François J. Joubert, Nico Taljaard,
... 6 and CM-10a) were purified from Naja haje haje (Egyptian cobra) venom. Whereas toxin CM-5 comprises ... the sequences of the three toxins from Naja haje haje venom reveal a high degree of homology with those of the corresponding neurotoxins isolated from Naja haje annulifera or Naja nivea venoms.
Tópico(s): Nicotinic Acetylcholine Receptors Study
1978 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Akindele Oluwatosin Adeyi, Babafemi Siji Ajisebiola, Olubisi E. Adeyi, Olarewaju Adekunle, Olanike Busirat Akande, Adewale Segun James, Babajide O. Ajayi, Peter Ofemile Yusuf, Babatunde A. Idowu,
Naja haje envenoming could activate multiple pathways linked to haematotoxic, neurological, and antioxidant systems dysfunctions. Moringa oleifera has been ... scientific information on its antivenom effects against Naja haje. This study thus, investigated the antivenom activities of ... extract partitions of M. oleifera leaves against N. haje envenoming. Forty five male rats were divided into ... with 0.025 mg/kg (LD50) of N. haje venom while group 1 was given saline. Group ... haemorrhagic, haemolytic and anti-coagulant activities of N. haje venom were best inhibited by ethanol partition. Envenoming ...
Tópico(s): Healthcare and Venom Research
2021 - Elsevier BV | Biochemistry and Biophysics Reports
François J. Joubert, Nico Taljaard,
... 11 and CM-12) were purified from Naja haje haje (Egyptian cobra) venom. Whereas toxin CM-11 contains ... of CM-11 and CM-12 from Naja haje haje venom show a high degree of homology with ...
Tópico(s): Plant-based Medicinal Research
1978 - Wiley | European Journal of Biochemistry
Amany A. Tohamy, Aly Fahmy Mohamed, Ahmed E. Abdel Moneim, Marwa S.M. Diab,
... biochemical and histopathological effect of Egyptian cobra (Naja haje; N. haje) crude venom at a sublethal dose have been ... the injection of crude venom of the N. haje induced a significant disturbance in liver and kidney functions. In addition, results revealed that N. haje venom has a potent oxidative activity by increasing ... factors that lead to death caused by N. haje venom.
Tópico(s): Healthcare and Venom Research
2014 - Elsevier BV | Journal of King Saud University - Science
Fatima Amin Adamude, Emeka John Dingwoke, Mujitaba Suleiman Abubakar, Sani Ibrahim, Gadija Mohamed, Ashwil Klein, Abdullahi Balarabe Sallau,
... of three medically important Nigerian Elapidae snakes Naja haje, Naja katiensis and Naja nigricollis was studied using ... and 46 proteins in the venoms of N. haje, N. katiensis, and N. nigricollis, respectively, with molecular ... proteins belonged to 14 protein families in N. haje and N. katiensis, and 12 protein families in ... most abundant protein family, constituting 52% in N. haje and N. katiensis, and 41% in N. nigricollis, ... constituting 37% in N. nigricollis, 26% in N. haje, and 24% in N. katiensis. Other protein families, ...
Tópico(s): Marine Invertebrate Physiology and Ecology
2021 - Elsevier BV | Toxicon
Jean‐François Trape, Laurent Chirio, Donald G. Broadley, Wolfgang Wüster,
... phylogeography and systematics of the Egyptian cobra (Naja haje) species complex. Phylogenetic analysis of mitochondrial haplotypes reveals ... West Africa, and that the haplotypes of Naja haje arabica form the sister group of North and East African N. h. haje. Multivariate morphometrics confirm the distinctness of the Arabian ... differs from all other members of the N. haje complex by a combination of colour pattern and ...
Tópico(s): Wildlife Ecology and Conservation
2009 - Q15088586 | Zootaxa
Carmen W. van den Berg, Piet C. Aerts, Johannes van Dijk,
... N. naja (C3- and C5-depleting) and N. haje (selectively C3-depleting) were studied. The animals received ... efficient in depleting total complement activity as N. haje CVF. Decreased CH50 values could largely be ascribed ... naja CVF, however, lasted longer than after N. haje CVF administration. Estimated functional half-lives of N. naja and N. haje CVF were 11.5 and 4.5 h, ...
