Gráinne Gilmore, Giles Smith, Andrew Robson, Janice Turner, Amanda Andrews, Christina Hardyment, John McNamara, Andrew Billen, Robert Cole, George Galloway, Yepoka Yeebo, Colin Self, David Borrow, MP, Charles Heyman Editor, David Brown, Alexandra Frean, Glenys Kinnock, MP, Caroline Stacey, Lord Hattersley, Greg Hurst Political Correspondent, Gary Duncan, Simon Barnes, Amanda Ursell, Jane MacQuitty, Peter Lansley, Simon Hills, Andrew Longmore, Robert Lindsay, R. F. Foster, Liz King, Mark Souster, John Mulvey, Clare Lazaro, Alexandra Frean Education Editor, Paula Adams, Tony Turnbull, Sarah Churchwell, Philip Howard, Simon Cambers, Elizabeth Garner, Carol Midgley, Dr Vincent Cable, MP, Jeremy Corbyn, MP, Christine Seib, David Chater, Ben Hoyle Arts Reporter, Suna Erdem, James Ducker, Kate Wighton, Melissa Katsoulis, Murad Ahmed, Rachel Campbell-Johnston, Lord Ramsbotham, Gabrielle Starkey, Lucia Van Der Post, Rob Clifford, Graham Stewart, Sam Marlowe, Wendy Ide, John Bungey, Nancy Farmer Beowulf, Kevin Eason, GrÁinne Gilmore, Lucy Bannerman, Gerald Davies, Mike Pattenden, Joe Joseph, David Lowder, Caroline Hendrie, Martin Fletcher, Sathnam Sanghera, Sean O'Neill Crime Editor, Ben Webster Transport Correspondent, David J. Brown, Valerie Elliott Countryside Editor, Dr Copperfield, Nancy Durrant, Jane MacArtney, Rob Crilly, Hannah Fletcher, Tom McPhail, Hilary Rose, Francis Elliott, Deborah Haynes, Tom Bawden, Steve Bird, Dan Sabbagh Media Editor, Dominic Walsh, Craig McLean, Debra Craine, Gary Jacob, Sam Branson, Les Webb, Nicky Raven, Christopher Welch President, Tom Charity, Greg Watts, Allan Simmons, Rani Mirza, Victoria Segal, Tim Reid, Dean Godson, Daniel Finkelstein, Peter Ackroyd, Phoebe Greenwood, Jo Morris, Nicholas Blanford, Elizabeth Colman, Helen Dunmore, Ben Machell, Adam Moss, Editor, Professor Michael Sternberg, Sophie Harris, Andrew Ellson Personal Finance Editor, Robert Chesshyre, Peter Davies, Brian Noton, Tina Gaudoin, Jonathan Richards, Ron Lewis, David Swallow, David Roffe, Will Lawrence, Jonathan Sacks, Lucy Sweeney, Tim Teeman, Hugo Rifkind, Derwent May, Paul H. Dear, Robin Amlot, Aggie MacKenzie, Dan Whitcombe, E. O. Wilson, John Howe, Tom Whitwell, Ed Potton, Suzy Jagger, Oliver Kay, Stephen Anderton, Sarah Vine, Mark Atherton, Dan Brennan, John Westerby, Lisa Armstrong, Rick Broadbent, Jane Wheatley, Tom Baldwin, Jill Sherman Whitehall Editor, Douglas Rankine, Joan Collins, Jane Knight Deputy Travel Editor, Neel Mukherjee, Simon de Bruxelles, John Hopkins Golf Correspondent, Rob Wright, Jane Fearnley-Whittingstall, Celia Brayfield, Christina Koning, Gabriel Rozenberg, David Morley, Raymond Keene, Adam Sage, Suzi Godson, Kate Saunders, Lewis Smith, Matt Hughes, Rebecca O'Connor, Sarah Birke, Gordon Ramsay, Bruce Dessau, Stuart Gendall, Sean O'Neill, John Bercow, MP, Kaveh Solhekol, Amos Oz, Roger Phillips, Jeremy Page, Andrew G. Marshall, Zoë Strimpel, Chris Campling, Adam Fresco Crime Correspondent, Hattie Garlick, Richard Owen, Chris Ross, Marcus Leroux, Rebecca O'connor, Ross Leckie, Karl