Emilie Pacheco Da Silva, Raphaëlle Varraso, Anne-Marine Lenzotti, Léopold Fezeu, Guillaume Sit, Pilar Galán, Serge Herçberg, Mathilde Touvier, Christophe Paris, Orianne Dumas, Nicole Le Moual,
... The use of household disinfectants and cleaning products (HDCPs) may negatively impact asthma control, but studies remain ... To assess the associations between the use of HDCPs, including disinfecting wipes and green products, and asthma ... Asthma Control Test < 20) and the use of HDCPs, including 2 types of products (irritants and green ... associations of the frequency of weekly use of HDCPs at home with asthma control, adjusted for sex, ... with a weekly use of at least 1 HDCP). Strong associations were observed between weekly use of ...
Tópico(s): Noise Effects and Management
2023 - Elsevier BV | The Journal of Allergy and Clinical Immunology In Practice
Pierre Lemire, Emmanuel Chevallier, Sarah Lyon-Caen, Étienne de Sevin, Anne Boudier, Emilie Pacheco Da Silva, Christian De Thuin, Rémy Slama, Orianne Dumas, Valérie Siroux, Nicole Le Moual, E. Eyriey, A. Licinia, A. Vellement, Isabelle Pin, P. Hoffmann, E. Hullo, Cielo Llerena, Xavier Morin, A. Morlot, Johanna Lepeule, Sarah Lyon-Caen, Claire Philippat, Isabelle Pin, J. Quentin, Valérie Siroux, Rémy Slama,
Considering household disinfectants and cleaning products (HDCP) as mixture of ingredients, rather than each ingredient individually, might help in characterizing their role in asthma. We investigated the association between HDCP and asthma, using the recently developed Ménag'Score®, ... assessment score based on exhaustive ingredient lists of HDCP.The study is based on 103 female volunteers ... data (up to 3 collection times, 200 observations). HDCP use was assessed from a barcode-based smartphone ... and environment were computed for each weekly used HDCP from their exhaustive ingredient data (from A: no ...
Tópico(s): Indoor Air Quality and Microbial Exposure
2022 - Springer Science+Business Media | International Archives of Occupational and Environmental Health
Shu Zhou, Yiping Ji, Haimei Wang,
Abstract Background The hypertensive disorders complicating pregnancy (HDCP) is common in patients with polycystic ovary syndrome (PCOS), yet the potential influencing factors remained unclear. We aimed to assess the independent risk factors of HDCP in patients with PCOS, to provide clinical evidences ... conducted to identify the independent risk factors of HDCP, Receiver operating characteristics (ROC)curve analysis was conducted ... 188 PCOS patients were included, the incidence of HDCP in patients with PCOS was 27.66 %. There ...
Tópico(s): Gestational Diabetes Research and Management
2021 - BioMed Central | BMC Pregnancy and Childbirth
Poppy Bristow, Richard Meeson, Rebecca Thorne, Steven J. Butterworth, Scott Rutherford, Alasdair Renwick, Brandan G. Wustefeld‐Janssens, Philip Witte, Samantha Woods, Kevin Parsons, B. Keeley, M. R. Owen, Alex Li, Gareth Arthurs,
... PCA) using either a hybrid dynamic compression plate (HDCP) or a CastLess Plate (CLP). Study Design Multicenter, ... lameness evaluation and radiographic healing) after use of HDCP and CLP plates. Results PCA was performed with HDCP in 125 cases, CLP in 105, and by ... hyperextension injury was the most common diagnosis in HDCP and CLP groups. Surgical site infection (18.3%) ... complication. There was no difference in intra‐ (11% HDCP, 21% CLP) or postoperative (34% HDCP, 41% CLP) complication rates. Use of external coaptation ...
Tópico(s): Orthopedic Surgery and Rehabilitation
2014 - Wiley | Veterinary Surgery
Sung-Yong Choi, Hisanori Imura, Kousaburo Ohashi,
... the absence and presence of 3,5-dichlorophenol (Hdcp) as the synergist. In the absence of Hdcp, aluminium(III) was not extracted with HMQ and ... with HA into heptane upon the addition of Hdcp. The large synergism of Hdcp was ascribed to the formation of an inner- ... an outer-sphere complex, Al(dcp)(A)2·Hdcp, in the organic phase. The compositions of extracted aluminium(III)-HA-Hdcp were assigned to be Al(dcp)(A)2·Hdcp. The synergistic extraction constants (Kex,s = [Al(dcp)(A)2·Hdcp]org[H+]3[Al3+]-1[HA]org-2[ ...
