Huaibing Jin, Xinyun Han, Zhaohui Wang, Yilin Xie, Kunpu Zhang, Xiaoge Zhao, Lina Wang, Jin Yang, Huiyun Liu, Xiang Ji, Lingli Dong, Hongyuan Zheng, Weijuan Hu, Yàn Liú, Xifeng Wang, Xueping Zhou, Yijing Zhang, Weiqiang Qian, Wenming Zheng, Qian‐Hua Shen, Mingyue Gou, Daowen Wang,
Viruses often usurp host machineries for their amplification, but it remains unclear if hosts may subvert virus proteins to regulate viral proliferation. Here, we show that the 17K protein, an important virulence factor conserved in barley yellow dwarf viruses (BYDVs) and related poleroviruses, is phosphorylated by host GRIK1-SnRK1 kinases, with the phosphorylated 17K (P17K) capable of enhancing the abundance of virus-derived small interfering RNAs (vsiRNAs) and thus antiviral RNAi. Furthermore, P17K ...
Tópico(s): Wheat and Barley Genetics and Pathology
2022 - Springer Nature | The EMBO Journal
Xinyun Han, Junxian Hu, Wenbo Zhao, Hongwei Lu, Jingjin Dai, Qingyi He,
Angiogenesis is essential for successful bone defect repair. In normal tissue repair, the physiological inflammatory response is the main regulator of angiogenesis through the activity of macrophages and the cytokines secreted by them. In particular, M2 macrophages which secrete high levels of PDGF-BB are typically considered to promote angiogenesis. A hexapeptide [WKYMVm, (Trp-Lys-Tyr-Met-Val-D-Met-NH2)] has been reported to modulate inflammatory activities. However, the underlying mechanisms by ...
Tópico(s): Protease and Inhibitor Mechanisms
2022 - Elsevier BV | Experimental Cell Research
Xinyun Han, Ling Zhang, Lifang Zhao, Pengya Xue, Ting Qi, Chunlei Zhang, Hongbo Yuan, Lixun Zhou, Daowen Wang, Jin‐Long Qiu, Qian‐Hua Shen,
Plants recognize pathogens and activate immune responses, which usually involve massive transcriptional reprogramming. The evolutionarily conserved kinase, Sucrose non-fermenting-related kinase 1 (SnRK1), functions as a metabolic regulator that is essential for plant growth and stress responses. Here, we identify barley SnRK1 and a WRKY3 transcription factor by screening a cDNA library. SnRK1 interacts with WRKY3 in yeast, as confirmed by pull-down and luciferase complementation assays. Förster resonance ...
Tópico(s): Plant Gene Expression Analysis
2020 - Elsevier BV | Plant Communications
Tengfei Xia, Yanping Yang, Hongyuan Zheng, Xinyun Han, Huaibing Jin, Zijun Xiong, Weiqiang Qian, Lanqin Xia, Xiang Ji, Guangwei Li, Daowen Wang, Kunpu Zhang,
Summary The LRK10‐like receptor kinases (LRK10L‐RLKs) are ubiquitously present in higher plants, but knowledge of their expression and function is still limited. Here, we report expression and functional analysis of TtdLRK10L‐1, a typical LRK10L‐RLK in durum wheat ( Triticum turgidum L. ssp. durum ). The introns of TtdLRK10L‐1 contained multiple kinds of predicted cis ‐elements. To investigate the potential effect of these cis ‐elements on TtdLRK10L‐1 expression and function, two types of transgenic wheat ...
