Produção Nacional
Revisado por pares
Ricardo Arraes de Alencar Ximenes, Demócrito de Barros Miranda-Filho, Elizabeth B. Brickley, Thália Velho Barreto de Araújo, Ulísses Ramos Montarroyos, Marília Rosa Abtibol‐Bernardino, Marisa Márcia Mussi‐Pinhata, Geraldo Duarte, Conrado Milani Coutinho, Sílvia Fabiana Biason de Moura Negrini, Maria das Graças Costa Alecrim, Lucíola de Fátima Albuquerque de Almeida Peixoto, Maria Elisabeth Lopes Moreira, Andréa Zin, José Paulo Pereira Júnior, Karin Nielsen‐Saines, Celina Maria Turchi Martelli, Laura C. Rodrigues, Wayner Vieira de Souza, Liana O. Ventura, Consuelo Silva de Oliveira, Haroldo de Matos, E Serra, Luna Thais Souza Gomes, Maurício Lacerda Nogueira, Cássia Fernanda Estofolete, Denise Cristina Mós Vaz-Oliani, Saulo Duarte Passos, Antônio Fernandes Moron, Maria Manoela Duarte Rodrigues, Stéphanno Gomes Pereira Sarmento, Marília Dalva Turchi, Luiza Emylce Pelá Rosado, Ana Laura de Sene Amâncio Zara, Maria Bárbara Franco Gomes, Lavínia Schüler‐Faccini, Juliana Herrero-Silva, Melânia Maria Ramos Amorim, Adriana Oliveira Melo, Antônio José Lêdo Alves da Cunha, Arnaldo Prata‐Barbosa, Joffre Amim, Jorge Fonte de Rezende Filho, Juan Ignácio Calcagno, Luíz Carlos Júnior Alcântara, Breno Lima de Almeida, Cristina Barroso Hofer, Elizabeth S. Machado, Isadora Cristina de Siqueira, Flor Ernestina Martínez-Espinosa, Patrícia Brasil, Mariana de Carvalho Leal Gouveia, Maria de Fátima Pessoa Militão de Albuquerque, Jociele Malacarne, Luana Damasceno, Ana María Bispo de Filippis, Cleiton Silva Santos, Alan Oliveira Duarte, Pedro Fernando da Costa Vasconcelos, Mariana Borges Machado, Ana Paula Antunes Pascalicchio Bertozzi, Thamirys Cosmo Gillo Fajardo, Adriana Aparecida Tiraboschi Bárbaro, Ligia Conceição Marçal Assef, Clarice Pimentel, Thalita Fernandes de Abreu, Jousilene de Sales Tavares, Fabiana de Oliveira Melo, Talita de Toledo Lima, Maria das Graças Nunes Brasil, Cláudia Pereira Terças-Trettel, Giovanny Vinícius de Araújo França, Camila Bôtto-Menezes, Silvana Gomes Benzecry, Jaqueline Rodrigues Robaina, Mariana Barros Genuíno de Oliveira,
Knowledge regarding the risks associated with Zika virus (ZIKV) infections in pregnancy has relied on individual studies with relatively small sample sizes and variable risk estimates of adverse outcomes, or on surveillance or routinely collected data. Using data from the Zika Brazilian Cohorts Consortium, this study aims, to estimate the risk of adverse outcomes among offspring of women with RT-PCR-confirmed ZIKV infection during pregnancy and to explore heterogeneity between studies.We performed ...
Tópico(s): Viral Infections and Vectors
2022 - Elsevier BV | The Lancet Regional Health - Americas
Produção Nacional
Revisado por pares
Nathália Ferreira Fregonezi, Lariane Teodoro Oliveira, Júnya de Lacorte Singulani, Caroline Maria Marcos, Cláudia Tavares dos Santos, Mária Lucía Taylor, Maria José Soares Mendes‐Giannini, Haroldo César de Oliveira, Ana Marisa Fusco‐Almeida,
Heat shock proteins (Hsps) are among the most widely distributed and evolutionary conserved proteins, acting as essential regulators of diverse constitutive metabolic processes. The Hsp60 of the dimorphic fungal Histoplasma capsulatum is the major surface adhesin to mammalian macrophages and studies of antibody-mediated protection against H. capsulatum have provided insight into the complexity involving Hsp60. However, nothing is known about the role of Hsp60 regarding biofilms, a mechanism of virulence ...
