Hideharu Honoki, Katsutoshi Tsushima, Kazuichi Hayakawa,
... intervals over 50 km from the coast of Hakui city in Ishikawa Prefecture leeward of the northwestern ... from the Sea of Japan decreased exponentially from Hakui city in Ishikawa Prefecture to Toyama city. The ... sea-salt sulfate ions until 25 km from Hakui city and higher in the farther regions. We ... 98 of the total at the coast of Hakui city and 0.65 at Toyama city, respectively, ... plain in Toyama than on the coast of Hakui city, suggesting that they mostly originated from the ...
Tópico(s): Urban Stormwater Management Solutions
2001 - Pharmaceutical Society of Japan | JOURNAL OF HEALTH SCIENCE
Toshihito Yagi, Nobuyoshi Hakui, Yoshimitsu Yamasaki, Ryuzo Kawamori, Motoaki Shichiri, Hiroshi Abe, Soonih Kim, Masatoshi Miyake, Kunihisa Kamikawa, Toshiaki Nishihata, Akira Kamada,
... this author on: Oxford Academic Google Scholar Nobuyoshi Hakui, Nobuyoshi Hakui First Department of Medicine, Osaka University Medical 1- ...
Tópico(s): Pharmaceutical studies and practices
1983 - Oxford University Press | Journal of Pharmacy and Pharmacology
Motoaki Shichiri, Yoshimitsu Yamasaki, Ryuzo Kawamori, Mikio Kikuchi, Nobuyoshi Hakui, Hiroshi Abe,
... this author on: Oxford Academic Google Scholar Nobuyoshi Hakui, Nobuyoshi Hakui First Department of Medicine, Osaka University, Medical School, ...
Tópico(s): Pancreatic function and diabetes
1978 - Oxford University Press | Journal of Pharmacy and Pharmacology
Masaki Kuro‐o, Chikako Ikebe, S. Kohno,
... i>Stejneger from Nakakubiki County, Niigata Prefecture, and Hakui County, Ishikawa Prefecture, were cultured in medium containing ... replication patterns in embryos obtained from Nakakubiki and Hakui Counties.
Tópico(s): Environmental DNA in Biodiversity Studies
1986 - Karger Publishers | Cytogenetic and Genome Research
Yuta Moriwaki, Yuma Morisaki, Shigehiro Karashima, Makoto Fujiu,
... receipt information from National Health Insurance data for Hakui, Ishikawa Prefecture, a small regional city in Japan, ... of medicines supplied to chronically ill patients in Hakui, Ishikawa Prefecture, were clarified on a town-by- ...
Tópico(s): Data-Driven Disease Surveillance
2023 - Multidisciplinary Digital Publishing Institute | Healthcare
Tatsuro Hitsumoto, Osamu Tsukamoto, Ken Matsuoka, Junjun Li, Li Liu, Yuki Kuramoto, Shuichiro Higo, Shou Ogawa, Noboru Fujino, Shohei Yoshida, Hidetaka Kioka, Hisakazu Kato, Hideyuki Hakui, Yuki Saito, Chisato Okamoto, Hijiri Inoue, Jo Hyejin, Kyoko Ueda, Takatsugu Segawa, Shunsuke Nishimura, Yoshihiro Asano, Hiroshi Asanuma, Akiyoshi Tani, Riyo Imamura, Shinsuke Komagawa, Toshio Kanai, Masayuki Takamura, Yasushi Sakata, Masafumi Kitakaze, Jun‐ichi Haruta, Seiji Takashima,
Cardiac-specific myosin light chain kinase (cMLCK), encoded by
Tópico(s): Cardiac Fibrosis and Remodeling
2023 - Lippincott Williams & Wilkins | Circulation
Hideyuki Hakui, Hidetaka Kioka, Yohei Miyashita, Shunsuke Nishimura, Ken Matsuoka, Hisakazu Kato, Osamu Tsukamoto, Yuki Kuramoto, Ayako Takuwa, Yusuke Takahashi, Shigeyoshi Saito, Kunio Ohta, Hiroshi Asanuma, Hai Ying Fu, Haruki Shinomiya, Noriaki Yamada, Tomohito Ohtani, Yoshiki Sawa, Masafumi Kitakaze, Seiji Takashima, Yasushi Sakata, Yoshihiro Asano,
Dilated cardiomyopathy (DCM) is a major cause of heart failure, characterized by ventricular dilatation and systolic dysfunction. Familial DCM is reportedly caused by mutations in more than 50 genes, requiring precise disease stratification based on genetic information. However, the underlying genetic causes of 60 to 80% of familial DCM cases remain unknown. Here, we identified that homozygous truncating mutations in the gene encoding Bcl-2–associated athanogene (BAG) co-chaperone 5 (BAG5) caused inherited ...