Tópico(s): Plant Reproductive Biology
2020 - Wiley | Plant Biotechnology Journal
Huaibing Jin, Z Du, Yanjing Zhang, Judit Antal, Zongliang Xia, Yan Wang, Yang Gao, Xiaoge Zhao, Xinyun Han, Yanjun Cheng, Qian‐Hua Shen, Kunpu Zhang, Robert Elder, Zsigmond Benkő, Csaba Fenyvuesvolgyi, Ge Li, Dionne Rebello, Jing Li, Shilai Bao, Yuqi Zhao, Daowen Wang,
Many animal viral proteins, e.g., Vpr of HIV-1, disrupt host mitosis by directly interrupting the mitotic entry switch Wee1-Cdc25-Cdk1. However, it is unknown whether plant viruses may use this mechanism in their pathogenesis. Here, we report that the 17K protein, encoded by barley yellow dwarf viruses and related poleroviruses, delays G
Tópico(s): Plant Parasitism and Resistance
2020 - American Association for the Advancement of Science | Science Advances
Jingjin Dai, Rui Dong, Xinyun Han, Jian‐Mei Li, Xiaoshan Gong, Yun Bai, Fei Kang, Mengmeng Liang, Fanchun Zeng, Zhiyong Hou, Shiwu Dong,
The invasion of osteoclasts into the cartilage via blood vessels advances the process of endochondral ossification, and dysregulation of dynamic intercellular interactions results in skeletal dysplasias. Although the regulation of osteoclasts by growth plate chondrocytes has been reported in detail, the effect of osteoclasts on chondrocytes remains to be determined. In this study, ATDC5 cells and bone marrow mesenchymal stem cells were differentiated into chondrocytes and treated with conditioned ...
Tópico(s): Cancer-related molecular mechanisms research
2020 - American Physical Society | AJP Cell Physiology
Li Li, Wanqian Liu, Yulan Zhao, Pingping Ma, Shenfang Zha, Peixin Chen, Hongwei Lu, Xiaorui Jiang, Shuang Wan, Jiangming Luo, Qijie Dai, Junxian Hu, Yohanes Kristo Sugiarto Utomo, Xinyun Han, Zhengwei Yang, Li Yang, Qingyi He,
Vasculogenesis (de novo formation of vessels) induced by endothelial progenitor cells (EPCs) is requisite for vascularized bone regeneration. However, there exist few available options for promoting vasculogenesis within artificial bone grafts except for exogenous EPC transplantation, which suffers from the source of EPC, safety, cost, and time concerns in clinical applications. This study aimed at endogenous EPC recruitment for vascularized bone regeneration by using a bioinspired EPC-induced graft. ...
Tópico(s): Protease and Inhibitor Mechanisms
2019 - American Chemical Society | ACS Applied Materials & Interfaces
Hongyuan Zheng, Lingli Dong, Xinyun Han, Huaibing Jin, Cui‐Cui Yin, Yali Han, Bei Li, Huanju Qin, Jin‐Song Zhang, Qian‐Hua Shen, Kunpu Zhang, Daowen Wang,
Summary Powdery mildew disease, elicited by the obligate fungal pathogen Blumeria graminis f.sp. tritici ( Bgt ), causes widespread yield losses in global wheat crop. However, the molecular mechanisms governing wheat defense to Bgt are still not well understood. Here we found that TuACO3 , encoding the 1‐aminocyclopropane‐1‐carboxylic acid (ACC) oxidase functioning in ethylene (ET) biosynthesis, was induced by Bgt infection of the einkorn wheat Triticum urartu , which was accompanied by increased ET content. ...
Tópico(s): Plant Pathogens and Fungal Diseases
2019 - Wiley | New Phytologist
Junxian Hu, Xianghe Li, Yueqi Chen, Xinyun Han, Li Li, Zhengwei Yang, Lianli Duan, Hongwei Lu, Qingyi He,
Abstract The balance between bone formation and bone resorption is closely related to bone homeostasis. Osteoclasts, originating from the monocyte/macrophage lineage, are the only cell type possessing bone resorption ability. Osteoclast overactivity is thought to be the major reason underlying osteoclast‐related osteolytic problems, such as Paget's disease, aseptic loosening of prostheses and inflammatory osteolysis; therefore, disruption of osteoclastogenesis is considered a crucial treatment option ...
Tópico(s): Synthesis and Characterization of Heterocyclic Compounds
2019 - Wiley | Journal of Cellular and Molecular Medicine
Cheng Hu, Xueyan Xia, Xinyun Han, Y. F. Chen, Yan Qiao, D. H. Liu, S. L. Li,
To study the effect of fertilization on soil nematode communities in a paddy-upland rotation system, an ongoing thirty-three years long-term fertilizer experiment is conducted which includes seven treatments; an unfertilized treatment (control), nitrogen (N), phosphorus (P), potassium (K) fertilizer treatments (N, NP, NPK) and organic manure (M) combined with chemical fertilizer treatments (MN, MNP, and MNPK). The soil nematode community structure and crop yields were determined in 2012 and 2013. Overall ...