Tópico(s): Clay minerals and soil interactions
2000 - Springer Nature | Analytical Sciences
Antonio Monroy‐Noyola, Miguel Á. Sogorb, Eugenio Vilanova,
... phosphoramidate O-hexyl O-2,5-dichlorophenyl phosphoramidate (HDCP) when recorded using different quantities of hen liver ... microsomes from 5mg tissue in the presence of HDCP stereoisomers and 2.5mM calcium, the R-HDCP isomer was hydrolysed at a rate similar to or slightly faster than S-HDCP isomer (14% v. 11%), while the S-HDCP stereoisomer was hydrolysed faster than R-HDCP (17% v. 25% and 21% v. 43%) when HDCP isomers hydrolysis was assayed in the presence of ... respectively. This stereospecific hydrolysis was verified assaying racemic HDCP and quantities of liver microsomes from 10 to ...
Tópico(s): Metabolism and Genetic Disorders
1999 - Elsevier BV | Toxicology in Vitro
David R. Gandara, John Crowley, Robert B. Livingston, Edith A. Perez, Charles W. Taylor, Geoffrey R. Weiss, John R. Neefe, Laura F. Hutchins, Ralph W. Roach, Steven M. Grunberg,
... day cycle for eight cycles, high-dose cisplatin (HDCP) 100 mg/m2 days 1 and 8 for four cycles, and high-dose cisplatin plus mitomycin (HDCP-M) 8 mg/m2 day 1. To isolate ... complete plus partial response rates were SDCP, 12%; HDCP, 14%; and HDCP-M, 27% (P < .05). Complete responses were uncommon (HDCP, 3%; HDCP-M, 4%) and were observed only in the ... frequently in the SDCP arm (57%) compared with HDCP (38%) or HDCP-M (34%) (P < .05). However, there were no ... in median survival times (SDCP, 6.9 months; HDCP, 5.3 months; HDCP-M, 7.2 months; ...
Tópico(s): Cancer Treatment and Pharmacology
1993 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Ting Yuan, Ting Zhang, Zhen Han,
Hypertensive disorders complicating pregnancy (HDCP) continues to be a leading cause of maternal and neonatal mortality and morbidity. The clinical value of placental three-dimensional power Doppler (3DPD) in assessing HDCP requires further confirmation. The research was developed to assess changes of placental vascularity in HDCP using 3DPD and to investigate the placental vascularity ... SGA) compared with not-SGA in patients with HDCP.There were 126 normotensive and 128 hypertensive pregnant ... between VI and umbilical artery S/D in HDCP group (r = -0.277, P = 0.001). In ...
Tópico(s): Gestational Diabetes Research and Management
2015 - BioMed Central | BMC Pregnancy and Childbirth
N. Dı́az-Alejo, Antonio Monroy‐Noyola, Eugenio Vilanova, José Luis Vicedo González, Miguel Á. Sogorb,
O-Hexyl, O-2,5-dichlorophenyl phosphoramidate (HDCP) is a chiral compound that induces delayed neuropathy in hens. This compound is hydrolyzed by a phosphotriesterase known as HDCPase in hen and ... a chromatographic method for analysis and quantification of HDCP stereoisomers. Hen and human plasma HDCPases were not ... rabbit plasma showed a remarkable stereospecificity to S-(-)-HDCP. High levels of stereospecific HDCPase were found in the particulate fraction of hen liver, where S-(-)-HDCP is hydrolyzed faster than R-(+)-HDCP. However, in ...
