brown, Stephen Dodgson, Kieran Thomas, Paul Nelson, Richard Ellis, Sir Thomas Bazley, Edward Lucas, John Davison, Graeme Norways, Rob Hughes, John Peter, Andrew Grice Political Correspondent, Joyce Caruso, Bemard Cafferty, Eric Dymock, Helen Sharman, Dr Chris Gill, Jill Hartley, Osman Streater, John Diamond, Graham Rose, Roy Porter, Norman Howell, Nicolette Jones, Sir Percy Cradock, Diana Wright Personal Finance Editor, Carolyn Hart, Sally Payne, David Smith, Humphrey Carpenter, Bob Holmes, William Green, G. B. Trudeau, Julian Joyce, Dalbert Hallenstein, John Rowland, Janetle Marshall, Alistair SCOTT's, Edward Welsh, Allson Smith, Geordie Greig, Patrick Stoddart, Susan Marling, Robert Sandall, Ian Houston Director, Iain Johnstone, Anthony Sattin, David Brierley, Ruth Harrison, Irwin Stelzer, Keith Austin, E Jane Dickson, Ivan Fallon, Mark Ottaway, Deryk Brown, David Scott Technical Director, David Dougill, Lester May, Ysenda Maxtone Graham, Geordie Greig Arts Correspondent, Joe Irving, Cliff Temple, Gillian Raab, Michael Durham Health Services Correspondent, Merlel McCooey, Dr Elizabeth Bryan Director, Margarette Driscoll, Jane Bird Technology Editor, Susan Crosland, David Cairns, John Melmoth, Norman Harris, Julia Neuberger, Marise Morland, Anne Moffat, Robert Harris, Michael Jones, Peter Millar, George Perry, John Cassidy, Sue Mott, Rose Shepherd, George Thomson, Adam LeBor, Peter Parker, Paul Donovan, Della Bearman, Dr John Ashworth, Leslie Thomas, Malcolm Smith, Jonathan Sale, Paul Driver, Chris Patridge, James Adams, Murray Armor, Sol Margolis Director, Austin MacCurtain, David Leppard, Tim Rayment, Peter Plant, Brian Jackman, Richard Girling, Elizabeth Grice, David Stena, David Lawrenson, John Hopkins, Peter Gammond, Dan Piraro, Michael Draper Chairman, Brian Walden, George Sassoon, Peter Wilsher, Gareth David, Neil Morgan, Brian Reading, Eavan Boland, Kate Saunders, David Brittain, Anton Mosimann, Malcolm Winton, James Wilson, Marie Colvin, Richard Cook, Diana Wright, Greg Hadfield, Ruby Wax, Craig Brown, Chris Horrie, Ali Ross, Stephen Jones, Stephen Thorpe, David Owen, Charles Oulton Home Affairs Correspondent, Brian Deer, Alison Smith, Andrew Grice, Digby Anderson, Ian Birrell, Patrick Rowley, Dilys Powell, Bryan Appleyard, Chris Jones, Andrew Hogg, Alison Beckett, Austin Lockyer Director, Frank Filed, Caroline McGhie, Richard Woods, Louise Branson, Peter Johnson, Frances Rafferty, George Ace, Des Wilson (Chairman), Maurice Chittenden, Anne Stevesun, Iola Smith, Ian Dunning, Baroness Warnock, Ruth Harrisan, Aileen Ballantyne Medical Correspondent, Brian MacArthur, Alan Tillier, Geoffrey Hobbs, Nigel Piercy, Ian Thomson, Mihir Bose, Jill Goolden, Philip Beresford, Godfrey Smith, Roy Greenslade, Charles Oulton, Greg Hadfield Education Correspondent, Matthew Campbell, Brian Glanville, John Carey, Michael Moynihan, Norman Macrae, Chris Dighton, Edward Pearce, Simon Jenkins, Godfrey Golzen, Deirdre Fernand, Michael Roberts, Paul Davies, Mark Coker, Gareth David Deputy City Editor, John Furbisher, Agela Wigglesworth, Michael Holroyd, Mark Porter, Jonathan Futrell, Valerie Grove, Chris Lightbown, Hugh Pearman, Marina Vaizey, Richard Caseby, Jane Dunmore, Margaret Park, David Smith Economics Editor, Penny Perrick, Neil MacLean, Tony Hetherington, Sue Nelson, Jim Muir, Kathleen Churchill, Walter Ellis, Chris Blackhurst, Joanna Simon, Iain Jenkins, Peter freedman, Hilary Bristow, Nigel Nicolson, Boris Schapiro,
... J. C. Trewin, drama critic and outhor, and hios son Ion, an editorial director, talk to Richard ...
