Kazuo Kojima, Hajime Taguchi, Jiro Matsuda,
... silica gels prepared by the sol-gel processKazuo Kojima, Hajime Taguchi, and Jiro MatsudaCite this: J. Phys. Chem. ...
Tópico(s): Magneto-Optical Properties and Applications
1991 - American Chemical Society | The Journal of Physical Chemistry
Masaharu Fujita, Yusuke Yamamoto, Shinichi Watanabe, Tsunetsugu Sugawara, Koji Wakabayashi, Yu Tahara, Nobuyuki Horie, Keiichi Fujimoto, Kei Kusakari, Yoshihiko Kurokawa, Tsuyoshi Kawakami, Kohichi Kojima, Hajime Kojima, Atsushi Ono, Yasuhiro Katsuoka, Hideto Tanabe, Hiroshi Yokoyama, Toshihiko Kasahara,
Abstract The amino acid derivative reactivity assay (ADRA) is an in chemico alternative to animal testing for skin sensitization that solves certain problems found in the use of the direct peptide reactivity assay (DPRA). During a recent validation study conducted at multiple laboratories as part of the process to include ADRA in an existing OECD test guideline, one of the nucleophilic reagents used in ADRA— N ‐(2‐(1‐naphthyl)acetyl)‐ l ‐cysteine (NAC)—was found to be susceptible to oxidation in much ...
Tópico(s): Pesticide Exposure and Toxicity
2018 - Wiley | Journal of Applied Toxicology
K. Narihara, K. Toi, Y. Hamada, K. Yamauchi, K Adachi, I. Yamada, K. Sato, K. Kawahata, A. Nishizawa, S. Ohdachi, K. Sato, T. Seki, T. Watari, J. Xu, A. Ejiri, S. Hirokura, K. Ida, Y. Kawasumi, M. Kojima, Hajime Sakakita, T. Ido, K. Kitachi, J. Koog, H Kuramotyo,
Laser scattering signals that indicate the presence of small dust particles (diameter ⩽ 2 μm) have been occasionally observed in the JIPPT-IIU tokamak chamber. This phenomenon was reproduced deliberately by spreading carbon dust from the top of the vacuum chamber. No noticeable effect on the plasma was observed for dust falls of up to at least 106 particles (10 μg) in 20 ms during discharges. Dust falling just before plasma startup seemed to be confined but it was soon ejected (in less than 30 ms)
Tópico(s): Vacuum and Plasma Arcs
1997 - IOP Publishing | Nuclear Fusion
Masanori Onda, Satoru Matsuda, Shozo Higaki, Takuo Iijima, Junichi Fukushima, Akira Yokokura, Tatsuyoshi Kojima, Hajime Horiuchi, Takahide Kurokawa, Tadashi Yamamoto,
BACKGROUND It has been reported that the c-erbB-2 protooncogene is frequently amplified and overexpressed in many types of cancers, except sarcomas and hematological malignancies. METHODS Expression of ErbB-2 in the tumors of 26 patients with conventional osteosarcoma was evaluated by immunoblotting. DNA from osteosarcoma tissues that expressed ErbB-2 were analyzed by Southern blot hybridization to examine gross rearrangement of the gene. The DNA was also surveyed for the presence of genetic mutation ...
Tópico(s): Peptidase Inhibition and Analysis
1996 - Wiley | Cancer
Michiel van der Vlist, Ramin Raoof, Hanneke L.D.M. Willemen, Judith Prado, Sabine Versteeg, Christian Martin Gil, Martijn Vos, Roeland E. Lokhorst, R. Jeroen Pasterkamp, Toshiyuki Kojima, Hajime Karasuyama, William Khoury-Hanold, Linde Meyaard, Niels Eijkelkamp,
The current paradigm is that inflammatory pain passively resolves following the cessation of inflammation. Yet, in a substantial proportion of patients with inflammatory diseases, resolution of inflammation is not sufficient to resolve pain, resulting in chronic pain. Mechanistic insight into how inflammatory pain is resolved is lacking. Here, we show that macrophages actively control resolution of inflammatory pain remotely from the site of inflammation by transferring mitochondria to sensory neurons. ...
Tópico(s): Stress Responses and Cortisol
2021 - Cell Press | Neuron
Shohei Hayashi, Tamotsu Yamashita, Junji Senzaki, Tomohisa Kato, Yoshiyuki Yonezawa, Kazutoshi Kojima, Hajime Okumura,
The influence of basal-plane dislocation (BPD) depth on the expansion of single Shockley-type stacking faults (1SSFs) was investigated during the forward-current degradation of 4H–SiC p–i–n diodes. The 1SSF expanded from the BPD converted into a threading edge dislocation (TED) in the substrate. The hole density that was injected into the substrate increased with the stress-current density; therefore, BPDs converted into TEDs at a greater depth caused the expansion of 1SSFs under higher stress-current ...