Tópico(s): Chemical Reaction Mechanisms
1998 - Elsevier BV | Chemico-Biological Interactions
Pierre Lemire, Sofia Temam, Sarah Lyon-Caen, Catherine Quinot, Étienne de Sevin, Sophie Remacle, Karine Supernant, Rémy Slama, Orianne Dumas, Valérie Siroux, Nicole Le Moual,
Household disinfectant and cleaning products (HDCPs) assessment is challenging in epidemiological research. We hypothesized that a newly-developed smartphone application was more objective than questionnaires in assessing HDCPs. Therefore, we aimed to compare both methods, in ... SEPAGES birth cohort completed repeated validated questionnaires on HDCPs and respiratory health and used an application to report HDCPs and scan products barcodes, subsequently linked with an ... Kappa coefficients. Logistic regression models estimated associations of HDCP with asthma symptom score. The 101 participants (18 ...
Tópico(s): Noise Effects and Management
2021 - Multidisciplinary Digital Publishing Institute | International Journal of Environmental Research and Public Health
Yan Wang, Lianlian Liu, Yuan Tian, Yang Chen, Wenhui Zha, Yang Li, Fuju Wu,
... of placental cells in hypertensive disorder complicating pregnancy (HDCP) through mTOR pathway. Microarray-based gene expression analysis ... to predict the differentially expressed genes related to HDCP. To investigate the specific mechanism of DAPK2 in HDCP cells, placental microvascular endothelial cells were treated with ... and oxidative damage. Finally, rats were modeled with HDCP to verify the cell experiment results. DAPK2 was downregulated in HDCP, and could activate mTOR. Besides, DAPK2 overexpression led ...
Tópico(s): Renal and related cancers
2018 - Elsevier BV | International Journal of Biological Macromolecules
Dong‐Tsamn Lin, Jian Yong, Shuhua Ni, Weichao Ou, Xuerui Tan,
... association of adropin and hypertensive disorders complicating pregnancy (HDCP).Methods: Patients with HDCP were matched with normotensive women (47 pairs). Adropin ... the serum adropin levels were lower in the HDCP group (P < 0.001) and in HDCP subgroups (gestational hypertension, mild preeclampisa, and severe preeclampsia, ... adjustment for confounders, adropin remained negatively associated with HDCP (P = 0.027).Conclusion: Lower adropin concentration is significantly associated with HDCP, suggesting that higher or normal adropin levels may ...
Tópico(s): Adipose Tissue and Metabolism
2019 - Informa | Hypertension in Pregnancy
Yiqi Zhang, Xi Lan, Congjie Cai, Run Li, Yan Gao, Liuqing Yang, Cheng Wu, Hongli Dong, Xinxin Pang, Dan Bai, Guo Zeng,
... gestational diabetes mellitus (GDM), hypertensive disorder complicating pregnancy (HDCP), and intrahepatic cholestasis of pregnancy (ICP). Study Design ... value of lipid profiles to predict GDM and HDCP. Results After adjusting for potential confounders, TG, TC, ... 43, 95% CI: 1.14–1.79) and HDCP (TG: OR = 2.42, 95% CI: 1.56– ... the other common predictors to predict GDM or HDCP owned stronger predictive power with the largest area ... 0.643 [95% CI: 0.613–0.673], HDCP: 0.707 [95% CI: 0.610–0.804]) ... the whole pregnancy are significantly associated with GDM, HDCP, and ICP. Combining lipid profiles in the first ...
Tópico(s): Birth, Development, and Health
2019 - Thieme Medical Publishers (Germany) | American Journal of Perinatology
Antonio Monroy‐Noyola, Miguel Á. Sogorb, Eugenio Vilanova,
O-hexyl O-2,5-dichlorophenyl phosphoramidate (HDCP) is a chiral analogous compound of the methamidophos insecticide that induces delayed neuropathy, and the R-(+)-HDCP enantiomer is an inhibitor of neuropathy target esterase ( ... in mammal tissues. Our group had reported R-(+)-HDCP hydrolysis in chicken serum enhanced by 30–250 ... kidney methallotionein in 1 mL containing 400 μM HDCP for 60 min showed no significant Cu2+-dependent ... and similar levels to the Cu2+-dependent R-(+)-HDCP hydrolysis. About 75% of R-(+)-HDCP were hydrolyzed ...
