Directory of Open Access Journals (DOAJ)
Liz Dolan, Anthony Harris, Godfrey Hodgson, Jon Ashworth, Tunku Varadarajan, Paul Heiney, Mark Van Dyck, Nick Nuttall, Andrew Pierce and Ben Wakeham, Andrew Pierce, Alan Martin, Willy Newlands, Patricia Davies, Rob Hughes, Mary Pachnos, Jane MacQuitty, Barbara Green, Jan Morris, Colin Fricker, Richard Thomson, Alexandra Frean, Media Correspondent, Ronald Faux, David Rhys Jones, John Diamond, Ray Hearn, Philip Howard, Susan Bell, Francis Martin, Hilary Finch, Ben Preston, Education Correspondent, Jeremy Kingston, Donu Kogbara, Noel Goodwin, Graham Ward, Dessa Trevisan, Christopher Donaldson, Richard Cleroux, Morag Preston, Kevin Eason, Eve-Ann Prentice, Diplomatic Correspondent, Stuart Jones Tennis Correspondent, Geoff Brown, Gerald Davies, Jonathan Eyal, Noel Falconer, Andrew Leggatt, Robert Sheehan, Steve Keenan, Sir Winston Churchill, David Hewson, Peter Ball, John O'leary, Education Editor, Brian Johnston, Jonathan Romain, Libby Purves, Michael Evans, Defence Correspondent, Richard Ford Home Correspondent, Robin Young, Daniel Johnson, Peter Millar, Mary Teale, Jenny MacArthur, Peter Smithers, Marcus Williams, Frances Bissell, R. J. B. Hoare, Sarah Bagnall, Peter Barnard, John Selwyn Gummer, Philip Bassett, Industrial Editor, Nigella Lawson, Michael Binyon Diplomatic Editor, Derwent May, Gerald Kaufman, Leslie Thomas, Russell Kempson, Nicole Swengley, Jessica Gorst-Williams, Stephen Anderton, Louise Goudie, Michael Theodoulou, Patrick Taylor, Rachel Kelly Property Correspondent, Matthew Perry, Lucy Berrington, Gillian Bowditch, Heather M. Bradley, Charles Bremner Brussels Correspondent, George Plumptre, Mark Hunter, Gillian Bowditch, Scotland Correspondent, David Powell Athletics Correspondent, Marcus Binney, Raymond Keene, Adam Sage, Christine Buckley, David Robinson, Richard Harwood, Sarah Forde, Paul Wilkinson, P. H. S, Marianne Darch, Stephanie Lewis, A. M. Evans, Richard Evans, Sarah Harding, Oliver Holt, N. Marcetic, Marcel Berlins, Nigel Hawkes, Science Editor, Nicholas Darby, Robert Miller and Janet Bush, Sallie Quin, Janet Bush Economics Correspondent, Teresa Gorman, David Hands Rugby Correspondent, Julian Muscat, G. D. Clarke, William Rees-Mogg, John Walsh, Sara McConnell, Giles Whittell, Nicholas Watt and Jill Sherman, Alan Copps, Sean Coughlan, Mel Webb, Kathryn Knight, Srikumar Sen Boxing Correspondent, Anjana Ahuja, Tim Wapshott, Helen Mound, Christine Wheeler, Roy Hattersley, Jane Laidlaw, Nadine Meisner, Simon Jenkins, Kate Bassett, John McDonald, Misha Glenny, Tom Rhodes, Jonathan Meades, Jill Sherman, Political Correspondent, Stacy Sullivan and Sam Kiley and Michael Evans, Gennie Peters, Jack Bailey, Ben Preston and John O'leary, Richard Morrison, Michael Henderson, Tony Douglass, John Phillips, Alan Jackson, Will Wyatt, Penny Perrick, Dr Dashboard, David Horne, Richard Ford, Catherine Milton, P. Taylor, Gill Hornby, Nick Nuttall and John Goodbody, Christopher Irvine, Melvyn Marckus,
... Kitchens Berkshire Chapel Kitchens The Kitchen Specialist Association HKS Inter Design Kitchen Art of Berkshire Ltd Lake ...