Sabbagh, Roger Boyes, James Charles, Tom Whipple, Nick Hasell, Thomasina Miers, Allan Mallinson, Jonathan Luxmoore, Dalya Alberge, Margaret Reynolds, Tom Dart, Kevin Maher, Paul Simons, Adam Fresco, Nicholas Clee, Mike Mulvihill, Steve Jelbert, Nigel Kendall, Nick Szczepanik, Joanna Pitman, Mary Ann Sieghart, Bettany Hughes, Jonathan Clayton, Nicholas Aldworth, Richard Ehrlich, Robert Crampton, Robin Kempster, Anna Stroman, Steve Hawkes, Dominic Maxwell, Matthew Parris, Mark Bridge, Virginia Blackburn, Amanda Craig, Frank Greaney, Sonia Verma, George Caulkin, Jimmy Carr, Russell Jenkins, Caitlin Moran, Sheila Keating, Baroness Ludford, MEP, Celia Dodd, Iain Finlayson, Nick Clegg, MP, Tim Wapshott, Neil Fisher, Ben MacIntyre, Jeremy Page South Asia Correspondent, Helen Pridham, Roy Hattersley, Richard Beeston, Robert Redford, Rajeev Syal, Andrew round, Michael Chabon, David Hutcheon, John Naish, Andrew George, MP, Mark Henderson, Chris Ayres, James Jackson, Patrick Foster, Ian Hunter, Nigel Hawkes Health Editor, Rory Stewart, Ashling O'Connor, Benedict Nightingale, Anna Shepard, Sarah Butler Retail Correspondent, Louise Cohen, Rick Broadbent Athletics Correspondent, Dr Thomas Stuttaford, Norman H. Bishop, Stephen Dalton, Nicola Woolcock, Leo Lewis, Richard Morrison, Tom Chesshyre, James Christopher, Peter Thorpe, Lloyd Jones, Alan Lee Racing Correspondent, Lisa Tuttle, Rick Stein, Alan Jackson, Amy Larocca, Olav Bjortomt, Patrick R. R. Chapman, Kim Newman, Kevin Smith, Mark Hilton, Will Hide, Lord Steel of Aikwood, Daphne Lockyer, David Robertson, Emma Haslett, Christopher Irvine, Richard Wheeler,
... Renegade Squadron Lucasarts/PSP (£34.99) The final two winners of the Crash of the Titans Sierra/PS2, Xbox 360, Wii, PSP, DS (£24.99-£39.99) Timeshift Sierra/PC, PS3, Xbox 360 (£34.99-£49.99) Folklore Sony/PS3 (£39.99) Half-Life 2: The Orange Box Valve/Xbox 360, PC, PS3 (£ ...
2007 - Gale Group | TDA
Amir Tejani, E. Kenneth Sullivan,
... transplants). Using standard statistical methods, the morbidity, rejection episodes, post‐transplant hospitalizations, renal function, long‐ and short‐term graft survival, and half‐life of primary recipients were compared in the two groups. Unlike adult patients, only 2.7% (87/3313) of CD recipients in the ...
Tópico(s): Organ Transplantation Techniques and Outcomes
2000 - Wiley | Pediatric Transplantation
Julio Delgado, Víctor Jiménez‐Yuste, F. Hernández‐Navarro, Ana Villar,
... The short half-life of this product (mean half-life in adults 2·7 h) necessitates such frequent infusions (Lindley et al, 1994). Minor episodes are usually treated with two or three doses, but the treatment of major ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2003 - Wiley | British Journal of Haematology
Joshua T. Schiffer, David A. Swan, Lawrence Corey, Anna Wald,
... 2 = 0.21) than the drug concentration at episode onset ( R 2 = 0.14 and 0.05, respectively), though the model projected that an agent with an equivalent potency but a two times longer half-life would decrease shedding by 80% compared to that ...