Tópico(s): Protein Interaction Studies and Fluorescence Analysis
2018 - Elsevier BV | Food and Chemical Toxicology
YAN-SHAN CHEN, Ling Shen, R. Mai, Ying Wang,
... pregnant females with a hypertensive disorder complicating pregnancy (HDCP). Placental tissue samples were obtained from 48 patients with HDCP and 40 females with a normal pregnancy. The ... 181b in the placental tissue of patients with HDCP were lower than those in the control group, ... mRNA in the placental tissue of patients with HDCP were higher than those in the control group. ... expression of the PAI-1 protein in the HDCP group was higher than that in the control ... and PAI-1 mRNA were strongly associated with HDCP. Thus, miRNA-181b may play an important role ...
Tópico(s): Blood Coagulation and Thrombosis Mechanisms
2014 - Spandidos Publishing | Experimental and Therapeutic Medicine
Juan Zhou, Xiaomin Xiao, Yinghua Wu,
Hypertensive disorder complicating pregnancy (HDCP) is one of the most frequent and serious pregnancy-related diseases, which is closely related to disorders of the maternal ... and function of dNK cells from women with HDCP.Decidual tissues were collected from women with normal pregnancy (normal control group, n = 15 cases) and HDCP (HDCP group, n = 20 cases), respectively. The mononuclear cells ... γ in the dNK cells from women with HDCP was on a lower trend than those from ... the phenotype of dNK cells from women with HDCP is of no difference, their functions are abnormal. ...
Tópico(s): Endometriosis Research and Treatment
2013 - Wiley | Journal of Obstetrics and Gynaecology Research
Antonio Monroy‐Noyola, Miguel Á. Sogorb, Eugenio Vilanova,
... of O-hexyl O-2,5-dicholorophenyl phosphoramidate (HDCP) were observed in serum and subcellular fractions of ... higher activity than kidney and brain. The S-HDCP isomer was hydrolysed to a higher extent than ... activity and a higher hydrolysis of the R-HDCP isomer. The Ca(2+)-dependent stereoselective biodegradation of S-HDCP is dominant in the most active tissues in ... rat. It can therefore be concluded that S-HDCP would be biodegraded faster than R-HDCP. Furthermore, R-HDCP is the isomer that will remain at a ...
Tópico(s): Biochemical Acid Research Studies
2007 - Elsevier BV | Toxicology Letters
Sung‐Yong Choi, Kousaburo Ohashi,
The large synergistic effect of 3,5-dichlorophenol (Hdcp) in the extraction of gallium(III) with 2- ... water, and the association constants between HA and Hdcp in heptane were determined. The extractability of gallium( ... HA was remarkably enhanced upon the addition of Hdcp. The synergistic effect of Hdcp was quantitatively evaluated in terms of both a ... extracted in both the absence and presence of Hdcp were assigned to be Ga(OH)(A)2 and Ga(dcp)(A)2•Hdcp, respectively. Moreover, the association constants of the synthesized ...
Tópico(s): Extraction and Separation Processes
2000 - Springer Nature | Analytical Sciences
Antonio Monroy‐Noyola, Miguel Á. Sogorb, N. Dı́az-Alejo, N. Ñı́guez, J. Barril, José Luis Vicedo González, M.A. Escudero, Eugenio Vilanova,
... Ca2+-dependent and EDTA-resistant hydrolysing activities against HDCP and paraoxon in the particulate and soluble fractions of hen, rat and rabbit liver. HDCP was more extensively hydrolysed than paraoxon in both ... of wide interindividual variations. However the ratio of HDCP versus paraoxon hydrolysing activity (HDCPase/paraoxonase), although within ... not inhibited by EDTA. The stereospecific hydrolysis of HDCP was mostly a Ca2+-dependant one, the S-HDCP isomer being hydrolysed faster than the R-HDCP ...
Tópico(s): Alkaline Phosphatase Research Studies
1999 - Elsevier BV | Chemico-Biological Interactions
N. Dı́az-Alejo, Eugenio Vilanova,
O-Hexyl O-2,5-dichlorophenyl phosphoramidate (HDCP) is a chiral organophosphorus compound that undergoes enzymatic hydrolysis in the rat and hen. Studies of the stereospecificity of its biodegradation are necessary to establish HDCP toxicity. To this effect, methods have been developed for the analysis of the HDCP stereoisomers by gas chromatography (GC) and high-performance ... v). The detection limit was 25 μM for HDCP and 5 μM for one of its hydrolytic ... method is described for the liquid extraction of HDCP and DCP with 1,2-dichloroethane in biological ...
