Alan Day, Andrew Drummond and Adrian Lee, Stewart Tendler and Michael Harvey, Barney Spender, David Adams, Joanne Rule, Chief Executive, Helen Johnstone, Joanna Hunter, Robert Cole, Robert Thicknesse, Paul Hoggart, Richard Hobson, David Rhys Jones, Ivo Tennant, Gavin Lumsden, Christopher Walker, Chief Ireland Correspondent, Robert Lea, Philip Howard, Hilary Finch, Keith Hill, Rachel Campbell-Johnston, Daniel Craig, Glen Owen and Susie Steiner, Alison Kervin and Mark Souster, Oliver Holt Football Correspondent, Michael Evans, Defence Editor, David Robinson and Perry Cleveland-Peck, Tony Patrick, Christine Buckley Industrial Correspondent, Fraser Nelson, Retail Correspondent, Raymond Snoddy, Robert Sheehan, Bridge Correspondent, Martin Fletcher, Pat Gibson, Valerie Elliott, Donald Hutera, Cornelius Lysaght, Norman Warner (Chairman), Thrasy Petropoulos, McNally, President, Dominic Walsh, Shirley English, Jim McCue, Raymond Snoddy and Chris Ayres, Carol Midgley, Media Correspondent, Raymond Keene Chess Correspondent, Michael Harvey, Mary Ann Siegbart, Stewart Tendler and Adam Fresco, Ray Kennedy, Alan Hamilton, Mark Inglefield, Ian Murray, Medical Correspondent, Jenny MacArthur, Max Clifford, John O'Leary, Lisa Armstrong, Fashion Editor, Keith Pike, Charles Bremner, Jill Sherman, Whitehall Editor, Marion Clayton, Helen Rumbelow, P. G. Wodehouse, Peter Barnard, Sharon Ring, Brian Totman, Paul Hemingway, Mohamed Lakhdar-Hamina, Russell Kempson, Paul Armstrong, John Wadham, Director, David Lister, Jill Sherman Whitehall Editor, Marit Hargie, Philip Webster and Peter Riddell, Ann Treneman, Fay Wertheimer, Tracy Connor, Geoffrey Dean, Christopher Martin-Jenkins, Chief Cricket Correspondent, Stephen Wood, David Watts, Raymond Keene, Tim Merryman's, Peter Campbell, Clive Mathieson, John Russell Taylor, Frances Gibb, Legal Correspondent, Paul Wilkinson, Stefano Hatfield, Ray Connolly, David Orr, Caroline Merrell, Carl Mortished, International Business Editor, Bronwen Maddox, Richard Owen, Damian Whitworth, Lisa Thomlinson, John Stern, Nick Hasell, Jennifer O'neill, Stewart Tendler, Robert Cole, City Correspondent, Alastair Lack, Jason Nissé and Dominic Walsh, Giles Whittell, Jane Shilling, Saeed Shah, Brian MacArthur, Jason Nissé, Mel Webb, Maureen Paton, Valerie Elliott and Lisa Thomlinson, George Caulkin, Julian le Maistre, Alan Lee, Peter Riddell, Ben MacIntyre, Ian Brodie, Nigel Hawkes and Nick Nuttall, Ben Macintyre, Alex Leach, David Sinclair, Simon Jenkins, Fraser Nelson, Tim Jones, Mark Henderson, Martin Waller, Chris Ayres, Perry Cleveland-Peck, Alexandra Frean, Social Affairs Correspondent, Chris Scott, Richard Morrison, Jack Bailey, Sam Kiley, Alyson Rudd, Alex O'connell, Michael Evans, Lea Paterson Economics Correspondent, Colin McQuillan, Lisa Verrico, Christine Buckley, Industrial Correspondent,
In the Saturday Times The world at the miillennium 8… Brown declares war on workshy Index Picture Gallery Wodehouse was in German pay No Title Protester ...
1999 - Gale Group | TDA
Maria Lahtinen, Anna‐Kaisa Salmi,
... of a large Medieval population buried in Iin Hamina, northern Finland, has been used to reconstruct palaeodiet. Iin Hamina is situated approximately 30 km away from the ... study is human skeletal material from an Iin Hamina cemetery dated as 15 to 17th centuries AD ... source for the people buried at the Iin Hamina cemetery.