Tópico(s): Soil Carbon and Nitrogen Dynamics
2018 - De Gruyter Open | Helminthologia
Kenneth Pak Leung Wong, Audrey Xinyun Han, Jeannie Leh Ying Wong, Dave Yee Han Lee,
Tópico(s): Sports injuries and prevention
2016 - Springer Science+Business Media | Knee Surgery Sports Traumatology Arthroscopy
Yixue Jiang, Evelyn Ling Ling Ng, Danielle Xinyun Han, Yinjia Yan, Siew Yin Chan, John Wang, B Chan,
Self-healing polymers have received widespread attention due to their ability to repair damage autonomously and increase material stability, reliability, and economy. However, the processability of self-healing materials has yet to be studied, limiting the application of rich self-healing mechanisms. Additive manufacturing effectively improves the shortcomings of conventional processing while increasing production speed, accuracy, and complexity, offering great promise for self-healing polymer applications. ...
Tópico(s): Advanced Polymer Synthesis and Characterization
2023 - Multidisciplinary Digital Publishing Institute | Polymers
Khai Cheong Wong, Xinyun Audrey Han, Kae Sian Tay, Suang Bee Koh, Tet Sen Howe,
World Health Organization declared coronavirus disease-19 (COVID-19) a global pandemic on 11 March 2020, after the coronavirus claimed 4628 lives worldwide. Mental health challenges such as making impossible decisions and working under extreme pressures are expected to be faced by frontline healthcare workers who are directly involved in the care of COVID-19 patients. However, we question if significant stress levels might also be observed in a subspecialty musculoskeletal outpatient department, ...
Tópico(s): COVID-19 and healthcare impacts
2020 - BioMed Central | Journal of Orthopaedic Surgery and Research
Han Xinyun Audrey, Hamid Rahmatullah Bin Abd Razak, Tan Hwee Chye Andrew,
Subchondral cysts have always been taught to be one of the cardinal radiological features of knee osteoarthritis but are not well understood. We aimed to evaluate the radiological prevalence and epidemiology of subchondral cysts in patients with knee osteoarthritis to determine if they are truly a cardinal radiological feature.All patients of a single surgeon with symptoms of knee osteoarthritis were selected for this study. All patients had failed a trial of conservative therapy and were planned ...
Tópico(s): Rheumatoid Arthritis Research and Therapies
2014 - Bentham Science Publishers | The Open Orthopaedics Journal
Ning Su, Xinyun Xu, Han Chen, Wenchao Gao, Canping Ruan, Qiang Wang, Yanping Sun,
The activation of K-ras gene and expression of annexin A1 play an important role in colorectal tumorigenesis. We initiated this study to analyze the possible relationship between the annexin A1 expression and the K-ras mutation status in colorectal cancer. K-ras mutations are present in one fourth to one half of colorectal cancers. Annexin A1, a 37-kDa calcium- and phospholipid-binding protein, is over-expressed in colorectal cancers and may be involved in invasive tumor growth and metastasis. Here, ...
Tópico(s): Heat shock proteins research
2010 - Tohoku University | The Tohoku Journal of Experimental Medicine
Hamid Rahmatullah Bin Abd Razak, Xinyun Audrey Han, Hwei Chi Chong, Andrew Hwee Chye Tan,
Objective To evaluate whether preoperative range of motion is a key determinant of postoperative range of motion in A sian patients undergoing conventional total knee arthroplasty. Methods A retrospective review of 302 patients who underwent primary total knee arthroplasty performed by a single surgeon was conducted. Patients who had a fixed flexion deformity of ≥15° were excluded. Postoperative range of motion (ROM) was measured prospectively. Patients were stratified into two groups: preoperative ...
Tópico(s): Knee injuries and reconstruction techniques
2014 - Wiley | Orthopaedic Surgery
Pengya Xue, Ling Zhang, Renchun Fan, Yanan Li, Xinyun Han, Ting Qi, Lifang Zhao, Deshui Yu, Qian‐Hua Shen,
Mitogen-activated protein kinase (MAPK) cascades play important roles in disease resistance in model plant species. However, the functions of MAPK signaling pathways in crop disease resistance are largely unknown. Here we report the function of HvMKK1-HvMPK4-HvWRKY1 module in barley immune system. HvMPK4 is identified to play a negative role in barley immune response against Bgh, as virus-induced gene silencing (VIGS) of HvMPK4 results in enhanced disease resistance whilst stably overexpressing HvMPK4 ...