Tópico(s): Advanced ceramic materials synthesis
2019 - Institute of Physics | Applied Physics Express
Shohei Hayashi, Tamotsu Yamashita, Junji Senzaki, Masaki Miyazato, Mina Ryo, M. Miyajima, Tomohisa Kato, Yoshiyuki Yonezawa, Kazutoshi Kojima, Hajime Okumura,
The origin of expanded single Shockley-type stacking faults in forward-current degradation of 4H-SiC p–i–n diodes was investigated by the stress-current test. At a stress-current density lower than 25 A cm−2, triangular stacking faults were formed from basal-plane dislocations in the epitaxial layer. At a stress-current density higher than 350 A cm−2, both triangular and long-zone-shaped stacking faults were formed from basal-plane dislocations that converted into threading edge dislocations near ...
Tópico(s): Semiconductor materials and interfaces
2018 - Institute of Physics | Japanese Journal of Applied Physics
Susumu Tsukimoto, T. Ise, Genta Maruyama, Satoshi Hashimoto, Tsuguo Sakurada, Junji Senzaki, Tomohisa Kato, Kazutoshi Kojima, Hajime Okumura,
Tópico(s): Diamond and Carbon-based Materials Research
2018 - Springer Science+Business Media | Journal of Electronic Materials
Shohei Hayashi, T. Naijo, Tamotsu Yamashita, Masaki Miyazato, Mina Ryo, Hiroyuki Fujisawa, M. Miyajima, Junji Senzaki, Tomohisa Kato, Yoshiyuki Yonezawa, Kazutoshi Kojima, Hajime Okumura,
Stacking faults expanded by the application of forward current to 4H-SiC p–i–n diodes were observed using a transmission electron microscope to investigate the expansion origin. It was experimentally confirmed that long-zonal-shaped stacking faults expanded from basal-plane dislocations converted into threading edge dislocations. In addition, stacking fault expansion clearly penetrated into the substrate to a greater depth than the dislocation conversion point. This downward expansion of stacking ...
Tópico(s): Semiconductor materials and interfaces
2017 - Institute of Physics | Applied Physics Express
Toru Miyamoto, Hirokazu Hasegawa, Masato Mikami, Naoya Kojima, Hajime Kabashima, Yasuhiro Urata,
The present study experimentally investigated the performance and emission characteristics of the diesel engine with hydrogen added to the intake air at late diesel-fuel injection timings. The diesel-fuel injection timing and the hydrogen fraction in the intake mixture were varied while the available heat produced by diesel-fuel and hydrogen per second of diesel fuel and hydrogen was kept constant at a certain value. NO showed minimum at specific hydrogen fraction. The maximum rate of incylinder ...
Tópico(s): Biodiesel Production and Applications
2011 - Elsevier BV | International Journal of Hydrogen Energy
Ryoji Kojima, Hajime Taniguchi, Aya Tsuzuki, Kanako Nakamura, Yumi Sakakura, Mikio Ito,
Abstract MCP1 is upregulated by various stimuli, including LPS, high glucose, and hyperosmolality. However, the molecular mechanisms of transcriptional regulation of the MCP1 gene under hyperosmolar conditions are poorly understood. Treatment of NRK52E cells with NaCl or mannitol resulted in significant elevation of MCP1 mRNA and protein in a time- and dose-dependent manner. Treatment with a p38MAPK inhibitor (SB203580), an ERK inhibitor (PD98059), or an MEK inhibitor (U0126), suppressed the increase ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2010 - American Association of Immunologists | The Journal of Immunology
Toru Miyamoto, Masato Mikami, Naoya Kojima, Hajime Kabashima, Yasuhiro Urata,
Tópico(s): Catalytic Processes in Materials Science
2009 - | SAE technical papers on CD-ROM/SAE technical paper series
Akio Oishi, Atsushi Otani, Manabu Sasahara, Hiroshi Kojima, Hajime Nakamura, Yuko Yodoi, Nagahisa Yoshimura,
Granulocyte colony stimulating factor (G-CSF) has been shown to have neuroprotective and anti-inflammatory effects in cerebral damage models. In addition, bone-marrow-derived hematopoietic cells, which can be mobilized with G-CSF, have a neuroprotective effect in hereditary retinal cell death. The present study was conducted to investigate whether G-CSF protects photoreceptors from light-induced cell death.G-CSF or vehicle was systemically injected before the light exposure and for four consecutive ...