Tópico(s): Indigenous Studies and Ecology
2018 - Taylor & Francis | Environmental Archaeology
... in northern Finland at the cemetery of Iin Hamina. The cemetery was in use in the 15th ... the main protein source for people at Iin Hamina was fish. In this study, I observe annual ... formation, the results show the inhabitants of Iin Hamina experienced only minor changes in diet over periods ...
Tópico(s): Forensic Anthropology and Bioarchaeology Studies
2017 - Cambridge University Press | Radiocarbon
... subtrees, center, and centroid of a tree Martti Hamina, Martti Hamina Mathematics Division, Faculty of Technology, University of Oulu, ... FinlandSearch for more papers by this author Martti Hamina, Martti Hamina Mathematics Division, Faculty of Technology, University of Oulu, ...
Tópico(s): Facility Location and Emergency Management
2010 - Wiley | Networks
Kaarina Parviainen, H Nordling, J Ainamo,
... fluoride content since 1959, and one‐third from Hamina, where the natural fluoride content of the drinking ... gingival bleeding was found to be highest in Hamina (2.5 parts/ 10 6 ). A highly significant ...
Tópico(s): Oral microbiology and periodontitis research
1977 - Wiley | Community Dentistry And Oral Epidemiology
Maria Lahtinen, Laura Arppe, Geoff Nowell,
... twelve individuals from the medieval Finnish site Iin Hamina with a known dietary history. Our study shows ... explaining the strontium isotope composition of the Iin Hamina human remains, with implication of erroneous conclusions about ...
Tópico(s): Pacific and Southeast Asian Studies
2020 - Springer Nature | Archaeological and Anthropological Sciences
Havu Pellikka, Terhi K. Laurila, Hanna Boman, Anu Karjalainen, Jan‐Victor Björkqvist, Kimmo K. Kahma,
... two tide gauges, Hanko for 1922–1989 and Hamina for 1928–1989, from the summer months of ... century shows a statistically significant increasing trend in Hamina, but not in Hanko.
Tópico(s): Ocean Waves and Remote Sensing
2020 - Copernicus Publications | Natural hazards and earth system sciences
Jorge García Fernández, Leonor Medeiros,
... place the International Summer School ‘Unveiling the Hidden Hamina’, in Finland. The course was focused on integrating ...
Tópico(s): Cultural Heritage Management and Preservation
2019 - Copernicus Publications | ISPRS annals of the photogrammetry, remote sensing and spatial information sciences
... at least four distinctly developed periods recorded at Hamina (Fredrikshamn) in the east part of the Gulf ...
Tópico(s): Geophysics and Gravity Measurements
1959 - Wiley | Tellus A Dynamic Meteorology and Oceanography
A. Naceri, Makhloufi Chikouche Hamina,
The aim of this study is to investigate the use of waste brick as a partial replacement for cement in the production of cement mortar. Clinker was replaced by waste brick in different proportions (0%, 5%, 10%, 15% and 20%) by weight for cement. The physico-chemical properties of cement at anhydrous state and the hydrated state, thus the mechanical strengths (flexural and compressive strengths after 7, 28 and 90 days) for the mortar were studied. The microstructure of the mortar was investigated using ...
Tópico(s): Recycling and utilization of industrial and municipal waste in materials production
2009 - Elsevier BV | Waste Management
Alexandre Ouattara, Hamina Benhaoua, Yannick Le Manach, Nejma Mabrouk-Zerguini, Omar S. Itani, Amer Osman, Marc Landi, Bruno Riou, Pierre Coriat,
Objective The aim of this study was to determine whether perioperative statin therapy was associated with a dose-dependent decrease in adverse cardiovascular events after coronary artery bypass graft (CABG) surgery. Design A prospective observational study. Setting A cardiovascular anesthesia unit in a university hospital. Participants Four hundred eighteen consecutive patients undergoing CABG surgery between October 2004 and October 2005. Interventions Patients were divided in 2 groups depending ...