Tópico(s): Erythrocyte Function and Pathophysiology
1991 - Elsevier BV | Journal of Immunological Methods
Rachelle Kornhauser, Geoffrey K. Isbister, Margaret A. O’Leary, Peter Mirtschin, Nathan Dunstan, Wayne C. Hodgson,
... effects of the E gyptian cobra, N aja haje , in vivo but it is unclear if this ... neutralise the in vitro neurotoxic effects of N . haje venom. Both N otechis scutatus (10 μg/ml) and N . haje (10 μg/ml) venoms caused inhibition of indirect ( ... immunoblotting indicated TSAV was able to detect N . haje venom, and enzyme immunoassay showed that in‐house ... N . scutatus antibodies were able to detect N . haje venom. These findings demonstrate cross‐neutralisation between different ...
Tópico(s): Rabies epidemiology and control
2012 - Wiley | Basic & Clinical Pharmacology & Toxicology
Saleh Al‐Quraishy, Mohamed A. Dkhil, Ahmed E. Abdel Moneim,
... apoptosis in rat liver cells provoked by Naja haje crude injection (LD50) after four hours.Wistar rats ... and activities of antioxidant enzymes were determined.N. haje crude venom (0.025 μg/kg of body ... apoptosis induction in the liver. In addition, N. haje crude venom caused hepatic injury as indicated by ... the present results, it can hypothesized that N. haje crude venom is a potent inducer of toxin- ...
Tópico(s): Healthcare and Venom Research
2014 - BioMed Central | The Journal of venomous animals and toxins including tropical diseases
Eraqi R. Khannoon, Weronika Rupik, Damian Lewandowski, Magda Dubińska–Magiera, E. Swadźba, Małgorzata Daczewska,
... myotomal myogenesis, the myotome of Egyptian cobra (Naja haje) is composed of homogenous populations of mononucleated primary ... compared to primary muscle fibre. Studies on N. haje myotomal myogenesis revealed some unique features of muscle differentiation. TEM analysis showed in the N. haje myotomes two classes of muscle fibres. The first ... the first time, described in studies on N. haje myogenesis.
Tópico(s): Bat Biology and Ecology Studies
2015 - Springer Science+Business Media | PROTOPLASMA
Soukaina Khourcha, Inès Hilal, Iatimad Elbejjaj, Mehdi Karkouri, Amal Safi, Abdelaziz Hmyene, Naoual Oukkache,
... only represented by the medically relevant cobra Naja haje, which is widely distributed in North Africa. However, ... has been demonstrated that the venom of Naja haje from Egypt causes hemorrhage, while the venom of ... known to significantly influence treatment efficacy against Naja haje cobra bites in the Middle East. In this ... mechanisms responsible for the lethality induced by Naja haje venom, as well as the evaluation of the ... two antivenoms; the monospecific antivenom made for Naja haje only and the antivenom marketed in the Middle ...
Tópico(s): Marine Invertebrate Physiology and Ecology
2023 - Multidisciplinary Digital Publishing Institute | Tropical Medicine and Infectious Disease
Dawie P. Botes, Daniël J. Strydom,
... from the venom of the Egyptian cobra (Naja haje haje) by gradient chromatography on Amberlite CG-50, and ...
Tópico(s): Healthcare and Venom Research
1969 - Elsevier BV | Journal of Biological Chemistry
Robert Chicheportiche, Jean Pierre Vincent, Charles Kopeyan, Hugues Schweitz, Michel Lazdunski,
... alkylation of the Cys30-Cys34 bridge of Naja haje neurotoxin III hardly alter the conformational properties of ... bridge decreases the affinity of the native Naja haje toxin only by a factor of 15. Carboxymethylation ... properties to Toredo membrane of long neurotoxins (Naja haje neurotoxin III) and short neurotoxins (Naje haje toxin I and Naja mossambica toxin I) have ...