1995 - Gale Group | TDA
Yusuke Kosugi, Arnon Plianchaisuk, Olivia Putri, Keiya Uriu, Yu Kaku, Alfredo A. Hinay, Chen Luo, Jin Kuramochi, Kenji Sadamasu, Kazuhisa Yoshimura, Hiroyuki Asakura, Mami Nagashima, Jumpei Ito, Naoko Misawa, Ziyi Guo, Jarel Elgin Tolentino, Shigeru Fujita, Lin Pan, Mai Suganami, Mika Chiba, Ryo Yoshimura, Kyoko Yasuda, Keiko Iida, Naomi Ohsumi, Adam Strange, Shiho Tanaka, Takasuke Fukuhara, Tomokazu Tamura, Rigel Suzuki, Saori Suzuki, Hayato Ito, Keita Matsuno, Hirofumi Sawa, Naganori Nao, Shinya Tanaka, Masumi Tsuda, Lei Wang, Yoshikata Oda, Zannatul Ferdous, Kenji Shishido, So Nakagawa, Kotaro Shirakawa, Akifumi Takaori‐Kondo, Kayoko Nagata, Ryosuke Nomura, Yoshihito Horisawa, Yusuke Tashiro, Yugo Kawai, Kazuo Takayama, Rina Hashimoto, Sayaka Deguchi, Yukio Watanabe, Ayaka Sakamoto, Naoko Yasuhara, Takao Hashiguchi, Tateki Suzuki, Kanako Kimura, Jiei Sasaki, Yukari Nakajima, Hisano Yajima, Takashi Irie, Ryoko Kawabata, Kaori Tabata, Terumasa Ikeda, Hesham Nasser, Ryo Shimizu, MST Monira Begum, Michael Jonathan, Yuka Mugita, Otowa Takahashi, Kimiko Ichihara, Takamasa Ueno, Chihiro Motozono, Mako Toyoda, Akatsuki Saito, Maya Shofa, Yuki Shibatani, Tomoko Nishiuchi, Kei Sato,
... L455F) variant has emerged and has been named HK.3 (XBB.1.9.2.5.1.1.3). HK.3 was initially discovered in east Asia and ... both S:L455F and S:F456L substitutions, including HK.3, are defined as FLip variants. These FLip ... Google Scholar We investigated the virological properties of HK.3 as a representative of the FLip variants. ... estimated the relative effective reproduction number (Re) of HK.3 on the basis of genome surveillance data ... from 13 countries reporting the substantial presence of HK.3 with a Bayesian hierarchical multinomial logistic regression ...