Tópico(s): Antiplatelet Therapy and Cardiovascular Diseases
2009 - Elsevier BV | Journal of Cardiothoracic and Vascular Anesthesia
... A Comparative Study. Folklore Fellows Communications, No. 24. Hamina: Suomalaisen Tiedeakatemian Kustantama. Collier, George A. 1987. Socialists ...
Tópico(s): Family Dynamics and Relationships
1992 - Wiley | Ethos
Sanna Vaalgamaa, Atte Korhola,
... spatial processes. These include the building of the Hamina port starting in the mid-1930s, establishment of ...
Tópico(s): Geochemistry and Elemental Analysis
2003 - Elsevier BV | Estuarine Coastal and Shelf Science
Marjo Paavola, Ari O. Laine, Markus Helavuori, Patrik Kraufvelin,
... of four Finnish coastal harbours (Naantali, Koverhar, Porvoo, Hamina) were investigated and compared with 'natural' reference areas ...
Tópico(s): Marine Biology and Ecology Research
2008 - | Boreal environment research
... the representation of indigenous suffering in Mohamed Lakhdar Hamina's 1966 film Le Vent des Aurès. Paying ...
Tópico(s): French Historical and Cultural Studies
2007 - Oxford University Press | French Studies
Stefano Crosignani, Catherine Jorand‐Lebrun, Gordon Campbell, Adeline Prêtre, Tania Grippi-Vallotton, Anna Quattropani, Gwenaelle Bouscary‐Desforges, Agnès Bombrun, Marc Missotten, Yves Humbert, Christèle Frémaux, Mikaël Pâquet, Kamel El Harkani, Charles G. Bradshaw, Christophe Cleva, Nada Abla, Hamina Daff, Olivier Schott, Pierre-André Pittet, Jean‐François Arrighi, Marilène Gaudet, Zoë Johnson,
Antagonism of the CRTH2 receptor represents a very attractive target for a variety of allergic diseases. Most CRTH2 antagonists known to date possess a carboxylic acid moiety, which is essential for binding. However, potential acid metabolites O-acyl glucuronides might be linked to idiosynchratic toxicity in humans. In this communication, we describe a new series of compounds that lack the carboxylic acid moiety. Compounds with high affinity (K i < 10 nM) for the receptor have been identified. Subsequent ...
Tópico(s): Hormonal and reproductive studies
2011 - American Chemical Society | ACS Medicinal Chemistry Letters
Andrzej Hellmann, Simon Rule, Jan Walewski, Ofer Shpilberg, Huaibao Feng, Helgi van de Velde, Hamina Patel, Donna Skee, Suzette Girgis, Vernon Louw,
Tópico(s): HIV/AIDS drug development and treatment
2011 - Adis, Springer Healthcare | Clinical Pharmacokinetics
Stefano Crosignani, Adeline Prêtre, Catherine Jorand‐Lebrun, Gaële Fraboulet, Jeyaprakashnarayanan Seenisamy, John Kallikat Augustine, Marc Missotten, Yves Humbert, Christophe Cleva, Nada Abla, Hamina Daff, Olivier Schott, Manfred Schneider, Fabienne Burgat-Charvillon, Delphine Rivron, Ingrid Hamernig, Jean‐François Arrighi, Marilène Gaudet, Simone C. Zimmerli, Pierre Juillard, Zoë Johnson,
New phenoxyacetic acid antagonists of CRTH2 are described. Following the discovery of a hit compound by a focused screening, high protein binding was identified as its main weakness. Optimization aimed at reducing serum protein binding led to the identification of several compounds that showed not only excellent affinities for the receptor (41 compounds with K(i) < 10 nM) but also excellent potencies in a human whole blood assay (IC(50) < 100 nM; PGD2-induced eosinophil shape change). Additional optimization ...