Tópico(s): Pharmacogenetics and Drug Metabolism
1993 - Elsevier BV | Journal of Chromatography B Biomedical Sciences and Applications
Jingyang Zhang, Xiaoxiao Cao, Hong-Xia Wen, Hongyan Zhang,
... blood of patients with hypertensive disorder complicating pregnancy (HDCP). A total of 60 patients diagnosed with HDCP in the Obstetrics Department of Wuhan Children's ... were selected. The patients were divided into the HDCP (n=20), mild pre-eclampsia (n=20) and ... α) and interleukin-6 (IL-6) in the HDCP group was significantly higher than that in the ... have independent predictive value for the occurrence of HDCP (P<0.05). The results show that, 24- ... cytokines are closely correlated with the occurrence of HDCP, which can reflect the severity and prognosis of ...
Tópico(s): Biomarkers in Disease Mechanisms
2018 - Spandidos Publishing | Experimental and Therapeutic Medicine
Richard Meeson, Allen E. Goodship, Gareth Arthurs,
... PCA): the Veterinary Instrumentation Hybrid Dynamic Compression Plate (HDCP), and the OrthoMed CastLess Arthrodesis Plate (CLP).In vitro mechanical analysis.HDCP(n = 10), CLP(10).Single-cycle load to ... failure: bending stiffness was significantly higher for the HDCP(2269 ± 175 N/mm) than CLP(1754 ± 88 ... 001). Bending structural stiffness was higher for the HDCP(3.8 ± 0.3 Nm(2) ) versus CLP( ... 2 plates for bending strength was not demonstrated; HDCP= 13.9 ± 1.4 Nm, CLP13.2 ± 0. ... in bending resistance afforded by the CLPover the HDCP. Fatigue failure of either plate during the convalescent ...
Tópico(s): Veterinary Orthopedics and Neurology
2012 - Wiley | Veterinary Surgery
Fred A. Wininger, Amy S. Kapatkin, Alex Radin, Frances S. Shofer, Gail K. Smith,
... mm/3.5 mm hybrid dynamic compression plate (HDCP) or a 3.5 mm dynamic compression plate ( ... stabilized with either a 2.7/3.5 HDCP or 3.5 DCP.Paired cadaveric canine antebrachii ( ... was calculated. Significance was set at P<.05.HDCP failed at higher loads than DCP for 9 ... between metacarpal diameter and failure loads for the HDCP and 3.5 DCP, respectively.There was a ... moment at failure between 2.7/3.5 HDCP and 3.5 DCP constructs; however, the difference ... in all patients.The 2.7/3.5 HDCP has physical and mechanical properties making it a ...
Tópico(s): Foot and Ankle Surgery
2007 - Wiley | Veterinary Surgery
Enriqueta Felip, Rafael Rosell, Vicente Alberola, José Gómez‐Codina, J Maestre, Julio Astudillo, Carlos Camps, J.L. González-Larriba, Isabel Moreno, Alfredo Paredes, Á. Artal, Ramón García-Gómez, Pilar Garrido, Enriqueta Felip, I. Barneto, José Javier Sánchez,
... randomly assigned to receive either high-dose cisplatin (HDCP) (100 mg/m2) or moderate-dose cisplatin (MDCP) ( ... February 1997, 83 patients were randomized: 46 received HDCP, and 37 received MDCP. Clinical characteristics were well matched. Radiographic response rate was 59% for HDCP patients and 30% for MDCP patients (P = 0. ... disease. Complete resection rate was 61% in the HDCP group, and 51% in the MDCP group (P = ... patient who received MDCP. Median survival in the HDCP and MDCP groups was 13 and 11 months, ... response rate is observed in patients who receive HDCP, but this study fails to show any significant ...