1989 - Gale Group | Sunday Times HA GDA
... both the MOH and the Health Insurance Organization (HIO). In 1999, the MOH regulations were amended (section ... amendment in the second way mentioned above. The HIO facilities provide health services for civilians working in ... of university education. It is estimated that the HIO covers 44% of the Egyptian population.11Egyptian Ministry of Health Health Insurance Organization.http://www.hio.gov.eg/Ar/Pages/default.aspxGoogle Scholar Although the MOH regulations should be applied in HIO facilities, in November 2003, the HIO created its ...
Tópico(s): Pharmacological Effects and Toxicity Studies
2009 - Elsevier BV | Journal of Pain and Symptom Management
Michael Prescott, Barbara Hall, John Smith, Richard Ellis, Helen Davidson, Michael De-la-Noy, John Peter, John Harlow Transport Correspondent, Jonathan Miller, Rufus Ollins, Eric Dymock, Andrew Shields, Barbara Ellis, Tony Francis, Susan d'Arcy, Nick Rufford, John Stansell, Sheridan Morley, Nicolette Jones, Markie Robson-Scott, Kirstle Hamilton, Margaret Jay, Imogen Edwards-jones, Lucy Hughes-Hallett, David Smith, Sally Payne, Gerry Whent, Sean Ryan Environment Correspondent, Robert Leedham, Nick Pitt, Julian Symons, Frederic Raphael, Charles Hymas, Richard Large, Edward Welsh, Richard Eaton, Geordie Greig, Neville Hodgkinson, Tony Allen-Mills, Martin James, Robert Sandall, Peter Campbell Smith, Iain Johnstone, Lord McAlpine, Nilgin Yusuf, Gerry Olyslager, Irwin Stelzer, Lyall Hakarala, E Jane Dickson, Cyril Dixon, David Dougill, Stafford Taylor, Howard L Ramsay, John Gribbin, Cliff Temple, Rehan Kularatne, Malcolm Wheatley, Haluk Sahin, Ian Mawson, Harvey Porlock, Hugh Canning, Margarette Driscoll, Jeremy Clarkson, John Melmoth, Jenny Ridgwell, Sean Ryan, K E Mawardy, Leonard Supwood Martin, Anne Moffat, Freda Ward, Peter Millar, Ridley Scott, Brian Morton, Steve Goldman, Tony Scott, Arnold Wesker, Andrew Barr, Sue Mott, George Perry, Robin Marlar, Mark Skipworth, Anatole Kaletsky, Nick Gardner, Shelley von Strunckel, Peter Silverton, Jonathan Margolis, Bernard Cafferty, Peter Keliner, Stuart Wavell, Roger Eglin, Paul Donovan, Steven Wheeler, Frances Spalding, John Burton, Simon Mills, Jeff Randall, James Bethell, Giles Marshall, James Adams, Paul Driver, Richard Supwood, Margaret Dibben, Caroline Scott, Liz Lightfoot, Matthew Gwyther, David Leppard, Tim Rayment, Judge Peter, Kirstie Hamilton, Tom Shone, Rufus Olins, Stephen Amidon, Nigel Bowden, Martin Jacques, Ira Miller, Oliver Rhodes, Nicola Davidson, Christopher Lloyd, Charles Hymas Education Correspondent, K H Colley, Francis Spufford, Jenny Diski, Liz Walkington, John Karter, Malcolm Winton, Greg Hadfield, Craig Brown, Richard Goswell, Stephen Jones, Paul Nuki Deputy Personal Finance Editor, Linda McDougall, Desmond Shawe-Taylor, Brian Deer, Imogen Edwards-Jones, John Morrish, Paul Nuki, Andrew Grice, Julie Cohen, Martin Searby, Rosie Thomas, Lois Rogers Medical Correspondent, Andrew Lorenz Associate Business Editor, Andrew Hogg, Bernard Fitzsimons, Brough Scott, Patricia Browne, Roland White, The Rev Dr R MacCarthy, Garth Alexander, Louise Branson, Peter Johnson, Rachel Cooke, Sasha Miller, Christopher Browne, Michael Jones Political Editor, D J Taylor, Michael Hanson, Mihir Bose, Godfrey Smith, Matthew Lynn, Michael Austin, David Charlesworth, Robert Leadham, Andrew Alderson, Roy Hattersley, Peter Victor, Peter McKay's, A A Gill, Stan Levenson, John Carey, Norman Macrae, Chris Dighton, Marianne Sorrell, Adrian Dannatt, Michael Horovitz, Chrissy Iley, Barry Morton, Dr Allan Starkie, Gilbert Adair, Leon Cych, Andrew Lorenz, Peter Semler, David Wickers, Judith Botham, Alan Ruddock, Colin Greenland, Margarett Dibben, Margarett Driscoll, John Parker, Nigel Roebuck, Jeff Randall City Editor, John Campbell, Dr Michael Elliott, Hugh Pearman, Owen Slot, John Burns, Steve Punt, Susan Ellicott, Julia Bright, Simon Reeve, Peter Roebuck, Douglas Kennedy, Walter Ellis, James Dalrymple, Louisa Buck, Michael Medved, Iain Jenkins, Dominic Rushe, Boris Schapiro, Mark Wallington,
... Items AITO Laskarina Ltd. Multiple Classified Advertising Items Hios Island Holidays Ltd. Villa Centre Holidays Ltd. Greece ...