Tópico(s): Viral gastroenteritis research and epidemiology
2024 - Elsevier BV | The Lancet Microbe
Miscellaneous Free eBooks
Victoria McKee, Colin Fenge, Kenneth McLeish, Mike Graham, Paul Nelson, Richard Ellis, Helen FIELDING's, Mary Dowey, John Davison, Helen Davidson, Rob Hughes, John Peter, Andrew Grice Political Correspondent, Bemard Cafferty, Eric Dymock, Susan d'Arcy, Matthew Bowman, Artyom Zaitsev Vilnius, Graham Rose, Nicolette Jones, Steward Else, Steve Clarke, Fidel Castro, Adam Nicolson, Julian Symons, Frederic Raphael, John Rowland, Mark Hosenball, Carol Sarler, Tom Bullimore, Marlna Valzey, Geordie Greig, Patrick Stoddart, Robert Sandall, Iain Johnstone, B Quirk, Donald Woods, Irwin Stelzer, Jeremy Isaacs General Director, John Newell, Franco Moschino, Ivan Fallon, Deryk Brown, Philip Ridley, Charles Wintour, David Dougill, Geordie Greig Arts Correspondent, Brian Moynahan Bonn, Jane Bird, J M Johnson, Sanjeeva Fernando, Tim Madge, John Swain, Joanna Goldsworthy, Hugh Canning, Margarette Driscoll, Jane Bird Technology Editor, Eric Detzer, Susan Crosland, Peter Kemp, Geoff Whitten, Robert Harris, Caroline Lees, Richard Palmer Environment Correspondent, John McVicar, George Perry, John Cassidy, Sue Mott, Robin Marlar, David Collins, Anita Brookner, Barry Burnett, Michael Jones Political Editor Dublin, Albert Armstrong, Carole Bettsworth, Tom Hervey, Jon Freeman, Judy Meweezen, Stuart Wavell, Paul Donovan, Chris Butlin, Janette Marshall, Nigella Lawson, B Riddleston Regional Opencast Director, Peter Lewis, Jeff Randall, Dr Peter Wilkins, Paul Driver, Elaine Cobbe, Frances Duffy, Hugh David, Austin MacCurtain, Peter Freedman, Jennie Hawthorne, Gillian Fairchild, Vera Rich, Rufus Olins, Stuart Weir Editor, Michael Durham, Tavleen Singh, David Lawrenson, John Hopkins, Martin Jacques, Brian Walden, Roger Williams, Desmon Shawe-Taylor, Gareth David, Brian Reading, Jim Wilson, Caspar Weinberger, Kate Saunders, Malcolm Winton, Anthony Isaacs, Richard Cook, Marie Colvin, Dr John Durant, Diana Wright, Craig Brown, S Punter, Andrew Lorenz Industrial Editor, Ian Anderson, Stephen Jones, Stephen Thorpe, Patrick Stodart, Rosemary Conley, Andrew Grice, Digby Anderson, Martin Searby, Ian Birrell, P G White, Peter Plani, Nigel Bowden Marbella, Chris Jones, Tim Willis, Andrew Hogg, Tony Rocca, Chris Stephen Bucharest, Norman Stone, Clive Everton, Richard Woods, Peter Johnson, Frances Rafferty, Shirley Harrison, Marion Hume, Maurice Chittenden, John Walsh, Ian Dunning, Iola Smith, David Hughes Chief Political Correspondent, Amin Rajan, Aileen Ballantyne Medical Correspondent, Brian MacArthur, Rebecca Fowler, Michael Jones Political Editor, Andrew Yates, James Blitz, Susan Raven, D J Taylor, Mike Smith, Elisabeth Rosenthal, Mihir Bose, Michael Smith, A Zenined, Susannah Herbert, Godfrey Smith, Paul Barker, Brian Glanville, Stan Levenson, John Carey, John Hill, Chris Dighton, J Ashmead, Norman Macrae, Tom Tickell, Gareth David Deputy City Editor, Lenny Henry, Judith Summers, Peter Dragadze, Liam Clarke, Colin Greenland, Pleasaunce Perry, Dr Glynis Breakwell, Jon Swain Panmunjom, Chris Lightbown, Jeff Randall City Editor, Hugh Pearman, Marina Vaizey, Richard Caseby, Margaret Park, Angela Long, Deborah Sacks, Frank Field, Penny Perrick, Tony Hetherington, G Easton Havant, Peter Roebuck, Richard Nixon, Walter Ellis, Joanna Simon, Iain Jenkins, Guy Williams, Boris Schapiro, Mark Wallington,
... Insurance Group BHP Petroleum Medical Research Council Caspe Hks Sundridge Park Management Centre City of Newcastle upon ...