Tópico(s): Chemical Synthesis and Analysis
2011 - American Chemical Society | Journal of Medicinal Chemistry
Jarmo J. Meril�inen, Virpi Hamina,
Tópico(s): Geological formations and processes
1993 - Springer Science+Business Media | Journal of Paleolimnology
Aafje Sierksma, Hamina J. Patel, Noriyuki Ouchi, Shinji Kihara, Tohru Funahashi, Robert J. Heine, Diederick E. Grobbee, Cornelis Kluft, H. Hendriks,
Epidemiological studies suggest that moderate alcohol consumers have enhanced insulin sensitivity and a reduced risk of type 2 diabetes. Adiponectin, an adipocyte-derived plasma protein, has been found to be negatively associated with adiposity and positively associated with insulin sensitivity. Moderate alcohol consumption may increase adiponectin, which in turn causes a decrease of tumor necrosis factor (TNF)-alpha. A decreased TNF-alpha level may consequently increase insulin sensitivity.To test ...
Tópico(s): Adipose Tissue and Metabolism
2004 - American Diabetes Association | Diabetes Care
Tobias Heckel, Roland Schmucki, Marco Berrera, Stephan Ringshandl, Laura Badi, Guido Steiner, Morgane Ravon, Erich Küng, Bernd Kuhn, Nicole A. Kratochwil, Georg Schmitt, Anna Kiialainen, Corinne Nowaczyk, Hamina Daff, Azinwi Phina Khan, Isaac Lekolool, Roger Pellé, Edward Okoth, Richard P. Bishop, Claudia Daubenberger, Martin Ebeling, Ulrich Certa,
In the past decade the Göttingen minipig has gained increasing recognition as animal model in pharmaceutical and safety research because it recapitulates many aspects of human physiology and metabolism. Genome-based comparison of drug targets together with quantitative tissue expression analysis allows rational prediction of pharmacology and cross-reactivity of human drugs in animal models thereby improving drug attrition which is an important challenge in the process of drug development. Here we ...
Tópico(s): RNA Research and Splicing
2015 - BioMed Central | BMC Genomics
Alain Combes, Nicolas Bréchot, Julien Amour, Nathalie Cozic, Guillaume Lebreton, C. Guidon, Élie Zogheib, Jean-Claude Thiranos, Jean‐Christophe Rigal, Olivier Bastien, Hamina Benhaoua, B. Abry, Alexandre Ouattara, Jean‐Louis Trouillet, Alain Mallet, Jean Chastre, Pascal Leprince, Charles‐Édouard Luyt,
Post-cardiac surgery shock is associated with high morbidity and mortality. By removing toxins and proinflammatory mediators and correcting metabolic acidosis, high-volume hemofiltration (HVHF) might halt the vicious circle leading to death by improving myocardial performance and reducing vasopressor dependence.To determine whether early HVHF decreases all-cause mortality 30 days after randomization.This prospective, multicenter randomized controlled trial included patients with severe shock requiring ...
Tópico(s): Mechanical Circulatory Support Devices
2015 - American Thoracic Society | American Journal of Respiratory and Critical Care Medicine
Rosa Vilkama, Ritva Kylli, Anna‐Kaisa Salmi,
This article examines the modernization of northern Finnish food culture, especially in 17th- and 18th-century urban Oulu, by applying the methods of archaeology and history research. During the 17th century, the food culture was still quite conservative. Coffee, sugar, wheat flour, and fruit began entering the diet of affluent northern Finnish people from the 18th century onwards. The food culture of Oulu inhabitants is studied by comparing dental material retrieved from Oulu Cathedral graveyard ...
Tópico(s): Archaeology and ancient environmental studies
2015 - Routledge | Scandinavian Journal of History
Aleksi Hamina, Heidi Taipale, Antti Tanskanen, Anna‐Maija Tolppanen, Niina Karttunen, Liisa Pylkkänen, Jari Tiihonen, Sirpa Hartikainen,
Abstract Persons with Alzheimer disease (AD) commonly present with chronic nonmalignant pain, but long-term use of opioids among this population has not been studied previously. Our aim was to investigate the prevalence of long-term (≥180 days) use of opioids for nonmalignant pain and associated factors among community-dwelling persons with AD and to compare the prevalence with a matched cohort without AD. The Medication use and Alzheimer's disease (MEDALZ) cohort was used for this study, comprising ...