1993 - Gale Group | Sunday Times HA GDA
Katie L. Sinagoga, James M. Wells,
... of PSCs into 3-dimensional human intestinal organoids (HIOs) in vitro. We will further describe current uses of HIOs in development and disease research and how additional tissue complexity might be engineered into HIOs for better functionality and disease modeling. Introduction The ... cells (PSCs) into three-dimensional, human intestinal organoids (HIOs) (Spence et al, 2011b). HIOs, generated either from embryonic stem cells or from ... intestinal development, function, and disease and discuss how HIO-based models are currently being used to understand ...
Tópico(s): Infant Nutrition and Health
2015 - Springer Nature | The EMBO Journal
Victoria McKee, Arthur Leathley, Transport Correspondent, Julian Hitchcock, John Naughton, Jon Ashworth, Cath Urquhart, Gerald Isaaman, David Adams, Joanna Hunter, Richard Rogers, Richard Whitehead, Robert Cole, Andy Bull, Patrick Sherwen, James Moore, Jonathan Dykes, Philip Barron, Jane MacQuitty, Simon Barnes, Gary Neville, John Morgan, Adam Barker, Clive King, Paul Hoggart, jonathan meades, Mark Souster, Richard Hobson, Terry Hope, Tom Pocock, Bill Thomas, Robert Lea, Stephen Brennan, Raymond Snoddy, Media Editor, Gavin Lumsden, S. L. Smaller, Philip Howard, James Bone, Clive Davis, Andrew Gordon Lennox, Kate Reardon, Eric E. Warburg, Peter Foster, Anne Robinson, Michael Evans, Defence Editor, Morag Preston, Barbara Hewson, john diamond, Kevin Eason, Geoff Brown, Raymond Snoddy, Clare Stewart, Nilgin Yusuf, Thunderer, Louise Godfrey, Adam Hopkins, Antonia Senior, Martin Fletcher, Carl Evans, Abby Tan, Noam Friedlander, Stephen McClarence, John O'leary Education Editor, Henry Harris, Robert Sheehan, David Lancaster, Steve Keenan, Thrasy Petropoulos, D. R., amandip uppal, Jean-Christophe Novelli, Dominic Walsh, Ruth Gledhill, Debra Craine, Shirley English, Carol Midgley, Media Correspondent, E. C., Michael Harvey, Rachel Kelly, Libby Purves, Henrietta Lake and Susan Emmett, Peter Hughes, Sarah Cunningham, Retail Correspondent, Candida Crewe, Robin Young, Nicholas Roe, Wakeham Chairman, Sanjeev bhaskar, Michael Clark, Alice Lagnado, Phil Gordon, Lois Letts, Doug Sager, Roland Watson, Frances Bissell, David Hands, P. B., Mike Laws, Sarah Jones, Anna Blundy, Katherine Bergen, Helen Rumbelow, Paul Donovan, Peter Barnard, Derwent May, Eric Caines (Personnel Director), Lisa Jardine, Susan Emmett, Stuart Bailie, Jasper Gerard, Ben Reed, Valerie Elliott Whitehall Editor, Paula Hawkins, John Ardagh, Howell and Jean Davies, Mary Gold, Paul Armstrong, Christine Buckley and Sigrid Aufterbeck, Richard Colwill, June Osborne, Sarah Johnson, Lisa Grainger, Stevie Chick, Michael Lynagh, Helen Wallace, George Brock, Maxwell McLeod, Michael Theodoulou, Martin Fletcher, Chief Ireland Correspondent, Audrey Magee, Ireland Correspondent, Paul Whyatt, L. G., Dave Thomas, Mark Inglefield and Jill Sherman, Sarah Turner, Dalya Alberge, Arts Correspondent, Raymond Keene, S. R. M. Wilson, Chris Oliver Wilson, David Robinson, John Russell Taylor, Sharon Pink, Matt Dickinson, Caroline Merrell and Patrick Sherwen, James Allcock, Kate Stronach, J. G. Riseley, Jeannette Hyde, Alette Lawson-Konijnenbelt, Richard Evans, Nigel Hawkes, Clive Petty, Bernard Donoughue, Min Cooper, Paul Wilkinson North East Correspondent, Jo Carlowe, Rob Chapman, Michael Arditti, Robert Elms, Vicki Butler-Henderson, Damian Whitworth, Andrew Stuart, Marcel Berlins, Roger Boyes, Nigel Hawkes, Science Editor, Cris Whetton, Oliver August, Tuliola Tybulewicz, Bill Bryson, Stephanie Billen, Adam Fresco, Richard Duce, Terry Timblick, Anne Ashworth, Angela Edmonds, Christopher Walker, Simon De Bruxelles, Saeed Shah, Jason Nissé, Srikumar Sen Boxing Correspondent, Susan Emmett and Fran Littlewood, Kevin McCarra, Matthew Parris, Deborah King, Dominic Kennedy and Jill Sherman, Richard Evans