1990 - Gale Group | Sunday Times HA GDA
Eric Yuk Fai Wan, Ran Zhang, Sukriti Mathur, Vincent Ka Chun Yan, Francisco Tsz Tsun Lai, Celine Sze Ling Chui, Xue Li, Carlos King Ho Wong, Esther W. Chan, Chak Sing Lau, Ian Chi Kei Wong,
... to 28 months until 15 August 2022 for HK cohort. Patients with COVID-19 infection over 6 ... employed. Result 10,759 (UKB) and 165,259 (HK) older adults with COVID-19 infection with matched 291,077 (UKB) and 1,100,394 (HK) non-COVID-19-diagnosed older adults were recruited. ... 4 (95% Confidence interval: 1.1,1.6), HK:1.2 (95% CI: 1.1,1.3)]; ... 1.8 (95% CI: 1.3,2.4), HK:1.2 (95% CI: 1.0,1.4)]; ... 3.4 (95% CI: 2.5,4.5), HK: 4.0 (95% CI: 1.3,12.8); ... 1.7 (95% CI: 1.3,2.2), HK:1.6 (95% CI: 1.3,2.1)]; ... 2.6 (95% CI: 1.7,4.1), HK: 1.6 (95% CI: 1.2,2.1)]; ...
Tópico(s): SARS-CoV-2 and COVID-19 Research
2023 - Oxford University Press | Journal of Travel Medicine
Peter Whittlesea, Victoria McKee, John Coleman, Frances Gibb, Legal Affairs Correspondent, Sheila Gunn, Political Reporter, Ghislanie Boddington, Philip Muston, Nick Nuttall, Michael Knipe Diplomatic Correspondent, Gerald Long, Pearce Wright, James Rusbridger, Charles Bremner and John Best, Earl of Perth (Chairman), Andrew Longmore Tennis Correspondent Bucharest, Sheridan Morley, Ivo Tennant, Qamar Ahmed, Douglas Broom, Education Reporter, Angela MacKay, Michael Seely, Racing Correspondent, Brian Buchanan Sydney, Maurice Gillibrand, Michael Binyon, Philip Ball, Tom Gibb, Norman Barry, Carol Leonard, Wolfgang Münchau, European Business Correspondent, Neil Bennett, Banking Correspondent, Simon Wilde, Stewart Tendler, Crime Correspondent, Geoff Brown, Colin Narbrough Economics Correspondent, Ray Clancy, Bernard Levin, Michael Hart, Martin Fletcher, Mitchell Platts, Joe Joseph Tokyo, Mitchell Platts, Golf Correspondent, Cris Check, Stuart Jones, Nicholas Wood Political Correspondent, Peter Stothard, US Editor, John Lewis, Political Staff, Ahmed Fazl, Norman Hammond, Archaeology Correspondent, R. K. Arthur, Jill Sherman, Social Services Correspondent, Paul Bates, Raymond Keene Chess Correspondent, Hugh Leggatt, Chistaine Boddington, Richard Ford Political Correspondent, David Taylor, Matthew May, Philip Robinson Los Angeles, Peter Bills, Michael Evans, Defence Correspondent, Robin Oakley, Politcal Editor, Anthony Quinton, John Durie, Ernest Beck, Anne Barnes, Jenny MacArthur, Michael Clark, Patricia Tisdall, Vernon Bogdanor, Charles Bremner, John Percival, Charles Knevitt Architecture Correspondent, Thomson Prentice, Barry Hughes, Robert Cockburn, Leslie Tilley, Harvey Elliott, Air Correspondent, Gavin Bell, Lindsay Cook, John Woodcock, Michael Theodoulou, Dennis Signy, Jeremy Mayrice, David Miller, Robin Oakley Political Editor, Barry Millington, Philip Webster, Chief Political Correspondent, Gillian Bowditch, C. J. Barker, John M. M. Banham Director General, Andrew McEwen, Diplomatic Editor, David L. HARRISON(Director), Peter Purton, James McGuinness, David Robinson, Elmore Dixon, Nicholas Beeston, Raymond Keene, Chess Correspondent, Judith Lyons, Alix Ramsay, Paul Griffiths, David Lowry, Liz Gill, Edwina Currie, George Donaldson, Penny Wheatcroft, Richard Owen, Barry Pickthall, Joyce Whitehead, Marcel Berlins, Roger Boyes, Ian Ross, Ronald Butt, Valerie