Tópico(s): Retinoids in leukemia and cellular processes
2008 - Cadmus Press | Investigative Ophthalmology & Visual Science
Akio Oishi, A. Otani, Manabu Sasahara, H. Kojima, Hajime Nakamura, Masafumi Kurimoto, Nagahisa Yoshimura,
To assess the correlation between macular morphology and visual acuity in retinitis pigmentosa (RP) patients with cystoid macular oedema (CME).Retrospective cross-sectional study.Forty-one eyes of 25 RP patients with CME. Patients underwent cross-sectional scans with optical coherence tomography (Stratus OCT). Age, total retinal thickness, photoreceptor thickness, and the transverse and vertical lengths of the cystoid space were measured. Correlation between visual acuity and each of the measurements ...
Tópico(s): Glaucoma and retinal disorders
2008 - Springer Nature | Eye
Mizue Suzuki, Masao Kanamori, Motoko Watanabe, Shingo Nagasawa, Emi Kojima, Hajime Ooshiro, Daiichirou Nakahara,
The present study investigated the effectiveness of music therapy for dementia patients using endocrinological and behavioral evaluations. The study comprised 10 patients with senile dementia who received music therapy; six had Alzheimer's dementia and four had vascular dementia. Music therapy was performed twice a week for 8 consecutive weeks (16 sessions). As a result, total scores on the Mini-Mental State Examination (MMSE) did not significantly change, but the scores of a subscale, "language", ...
Tópico(s): Olfactory and Sensory Function Studies
2004 - Wiley | Nursing and Health Sciences
Kazutoshi Kojima, Hajime Okumura, S. Kuroda, Kazuo Arai,
4H-SiC homoepitaxial layers were grown on on-axis (0001̄) C-face substrates at an inclination of 0.5° or less by horizontal hot wall chemical vapor deposition. After H2 etching, the surface morphology of the on-axis (0001̄) C-face substrate showed a straight step structure that had the same height as a 4H-SiC lattice constant along the c-axis. Specular surface morphology of a wide area of up to 80% of a 2-in wafer was obtained at a low C/Si ratio of 0.6. It was found that that appearance of basal ...
Tópico(s): Semiconductor materials and interfaces
2004 - Elsevier BV | Journal of Crystal Growth
Akiko Kojima, Hajime Maeda, Yoshihiko Sugita, Seiya Tanaka, Yoichiro Kameyama,
In this study, 53 paraffin-embedded oral squamous cell carcinoma (OSCC) biopsy specimens were used. Human papillomavirus type 38 (HPV-38) infection was demonstrated in OSCCs using the PCR technique, DNA sequencing analysis, in situ hybridization, and immunohistochemical techniques. Additionally, the correlation between HPV-38 infection and expressions of proliferating cell nuclear antigens (PCNA) or p53 protein was analyzed immunohistochemically. Using consensus primers for the L1 region (L1-PCR), we ...
Tópico(s): Oral and Maxillofacial Pathology
2002 - Elsevier BV | Oral Oncology
Michiyasu Yagura, Seiyou Murai, Hiroshi Kojima, Hajime Tokita, Hiroshi Kamitsukasa, H HARADA,
Tópico(s): Hepatitis C virus research
2000 - Springer Science+Business Media | Journal of Gastroenterology
M. Kojima, Hajime Handa, Nobuo Hashimoto, C Kim, Fumitada Hazama,
To obtain information about the early changes of experimentally induced cerebral aneurysms in rats, the luminal surface of branching areas of their cerebral arteries was examined with a scanning electron microscope. At the branching sites of major cerebral arteries in the control animals, the intima just distal to the apex markedly protruded into the lumen forming a linear bank-like intimal pad. Along and distal to this pad, there was a shallow long groove (juxta-apical groove). Such grooves were ...
Tópico(s): Intracranial Aneurysms: Treatment and Complications
1986 - Lippincott Williams & Wilkins | Stroke
Eiichi Kojima, Hajime Unno, Yukinari Sato, Tadashi Chida, Hiroshi Imai, Kazuo Endo, Ichiro Inoue, Jiro Kobayashi, Hisatsugu Kaji, Hajime Nakanishi, Kazuo Yamamoto,
Liquid Telocity distribution was measured in a bubble column 5.5 m in diameter and approximately 7 m in liquid height. Liquid flow was upward in the column center and downward near the wall. The upward velocities were from 52 to 115 cm/sec in the superficial gas velocity range from 2.4 to 8.5 cm/sec. The liquid velocity distribution is analyzed by a circulating flow model. Values of the turbulent viscosity-the parameter of the model-are in the range from 3000 to 4000 g/cm • sec. These values agree ...