Racing Correspondent, Angus Clarke, Mark Hodkinson, B. J. Lennox, Jodle Kidd, Tim Wapshott, Sheila Keating, Simon Brooke, Jane Owen, Walter Gammie, Helen Pridham, Ian Brodie, Richard Beeston, David Bowker, Graham Searjeant, John Naish, Richard Miles, Anne Ashworth Personal Finance Editor, Jason Cowley, Martin Waller, Elizabeth Cowley, Peter Melchett, Lisa Verrico, Eric Brown, Danny Baker, Fran Littlewood, Marianne Curphey Insurance Correspondent, Lottie Moggach, Lee Evans, Benedict Nightingale, Marianne Curphey, Jill Crawshaw, Dominic Kennedy and Stewart Tendler, David Powell, Alyson Rudd, Sam Kiley, Joe Warwick, Tom Chesshyre, Arthur Leathley, Michael Henderson, Adam Sherwin, McNALLY, Paul Connolly, John Phillips, Andy Enright, Stephen Wood and Russell Kempson, Granville Davies (Nhs District Personnel Manager), Hazel Spink, David Hands, Rugby Correspondent, Henrietta Lake, Matthew Westwood, Alasdair Murray, Economics Correspondent, Christopher Irvine, Jan Evans, Christine Buckley, Industrial Correspondent, Jayne Dowle, Richard Allen,
... Armpit Many-Splendoured Continent John Julius Norwich gives hios guid to the finest historic sites in Europe. ...
1999 - Gale Group | TDA
Mark H Wimmer, Kenneth Heffner, Michael J. Smithers, Richard Culley, Jennifer L. Coyner, Michael Loughren, Don Johnson,
... conducted to determine the effects of humeral IO (HIO) access with vasopressin in the return of spontaneous ... compared the kinetics of vasopressin and ROSC with HIO with IV access in the hypovolemic swine model. ... two Yorkshire swine were divided into three groups: HIO (n = 7), IV (n = 8), and a control group (n = 7). The IV and HIO group received vasopressin and cardiopulmonary resuscitation (CPR), while ... in every subject that received vasopressin via the HIO route. Data analysis using a MANOVA pairwise comparison ...
Tópico(s): Healthcare Technology and Patient Monitoring
2016 - | American Journal of Disaster Medicine
Jeremy Rundall, James Margach, Will Ellsworth-Jones, Beilen, John Fryer, Philip Norman, Harold Hobson, Chris Ryder, Rob Hughes, E. J. P. Lombard Knight, Micheal Jones, Sir Martin Lindsay, Julian Everitt, Roger Cawley, Robin Gregg, Graham Rose, Berry Ritchie, Peter Cadogan, Antony Terry, E. C. Jones, Steohen Fry, Dr Wilfred Beckerman, Colin Tilney, Peter Horrobin, Collin Simpson, Richard Streeton, Henry Brandon, Howard Watson, Dr Beverly Halstead, Deryk Brown, David Dougill, Edith Lenart, Cliff Temple, Philip Clarke, Derek Jewell, Patrick Campbell, Vivian Jenkins, Murray Sayle, Peter Watson, John Ballantine, Norman Harris, Gillian Widdicombe, Stonley Leyenson, Ruth Hall, Micheal Green, Geoff Whitten, Peter Kellner, Barry Cockcroft, Robin Marlar, Norman Lamont, Alee Ponton, Roger Eglin, Woodrow Wyatt, Irma Kurtiz, Peter Lennon, Michael Heseltine, Keith Rotsford, Julia Cave, Putrick Rowley, Louise, Leonard Barras, Micheal Roberts, Brian Jackman, Peter Gammond, Denis Herbstein, James Fox, Peter Wilsher, Sanjoy Roy-Chowdhury, John Morris, Desmond Shawe-Taylor, C A Johnson, Melanie Friesen, Ben Folley, Gwen Nuttall, Stephen Aris, Mica Panic Chief Economist, Dilys Powell, Brough Scott, Oliver Gillie, Tony Rocca, Gordon Best, Elkan Allan, Elakan Allan, Hugo Young, Tim Brown, Ian Nairn, Felix Aprahamian, Denis Herstein, Jack Fingleton, Ian Jack, J W Lambert, Henry Longhurst, Godfrey Hodson, William Allsopp, Peter Draper, Peggy Crane, Peter Kenyon, Peter Clarke, Peter Pringle, Richard Burnell, Christopher Ricks, Bernard Keeffe, Brian Glanville, Helgi P Brlem, R Gilmore Machynlleth, Anthony Holden, Simon Jenkins, Graham Searjeant, Maureen Walker, Juson Tomas, Roman Eisenstein, Marina Vaizey, Chris Lightbown, Robert Whymant, Allan Hall, Philip Radcliffe, Peter Sedwick, Bill Glendon, Malcolm Crawford, Roland Adburgham, Hugh Trevor-Roper, Boris Schapiro,
... The death of a diver 'I saw Peter. hios mask was off. My mask went. Then I ...