Tópico(s): Cardiovascular Effects of Exercise
2022 - American Association for the Advancement of Science | Science Translational Medicine
Christoph P. Hofmann, Hugo A. Katus, Shirin Doroudgar,
... 8091-8112), Online publication date: 23-Jun-2022. Hakui H, Kioka H, Miyashita Y, Nishimura S, Matsuoka ...
Tópico(s): Cardiovascular Function and Risk Factors
2019 - Lippincott Williams & Wilkins | Circulation
Hiroshi Matsumura, Akihiro Toyoda, K. Masumoto, Go Yoshida, Tomohiro Yagishita, T. Nakabayashi, Hirokazu Sasaki, Kazuhiro Matsumura, Yoshifumi Yamaya, Y. Miyazaki,
... the Medical and Pharmacological Research Center Foundation in Hakui, Ishikawa, Japan. Accordingly, the specific activity could be ...
Tópico(s): Graphite, nuclear technology, radiation studies
2018 - IOP Publishing | Journal of Physics Conference Series
Daiki Kanbayashi, Atsushi Kaida, Seiji P. Yamamoto, Yuki Hirai, Hideyuki Kubo, Ryoko Fujimori, Noritaka Hakui, Hidetetsu Hirokawa, Nobuhiro Iritani,
Hand, foot, and mouth disease (HFMD) is an acute febrile illness characterized by fever; sore throat; and vesicular eruptions on the hands, feet, and oral mucosa. Until 2010, HFMD was predominantly associated with enterovirus (EV) A71 and coxsackievirus (CV) A16 in Japan. In 2011, CV‐A6 emerged as a primary causative agent, causing the largest HFMD epidemic in Japan since 1981. Since then, CV‐A6 has caused large HFMD epidemics every 2 years. The phylogenetic analysis of complete Viral Protein 1 (VP1) ...
Tópico(s): T-cell and Retrovirus Studies
2017 - Wiley | Journal of Medical Virology
Teki Hakui, Keiji Konishi, Naoyuki Hara,
This paper shows that, in a pair of one-dimensional complex Ginzburg-Landau (CGL) systems, diffusive connections can induce amplitude death. Stability analysis of a spatially uniform steady state in coupled CGL systems reveals that amplitude death never occurs in a pair of identical CGL systems coupled by no-delay connection, but can occur in the case of delay connection. Moreover, amplitude death never occurs in coupled identical CGL systems with zero nominal frequency. Based on these analytical ...
Tópico(s): Chaos control and synchronization
2017 - American Physical Society | Physical review. E
... Motooka D, Okuzaki D, Matsuoka K, Tsukamoto O, Hakui H, Yamada N, Lee J, Kioka H, Kitakaze ...
Tópico(s): BRCA gene mutations in cancer
2014 - Lippincott Williams & Wilkins | Circulation Research
Richard L. Moss, Daniel P. Fitzsimons,
... Fujino N, Yoshida S, Kioka H, Kato H, Hakui H, Saito Y, Okamoto C, Inoue H, Hyejin ...