Tópico(s): Heat shock proteins research
2021 - Frontiers Media | Frontiers in Cellular and Infection Microbiology
Produção Nacional
Revisado por pares
Haroldo César de Oliveira, Rafael F. Castelli, Flavia C. G. Reis, Kirandeep Samby, Joshua D. Nosanchuk, Lysangela R. Alves, Márcio L. Rodrigues,
The development of novel antifungals is a matter of urgency. In this study, we evaluated antifungal activities in a collection of 400 molecules, using highly lethal fungal pathogens as targets.
Tópico(s): Plant-Microbe Interactions and Immunity
2022 - American Society for Microbiology | Microbiology Spectrum
Produção Nacional
Revisado por pares
Leandro Honorato, Joana Feital Demetrio de Araujo, Cameron C. Ellis, Alícia Corbellini Piffer, Yan Pereira, Susana Frasés, Glauber Ribeiro de Sousa Araújo, Bruno Pontes, Maria Tays Mendes, Marcos D. Pereira, Allan J. Guimarães, Natalia Martins da Silva, Gabriele Vargas, Luna S. Joffe, Maurizio Del Poeta, Joshua D. Nosanchuk, Daniel Zamith‐Miranda, Flavia C. G. Reis, Haroldo César de Oliveira, Márcio L. Rodrigues, Sharon de Toledo Martins, Lysangela R. Alves, Igor C. Almeida, Leonardo Nimrichter,
The ability to undergo morphological changes during adaptation to distinct environments is exploited by Candida albicans and has a direct impact on biofilm formation and virulence. Morphogenesis is controlled by a diversity of stimuli, including osmotic stress, pH, starvation, presence of serum, and microbial components, among others.
Tópico(s): Fungal Infections and Studies
2022 - American Society for Microbiology | mBio
Produção Nacional
Revisado por pares
Haroldo César de Oliveira, Bárbara Tavares Bezerra, Márcio L. Rodrigues,
Fungal infections are a major public health problem resulting from the lack of public policies addressing these diseases, toxic and/or expensive therapeutic tools, scarce diagnostic tests, and unavailable vaccines. In this Perspective, we discuss the need for novel antifungal alternatives, highlighting new initiatives based on drug repurposing and the development of novel antifungals.
Tópico(s): Nail Diseases and Treatments
2022 - American Chemical Society | ACS Bio & Med Chem Au
Produção Nacional
Revisado por pares
Flavia C. G. Reis, Bianca Gimenez, Luísa J. Jozefowicz, Rafael F. Castelli, Sharon T. Martins, Lysangela R. Alves, Haroldo César de Oliveira, Márcio L. Rodrigues,
Extracellular vesicles (EVs) produced by members of the Cryptococcus genus are associated with fundamental processes of fungal physiology and virulence. However, several questions about the properties of cryptococcal EVs remain unanswered, mostly because of technical limitations. We recently described a fast and efficient protocol of high-yield EV isolation from solid medium. In this study, we aimed at using the solid medium protocol to address some of the open questions about EVs, including the ...
Tópico(s): Studies on Chitinases and Chitosanases
2021 - American Society for Microbiology | Microbiology Spectrum
Produção Nacional
Revisado por pares
Haroldo César de Oliveira, Suélen Andreia Rossi, Irene García-Barbazán, Óscar Zaragoza, Nuria Trevijano‐Contador,
Due to its location, the fungal cell wall is the compartment that allows the interaction with the environment and/or the host, playing an important role during infection as well as in different biological functions such as cell morphology, cell permeability and protection against stress. All these processes involve the activation of signaling pathways within the cell. The cell wall integrity (CWI) pathway is the main route responsible for maintaining the functionality and proper structure of the ...