1975 - Gale Group | Sunday Times HA GDA
... billion dollars in creating community health information organizations (HIOs) to foster health information exchange. Community HIOs provide exchange services to health care organizations within ... geography is a key organizing principle for community HIOs, it is unclear if geography is an effective ... This study describes the extent of reported community HIO coverage in the United States and explores the ... and policy implications of overlaps and gaps in HIO service areas. Furthermore, because self-reported service areas ...
Tópico(s): Public Health Policies and Education
2016 - Lippincott Williams & Wilkins | Health Care Management Review
Sunny C. Lin, Julia Adler‐Milstein,
Health Information Organizations (HIOs) are third party organizations that facilitate electronic health information exchange (HIE) between providers in a geographic area. Despite benefits from HIE, HIOs have struggled to form and subsequently gain broad ... with presence and level of hospital participation in HIOs. 2014 data on 4523 hospitals and their EHR ... hospital and vendor dynamics and (1) probability of HIO presence and (2) percent of hospitals participating in an HIO. 298 of 469 markets (64%) had HIO presence, ...
Tópico(s): Healthcare Policy and Management
2018 - BioMed Central | BMC Medical Informatics and Decision Making
Meghan M. Capeling, Michael Czerwinski, Sha Huang, Yu-Hwai Tsai, Angeline Wu, Melinda Nagy, Benjamin A. Juliar, Nambirajan Sundaram, Yang Song, Woojin M. Han, Shuichi Takayama, Eben Alsberg, Andrés J. Garcı́a, Michael A. Helmrath, Andrew J. Putnam, Jason R. Spence,
Human intestinal organoids (HIOs) represent a powerful system to study human development and are promising candidates for clinical translation as drug-screening tools ... engineered tissue. Experimental control and clinical use of HIOs is limited by growth in expensive and poorly ... matrices, prompting investigation of synthetic ECM-mimetics for HIO culture. Since HIOs possess an inner epithelium and outer mesenchyme, we ... provided by the matrix may be dispensable for HIO culture. Here, we demonstrate that alginate, a minimally ...
Tópico(s): 3D Printing in Biomedical Research
2019 - Elsevier BV | Stem Cell Reports
Kwang Bo Jung, Ohman Kwon, Mi‐Ok Lee, Hana Lee, Ye Seul Son, Omer Habib, Jung‐Hwa Oh, Hyun‐Soo Cho, Cho‐Rok Jung, Janghwan Kim, Mi‐Young Son,
Human intestinal organoids (hIOs), which resemble the human intestine structurally and physiologically, have emerged as a new modality for the study of the ... an in vitro maturation technique for generating functional hIOs from human pluripotent stem cells (hPSCs). Here, we ... of STAT3 for inducing in vitro maturation of hIOs. This was accompanied by the tyrosine phosphorylation of ... does not affect the differentiation of hESCs into hIOs but rather affects the in vitro maturation of hIOs. STAT3 KO hIOs displayed immature morphologies with decreased ...
Tópico(s): Digestive system and related health
2019 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Jana Krüger, Rüdiger Groß, Carina Conzelmann, Janis A. Müller, Lennart Koepke, Konstantin M. J. Sparrer, Tatjana Weil, Desirée Schütz, Thomas Seufferlein, Thomas F.E. Barth, Steffen Stenger, Sandra Heller, Jan Münch, Alexander Kleger,
... intestinal organoids derived from pluripotent stem cells (PSC-HIOs) have led, due to their complexity in mimicking ... models including gastrointestinal infections. Here, we employed PSC-HIOs to dissect SARS-CoV-2 pathogenesis and its ... the intestine, the latter faithfully recapitulated by PSC-HIOs. Organoids could be readily infected with SARS-CoV-2 followed by viral spread across entire PSC-HIOs, subsequently leading to organoid deterioration. However, SARS-CoV- ... cells lacking ACE2 expression. Importantly, we challenged PSC-HIOs for drug testing capacity. Specifically, remdesivir effectively inhibited ...
Tópico(s): SARS-CoV-2 and COVID-19 Research
2020 - Elsevier BV | Cellular and Molecular Gastroenterology and Hepatology
Anna Nakanishi, Satoshi Toyama, Daichi Onozato, Chihiro Watanabe, Tadahiro Hashita, Takahiro Iwao, Tamihide Matsunaga,
... Recently developed human iPS cell-derived intestinal organoids (HIOs) aim to generate organoids that closely resemble the ... intestine. However, no study till date has reported HIOs injected into in vivo inflammatory models, and it remains unclear whether HIOs with cells that closely resemble the adult intestine ... tissue in colitis.We generated two types of HIOs via suspension culture with and without small-molecule compounds: HIOs that include predominantly more intestinal stem cells [HIO (A)] and those that include predominantly more intestinal ...