Tópico(s): Plant Gene Expression Analysis
2023 - Elsevier BV | Journal of genetics and genomics/Journal of Genetics and Genomics
Yingchun Yin, Xinmei Wang, Tangyue Li, Qi Ren, Liang Li, Xiaoyu Sun, Baohua Zhang, Xinyun Wang, Hongmei Han, Yangyang He, Zhen Cao, Xiaojie Sun, Ziqiang Zhou,
Abstract As a prevalent tumor among women, breast cancer is still an incurable disease due to drug resistance. In this study, we report microRNA‐221 to have a significant effect on breast cancer resistance to adriamycin. The microRNA‐221 is elevated in tumor tissue compared with nearby nontumor samples, as well as in breast cancer cell line with adriamycin resistance (MCF‐7/ADR) compared to its parental line (MCF‐7) and the normal breast epithelial cell line (MCF‐10A). Enforced level of microRNA‐221 ...
Tópico(s): Circular RNAs in diseases
2020 - Wiley | Cancer Medicine
Fuchuan Guo, Xinyun Zhuang, Mengyuan Han, Wenting Lin,
EPP protected against hepatic injury induced by CCl 4 -derived reactive intermediates through the suppression of hepatic oxidative stress, inflammation, and apoptosis.
Tópico(s): Genomics, phytochemicals, and oxidative stress
2020 - Royal Society of Chemistry | Food & Function
Jianhai Chen, Pan Ni, Xinyun Li, Jianlin Han, Ivan Jakovlić, Chengjun Zhang, Shuhong Zhao,
Population genetics theory predicts an important role of differences in the effective population size (N e ) among species on shaping the accumulation of functional mutations by regulating the selection efficiency. However, this correlation has never been tested in domesticated animals. Here, we synthesized 62 whole genome data in eight domesticated species (cat, dog, pig, goat, sheep, chicken, cattle and horse) and compared domesticates with their wild (or ancient) relatives. Genes with significantly ...
Tópico(s): Genomics and Phylogenetic Studies
2018 - Springer Science+Business Media | BMC Evolutionary Biology
Bing Han, Xinyun Zhang, Shuang Ren,
Real-scanned point clouds are often sparse and non-uniform. To conquer the problem, researchers propose point cloud upsampling techniques, whose efficiency and effectiveness heavily rely on their feature extractors and feature expanders used therein. Therefore, in this paper, to capture the global and local structured features of point clouds, we first design a Graph Attention Convolution (GAC) module as a feature extractor by assigning different attentional weights to combine spatial positions and ...
Tópico(s): Remote Sensing and LiDAR Applications
2022 - Elsevier BV | Image and Vision Computing
Shuihua Han, Xinyun Jia, Xinming Chen, Shivam Gupta, Ajay Kumar, Zhibin Lin,
A good location is critical for the sales performance of a hotel or a restaurant. This study proposes a machine learning-based model for location selection that focuses on the estimation of sales potential of a prospective site and helps to overcome the lack of historical data for the prospective site and the subjective criteria used in conventional models. The proposed model involves three major steps. First, we use an attribute selection algorithm to identify the key factors that contribute to ...
Tópico(s): Consumer Retail Behavior Studies
2022 - Elsevier BV | Journal of Business Research
Yunxia Zhao, Ye Hou, Yueyuan Xu, Yu Luan, Huanhuan Zhou, Xiaolong Qi, Mingyang Hu, Daoyuan Wang, Zhangxu Wang, Yuhua Fu, Jingjin Li, Saixian Zhang, Jianhai Chen, Jianlin Han, Xinyun Li, Shuhong Zhao,
Abstract Although major advances in genomics have initiated an exciting new era of research, a lack of information regarding cis -regulatory elements has limited the genetic improvement or manipulation of pigs as a meat source and biomedical model. Here, we systematically characterize cis -regulatory elements and their functions in 12 diverse tissues from four pig breeds by adopting similar strategies as the ENCODE and Roadmap Epigenomics projects, which include RNA-seq, ATAC-seq, and ChIP-seq. In ...