Tópico(s): Lung Cancer Research Studies
2000 - Elsevier BV | Clinical Lung Cancer
Miguel Á. Sogorb, Inés Sánchez, Manuel López‐Rivadulla, Virtudes Céspedes, Eugenio Vilanova,
... substrates O-hexyl O-2, 5-dichlorophenyl phosphoramidate (HDCP) and O,O'-diethyl p-nitrophenyl phosphate were ... was resistant to EDTA inhibition. The EDTA-resistant HDCP hydrolyzing activity and paraoxonase activities of rabbit serum ... activity exhibited no stereoselectivity in the hydrolysis of HDCP. The EDTA-sensitive activity was isolated in the lipoprotein fraction and stereoselectively hydrolyzed the S-HDCP over the R-HDCP. Other differences between the EDTA-sensitive paraoxonase and HDCP hydrolyzing activity were discovered in response to p- ...
Tópico(s): Pesticide Exposure and Toxicity
1999 - American Society for Pharmacology and Experimental Therapeutics | Drug Metabolism and Disposition
Miguel Á. Sogorb, N. Dı́az-Alejo, Marı́a C Pellı́n, Eugenio Vilanova,
... of O-hexyl O-2,5-dichlorophenyl phosphoramidate (HDCP) were isolated by chiral column chromatography, followed by ... used as criterion of aging. The stereoisomer S-(−)-HDCP inhibited hen brain NTE with an I50 of ... and much lower than that recorded for R-(+)-HDCP (I50=191 nM). NTE inhibited by HDCP racemic mixture and the stereoisomer S-(−)-HDCP was reactivated by KF after 20 h of ... at 37°C. The NTE inhibited by R-(+)-HDCP could not be fully reactivated after inhibition.
Tópico(s): Synthesis and Reactivity of Sulfur-Containing Compounds
1997 - Elsevier BV | Toxicology Letters
Xinchang Zhang, Weidong Gu, Haijun Zhang, Maoli Wang,
... interior node along a hybrid device communication path (HDCP). HDCPs can be used for communications between two user ... backhaul links. Application- layer-assisted data forwarding allows HDCP to include various communication links including access links, ... device links using licensed and unlicensed spectrum resources. HDCPs are centrally arranged to meet specific requirements and designated optimization objectives. We introduce two HDCP orchestration methods in this article. Our proposed solution ...
Tópico(s): Telecommunications and Broadcasting Technologies
2019 - Institute of Electrical and Electronics Engineers | IEEE Network
Juan Manuel Ramírez, Carlos Macías,
... plate (DCP) hybrid pancarpal arthrodesis plate (hybrid DCP [HDCP]) without rigid coaptation in the postoperative period. Study ... had PCA using 3.5/2.7 mm HDCP (1 or 2 plates) and a Robert‐Jones ... Fourteen dogs had PCA stabilized with a single HDCP and 1 giant breed dog had PCA stabilized with 2 HDCP on the dorsal aspect of the carpus secured ... rigid coaptation can successfully be performed using the HDCP.
Tópico(s): Veterinary Oncology Research
2016 - Wiley | Veterinary Surgery
... of lipid metabolism in hypertensive disorder complicating pregnancy (HDCP). The study included 178 pregnant women with HDCP and 243 healthy pregnant controls. Using PCR-restriction ... TT genotype was significantly associated with protection against HDCP compared to the pooled G genotypes. The genotype ... evaluated the correlation between the two SNPs and HDCP development, and revealed an association between the two ... and disorders of lipid metabolism in patients with HDCP. Except for fasting insulin levels, which was higher ...
Tópico(s): Birth, Development, and Health
2015 - Research Foundation of Ribeirão Preto | Genetics and Molecular Research
Philippa King, Rodolphe Clérac, Christopher E. Anson, Annie K. Powell,
... their structures have been characterised. Simple mononuclear [Ni(Hdcp)(H2O)4] (1), Na2(μ-H2O)2(H2O)8[Ni(Hdcp)2(H2O)2] (2), [M(H2dcp)2(H2O) ... and subsequently linked into 1-D chains [Mn(Hdcp)(H2O)2]∞ (6), [{Mn(H2O)4}{Mn(Hdcp)2(H2O)2}·4H2O]∞ (7), [Ni2(Hdcp)2(μ-H2O)2(H2O)2]∞ (8), [{Ni( ...
Tópico(s): Metal complexes synthesis and properties
2004 - Royal Society of Chemistry | Dalton Transactions