Tópico(s): Ion channel regulation and function
1975 - American Chemical Society | Biochemistry
M. Ismail, M.H.M. Aly, M.A. Abd-Elsalam, A. M. Morad,
... Naja melanoleuca, Naja nivea, Naja nigricollis and Naja haje venoms and their alpha neurotoxins were determined following ... and 240 min for N. nivea and N. haje venoms and their toxins. Steady-state distribution between ... nigricollis) and 1.70 and 1.03 (N. haje) for the venoms and their toxins, respectively. The ... nigricollis) and 1.39 and 2.46 (N. haje) for the venoms and their toxins, respectively. Ratios ...
Tópico(s): Venomous Animal Envenomation and Studies
1996 - Elsevier BV | Toxicon
... liver, brain, cardiac and skeletal muscles of Naja haje haje were determined during the different phases of the ...
Tópico(s): Thermal Regulation in Medicine
2004 - Elsevier BV | Journal of Thermal Biology
Ahmed E. Abdel Moneim, Francisco Ortiz, Roberto C. Leonardo-Mendonça, Roberto Vergano-Villodres, José A. Guerrero-Martínez, Luís C. López, Darío Acuña‐Castroviejo, Germaine Escames,
Naja haje envenomation is one of the leading causes of death due to snakebite. Antiserum therapy sometimes fails to ... investigated the protective effects of melatonin against N. haje venom in rats. The animals were injected with ... may ameliorate some of the effects of N. haje envenomation.
Tópico(s): Healthcare and Venom Research
2014 - Elsevier BV | Acta Tropica
Eraqi R. Khannoon, Susan E. Evans,
Abstract The E gyptian cobra, N aja h. haje , is the largest of the A frican cobras ... present a normal staging table for N . h. haje , based on external features. Comparison with firstly the ... found a similar level of disparity. N . h. haje embryos lagged behind those of N . kaouthia in ...
Tópico(s): Turtle Biology and Conservation
2013 - Wiley | Acta Zoologica
... 26–32. The two southern "races" of Naja haje (Linnaeus) represent a distinct species, Naja annulifera Peters, ... of the premaxilla. It also differs from Naja haje in having lower counts for midbody scale rows ( ... in N. annulifera: usually above 200 in N. haje). Although both species are very variable in colour ... gets its name, is not found in N. haje.
Tópico(s): Identification and Quantification in Food
1995 - Taylor & Francis | The Journal of the Herpetological Association of Africa
Z Takacs, Kirk C. Wilhelmsen, Steve Sorota,
... ligand binding domain of the Egyptian cobra (Naja haje) nAChR alpha subunit. When expressed as part of ... ligand binding domain that is unique to N. haje is responsible for alpha-BTX resistance. However, when ... signal is eliminated, the nAChR containing the N. haje sequence is inhibited by alpha-BTX with a ...
Tópico(s): Insect and Pesticide Research
2001 - Oxford University Press | Molecular Biology and Evolution
Mohamed Alaa A. Omran, Ismail M. Abdel-Nabi,
1. The effect of Egyptian cobra (Naja haje) venom on the normal electrical activity of the cardiac muscles (ECG) and arterial blood pressure of envenomated rats were investigated in this study. ... low dose (0.02 micrograms/g) of N. haje venom caused hypotension accompanied by an increase in ... present results indicate that the Egyptian cobra (N. haje) venom significantly alters the arterial blood pressure and ...
Tópico(s): Ion channel regulation and function
1997 - SAGE Publishing | Human & Experimental Toxicology
Ayoub Lafnoune, Su‐Yeon Lee, Jinyeong Heo, Imane Gourja, Bouchra Darkaoui, Zaineb Abdelkafi-Koubaa, Fatima Chgoury, Khadija Daoudi, Salma Chakir, Rachida Cadi, Khadija Mounaji, Najet Srairi‐Abid, Naziha Marrakchi, David Shum, Haengran Seo, Naoual Oukkache,
... anticancer effect on HCC of Moroccan cobra Naja haje venom and its fraction obtained by gel filtration ... an anti HCC activity of Moroccan cobra Naja haje venom and, more specifically, the F7 fraction of ... that the F7 fraction of Moroccan cobra Naja haje venom obtained by gel filtration chromatography possesses the ...