Tópico(s): Pain Mechanisms and Treatments
2016 - Lippincott Williams & Wilkins | Pain
Anna Lenard, Elisa Alghisi, Hamina Daff, Massimiliano Donzelli, C. McGinnis, Claudia Lengerke,
The zebrafish is a vertebrate model organism widely used to study developmental and malignant hematopoiesis. All major mammalian blood cell lineages are present in zebrafish, and many genes and pathways involved in vertebrate hematopoiesis are conserved between fish and mammals.[1][1]–[3][2] The
Tópico(s): Epigenetics and DNA Methylation
2016 - Ferrata Storti Foundation | Haematologica
Aleksi Hamina, Heidi Taipale, Antti Tanskanen, Anna‐Maija Tolppanen, Jari Tiihonen, Sirpa Hartikainen,
There are conflicting findings about analgesic use among persons with cognitive impairment compared to cognitively intact older persons. The objective of our study was to investigate the prevalence of analgesic use in community-dwelling persons with and without Alzheimer's disease (AD), within six months after AD diagnosis and to find out factors associated with the use of analgesics and specific analgesic groups.We utilized data from register based MEDALZ (Medication use and Alzheimer's disease) ...
Tópico(s): Pain Mechanisms and Treatments
2016 - Wiley | European Journal of Pain
Heidi Taipale, Aleksi Hamina, Pasi Lampela, Antti Tanskanen, Jari Tiihonen, Niina Karttunen, Anna‐Maija Tolppanen, Sirpa Hartikainen,
We investigated whether opioid use, duration of use, and cumulative dose are associated with an increased risk of Alzheimer's disease (AD).A Finnish nationwide nested case-control study, MEDALZ, included 70,718 individuals with AD and up to four age-, sex-, and region of residence-matched comparison individuals. The cohort included all Finnish persons with a clinically verified AD diagnosis during 2005 to 2011; the mean age was 80 years (SD = 7 years), and 65% were women. Register-based data on opioid ...
Tópico(s): Intensive Care Unit Cognitive Disorders
2017 - Oxford University Press | Pain Medicine
Jan Hofland, Alexandre Ouattara, Jean-Luc Fellahi, Matthias Gruenewald, J. Hazebroucq, Claude Ecoffey, Pierre Joseph, Matthias Heringlake, A. Steib, Mark Coburn, Julien Amour, Bertrand Rozec, Inge de Liefde, Patrick Meybohm, Benedikt Preckel, Jean‐Luc Hanouz, Luigi Tritapepe, Peter H. Tonner, Hamina Benhaoua, Jan P. Roesner, Berthold Bein,
Abstract Background Ischemic myocardial damage accompanying coronary artery bypass graft surgery remains a clinical challenge. We investigated whether xenon anesthesia could limit myocardial damage in coronary artery bypass graft surgery patients, as has been reported for animal ischemia models. Methods In 17 university hospitals in France, Germany, Italy, and The Netherlands, low-risk elective, on-pump coronary artery bypass graft surgery patients were randomized to receive xenon, sevoflurane, ...
Tópico(s): Anesthesia and Sedative Agents
2017 - Lippincott Williams & Wilkins | Anesthesiology
Heidi Taipale, Aleksi Hamina, Niina Karttunen, Marjaana Koponen, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Anna‐Maija Tolppanen,
Abstract The objective of this study was to investigate whether incident opioid use is associated with an increased risk of hip fractures among community-dwelling persons with Alzheimer disease (AD) and to assess the association in terms of duration of use and opioid strength. Among community-dwelling persons with AD diagnosed in 2010 to 2011 (N = 23,100), a matched cohort study comparing incident opioid users (N = 4750) with opioid nonusers (N = 4750) was constructed. Matching was based on age, sex, and ...
Tópico(s): Musculoskeletal pain and rehabilitation
2018 - Lippincott Williams & Wilkins | Pain
Kaisa Granqvist, Alois Humer, Raine Mäntysalo,
... meaning. Through the case study of the Kotka-Hamina city-region of Finland, the paper explores a ...
Tópico(s): Public Policy and Administration Research
2020 - Routledge | Regional Studies