Tópico(s): Minerals Flotation and Separation Techniques
1980 - Society of Chemical Engineers, Japan | JOURNAL OF CHEMICAL ENGINEERING OF JAPAN
Akira Katsumi, Tomonaga Matsushita, Takumi Yamazaki, Isamu Sugiura, T Kojima, Hajime Saito,
Factor VII is a vitamin K-dependent zymogen that plays a key role in the initiation of the extrinsic pathway. A severe factor VII deficiency was identified in a 45-year old male whose plasma factor VII antigen was less than 60 ng/ml and expressed 5.2% of normal factor VII activity. DNA sequence analysis of the patient's factor VII gene showed a thymidine to guanine transversion at nucleotide 10968 in exon VIII that results in a novel amino acid substitution of His348 to Gln. The patient was homozygous ...
Tópico(s): Platelet Disorders and Treatments
2000 - Thieme Medical Publishers (Germany) | Thrombosis and Haemostasis
Masanori Onda, Satoru Matsuda, Shozo Higaki, Takuo Iijima, Jun‐ichi Fukushima, Akira Yokokura, Tatsuyoshi Kojima, Hajime Horiuchi, Takahide Kurokawa, Tadashi Yamamoto,
BACKGROUND It has been reported that the c-erbB-2 protooncogene is frequently amplified and overexpressed in many types of cancers, except sarcomas and hematological malignancies. METHODS Expression of ErbB-2 in the tumors of 26 patients with conventional osteosarcoma was evaluated by immunoblotting. DNA from osteosarcoma tissues that expressed ErbB-2 were analyzed by Southern blot hybridization to examine gross rearrangement of the gene. The DNA was also surveyed for the presence of genetic mutation ...
Tópico(s): Radiopharmaceutical Chemistry and Applications
1996 - Wiley | Cancer
Toshihisa Kojima, Hajime Ishikawa, Sakae Tanaka, Nobuhiko Haga, Keiichiro Nishida, Masao Yukioka, Jun Hashimoto, Hisaaki Miyahara, Yasuo Niki, Tomoatsu Kimura, Hiromi Oda, Shuji Asai, Koji Funahashi, Masayo Kojima, Naoki Ishiguro,
Objective: To explore the characteristics of functional impairment in patients with established rheumatoid arthritis (RA) based on the range of motion (ROM) of joints in a prospective observational study of RA patients undergoing joint surgery. Methods: We collected data on demographics, Health Assessment Questionnaire Disability Index (HAQ-DI), and the ROM of large joints including the shoulder, elbow, wrist, hip, knee, and ankle. Associations between the ROM of each joint and disability in the eight ...
Tópico(s): Peripheral Neuropathies and Disorders
2017 - Oxford University Press | Modern Rheumatology
Yuuki Ishida, Tomoyuki Takahashi, Kazutoshi Kojima, Hajime Okumura, Kazuo Arai, Sadafumi Yoshida,
Tópico(s): Advanced ceramic materials synthesis
2004 - Trans Tech Publications | Materials science forum
Xu‐Qiang Shen, Kazutoshi Kojima, Hajime Okumura,
Single-phase flat semipolar (10–13) AlN epilayers on m-plane (10–10) sapphire substrates grown by ammonia-free high-temperature metalorganic vapor phase epitaxy are firstly demonstrated. It is found that twins and basal-plane stacking faults are undetectable by X-ray diffraction and cross-sectional characterization. An X-ray rocking curve (XRC) shows the full widths at half maximum (FWHM) of the (10–13) and the (0002) diffraction peaks from a ∼2.3 μm thick AlN film as narrow as 322 and 373 arcsec, respectively, ...
Tópico(s): Metal and Thin Film Mechanics
2020 - Institute of Physics | Applied Physics Express
Produção Nacional
Revisado por pares
Matthew Dent, Eric Vaillancourt, Russell S. Thomas, Paul L. Carmichael, Gladys Ouédraogo, Hajime Kojima, José G. Barroso, Jay Ansell, Tara S. Barton‐Maclaren, Susanne Hougaard Bennekou, Kim Boekelheide, Janine Ezendam, J.G. Field, Suzanne Fitzpatrick, Masato Hatao, Reinhard Kreiling, Márcio Lorencini, Catherine Mahony, Beta P. Montemayor, Renata Mazaro‐Costa, Jonas Santana-de Oliveira, Vera Rogiers, D. Smegal, R. Taalman, Yoshinori Tokura, Ravi Verma, Catherine Willett, Chihae Yang,
Next generation risk assessment (NGRA) is an exposure-led, hypothesis-driven approach that has the potential to support animal-free safety decision-making. However, significant effort is needed to develop and test the in vitro and in silico (computational) approaches that underpin NGRA to enable confident application in a regulatory context. A workshop was held in Montreal in 2019 to discuss where effort needs to be focussed and to agree on the steps needed to ensure safety decisions made on cosmetic ...