Tópico(s): Healthcare and Venom Research
2021 - Multidisciplinary Digital Publishing Institute | Toxins
Walaa H. Salama, Mohamed N. F. Shaheen, Yasser E. Shahein,
... A2 (PLA2) enzyme from the Egyptian cobra Naja haje haje venom. The purified N. haje PLA2 showed a specific activity of 22 units/ ... fold purification. The antiviral activity of purified N. haje PLA2 has been investigated in vitro against bovine ... MA104 cell lines, respectively. Antiviral analysis of N. haje PLA2 showed an inhibition of BCoV and RV ... to 33.6 and 16, respectively. Moreover, N. haje PLA2 decreased the BCoV and RV SA-11 ... suggests the potential antiviral activity of purified N. haje PLA2 against BCoV and RV SA-11 infections ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2022 - Springer Science+Business Media | Archives of Microbiology
François Miranda, Charles Kupeyan, Hervé Rochat, Catherine Rochat, Serge Lissitzky,
... isolated from the venom of the cobra Naja haje . N. haje venom from the Miami Serpentarium contains two neurotoxins ( ... the difference observed in neurotoxin composition of N. haje venoms from two different sources has a taxonomical ...
Tópico(s): Erythrocyte Function and Pathophysiology
1970 - Wiley | European Journal of Biochemistry
... serum and tissues of the Egyptian Cobra “Naja haje haje” during the hibernation cycleJournal of Thermal Biology, Vol. ... acids and protein metabolism in Egyptian cobra (Naja haje) during hibernationJournal of Thermal Biology, Vol. 15, No. ...
Tópico(s): Metabolomics and Mass Spectrometry Studies
1968 - American Physiological Society | American Journal of Physiology-Legacy Content
... either Naja naja, the Indian cobra, or Naja haje, the Egyptian cobra, and is not marked as to source. Cobra factor from Naja haje (CVFh), although able to generate C3-cleaving activity, ...
Tópico(s): Cellular transport and secretion
1978 - American Association of Immunologists | The Journal of Immunology
Charles Kopeyan, François Miranda, Hervé Rochat,
... amino acid sequence of toxin III of Naja haje (72 residues) has been established mainly by use ... degradation. The sequence of toxin III of Naja haje is unique and is very similar to that ...
Tópico(s): Protein Structure and Dynamics
1975 - Wiley | European Journal of Biochemistry
... tyrosine residues of cardiotoxins, naja melanoleuca VII1, Naja haje annulifera VII1 and Hemachatus haemachates toxin 12B. Various ... modified in both N. melanoleuca VII1 and N. haje annulifera VII1. In contrast, other workers had found ... melanoleuca VII1 (Tyr-22, -25 and -51), N haje annulifera VII1 (Tyr-22 and -51) and H. ...
Tópico(s): Insect and Pesticide Research
1980 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
A.H. Mohamed, Medhat A. Darwish, M. Hani-Ayobe,
... prepared in horses against the Egyptian cobra (Naje haje) venom; using bentonite as an adjuvant. One ml ... Identity patterns were established between venoms of N. haje, N. nigricollis, N. flava, N. naja, Walterinnesia aegyptia ... as those of Echis carinatus and Ethiopian N. haje. Partial identity with the two vipers Cerastes cerastes ...
Tópico(s): Rabies epidemiology and control
1973 - Elsevier BV | Toxicon
A.H. Mohamed, Medhat A. Darwish, M. Hani-Ayobe,
... was prepared against the Egyptian snake venoms Naja haje, N. nigricollis, Cerastes cerastes and C. vipera, and ... vipera, followed by Echis carinatus, E. coloratus, N. haje, N. nigricollis and Walterinnesia aegyptia. The titre against ... African and Indian cobra venoms N. nivea, N. haje (Ethiopian) and N. naja was lower, while poor ...
Tópico(s): Research on Leishmaniasis Studies
1973 - Elsevier BV | Toxicon
Michael R. Flick, J. Horn, J. M. Hoeffel, Ira M. Goldstein,
... of reducing total hemolytic complement activity with Naja haje cobra venom factor on the lung injury caused ... total hemolytic complement activity by treatment with Naja haje cobra venom factor (12 to 17 U/kg ...
Tópico(s): Hepatitis B Virus Studies
1986 - American Thoracic Society | American Review of Respiratory Disease