Goldberg, David Sapsted, Jamie Dettmer, Peter F. Bates, Colin Campbell, Mining Correspondent, David Brewerton, Christopher Thomas, John Goodbody, David Young, Philip Robinson, Los Angeles, Peter Stothard, us Editor, Clive White, Matthew Parris, David Clutterbuck, Keith Blackmore, Michael Phillips, Joe Smith, Graham Searjeant, Tania Glyde, John Horn, Philip Pangalos, Norma Osmond, Martin Waller, Benedict Nightingale, Tim KING(Tourism Officer), Marcas Williams, Rebecca Huxley, Hiilary Finch, Dr Thomas Stuttaford, Peter F. Portwood, Richard Morrison, Frances Gibb, Derek Harris Industrial Editor, Anne McElvoy, K. J. McNAMARA, Matthew Bond, Tim Jones, Employment Affairs Correspondent, David Hands, Rugby Correspondent, Michael Coleman, Colin McQuillan, Ann Hills, Rodney Lord Economics Editor, Mary Dejevsky, John Watson, Michael Hornsby Agriculture Correspondent,
... Group Alasdair Graham Associates Medical Research Council CASPE HKS Ltd Sundridge Park Management Centre City of Newcastle ...
1990 - Gale Group | TDA
Lauren H. Fairley, Kei Onn Lai, Jia Hui Wong, Wei Jing Chong, A. Vincent, Giuseppe D’Agostino, Xiaoting Wu, Roshan Ratnakar Naik, Anusha Jayaraman, Sarah R. Langley, Christiane Ruedl, Anna M. Barron,
... a member of its mitochondrial complex, hexokinase-2 (HK), play critical roles in microglial respiratory-glycolytic metabolism ... enriched in phagocytic microglia of AD mice. Meanwhile, HK controlled glycolytic metabolism and phagocytosis via mitochondrial binding ... impaired mitochondrial respiration and increased mitochondrial recruitment of HK, inducing a switch to glycolysis and reducing phagocytosis. To determine the functional significance of mitochondrial HK recruitment, we developed an optogenetic tool for reversible ...
Tópico(s): Immune cells in cancer
2023 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Yuting Zhang, Xiping Qin, Yufang Yang, Jinxiu Li, Xiaolian Li, Xiaoqin Zou, Zhenguang Huang, Songqing Huang,
... EGb, 2ME2 (HIF-1α inhibitor) or amifostine. After HK-2 cells and HIF-1α siRNA HK-2 cells were treated with CDDP, EGb or ... STAT3 and IL-6 were significantly increased in HK-2 cells and HIF-1α siRNA HK-2 cells induced by CDDP. Notably, HIF-1α ... of HIF-1α, STAT3 and IL-6 in HK-2 cells, as well as the IL-6 level in medium from HK-2 cells. Additionally, the α-SMA level in ... increased after being cultured with conditioned medium from HK-2 cells or HIF-1α siRNA HK-2 cells exposed to CDDP. Furthermore, exogenous IL- ...
Tópico(s): Tuberous Sclerosis Complex Research
2023 - Elsevier BV | Phytomedicine
OAPEN Free
Chan Li, Awital Bar Barroeta, Szu Shen Wong, Hyo Jung Kim, Monika Pathak, Ingrid Dreveny, Joost C.M. Meijers, Jonas Emsley,
Background: High-molecular weight kininogen (HK) circulates in plasma as a complex with zymogen prekallikrein (PK).HK is both a substrate and a cofactor for activated plasma ... domains and the C-terminal D6 domain of HK.Objectives: To determine the structure of the complex ... compare this with the coagulation factor XI (FXI)-HK complex.Methods: We produced recombinant FXI and PK ... with a 31-amino acid synthetic peptide spanning HK residues Ser565-Lys595 and determined the crystal structure.We also analyzed the full-length FXI-HK complex in solution using hydrogen deuterium exchange mass ...