Tópico(s): Pluripotent Stem Cells Research
2022 - Elsevier BV | Regenerative Therapy
Satoru Tsuruta, Tomoyuki Kawasaki, Masakazu Machida, Ken Iwatsuki, Akihiko Inaba, Shinsuke Shibata, Tomoko Shindo, Kazuhiko Nakabayashi, Kenichi Hakamada, Akihiro Umezawa, Hidenori Akutsu,
... developed novel xenogeneic-free human intestinal organoids (XF-HIOs) that are uniquely structured with an apical-out ... 1-10Crossref Google Scholar To further develop XF-HIOs containing tissue macrophages, we first prepared human-induced ... injected into the cystic cavity of an XF-HIO, followed by differentiation into macrophage-like cells (pGMACs) within XF-HIOs in the presence of macrophage colony-stimulating factor ( ... were observed to evenly disperse inside the XF-HIOs, and image analysis showed pGMACs with short-elongated ...
Tópico(s): Digestive system and related health
2022 - Elsevier BV | Cellular and Molecular Gastroenterology and Hepatology
Timothy Adams, Dawn Blouin, Don Johnson,
... vasopressin administration by tibial intraosseous (TIO), humerus intraosseous (HIO), and intravenous (IV) routes in a hypovolemic cardiac ... 40 units of vasopressin was administered by TIO, HIO, or the IV routes. Blood samples were collected ... ROSC or time to ROSC between the TIO, HIO, and IV groups (p > 0.05). The Cmax ... but no significant difference between the TIO versus HIO or HIO versus IV groups (p > 0.05). The Tmax was significantly shorter for the HIO compared to the TIO group (p = 0.034), ... the IV group compared to the TIO or HIO groups (p > 0.05). The odds of survival ...
Tópico(s): Anesthesia and Neurotoxicity Research
2016 - | American Journal of Disaster Medicine
Ltc Denise Beaumont, Asal Baragchizadeh, Charles L. Johnson, Don Johnson,
... survival relative to epinephrine administration by humerus intraosseous (HIO), tibial intraosseous (TIO), and intravenous (IV) routes in ... of 1 mg of epinephrine was administered by HIO, TIO, or the IV routes. Blood samples were ... in rate of the ROSC among the TIO, HIO, and IV groups (p > 0.05). There were significant differences in Cmax: the HIO group was significantly higher than the TIO group ( ... but no significant difference between the IV and HIO (p = 0.33) or the IV and TIO ... was significantly shorter for both the IV and HIO versus the TIO group (p < 0.05), but ...
Tópico(s): Non-Invasive Vital Sign Monitoring
2016 - | American Journal of Disaster Medicine
Senthil Arun Kumar, Leigh C. Ward, Lindsay Brown,
... and high-carbohydrate, high-fat with inulin oligofructose (HIO) rats, respectively. IO reduced plasma concentrations of free ... 26·2 % and TAG by 75·8 % in HIO rats. IO increased faecal output by 93·2 %, ... 23·4 % and colon by 41·5 % in HIO rats. IO improved ileal morphology by reducing inflammation and improving the density of crypt cells in HIO rats. IO attenuated H diet-induced increases in ... CIO 264 (sem 40), H 688 (sem 55), HIO 419 (sem 32) mg/mm tibial length), fasting ... 0·1), H 5·2 (sem 0·1), HIO 4·3 (sem 0·1) mmol/l), systolic ...
Tópico(s): Food composition and properties
2016 - Cambridge University Press | British Journal Of Nutrition
James Burgert, Don Johnson, J Garcia-Blanco, Lawrence Fulton, Michael Loughren,
... effects of vasopressin administered by the humeral IO (HIO) route for treatment of VF. The purpose of this study was to evaluate the effects of HIO and IV vasopressin, on the occurrence, odds, and ... 80 kg) were assigned randomly to three groups: HIO (n=9), IV (n=9), and a control ... test determined ROSC was significantly higher in the HIO 5/7 (71.5%) and IV 8/11 ( ... groups ( P =.68) but significant differences between the HIO and control, and the IV and control groups ( ... ANOVA) indicated the mean time to ROSC for HIO and IV was 621.20 seconds (SD=204. ...