Tópico(s): Systemic Lupus Erythematosus Research
2013 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Celeste Lindley, William T. Sawyer, B. Gail Macik, Jean Lusher, Justin F Harrison, Kelly Baird-Cox, Kel Birch, Stephen Glazer, Harold R. Roberts,
... and 17 bleeding episodes. rFVIIa distribution volume is two to three times that of plasma. Median clearance was low—31.0 ml/hr · kg in nonbleeding episodes and 32.5 mg/hr · kg in bleeding episodes. In nonbleeding episodes, median mean residence time was 3.44 hours and median half-life was 2.89 hours. In bleeding episodes, the elimination rate ...
Tópico(s): Platelet Disorders and Treatments
1994 - Wiley | Clinical Pharmacology & Therapeutics
Frank R. Ervin, Ward E. Bullock,
... to ticarcillin than the primary isolate. The serum half-life of ticarcillin in three patients with renal failure was 11.2 ± 1.0 h, and during hemodialysis it decreased to 6.3 ± 1.8 h. There were two episodes of superinfection with resistant organisms. Thirteen patients (48%) ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
1976 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Gordon C. Jayson, C Mulatero, Malcolm Ranson, Jamal Zweit, Alan Jackson, L. Broughton, John Wagstaff, Leif Håkansson, Gerard Groenewegen, Jeremy Lawrance, Meina Tang, Linda Z. Wauk, Dan Levitt, Sandrine Marréaud, Frédéric Lehmann, Manfred Herold, H. Zwierzina,
... early follow-up. There were eight grade I episodes of asymptomatic elevation of activated partial thromboplastin time (APTT) and two grade III events; one in a patient receiving 1 mg/kg and the other receiving extended doses of 10 mg/kg. Pharmacokinetic analysis revealed a non-linear kinetic and an elimination half-life of between 8.2 (0.3 mg/kg) and 18.7 (10 ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2005 - Elsevier BV | European Journal of Cancer
Roshni Kulkarni, Allison James, M. Norton, Amy D. Shapiro,
... 62). In women and girls, 132 assessable bleeding episodes (61 heavy menstrual bleeds, 47 joint bleeds, 15 muscle bleeds, and nine other bleeds) were treated with pdFX, with a 98% treatment success rate versus 100% in men and boys. Mean pdFX incremental recovery was similar in the two groups (2.05 IU dL-1 versus 1.91 IU dL-1 per IU kg-1 ), as was the mean half-life (29.3 h versus 29.5 h). Of ...
Tópico(s): Blood Coagulation and Thrombosis Mechanisms
2018 - Elsevier BV | Journal of Thrombosis and Haemostasis
Edward G. D. Tuddenham, R. S. Lane, Frances Rotblat, Alison Johnson, Timothy J. Snape, S. Middleton, P. B. A. Kernoff,
... to that of VIII:C. In contrast, the half life of VIII:C and of VIII:CAg was very short after infusion of PE VIII in the patient wih von Willebrand's disease (2.4 h). IPC when infused in this patient produced a typical secondary rise of VIII:C. Two bleeding episodes in severe haemophiliacs were satisfactorily treated with PE ...
Tópico(s): Chronic Myeloid Leukemia Treatments
1982 - Wiley | British Journal of Haematology
Xuexin He, Su Li, He Huang, Zhiming Li, Likun Chen, Sheng Ye, Jiajia Huang, Jing Zhan, Tong-Yu Lin,
... toxicity at doses ≥65 mg m(-2), including two episodes of reversible ataxia at 85 mg m(-2).For CA4, at 50 mg m(-2),mean (SD) peak plasma concentration (C(max) was 0.99 (0.33) mM, area under the curve from time zero to time of last quantifiable concentration (AUC(0,t)) was 1.42 (0.30) mM h and terminal elimination half-life (t(1/2)was 1.81 (0.61) ...