Tópico(s): Muscle Physiology and Disorders
2006 - Lippincott Williams & Wilkins | Circulation Research
Kazue Tazaki, Rie Wakimoto, Yukiya Minami, Masayoshi Yamamoto, Koshirou Miyata, Kazuhiro Sato, Ichiro Saji, Siti Khodijah Chaerun, Guoping Zhou, Tomoaki Morishita, Ryuji Asada, Hiromi Segawa, Hiroki Imanishi, Rie Kato, Yusuke Otani, Tomoko Watanabe,
... of February–April, 2003 in Kanazawa University and Hakui, Ishikawa Prefecture, Japan, was investigated by ion chromatography ...
Tópico(s): Atmospheric chemistry and aerosols
2004 - Elsevier BV | Atmospheric Environment
Hiroshi Tanaka, Tetsuo Nishimura, Mikiko Hakui, Hisashi Sugimoto, Keiko Tanaka‐Taya, Koichi Yamanishi,
Virus-associated hemophagocytic syndrome is a fulminant disorder associated with systemic viral infection and characterized pathologically by multiple-organ infiltration of hemophagocytic histiocytes into the lymphoreticular tissues. This is the first report of a previously healthy adult in whom Human herpesvirus 6 reactivation induced this syndrome with severe hemodynamic and respiratory distress.
Tópico(s): Viral-associated cancers and disorders
2002 - Centers for Disease Control and Prevention | Emerging infectious diseases
T. Shinoda-Tagawa, Yoshimitsu Yamasaki, Shohei Yoshida, Yoshitaka Kajimoto, Toshiaki Tsujino, Nobuyoshi Hakui, Masahiro Matsumoto, M Hori,
This study aimed to evaluate the effect of a phosphodiesterase inhibitor, cilostazol, on the prevention of silent brain infarction in diabetic patients without symptoms of vascular events. A total of 89 subjects were allocated at random to the cilostazol group (n = 43) or the control group (n = 46). After the study period (3.2 ± 0.5 years), carotid intima-media thickness (IMT) (means ± SD) had increased (p < 0.01) by 0.18 ± 0.19 mm in the control group. In the cilostazol group, intima-media thickness showed almost ...
Tópico(s): Neurological Disorders and Treatments
2002 - Springer Science+Business Media | Diabetologia
M. Shichiri, R. Kawamori, N. Hakui, Yoshimitsu Yamasaki, H. Abe,
Tópico(s): Hyperglycemia and glycemic control in critically ill and hospitalized patients
1984 - American Diabetes Association | Diabetes
Motoaki Shichiri, Ryuzo Kawamori, Nobuyoshi Hakui, Yoshimitsu Yamasaki, Hiroshi Abe,
We succeeded in miniaturizing a needle-type glucose monitoring system with characteristics suitable for application in a wearable, closed-loop control system. A wearable artificial endocrine pancreas (12 × 15 × 6 cm, 400 g) consisting of a sensor, a microcomputer system that calculates insulin and glucagon infusion rates, and two roller pumps was developed. Continuous glucose monitoring by a glucose sensor inserted in the subcutaneous tissue of the forearm or abdomen of healthy and diabetic volunteers ...
Tópico(s): Diabetes Management and Research
1984 - American Diabetes Association | Diabetes
Masayoshi Shichiri, Ryuzo Kawamori, Yoshikazu Goriya, Yoshimitsu Yamasaki, M. Nomura, Nobuyoshi Hakui, Hiroshi Abe,
Tópico(s): Pediatric Pain Management Techniques
1983 - Springer Science+Business Media | Diabetologia
Motoaki Shichiri, Yoshimitsu Yamasaki, Ryuzo Kawamori, Nobuyoshi Hakui, Hiroshi Abe,
Miniaturisation of the bedside artificial endocrine pancreas is necessary to provide a means of restoring physiological glycaemic excursions in diabetic patients in the long term. One of the remaining problems in producing such a sophisticated device is the difficulty in developing a sufficiently small glucose-monitoring system. A needle-type glucose sensor has been developed which is suitable for use in a closed-loop glycaemic control system. The wearable artificial endocrine pancreas, incorporating ...