Tópico(s): Cardiac Ischemia and Reperfusion
2017 - Cambridge University Press | Prehospital and Disaster Medicine
Xu‐Cheng He, Mario Simon, Siddharth Iyer, Hong‐Bin Xie, Birte Rörup, Jiali Shen, Henning Finkenzeller, Dominik Stolzenburg, Rongjie Zhang, Andrea Baccarini, Yee Jun Tham, Mingyi Wang, Stavros Amanatidis, Ana A. Piedehierro, A. Amorim, Rima Baalbaki, Zoé Brasseur, Lucía Caudillo, Biwu Chu, Lubna Dada, Jonathan Duplissy, Imad El Haddad, Richard C. Flagan, Manuel Granzin, Armin Hansel, Martin Heinritzi, Victoria Hofbauer, Tuija Jokinen, Deniz Kemppainen, Weimeng Kong, Jordan Krechmer, Andreas Kürten, Houssni Lamkaddam, Brandon Lopez, Fangfang Ma, Naser G. A. Mahfouz, В. С. Махмутов, Hanna E. Manninen, Guillaume Marie, Ruby Marten, Dario Massabò, Roy L. Mauldin, Bernhard Mentler, Antti Onnela, Tuukka Petäjä, Joschka Pfeifer, Maxim Philippov, Ananth Ranjithkumar, Matti Rissanen, Siegfried Schobesberger, Wiebke Scholz, Benjamin C. Schulze, Mihnea Surdu, Roseline C. Thakur, António Tomé, Andrea C. Wagner, Dongyu Wang, Yonghong Wang, Stefan K. Weber, André Welti, Paul M. Winkler, Marcel Zauner-Wieczorek, Urs Baltensperger, Joachim Curtius, Theo Kurtén, Douglas R. Worsnop, Rainer Volkamer, Katrianne Lehtipalo, J. Kirkby, Neil M. Donahue, Mikko Sipilä, Markku Kulmala,
... 4 is frequently found together with iodine oxoacids [HIO x , i.e., iodic acid (HIO 3 ) and iodous acid (HIO 2 )]. In experiments performed with the CERN CLOUD ( ... the interplay of H 2 SO 4 and HIO x during atmospheric particle nucleation. We found that HIO x greatly enhances H 2 SO 4 (-NH 3 ) nucleation through two different interactions. First, HIO 3 strongly binds with H 2 SO 4 ... clusters so they drive particle nucleation synergistically. Second, HIO 2 substitutes for NH 3 , forming strongly bound H 2 SO 4 -HIO 2 acid-base pairs in molecular clusters. Global ...
Tópico(s): Atmospheric and Environmental Gas Dynamics
2023 - American Association for the Advancement of Science | Science
Toshitaka Hori, Masahito Sugiyama,
Adsorption onto hydrous iron oxide (HIO) was compared as a function of pH for a variety of organophosphorus compounds (OPs), including phosphate esters of ethanolamine, hydroxyamino acids ... P–O moieties should be collected quantitatively by HIO from waters of pH 5.0–6.5. The OPs collected by adsorption onto HIO did not show appreciable degradation during storage for ... In addition, they could be released from the HIO by using pentane-2,4-dione [acetylacetone (Hacac)] ... volume awueous phase which was derived from the HIO by the following reaction: Fe2O3·nH2O·(OPs)+ 6Hacac → ...
Tópico(s): Pesticide Exposure and Toxicity
1992 - Royal Society of Chemistry | The Analyst
J.P. Grobbel, Michael E. Dikeman, Melvin C. Hunt, George A. Milliken,
... 18-d [80% O(2), 20% CO(2) (HiO(2)) modified atmosphere packaging (MAP)] or 28-d [ ... packaging (VP); 80% O(2), 20% CO(2) (HiO(2)); 0.4% CO, 35% CO(2), 64. ... 6% Ar (ULO(2)COAr). Steaks packaged in HiO(2) MAP were in dark storage (2 degrees ... little or no surface discoloration. Steaks packaged in HiO(2) MAP discolored faster (P < 0.05) and ... force on d 14 postmortem. Steaks packaged in HiO(2) MAP were less tender (P < 0.05) ... a shorter dark storage period. Steaks packaged in HiO(2) had the lowest (P < 0.05) a* ... longer fresh color stability than steaks packaged in HiO(2) MAP and equal or better tenderness. Packaging ...
Tópico(s): Advanced Chemical Sensor Technologies
2008 - Oxford University Press | Journal of Animal Science
Stacy R. Finkbeiner, Jennifer Freeman, Minna M. Wieck, Wael N. El‐Nachef, Christopher Altheim, Yu-Hwai Tsai, Sha Huang, Rachel Dyal, Eric S. White, Tracy C. Grikscheit, Daniel H. Teitelbaum, Jason R. Spence,
... pluripotent stem cells (iPSCs), called human intestinal organoids (HIOs), have the potential to offer a personalized and ... of intestine for regenerative therapies. However, given that HIOs are small three-dimensional structures grown in vitro, methods to generate usable HIO-derived constructs are needed. We investigated the ability of hESCs or HIOs to populate acellular porcine intestinal matrices and artificial ... endodermal or intestinal fate. We observed that while HIOs reseed acellular porcine matrices in vitro, the HIO- ...