Tópico(s): Plant-Microbe Interactions and Immunity
2021 - Multidisciplinary Digital Publishing Institute | Journal of Fungi
Produção Nacional
Revisado por pares
Rocio Garcia‐Rubio, Haroldo César de Oliveira, Johanna Rivera, Nuria Trevijano‐Contador,
The fungal cell wall is located outside the plasma membrane and is the cell compartment that mediates all the relationships of the cell with the environment. It protects the contents of the cell, gives rigidity and defines the cellular structure. The cell wall is a skeleton with high plasticity that protects the cell from different stresses, among which osmotic changes stand out. The cell wall allows interaction with the external environment since some of its proteins are adhesins and receptors. ...
Tópico(s): Nail Diseases and Treatments
2020 - Frontiers Media | Frontiers in Microbiology
Produção Nacional
Revisado por pares
Haroldo César de Oliveira, Rafael F. Castelli, Flavia C. G. Reis, Juliana Rizzo, Márcio L. Rodrigues,
Extracellular vesicles (EVs) are produced by all domains of life. In fungi, these structures were first described in Cryptococcus neoformans and, since then, they were characterized in several pathogenic and non-pathogenic fungal species. Cryptococcal EVs participate in the export of virulence factors that directly impact the Cryptococcus–host interaction. Our knowledge of the biogenesis and pathogenic roles of Cryptococcus EVs is still limited, but recent methodological and scientific advances have ...
Tópico(s): Extracellular vesicles in disease
2020 - Multidisciplinary Digital Publishing Institute | Pathogens
Produção Nacional
Revisado por pares
Suélen Andreia Rossi, Haroldo César de Oliveira, Daniel Agreda-Mellon, J. L. Lucio, Maria José Soares Mendes‐Giannini, Jesús Pablo García-Cambero, Óscar Zaragoza,
Amphotericin B (AmB) is the antifungal with the strongest fungicidal activity, but its use has several limitations, mainly associated with its toxicity. Although some lipidic and liposomal formulations that present reduced toxicity are available, their price limits their application in developing countries. Flucytosine (5FC) has shown synergistic effect with AmB for treatment of some fungal infections, such as cryptococcosis, but again, its price is a limitation for its use in many regions. In the ...
Tópico(s): Synthesis and Biological Evaluation
2020 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Produção Nacional
Revisado por pares
Haroldo César de Oliveira, Luna S. Joffe, Karina Smidt Simon, Rafael F. Castelli, Flavia C. G. Reis, Arielle M. Bryan, Beatriz S. Borges, Lia Carolina Soares Medeiros, Anamélia Lorenzetti Bocca, Maurizio Del Poeta, Márcio L. Rodrigues,
The human diseases caused by the fungal pathogens Cryptococcus neoformans and Cryptococcus gattii are associated with high indices of mortality and toxic and/or cost-prohibitive therapeutic protocols. The need for affordable antifungals to combat cryptococcal disease is unquestionable. Previous studies suggested benzimidazoles as promising anticryptococcal agents combining low cost and high antifungal efficacy, but their therapeutic potential has not been demonstrated so far.
Tópico(s): Cytomegalovirus and herpesvirus research
2020 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Produção Nacional
Revisado por pares
Haroldo César de Oliveira, Maria Cândida Monteiro, Suélen Andreia Rossi, Javier Pemán, Alba Ruiz‐Gaitán, Maria José Soares Mendes‐Giannini, Emilia Mellado, Óscar Zaragoza,
Candida auris is an emerging fungal pathogen of great concern among the scientific community because it is causing an increasing number of hospital outbreaks of difficult management worldwide. In addition, isolates from this species frequently present reduced susceptibility to azole and echinocandin drugs. For this reason, it is necessary to develop new antifungal strategies to better control the disease caused by this yeast. In this work, we screened drugs from the Prestwick chemical library, which ...