Tópico(s): Multiple Myeloma Research and Treatments
2011 - Wiley | British Journal of Clinical Pharmacology
Henry J. Duff, John A. Oates, Dan M. Roden, Raymond L. Woosley,
... neuronal blockage (loss of the venous reflex response); two at dosages of 16.2 mg/kg, one at 24.3 mg/kg, and one at 34.2 mg/kg. In one individual (24.3 mg/kg), the adrenergic neuronal blockade was associated with an acute episode of shortness of breath, orthopnea, and cough. With intravenous meobentine, there was a linear relationship between dosage and AUC, and the elimination half-life ranged from 11-27 h.(ABSTRACT TRUNCATED AT ...
Tópico(s): Nitric Oxide and Endothelin Effects
1984 - Lippincott Williams & Wilkins | Journal of Cardiovascular Pharmacology
Jayesh Desai, Stephen Q. Wong, Geoffrey Chong, David C. Bibby, Annabell F. Leske, Gabriel Kremmidiotis, Marc Rosen, Danny Rischin,
... Gr 1 febrile episode possibly related to infusion, two episodes of Gr 1 fatigue and one Gr 1 rash. PK data of BNC105 indicates a linear increase in plasma AUC levels (Table) and plasma half life of < 0.5 h. Best observed responses were SD in 2/9 pts including one pt with mesothelioma (progression ...
Tópico(s): Boron Compounds in Chemistry
2009 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Robert Lenz, Tushar Garimella, Sandeep Dutta, Charles Locke, Jeffrey D. Baker, Keith Wesnes, Paul Maruff, Walid Abi‐Saab, Mario Saltarelli,
... and generally well tolerated by the AD patients. Two adverse events (paresthesia and headache, n = 2 each) occurred in greater than one subject receiving ABT-089. All adverse events were mild in severity except one syncopal vasovagal episode experienced by a subject during a phlebotomy procedure. No clinically significant findings were noted in vital signs or ECG parameters. ABT-089 exhibited a terminal half-life of 12 hours and approximately 50% greater serum ...
Tópico(s): Computational Drug Discovery Methods
2009 - Wiley | Alzheimer s & Dementia
Luca Gabutti, Filippo Nobile, Valentina Forni, Fabio Rigamonti, Nadir Weibel, Michel Burnier,
... half-lives (24, 48 and 138 hours) and 2 administration intervals (weekly vs. monthly). Two groups of 25 nephrologists were exposed to the six randomised combinations of half-life and administration interval. They were asked to achieve and maintain, as precisely as possible, the haemoglobin target of 11-12 g/dL in a simulated naïve patient. Each simulation was repeated twice, with or without randomly generated bleeding episodes.The simulation using an ESA with a half- ...
Tópico(s): Dialysis and Renal Disease Management
2011 - BioMed Central | BMC Nephrology
Karin Kurnik, Christoph Bidlingmaier,
... kg/week) from 6 years of age. Bleeding episodes were rare. Aged 13 she developed two large spontaneous haematomas. In-depth analysis confirmed decreased FVIII-recovery, –half-life and an inhibitor titre of 7.6 BU following type-2 kinetics (haemophilic autoantibodies). All of the few reported ...
Tópico(s): Platelet Disorders and Treatments
2008 - Elsevier BV | Blood
U. de Vonderweid, A. Benettoni, Donatella Piovan, Roberto Padrini,
Efficacy and pharmacokinetics of verapamil were studied in two neonates affected by supraventricular paroxysmal tachycardia, under maintenance treatment with the drug. Verapamil proved to be fully effective in suppressing arrhythmic episodes at the daily doses of 1.5 mg/kg four times a day in case 1 and of 2 mg/kg in case 2. The results of plasma half-life of the drug, calculated in a dose interval, ...