Tópico(s): RNA and protein synthesis mechanisms
2021 - Nature Portfolio | Nature Communications
Guanglei Li, Yuhua Fu, Xiaosong Han, Xinyun Li, Changchun Li,
Clenbuterol is a β-adrenergic agonist used as additive to increase the muscle mass of meat-producing animals. Previous studies were limited to evaluations of animal growth performance and determination of the residues. Several studies have focused on urine samples. Little information about the underlying molecular mechanisms that can explain Clenbuterol metabolism and promote energy repartition in animal muscle and fatty tissue is available. Therefore, this research aims to detect the metabolite ...
Tópico(s): Hormonal and reproductive studies
2016 - Elsevier BV | Journal of Chromatography A
Cancan Cui, Lin Liu, Yitian Qi, Ning Han, Haikun Xu, Zhijia Wang, Xinyun Shang, Tian-Jiao Han, Yining Zha, Xin Wei, Zhiyuan Wu,
Both the triglyceride-glucose (TyG) index, as a surrogate marker of insulin resistance, and systemic inflammation are predictors of cardiovascular diseases; however, little is known about the coexposures and relative contributions of TyG index and inflammation to cardiovascular diseases. Using the nationally representative data from the China Health and Retirement Longitudinal Study (CHARLS), we conducted longitudinal analyses to evaluate the joint and mutual associations of the TyG index and high- ...
Tópico(s): Lipoproteins and Cardiovascular Health
2024 - BioMed Central | Cardiovascular Diabetology
Xiaojie Yin, Yanjun Yin, Nannan Wang, Jing Li, Jinpei He, Xiudong Chen, Xinyun Wang, Yang Han, Mingling Li,
As electrode for lithium ion batteries (LIBs), Coordination polymers (CPs) have exhibited considerable potential. However, due to the unsatisfactory cycling and rate performance, their practical application often encounters obstacles. This work reports Fe-based coordination polymers with improved lithium storage performance induced by cobalt ions for the first time. The introduction of cobalt ions is confirmed to obviously increase the active sites and conductivity for the electrode. When used as ...
Tópico(s): Advanced Battery Materials and Technologies
2022 - Elsevier BV | Microporous and Mesoporous Materials
Ping Chen, Xinyun Jing, Jian Ren, Han Cao, Pei Hao, Xuan Li,
The launch of the BioNano next-generation mapping system has greatly enhanced the performance of physical map construction, thus rapidly expanding the application of optical mapping in genome research. Data biases have profound implications for downstream applications. However, very little is known about the properties and biases of BioNano data, and the very factors that contribute to whole-genome optical map assembly.We generated BioNano molecule data from eight organisms with diverse base compositions. ...
Tópico(s): RNA and protein synthesis mechanisms
2018 - Oxford University Press | Bioinformatics
Audrey Xinyun Han, Tien Jin Tan, Tiep Van Nguyen, Dave Yee Han Lee,
We aimed to identify the anterolateral ligament (ALL) tears in anterior cruciate ligament (ACL)-deficient knees using standard 1.5-Tesla magnetic resonance imaging (MRI).We included all patients who underwent primary ACL reconstruction at our center between 2012 and 2015. Exclusion criteria included patients with multiple ligament injuries, lateral collateral ligament, posterolateral corner, and infections, and patients who underwent MRI more than 2 months after their injury. All patients (n = 148) had ...
Tópico(s): Adhesion, Friction, and Surface Interactions
2020 - BioMed Central | Knee Surgery and Related Research
Jianzhong Sun, Zichen Yan, Han Ying, Xinyun Zhu, Caiqiong Yang,
Digital twin technology has emerged as a research hotspot in the field of intelligent operation and maintenance of gas turbines. This paper proposes a data-driven Digital Twin approach for gas turbine performance monitoring and degradation prognostics from an airline operator perspective. The framework adopts a semi-supervised deep learning method to construct a data-driven Performance Digital Twin (PDT) rather than a physics-based performance model. The PDT-derived multi-dimensional health features ...
Tópico(s): Advanced Sensor Technologies Research
2023 - Elsevier BV | Reliability Engineering & System Safety
Suqi Zhang, Xinyun Xu, Yanwei Pang, Jungong Han,
Tópico(s): Text and Document Classification Technologies
2019 - Springer Science+Business Media | Neural Processing Letters