Tópico(s): Mast cells and histamine
2023 - Elsevier BV | Journal of Thrombosis and Haemostasis
Anke Adenaeuer, Stefano Barco, Alice Trinchero, Sarah Krutmann, Hanan Nazir, Chiara Ambaglio, Vincenzo Rocco, Ylenia Pancione, Luigi Tomao, Arlette Ruiz‐Sàez, Marión Echenagucia, Sonja Alesci, Stefanie Sollfrank, Eyiuche D. Ezigbo, Friederike Häuser, Karl J. Lackner, Bernhard Lämmle, Heidi Rossmann,
Severe high-molecular-weight kininogen (HK) deficiency is a poorly studied autosomal recessive contact system defect caused by pathogenic, biallelic KNG1 variants.We performed the first comprehensive ... of diagnostic, clinical, genetic, and epidemiological aspects of HK deficiency.We collected clinical information and blood samples from a newly detected HK-deficient individual and from published cases identified by ... were performed by Sanger sequencing. The frequency of HK deficiency was estimated considering truncating KNG1 variants from ...
Tópico(s): Hemophilia Treatment and Research
2023 - Elsevier BV | Journal of Thrombosis and Haemostasis
Yanqi Ma, Qikai Zhou, Pingping Zhao, Xiaoyu Lv, Caixia Gong, Jie Gao, Jingfang Liu,
... AGE-Tf on human renal tubular epithelial cells (HK-2) was investigated. Methods In vitro Tf was ... glycation sites were identified with LC-MS/MS. HK-2 cells were treated with AGE-Tf prepared ... in vitro . The effects of AGE-Tf on HK-2 cell viability, proliferation, oxidative stress index, and ... differences were found in the survival rate of HK-2 cells among the AGE-Tf (500 mM), ... p > 0.05). The apoptosis rate of HK-2 cells in the AGE-Tf (500 mM) ... p < 0.05). The MDA levels of HK-2 cells in the AGE-Tf (500 mM) ...
Tópico(s): Chronic Kidney Disease and Diabetes
2023 - Frontiers Media | Frontiers in Endocrinology
Sijie Yang, Yuanling Yu, Yanli Xu, Fanchong Jian, Weiliang Song, Ayijiang Yisimayi, Peng Wang, Jing Wang, Jingyi Liu, Lingling Yu, Xiaofeng Niu, Jing Wang, Yao Wang, Fei Shao, Ronghua Jin, Youchun Wang, Yunlong Cao,
... dominant variants, such as EG.5.1 and HK.3, it showed remarkably high ACE2 binding affinity. ... except JN.1), HV.1, FLip+A475V, and HK.3. The growth advantages relative to HK.3 in past two months of these strains ... ACE2 (angiotensin-converting enzyme 2) binding affinities of HK.3 (XBB.1.5+L455F+F456L), BA.2. ... of XBB.1.5, EG.5, HV.1, HK.3, JD.1.1, BA.2.86, and ... against XBB.1.5, EG.5, HV.1, HK.3, JD.1.1, BA.2.86, and ... except JN.1), HV.1, FLip+A475V, and HK.3. The growth advantages relative to HK.3 in past two months of these strains ...
Tópico(s): Viral gastroenteritis research and epidemiology
2023 - Elsevier BV | The Lancet Infectious Diseases
A.M. Hubner, Igor F. Canisso, P.M. Peixoto, W.M. Coelho, Lilian dos Santos Ribeiro, Brian Aldridge, P.R. Menta, V.S. Machado, F.S. Lima,
... and reproductive outcomes of cows diagnosed with hyperketonemia (HK; β-hydroxybutyrate ≥1.2 mmol/L), hypoglycemia (HG; glucose ≤2.2 mmol/L), or concurrent HK and HG (HKHG). Glucose and β-hydroxybutyrate concentrations ... postpartum. Cows were categorized into 4 groups: no HK or HG (healthy; Norm = 1,821), HK only (HK = 232), HG only (HG = 161), and concurrent HK and HG (HKHG = 204). Subsequent milk production, along ... fewer metabolic disturbances (hypomagnesemia, hypocalcemia, elevated NEFA) than HK cows. Cows with HKHG had an increased incidence ...
