Nicolau Beckmann, Catherine Cannet, Madeleine Fringeli-Tanner, Diana Baumann, Charles Pally, Christian Bruns, Hans‐Günter Zerwes, Emile Andriambeloson, Marc Bigaud,
Anatomical and functional information (renography, perfusion) was obtained by MRI in a life-supporting transplantation model, in which Lewis rats received kidneys from Fisher 344 donors. Renography and perfusion analyses were carried out with Gd-DOTA and small particles of iron oxide (SPIO), respectively. Starting 12 weeks posttransplantation, images from grafts of untreated recipients exhibited distinctive signal attenuation in the cortex. Animals treated with cyclosporin (Sandimmune Neoral; Novartis ...
Tópico(s): Pharmacological Effects and Toxicity Studies
2003 - Wiley | Magnetic Resonance in Medicine
Emile Andriambeloson, Charles Pally, Bastian Hengerer, Catherine Cannet, Zariana Nikolova, Christian Bruns, Hans‐Günter Zerwes, Marc Bigaud,
Clinical evidence indicates that vascular endothelial cell (EC) dysfunction occurs early after transplantation (Tx) and initiates chronic graft vasculopathy. This study explored this phenomenon in rat aorta Tx using the stringent Dark Agouti (DA)-to-Lewis (LEW) and the weak Fischer 344 (F344)-to-LEW strain combinations.Donor abdominal aortae were orthotopically grafted into LEW rats. At post-Tx days 7, 14, 28, and 56, grafts were collected to assess changes in EC morphology (en face silver staining) and ...
Tópico(s): Organ Transplantation Techniques and Outcomes
2001 - Wolters Kluwer | Transplantation
Marc Bigaud, E. O. Schraa, Emile Andriambeloson, Valerie Lobstein, Charles Pally, Tanja Kobel, Christian Bruns, Hans‐Günter Zerwes,
The functional consequences of vascular remodeling in rat aorta allografts were studied at different times after transplantation (Tx).At days 1, 3, 7, 14, 28, and 56 after Tx, rat aorta allografts (Dark Agouti [DA]-to-Lewis) were mounted as isolated organs, and their contractile properties tested with phenylephrine, KCl, or endothelin-1. Controls were native DA-aortae and DA-syngeneic grafts. Changes in alpha smooth muscle actin and morphology were assessed by immunoblotting and histology.PostTx syngeneic ...
Tópico(s): Renal Transplantation Outcomes and Treatments
1999 - Wolters Kluwer | Transplantation
Emile Andriambeloson, Catherine Cannet, Charles Pally, Bernd Klanke, Christian Bruns, Hans‐Günter Zerwes, Marc Bigaud,
The functional/morphological changes observed in rat aorta allografts were compared with those seen in the arteries of rat kidney allografts. Untreated allografts (F344-to-LEW) were collected at various times post-transplantation (Tx). Vascular smooth muscle cell (SMC) constriction to phenylephrine (Phe) and endothelial cell (EC)-dependent relaxation to acetylcholine (Ach) were assessed. Neointima formation in graft vessels was assessed by histology. In aorta allografts, the effects of Phe and Ach were ...
Tópico(s): Infectious Aortic and Vascular Conditions
2004 - Elsevier BV | American Journal of Transplantation
Marc Bigaud, Patrick Gfeller, S Deveze, G Vogt, J. P. Evenou, Christian Bruns, Hans‐Günter Zerwes,
Tópico(s): Anesthesia and Neurotoxicity Research
1998 - Elsevier BV | Transplantation Proceedings
Gebhard Thoma, Christian Beerli, Marc Bigaud, Christian Bruns, Nigel G. Cooke, Markus Streiff, Hans‐Günter Zerwes,
Introduction of polar groups in a series of potent CCR5 antagonists which are very likely to adversely affect the conduction system in the heart led to the identification of NIBR-1282 which did not show adverse effects when tested in an isolated rabbit heart ex vivo model. Administration of NIBR-1282 in combination with a non-efficacious dose of CsA led to significant prolongation of kidney allograft survival in cynomolgus monkeys.
Tópico(s): Neuropeptides and Animal Physiology
2008 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Rudolf Waelchli, Birgit Bollbuck, Christian Bruns, Thomas Buhl, Jörg Eder, Roland Feifel, René Hersperger, Philipp Janser, Láśzló Révész, Hans‐Günter Zerwes, Achim Schlapbach,
The design, synthesis, and the biological evaluation of 2-benzamido-pyrimidines as novel IKK inhibitors are described. By optimization of the lead compound 3, compounds 16 and 24 are identified as good inhibitors of IKK2 with IC(50) values of 40 and 25 nM, respectively. Compound 16 also demonstrated significant in vivo activity in an acute model of cytokine release.
Tópico(s): Cytokine Signaling Pathways and Interactions
2005 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Gebhard Thoma, François Nuninger, Marc Schaefer, Kayhan G. Akyel, Rainer Albert, Christian Beerli, Christian Bruns, Eric Francotte, Marcel Luyten, Duncan MacKenzie, Lukas Oberer, Markus Streiff, Trixie Wagner, Hansrudolf Walter, Gisbert Weckbecker, Hans‐Günter Zerwes,
The chemokine receptor CCR5 plays an important role in inflammatory and autoimmune disorders as well as in transplant rejection by affecting the trafficking of effector T cells and monocytes to diseased tissues. Antagonists of CCR5 are believed to be of potential therapeutic value for the disorders mentioned above and HIV infection. Here we report on the structure−activity relationship of a new series of highly potent and selective competitive CCR5 antagonists. While all compounds tested were inactive ...
Tópico(s): Immune Cell Function and Interaction
2004 - American Chemical Society | Journal of Medicinal Chemistry
Dominique Gros, R. Otto, C Hessler, J.R. Rüttner, G. Pedio, R. Brun del Re, D. Stucki, W. Dickreuter, A. Almendral, K. Lüscher, J. Torhorst, Regina Kunz, E. Mühlen, B. Preter, Claude Yves Genton, A. Willemin, S. Coste, R.A. Egeli, Jerome A. Urban, H. Ramioul, A. Liégeois, R. Dejardin, C. Lefèbvre, H. A. Dieterich, W. Audretsch, S. Westenfelder, Hans-Günter Kochem, W. Dickreuter, D. Stucki, R. Brun del Re, A. Almendral, R. Paridaens, R. Sylvester, E. Ferrazzi, N. Legros, G. Leclercq, J.C. Heuson, U. Eppenberger, K. Biedermann, W Roos, Akira Takahashi, P Huber, J. Torhorst, D. Stucki, K. Biedermann, R. Brun del Re, U. Eppenberger, J. Torhorst, P. Schäfer, G. Rosset, Pascal Becker, Claus Buddeberg, L. Clodius, R. Amalric, F Robert, C Altschuler, F. Amalric, J.M. Spitalier, W.E. Schreiner, V. Engeler, Hans-Günter Kochem, G. Kammer, G.-F. Maillard, D. Viloux, J. Pettavel, F. Largiadèr, F. Wuilleumier, E Pluygers, M. Beauduin, J Hermans, F. Majois, C. Six, R Meyer, U.K. Kesselring, K. Schneider, W. Audretsch, H. A. Dieterich, S. Westenfelder,
1981 - Karger Publishers | Gyn�kologisch-geburtshilfliche Rundschau