Tópico(s): Fungal Infections and Studies
2019 - Frontiers Media | Frontiers in Cellular and Infection Microbiology
Rocío García‐Rodas, Haroldo César de Oliveira, Nuria Trevijano‐Contador, Óscar Zaragoza,
Cryptococcus neoformans is a human pathogenic yeast that causes hundreds of thousands of deaths worldwide among susceptible individuals, in particular, HIV+ patients. This yeast has developed several adaptation mechanisms that allow replication within the host. During decades, this yeast has been well known for a very peculiar and unique structure that contributes to virulence, a complex polysaccharide capsule that surrounds the cell wall. In contrast to other fungal pathogens, such as Candida albicans ...
Tópico(s): Nail Diseases and Treatments
2018 - Springer Science+Business Media | Current topics in microbiology and immunology
Produção Nacional
Revisado por pares
Nuria Trevijano‐Contador, Haroldo César de Oliveira, Rocío García‐Rodas, Suélen Andreia Rossi, Irene Llorente Muñoz, Ángel Zaballos, Guilhem Janbon, Joaquı́n Ariño, Óscar Zaragoza,
Cryptococcus neoformans is an encapsulated pathogenic yeast that can change the size of the cells during infection. In particular, this process can occur by enlarging the size of the capsule without modifying the size of the cell body, or by increasing the diameter of the cell body, which is normally accompanied by an increase of the capsule too. This last process leads to the formation of cells of an abnormal enlarged size denominated titan cells. Previous works characterized titan cell formation ...
Tópico(s): Parasitic Infections and Diagnostics
2018 - Public Library of Science | PLoS Pathogens
Produção Nacional
Revisado por pares
Júnya de Lacorte Singulani, Liliana Scorzoni, Haroldo César de Oliveira, Caroline Maria Marcos, Patrícia Akemi Assato, Ana Marisa Fusco‐Almeida, Maria José Soares Mendes‐Giannini,
Dimorphic fungi can be found in the yeast form during infection and as hyphae in the environment and are responsible for a large number of infections worldwide. Invertebrate animals have been shown to be convenient models in the study of fungal infections. These models have the advantages of being low cost, have no ethical issues, and an ease of experimentation, time-efficiency, and the possibility of using a large number of animals per experiment compared to mammalian models. Invertebrate animal ...
Tópico(s): Plant-Microbe Interactions and Immunity
2018 - Multidisciplinary Digital Publishing Institute | Journal of Fungi
Produção Nacional
Revisado por pares
Alexandre Cardoso, Bruno Galvêas Laviola, Gilmar Souza Santos, H. U. de Sousa, Haroldo Bezerra de Oliveira, Luiz Castro Veras, Rodrigo Ciannella, S. P. Favaro,
Macaw palm is regarded as one of the most promising alternative raw materials for the production of oil for biofuels and other uses. The potential yield up to 6000 kg of oil per hectare, and the quality of the oil, makes it a suitable feedstock for biofuel production, whether for biodiesel or bio-kerosene. The diversification of oilseed crops consists in a goal not only for Brazil, but for many Latin American countries. While the palm oil is an important component of the food industry, it is not ...
Tópico(s): Cassava research and cyanide
2017 - Elsevier BV | Industrial Crops and Products
Produção Nacional
Revisado por pares
Liliana Scorzoni, Ana Carolina Alves de Paula e Silva, Caroline Maria Marcos, Patrícia Akemi Assato, Wanessa C. M. A. Melo, Haroldo César de Oliveira, Caroline Barcelos Costa-Orlandi, Maria José Soares Mendes‐Giannini, Ana Marisa Fusco‐Almeida,
The high rates of morbidity and mortality caused by fungal infections are associated with the current limited antifungal arsenal and the high toxicity of the compounds. Additionally, identifying novel drug targets is challenging because there are many similarities between fungal and human cells. The most common antifungal targets include fungal RNA synthesis and cell wall and membrane components, though new antifungal targets are being investigated. Nonetheless, fungi have developed resistance mechanisms, ...