Tópico(s): Lipid metabolism and disorders
2022 - Elsevier BV | Journal of Dairy Science
Abiy Agiro, Ian Duling, James M. Eudicone, Jill Davis, Yasmin Brahmbhatt, Kerry Cooper,
Abstract Introduction Hyperkalemia (HK), defined as serum potassium (K + ) >5.0 mEq/L, is an independent predictor of mortality in patients on maintenance ... HD). This study investigated the annual prevalence of HK and examined patient characteristics potentially associated with a higher annual HK prevalence. Methods This retrospective observational cohort study used ... was the proportion of patients with any predialysis HK (K + >5.0 mEq/L) within 1 year ... L) or severe (K + >6.0 mEq/L) HK. Findings Overall, 9347 patients on HD were included ...
Tópico(s): Heart Failure Treatment and Management
2022 - Wiley | Hemodialysis International
Damla Uludağ, Sadık Bay, Bilgesu Onur Sucu, Özgecan Şavluğ İpek, Thomas Mohr, Mustafa Güzel, Nihal Karakaş,
... cancers. One of the metabolic enzymes, hexokinase-II (HK-II) is involved in glycolysis, and inhibiting the HK-II activity may be a potential metabolic target ... jasmonate (MJ) is one of the compounds blocking HK-II activity in cancer cells. In a previous ... we showed that the novel MJ analogs inhibit HK-II activity through VDAC detachment from the mitochondria. ... this study, to evaluate the potential of targeting HK-2 activity, through patient cohort analysis, we first determined HK-2 expression levels and prognostic significance in highly ...
Tópico(s): Endoplasmic Reticulum Stress and Disease
2022 - Frontiers Media | Frontiers in Pharmacology
Qiang Sun, Houfa Geng, Meng Zhao, Yang Li, Xi Chen, Qian Sha, Peng Lai, Daoquan Tang, Dongzhi Yang, Jun Liang, Mengzhe Guo,
... analyses of FTO mRNA expression in HMC or HK-2 cells after treatment with high-concentration glucose, ... blot analyses of indicated proteins in HMC or HK-2 cells after treatment with high-concentration glucose, ... mannitol; (c) overall m6A levels in HMC and HK-2 cells after treatment with high-concentration glucose, ... between m6A levels and FTO protein expression in HK-2 and HMC cells; (e) Western blot analyses of indicated proteins in HMC or HK-2 cells after FTO overexpression; (f) overall m6A levels in HMC and HK-2 cells after FTO overexpression by LC–MS/ ...
Tópico(s): Cancer-related molecular mechanisms research
2022 - Springer Science+Business Media | Clinical and Translational Medicine
Lei Yan, Jinhu Chen, Weihua Fang,
... in regulating apoptosis of human proximal tubular cells (HK-2). Exosomes (CaOx-Exo) were isolated from CaOx-treated macrophages and then incubated with HK-2 cells. CaOx-Exo treatment reduced cell viability and promoted apoptosis of HK-2 cells. The expression of Caspase-3 and ... increased, and Bcl-2 expression was decreased in HK-2 cells following CaOx-Exo treatment. Moreover, CaOx- ... 1 expression and a downregulation of p62 in HK-2 cells. GFP-LC3 puncta were increased in HK-2 cells following CaOx-Exo treatment. Additionally, CaOx- ...
Tópico(s): Connexins and lens biology
2022 - Taylor & Francis | Bioengineered