Tópico(s): Hyperglycemia and glycemic control in critically ill and hospitalized patients
1982 - Elsevier BV | The Lancet
Yoshimitsu Yamasaki, Motoaki Shichiri, Ryuzo Kawamori, Mikio Kikuchi, Toshihito Yagi, Sadao Arai, Ryohei Tohdo, Nobuyoshi Hakui, Nobuyoshi Oji, Hiroshi Abe,
The effectiveness of insulin administration by rectal suppository was examined in normal and non-insulin-dependent nonobese diabetic subjects. A 100-U insulin suppository (mean 1.8 U/kg) given to the diabetic subjects caused four times as great a fall in plasma glucose compared with the normal subjects given the same dose (mean 1.6 U/kg). The insulin response after suppository administration demonstrated a significantly positive correlation (r = 0.83, P less than 0.01) with the plasma glucose level before ...
Tópico(s): Pharmacology and Obesity Treatment
1981 - American Diabetes Association | Diabetes Care
Tsutomu Kawai, Takahisa Yamada, Shunsuke Tamaki, Takashi Morita, Yoshio Furukawa, Yusuke Iwasaki, Masato Kawasaki, Atsushi Kikuchi, Takumi Kondo, Satoshi Takahashi, Masashi Ishimi, Hideyuki Hakui, Tatsuhisa Ozaki, Yoshihiro Sato, Masahiro Seo, Yasushi Sakata, Masatake Fukunami,
Patients with chronic heart failure (CHF) at risk of sudden cardiac death (SCD) are often treated with implantable cardiac defibrillators (ICDs). However, current criteria for device use that is based largely on left ventricular ejection fraction (LVEF) lead to many patients receiving ICDs that never deliver therapy. It is of clinical significance to identify patients who do not require ICDs. Although cardiac I-123 meta-iodobenzylguanidine (MIBG) imaging provides prognostic information about CHF, whether ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2015 - Elsevier BV | The American Journal of Cardiology
Gye-Woon Choi, Hyea-Ju Kim, Jong‐Sik Park, Man-Shin Han,
... stream, Yangjae stream, Osan stream, Jangsu stream, and Hakui stream 5 years the after close to nature ...
Tópico(s): Ecology and Conservation Studies
2010 - Korea Water Resources Association | Journal of Korea Water Resources Association
Yoshimitsu Yamasaki, Motoaki Shichiri, Ryuzo Kawamori, Toyohiko Morishima, Nobuyoshi Hakui, Toshihiko Yagi, Hiroshi Abe,
Six alloxan-diabetic dogs with fasting plasma glucose levels above 200 mg/100 mL were treated with rectal administration of insulin suppositories twice a day for 6--9 days. The effectiveness was compared with that of subcutaneous insulin injections. In three diabetic dogs with fasting plasma glucose levels below 300 mg/100 mL, both insulin suppository at a dose of 20 U (2.3 U/kg) and subcutaneous insulin at a dose of 0.2 U/kg showed a similar effect in reducing fasting glucose levels and daily urinary ...
Tópico(s): Hyperglycemia and glycemic control in critically ill and hospitalized patients
1981 - NRC Research Press | Canadian Journal of Physiology and Pharmacology
Haruki Shinomiya, Hisakazu Kato, Yuki Kuramoto, Nozomi Watanabe, Toshihiro Tsuruda, Tadaaki Arimura, Yohei Miyashita, Yoshiki Miyasaka, Tomoji Mashimo, Ayako Takuwa, Daisuke Motooka, Daisuke Okuzaki, Ken Matsuoka, Osamu Tsukamoto, Hideyuki Hakui, Noriaki Yamada, Jong‐Kook Lee, Hidetaka Kioka, Masafumi Kitakaze, Seiji Takashima, Yasushi Sakata, Yoshihiro Asano,
Arrhythmogenic cardiomyopathy (ACM) caused by TMEM43 p.S358L is a fully penetrant heart disease that results in impaired cardiac function or fatal arrhythmia. However, the molecular mechanism of ACM caused by the TMEM43 variant has not yet been fully elucidated. In this study, we generated knock-in (KI) rats harboring a Tmem43 p.S358L mutation and established induced pluripotent stem cells (iPSCs) from patients based on the identification of TMEM43 p.S358L variant from a family with ACM. The Tmem43- ...