Tópico(s): Antimicrobial Peptides and Activities
2017 - Frontiers Media | Frontiers in Microbiology
Produção Nacional
Revisado por pares
Caroline Barcelos Costa-Orlandi, Janaína de Cássia Orlandi Sardi, Nayla de Souza Pitangui, Haroldo César de Oliveira, Liliana Scorzoni, Mariana Cristina Galeane, Kaila Petronila Medina‐Alarcón, Wanessa Melo, M. Marcelino, Jaqueline Derissi Braz, Ana Marisa Fusco‐Almeida, Maria José Soares Mendes‐Giannini,
Biofilm formation is an important virulence factor for pathogenic fungi. Both yeasts and filamentous fungi can adhere to biotic and abiotic surfaces, developing into highly organized communities that are resistant to antimicrobials and environmental conditions. In recent years, new genera of fungi have been correlated with biofilm formation. However, Candida biofilms remain the most widely studied from the morphological and molecular perspectives. Biofilms formed by yeast and filamentous fungi present ...
Tópico(s): Fungal Infections and Studies
2017 - Multidisciplinary Digital Publishing Institute | Journal of Fungi
Produção Nacional
Revisado por pares
Suélen A. Rossi, Nuria Trevijano‐Contador, Liliana Scorzoni, Ana Cecilia Mesa-Arango, Haroldo César de Oliveira, Karin Werther, Tânia de Freitas Raso, Maria José Soares Mendes‐Giannini, Óscar Zaragoza, Ana Marisa Fusco‐Almeida,
Cryptococcus sp. are responsible for around 1 million cases of meningitis every year. Fluconazole (FLU) is commonly used in the treatment of cryptococcosis, mainly in immunocompromised patients and the resistance is usually reported after long periods of treatment. In this study, the morphological characterization and virulence profile of FLU-susceptible and FLU-resistant clinical and environmental isolates of C. neoformans and C. gattii were performed both in vitro and in vivo using the Galleria ...
Tópico(s): Nail Diseases and Treatments
2016 - Frontiers Media | Frontiers in Microbiology
Caroline Maria Marcos, Haroldo César de Oliveira, Wanessa Melo, Julhiany de Fátima da Silva, Patrícia Akemi Assato, Liliana Scorzoni, Suélen Andreia Rossi, Ana Carolina Alves de Paula e Silva, Maria José Soares Mendes‐Giannini, Ana Marisa Fusco‐Almeida,
Pathogenic fungi have developed many strategies to evade the host immune system. Multiple escape mechanisms appear to function together to inhibit attack by the various stages of both the adaptive and the innate immune response. Thus, after entering the host, such pathogens fight to overcome the immune system to allow their survival, colonization and spread to different sites of infection. Consequently, the establishment of a successful infectious process is closely related to the ability of the ...
Tópico(s): Plant-Microbe Interactions and Immunity
2016 - Frontiers Media | Frontiers in Cellular and Infection Microbiology
Produção Nacional
Revisado por pares
Haroldo César de Oliveira, Jussara S. Michaloski, Julhiany de Fátima da Silva, Liliana Scorzoni, Ana Carolina Alves de Paula e Silva, Caroline Maria Marcos, Patrícia Akemi Assato, Daniella Sayuri Yamazaki, Ana Marisa Fusco‐Almeida, Ricardo J. Giordano, Maria José Soares Mendes‐Giannini,
Paracoccidioides brasiliensis and Paracoccidioides lutzii are dimorphic fungi and are the etiological agents of paracoccidioidomycosis (PCM). Adhesion is one of the most important steps in infections with Paracoccidioides and is responsible for the differences in the virulence of isolates of these fungi. Because of the importance of adhesion to the establishment of an infection, this study focused on the preliminary development of a new therapeutic strategy to inhibit adhesion by Paracoccidioides, ...