Tópico(s): Immunotoxicology and immune responses
2021 - Elsevier BV | Regulatory Toxicology and Pharmacology
Akiyoshi Nishikawa, Kasuke Nagano, Hajime Kojima, Kumiko Ogawa,
According to the International Agency for Research on Cancer classification, formaldehyde is a human carcinogen that targets the nasal cavity. In humans and rats, inhaled formaldehyde is primarily deposited in the nasal cavity mucosa, metabolized to the less toxic formic acid, and finally excreted into the urine or exhaled. Thus, formaldehyde-induced nasal carcinogenicity may be a direct effect of formaldehyde itself, although the underlying mechanisms remain unclear. With regard to cytotoxicity, ...
Tópico(s): Air Quality and Health Impacts
2021 - Elsevier BV | Regulatory Toxicology and Pharmacology
Elke Anklam, Martin Iain Bahl, Robert Ball, Richard D. Beger, Jonathan E. Cohen, Suzanne Fitzpatrick, Philippe Girard, Blanka Halamoda‐Kenzaoui, Denise Hinton, Akihiko Hirose, Arnd Hoeveler, Masamitsu Honma, Marta Hugas, Seichi Ishida, George E.N. Kass, Hajime Kojima, Ira Krefting, Serguei Liachenko, Yan Liu, Shane C. Masters, Uwe Marx, Timothy J. McCarthy, Tim R. Mercer, Anil K. Patri, Carmen Peláez, Munir Pirmohamed, Stefan Platz, Alexandre J. S. Ribeiro, Joseph V. Rodricks, Ivan Rusyn, Reza M. Salek, Reinhilde Schoonjans, Primal Silva, Clive N. Svendsen, Susan Sumner, Kyung E. Sung, Danilo A. Tagle, Tong Li, Weida Tong, Janny van den Eijnden–van Raaij, Neil Vary, Tao Wang, John C. Waterton, May D. Wang, Hairuo Wen, David S. Wishart, Yinyin Yuan, William Slikker,
There is an evolution and increasing need for the utilization of emerging cellular, molecular and in silico technologies and novel approaches for safety assessment of food, drugs, and personal care products. Convergence of these emerging technologies is also enabling rapid advances and approaches that may impact regulatory decisions and approvals. Although the development of emerging technologies may allow rapid advances in regulatory decision making, there is concern that these new technologies ...
Tópico(s): Viral Infectious Diseases and Gene Expression in Insects
2021 - SAGE Publishing | Experimental Biology and Medicine
Chih-Ching Liao, Ching‐Yi Wu, Meng-Hsueh Lin, Feng-Koo Hsieh, Lih-Tao Hsu, Shiun-Yin Chang, Kuan‐Jen Chen, Hui-Ting Huang, Hui‐Chun Hsu, Chiu-Hsing Lin, Pei‐Ju Lin, Huey-Min Lai, Hajime Kojima, Hiroaki Todo, Sung‐Jan Lin, Jih‐Heng Li, Wannhsin Chen,
Following the global trend of reducing animal testing, various reconstructed human epidermis (RHE) models for skin irritation test (SIT) have been developed, verified, validated and included in OECD TG 439. We developed a new RHE called EPiTRI and a SIT method using EPiTRI (EPiTRI-SIT model) following the OECD guidelines. EPiTRI possesses morphological, biochemical and physiological properties similar to human epidermis with well-differentiated multilayered viable cells with barrier function. The EPiTRI- ...
Tópico(s): Immunotoxicology and immune responses
2021 - Elsevier BV | Toxicology in Vitro
Kenta Mizoi, Hiroshi Arakawa, Kentarô Yano, Satoshi Koyama, Hajime Kojima, Takuo Ogihara,
This paper reviews the usefulness, current status, and potential of primary human hepatocytes (PHHs) in three-dimensional (3D) cultures, also known as spheroids, in the field of pharmacokinetics (PK). Predicting PK and toxicity means pharmaceutical research can be conducted more efficiently. Various in vitro test systems using human hepatocytes have been proposed as tools to detect hepatic toxicity at an early stage in the drug development process. However, such evaluation requires long-term, low-level ...
Tópico(s): Drug-Induced Hepatotoxicity and Protection
2020 - Multidisciplinary Digital Publishing Institute | Biomedicines