Tópico(s): 3D Printing in Biomedical Research
2015 - The Company of Biologists | Biology Open
Eva S. Rodansky, Laura A. Johnson, Sha Huang, Jason R. Spence, Peter Higgins,
... advances in stem cell derived human intestinal organoids (HIOs) as a new human model of fibrosis in CD. Human pluripotent stem cells were differentiated into HIOs. We identified myofibroblasts, the key effector cells of ... and desmin. We examined the fibrogenic response of HIOs by treatment with transforming growth factor beta (TGFβ) ... organoids identified a population of myofibroblasts within the HIO mesenchyme. TGFβ stimulation of HIOs produced a dose-dependent pro-fibrotic response. Spironolactone treatment blocked the fibrogenic response of HIOs to TGFβ. HIOs contain myofibroblasts and respond to ...
Tópico(s): Gastrointestinal motility and disorders
2015 - Elsevier BV | Experimental and Molecular Pathology
Kwang Bo Jung, Hana Lee, Ye Seul Son, Ji Hye Lee, Hyun‐Soo Cho, Mi‐Ok Lee, Jung‐Hwa Oh, Jaemin Lee, Seokho Kim, Cho‐Rok Jung, Janghwan Kim, Mi‐Young Son,
Human intestinal organoids (hIOs) derived from human pluripotent stem cells (hPSCs) have immense potential as a source of intestines. Therefore, an efficient system ... the stage of intestinal differentiation and further identifying hIOs derived from hPSCs. Here, 2 fluorescent biosensors were ... specific homeobox enhanced green fluorescence protein (ISXeGFP). Then hIOs were efficiently induced from those transgenic hiPSC lines ... expression had no adverse effects on differentiation into hIOs and proliferation. Using our reporter system to screen ...
Tópico(s): Cancer Cells and Metastasis
2017 - Wiley | The FASEB Journal
Carol Parker, Mathew J. Reeves, Michael Weiner, Julia Adler‐Milstein,
Federal investment spurred health information exchange organization (HIO) development and maturation to provide third-party approaches to electronic health information exchange across disparate electronic health record (EHR) systems. By creating opportunities for data aggregation across multiple medical institutions, HIOs also spur research. Using data from a 2015 national web-based survey of HIOs (N = 64), we identified HIOs supporting or not supporting research, and compared characteristics ... We found that 15 (23%) of the 64 HIOs reported supporting research, 30 (47%) reported planning to ...
Tópico(s): Ethics in Clinical Research
2017 - SAGE Publishing | INQUIRY The Journal of Health Care Organization Provision and Financing
Yuxiao Tang, Dongyao Wang, Xiaowen Niu, Hui‐Wen Wu, Jianxin Yang, Yinyin Zhang, Shangjin Song, Diya Lv, Yifeng Chai, Hongtao Lu, Hui Shen, Chen Ling, Min Li,
... are found to bear mild hepatic iron overload (HIO) due to unhealthy lifestyles, metabolic diseases, etc., whether this mild but chronic HIO induces hepatic inflammation is unknown. In the present ... months 0.3% dextran-iron diet show mild HIO with no detectable oxidative damages in the liver ... induce macrophages infiltration, is initiated by chronic mild HIO. After excluding the role of DNA methylation, a ... find that transcription factor YY1 is responsible for HIO-decreased HNF4α expression. Then the E3 ubiquitin ligase ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2020 - Elsevier BV | Free Radical Biology and Medicine
Suman Pradhan, Sayali Karve, Alison A. Weiss, Jennifer Hawkins, Holly M. Poling, Michael A. Helmrath, James M. Wells, Heather A. McCauley,
... to Stx was assessed using human intestinal organoids (HIOs) derived from embryonic stem cells, or enteroids derived from multipotent intestinal stem cells. HIOs contain a lumen, with a single layer of ... contain epithelium. In vivo susceptibility was assessed using HIOs, with or without an enteric nervous system, transplanted ... in mesenchymal–epithelial transition. In vivo responses of HIO transplants injected with Stx mirrored those seen in ... to Stx was assessed using human intestinal organoids (HIOs) derived from embryonic stem cells, or enteroids derived ...
Tópico(s): Digestive system and related health
2020 - Elsevier BV | Cellular and Molecular Gastroenterology and Hepatology
Basel H. Abuaita, Anna-Lisa E. Lawrence, Ryan P. Berger, David R. Hill, Sha Huang, Veda K. Yadagiri, Brooke Bons, Courtney Fields, Christiane E. Wobus, Jason R. Spence, Vincent B. Young, Mary O’Riordan,
... model systems. Here we used human intestinal organoids (HIOs), a three-dimensional "gut-like" in vitro system ... in host responses to NTS and typhoidal serovars. HIOs discriminated between the two most prevalent NTS, Salmonella ... and cytokine output was reduced in ST-infected HIOs compared to NTS infections, consistent with early stages ... and mitochondrial functions were downregulated in STM-infected HIOs and upregulated in SE-infected HIOs. These results correlated with suppression of cellular proliferation ...
Tópico(s): Cancer Research and Treatments
2021 - Public Library of Science | PLoS Pathogens