Tópico(s): Cardiac pacing and defibrillation studies
1984 - Elsevier BV | International Journal of Cardiology
... completely successfully.There were 2 airway complications noted.Two patients had a desaturation to 90, this was treated with supplemental oxygen in 1 child (2 REMI doses) and no treatment was required in the other (3 REMI doses).There were no episodes of apnea, airway obstruction, or bradycardia. Conclusion:The REMI appeared to be an effective adjunct to oral MID.Due to its short half life, repeat dosing of the REMI appears necessary to ...
Tópico(s): Anesthesia and Neurotoxicity Research
2017 - | Journal of Anesthesia & Intensive Care Medicine
Bartholomew J. Tortella, José Alvir, Margaret McDonald, Dean Spurden, Patrick F. Fogarty, Amit Chhabra, Andreas M. Pleil,
... FIX) coagulation products to treat and prevent bleeding episodes. A recently introduced extended half-life (EHL) recombinant FIX replacement product provided the opportunity ...
Tópico(s): Hemophilia Treatment and Research
2018 - AMCP | Journal of Managed Care & Specialty Pharmacy
Hérvè Chambost, Christoph Male, Thierry Lambert, Susan Halimeh, Tatiana A. Chernova, Maria Elisa Mancuso, Julie Curtin, C. Voigt, Yanyan Li, Iris Jacobs, Elena Santagostino, Gili Kenet,
... up to 77 weeks, and treated any bleeding episodes on-demand. The mean terminal half-life of rIX-FP was 91.4 hours (h), ...
Tópico(s): Platelet Disorders and Treatments
2016 - Thieme Medical Publishers (Germany) | Thrombosis and Haemostasis
Hans-Arne Myhre, Dagny Haug Dorenberg, Knut Ivan Kristiansen, Halvor Rollag, Torbjørn Leivestad, Anders Åsberg, Anders Hartmann,
... and none had UL54 gene mutations. Mean DNAemia half-life for the first (nonresistance) episode of CMV viremia was 3.8 ± 1.2 days. After established resistance, 25 of 27 patients had their mycophenolate mofetil dose reduced by approximately 50%, and 10 of these were also treated with intravenous foscarnet. The DNAemia half-life was 3.7 ± 1.4 days in the ...
Tópico(s): Toxoplasma gondii Research Studies
2011 - Wolters Kluwer | Transplantation
Kathelijn Fischer, Roshni Kulkarni, Myles Bradbury, Margaret V. Ragni, Savita Rangarajan, Yingwen Dong, Shuanglian Li, Haiyan Jiang, Karen Nugent, Glenn F. Pierce, Geoffrey Allen,
... frequent injections may be required to prevent bleeding episodes. To prolong half-life and reduce injection frequency, a long-acting recombinant ...
Tópico(s): Chronic Myeloid Leukemia Treatments
2013 - Elsevier BV | Blood
Ming Dong, Ajay K. Parsaik, Walter K. Kremers, A. Sun, Patrick G. Dean, Mikel Prieto, Borja G. Cosío, Manish J. Gandhi, L. Zhang, Thomas C. Smyrk, Mark D. Stegall, Yogish C. Kudva,
... protocol biopsies accounted for 29% of the AR episodes in the current study. In addition, graft survival in that study was estimated by graft half-life with the assumption of steady graft attrition after ... always be the case and this will impact half-life calculations. A possible explanation for the negative effect of AR on long-term allograft function may be chronic rejection. A previous study reported that the most significant risk factor for chronic rejection was a previous AR episode (RR = 4.41, p < 0.001), and 91% ...
Tópico(s): Organ Donation and Transplantation
2013 - Elsevier BV | American Journal of Transplantation
... viable tumor cells to prevent their repopulation. One episode of OncoCiDia exerts persistent theragnostic effects over weeks to months due to the long decay half-life of 8 days with iodine-131 and prolonged ...
Tópico(s): Photodynamic Therapy Research Studies
2014 - American Association for Cancer Research | Cancer Research
Monica Colvin, Jennifer Cook, Patricia P. Chang, Gary L. Francis, Daphne T. Hsu, Matthew C. Kiernan, Jon Kobashigawa, JoAnn Lindenfeld, Sofia Carolina Masri, Dylan Miller, John B. OʼConnell, E. René Rodríguez, Bruce R. Rosengard, Sally Self, Connie White‐Williams, Adriana Zeevi,
... however, their detection is limited by a short half-life in vivo and consequently a short window of detection during a rejection episode. Nevertheless, complement deposition is the sine qua non ...