Tópico(s): Viral Infections and Immunology Research
2021 - Wiley | The FASEB Journal
Takumi Kondo, Takahisa Yamada, Takashi Morita, Yoshio Furukawa, Shunsuke Tamaki, Yusuke Iwasaki, Masato Kawasaki, Atsushi Kikuchi, Tsutomu Kawai, Satoshi Takahashi, Masashi Ishimi, Hideyuki Hakui, Tatsuhisa Ozaki, Yoshihiro Sato, Masahiro Seo, Yasushi Sakata, Masatake Fukunami,
Tópico(s): Cardiovascular Function and Risk Factors
2016 - Springer Science+Business Media | Heart and Vessels
Moeko Noguchi‐Shinohara, Kohei Hirako, Hiromasa Tsujiguchi, Tomoya Itatani, Kiyoko Yanagihara, Hikaru Samuta, Hiroyuki Nakamura,
... the individual level of self-rated health. The Hakui City Health Interview Survey targeted 15,242 people ...
Tópico(s): Community Health and Development
2020 - Public Library of Science | PLoS ONE
Hideyuki Hakui, Takahisa Yamada, Shunsuke Tamaki, Takashi Morita, Yoshio Furukawa, Yusuke Iwasaki, Masato Kawasaki, Atsushi Kikuchi, Takumi Kondo, Masashi Ishimi, Yoshihiro Sato, Masahiro Seo, Tatsuhisa Ozaki, Iyo Ikeda, Eiji Fukuhara, Yasushi Sakata, Masatake Fukunami,
Liver dysfunction has a prognostic impact on the outcomes of patients with advanced heart failure (HF). The model for end-stage liver disease (MELD) score is a robust system for rating liver dysfunction, and a high score has been shown to be associated with a poor prognosis in ambulatory patients with HF. In addition, cardiac metaiodobenzylguanidine (MIBG) imaging provides prognostic information in patients with chronic HF (CHF). However, the long-term predictive value of combining the MELD score and ...
Tópico(s): Cardiac Imaging and Diagnostics
2016 - Elsevier BV | The American Journal of Cardiology
Akikazu Kakehi, Suketaka Ito, Jun-ichi Hakui, Hiroaki Fukazawa,
Abstract Reactions of the title compounds with 2,3-dichloro-4,5-dicyano-p-benzoquinone were reinvestigated; it was found that the corresponding products were not the ring-contracted and rearranged thieno[2,3-b]indolizines, as described previously by us, but were ordinary dehydrogenated compounds, pyrido[2,1-c]thieno[3,2-e][1,4]thiazines. In contrast with pyrido[2,1-c]thieno[3,2-e][1,4]thiazine derivatives which have no substituent or only one methyl group on the pyridine ring, their 6,8-dimethyl ...
Tópico(s): Synthesis of heterocyclic compounds
1992 - Oxford University Press | Bulletin of the Chemical Society of Japan
Akikazu Kakehi, Suketaka Ito, Jun-ichi Hakui,
Abstract Various 1-pyridinio(thiocarbonyl)methylides and 2-isoquinolinio(thiocarbonyl)methylides react smoothly with dimethyl acetylenedicarboxylate at room temperature or at the reflux temperature in chloroform to give new heterocycles, dimethyl 10aH-pyrido[1,2-d][1,4]thiazepine-1,2-dicarboxylate derivatives, in moderate yields. Similarly, the reactions of some 3-(1-pyridinio)thiophene-2-thiolates with the same reagent afforded the corresponding dimethyl 6aH-pyrido[1,2-d]thieno[2′,3′-b][1,4]thiazepine- ...
Tópico(s): Chemical Synthesis and Analysis
1993 - Oxford University Press | Bulletin of the Chemical Society of Japan