Tópico(s): Antifungal resistance and susceptibility
2016 - Frontiers Media | Frontiers in Pharmacology
Produção Nacional
Revisado por pares
Fernanda Sangalli-Leite, Liliana Scorzoni, Ana Carolina Alves de Paula e Silva, Julhiany de Fátima da Silva, Haroldo César de Oliveira, Júnya de Lacorte Singulani, Fernanda Patrícia Gullo, Rosangela Moraes da Silva, Luís Octávio Regasini, Dulce Helena Siqueira Silva, Vanderlan da Silva Bolzani, Ana Marisa Fusco‐Almeida, Maria José Soares Mendes‐Giannini,
Cryptococcosis is an opportunistic fungal infection responsible for high morbidity and mortality in immunocompromised patients. Combination of antifungal substances is a promising way to increase the percentage of successful treatment. Pedalitin (PED) is a natural substance obtained from Pterogyne nitens. The aim of this study was to verify the efficacy of PED alone and in combination with amphotericin B (AmB) in vitro and in vivo against Cryptococcus spp. In the in vitro assay, minimum inhibitory ...
Tópico(s): Nail Diseases and Treatments
2016 - Elsevier BV | International Journal of Antimicrobial Agents
Produção Nacional
Revisado por pares
Julhiany de Fátima da Silva, Haroldo César de Oliveira, Caroline Maria Marcos, Rosângela Aparecida Moraes da Silva, Tânia A. Costa, Vera Lúcia Garcia Calich, Ana Marisa Fusco‐Almeida, Maria José Soares Mendes‐Giannini,
Paracoccidoides brasiliensis adhesion to lung epithelial cells is considered an essential event for the establishment of infection and different proteins participate in this process. One of these proteins is a 30 kDa adhesin, pI 4.9 that was described as a laminin ligand in previous studies, and it was more highly expressed in more virulent P. brasiliensis isolates. This protein may contribute to the virulence of this important fungal pathogen. Using Edman degradation and mass spectrometry analysis, ...
Tópico(s): Peptidase Inhibition and Analysis
2015 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Caroline Maria Marcos, Julhiany de Fátima da Silva, Haroldo César de Oliveira, Patrícia Akemi Assato, Júnya de Lacorte Singulani, Angela López, Diana Tamayo, Orville Hernández-Ruiz, Juan G. McEwen, Maria José Soares Mendes‐Giannini, Ana Marisa Fusco‐Almeida,
The interaction between the fungal pathogen Paracoccidioides brasiliensis and host cells is usually mediated by specific binding events between adhesins on the fungal surface and receptors on the host extracellular matrix or cell surface. One molecule implicated in the P. brasiliensis-host interaction is the 14-3-3 protein. The 14-3-3 protein belongs to a family of conserved regulatory molecules that are expressed in all eukaryotic cells and are involved in diverse cellular functions. Here, we investigated ...
Tópico(s): Antifungal resistance and susceptibility
2015 - Taylor & Francis | Virulence
Produção Nacional
Revisado por pares
Liliana Scorzoni, Ana Carolina Alves de Paula e Silva, Júnya de Lacorte Singulani, Fernanda Sangalli Leite, Haroldo César de Oliveira, Rosângela Aparecida Moraes da Silva, Ana Marisa Fusco‐Almeida, Maria José Soares Mendes‐Giannini,
Paracoccidioidomycosis is a systemic mycosis, endemic in Latin America. The etiologic agents of this mycosis are composed of 2 species: Paracoccidioides brasiliensis and P. lutzii. Murine animal models are the gold standard for in vivo studies; however, ethical, economical and logistical considerations limit their use. Galleria mellonella is a suitable model for in vivo studies of fungal infections. In this study, we compared the virulence of P. brasiliensis and P. lutzii in G. mellonella model. ...