Tópico(s): Viral Infections and Immunology Research
2015 - Lippincott Williams & Wilkins | Circulation
Hervé Spechbach, Philippe Morel, Kuntheavy Ing Lorenzini, Marie Besson, Laurent Gétaz, Henri Sunthorn, Yves Chalandon,
... of dasatiib treatment and during the ventricular arrhythmia episodes, cardiac ultrasound was performed with normal values observed, including no valve or structural anomalies, and normal ventricular ejection fraction. Dasatinib treatment was interrupted for 7 days to ensure total body clearance (elimination half-life of 3–5 h) 14. A 24 h ECG (Fig 3) was then performed and showed a return to baseline values before the introduction of TKI and onset of ventricular excitability (17 episodes/day of NSVT and 22% of QRS complexes ...
Tópico(s): Lung Cancer Treatments and Mutations
2013 - Wiley | Clinical Case Reports
Antonio Coppola, Flora Peyvandi, Laura Banov, Dorina Cultrera, Maurizio Margaglione, Alberto Tosetto, Lelia Valdré, Irene Schiavetti, Anna Loraschi, Giancarlo Castaman,
... 35.7%) reported a total of seven bleeding episodes, two spontaneous gum bleeds and five traumatic bleeds (two ...
Tópico(s): Cancer-related gene regulation
2024 - Wiley | Haemophilia
Henriette Farkas, Dorottya Csuka, Zsuzsanna Zotter, Erika Szabó, Ibolya Czaller, Lilian Varga, János Fejes, George Füst, George Harmat,
... which constituted one third of the treated acute episodes (patients with UAE were hospitalized until their symptoms resolved completely). Repeated dosing was necessary only infrequently, when the symptoms persisted. Recurrence of the attack was not observed within 48 hours; this may be explained by the long half-life of the pdC1-INH concentrate (∼33 hours in ... which constituted one third of the treated acute episodes (patients with UAE were hospitalized until their symptoms resolved completely). Repeated dosing was necessary only infrequently, when the symptoms persisted. Recurrence of the attack was not observed within 48 hours; this may be explained by the long half-life of the pdC1-INH concentrate (∼33 hours in ...
Tópico(s): Autoimmune Bullous Skin Diseases
2012 - Elsevier BV | Journal of Allergy and Clinical Immunology
Stefan Tiefenbacher, R. Bohra, Jean Amiral, Annette Bowyer, Steve Kitchen, A. Lochu, S. Rosén, Mirella Ezban,
... Nonacog beta pegol (N9-GP) is an extended half-life, glycoPEGylated recombinant human factor IX that is under development for the prophylaxis and treatment of bleeding episodes in hemophilia B patients. Considerable reagent-dependent variability ...
Tópico(s): Blood Coagulation and Thrombosis Mechanisms
2017 - Elsevier BV | Journal of Thrombosis and Haemostasis
Ross J. Baldessarini, Leonardo Tondo, C Ghiani, B. Lepri,
... discontinuation had less effect with drugs of prolonged half-life. The effect also varied by diagnosis (bipolar I ≥ panic > bipolar II ≥ major depressive disorder) but not by episodes per year, duration of index illness, use of ...
Tópico(s): Treatment of Major Depression
2010 - American Psychiatric Association | American Journal of Psychiatry
Paul Gomez, Alan Naim, Kelly Zucker, Mark Wong,
... a type of immune reconstitution. Given the long half- life of Nivolumab, a high dose of immunosuppression (IS) is needed for a prolonged time in face of an episode of rejection. This in turn increases the risk ...
Tópico(s): Hepatocellular Carcinoma Treatment and Prognosis
2018 - Lippincott Williams & Wilkins | The American Journal of Gastroenterology