Tópico(s): Invertebrate Immune Response Mechanisms
2015 - Taylor & Francis | Virulence
Produção Nacional
Revisado por pares
Haroldo César de Oliveira, Patrícia Akemi Assato, Caroline Maria Marcos, Liliana Scorzoni, Ana Carolina Alves de Paula e Silva, Julhiany de Fátima da Silva, Júnya de Lacorte Singulani, Kaila Petronila Medina‐Alarcón, Ana Marisa Fusco‐Almeida, Maria José Soares Mendes‐Giannini,
Paracoccidioides brasiliensis and P. lutzii are etiologic agents of paracoccidioidomycosis (PCM), an important endemic mycosis in Latin America. During its evolution, these fungi have developed characteristics and mechanisms that allow their growth in adverse conditions within their host through which they efficiently cause disease. This process is multi-factorial and involves host-pathogen interactions, as well as fungal virulence and host immune response. In this review, we demonstrated the glycoproteins ...
Tópico(s): Plant Pathogens and Fungal Diseases
2015 - Frontiers Media | Frontiers in Microbiology
Produção Nacional
Revisado por pares
Julhiany de Fátima da Silva, Juliana Vicentim, Haroldo César de Oliveira, Caroline Maria Marcos, Patrícia Akemi Assato, Patrícia Ferrari Andreotti, Juliana Leal Monteiro da Silva, Christiane Pienna Soares, Gil Benard, Ana Marisa Fusco‐Almeida, Maria José Soares Mendes‐Giannini,
The fungal strain Paracoccidioides brasiliensis remains viable inside of epithelial cells and can induce apoptosis in this population. However, until now, the molecules that participate in this process remained unknown. Thus, this study evaluated the contribution of two P. brasiliensis molecules, the 14-3-3 and glycoprotein of 43 kDa proteins, which had been previously described as extracellular matrix adhesins and apoptosis inductors in human pneumocytes. Accordingly, epithelial cells were treated ...
Tópico(s): Plant Disease Resistance and Genetics
2015 - Instituto Oswaldo Cruz, Ministério da Saúde | Memórias do Instituto Oswaldo Cruz
Produção Nacional
Revisado por pares
Julhiany de Fátima da Silva, Haroldo César de Oliveira, Caroline Maria Marcos, Patrícia Akemi Assato, Ana Marisa Fusco‐Almeida, Maria José Soares Mendes‐Giannini,
Understanding the possible methodologies for the rapid and inexpensive identification of fungal infections is essential for disease diagnosis, but there are some limitations. To help with this problem, serological methods that detect antigens or antibodies are widely used and are useful for the diagnosis of paracoccidioidomycosis (PCM) through the detection of gp43, which is the main antigen employed for the immunodiagnosis of this disease caused by Paracoccidioides brasiliensis. However, the use ...
Tópico(s): Nail Diseases and Treatments
2015 - Elsevier BV | Diagnostic Microbiology and Infectious Disease
Produção Nacional
Revisado por pares
Haroldo César de Oliveira, Julhiany de Fátima da Silva, Liliana Scorzoni, Caroline Maria Marcos, Suélen Andreia Rossi, Ana Carolina Alves de Paula e Silva, Patrícia Akemi Assato, Rosângela A. M. da Silva, Ana Marisa Fusco‐Almeida, Maria José Soares Mendes‐Giannini,
Members of the Paracoccidioides genus are dimorphic fungi that are the etiologic agents of paracoccidioidomycosis (PCM). This genus is composed of two species: Paracoccidioides brasiliensis and Paracoccidioides lutzii. The correct molecular taxonomic classification of these fungi has created new opportunities for studying and understanding their relationships with their hosts. Paracoccidioides spp. have features that permit their growth under adverse conditions, enable them to adhere to and invade ...
Tópico(s): Invertebrate Immune Response Mechanisms
2015 - Frontiers Media | Frontiers in Microbiology
Produção Nacional
Revisado por pares
Caroline Maria Marcos, Haroldo César de Oliveira, Julhiany de Fátima da Silva, Patrícia Akemi Assato, Ana Marisa Fusco‐Almeida, Maria José Soares Mendes‐Giannini,
Paracoccidioides species are dimorphic fungi, and are the etiologic agents of paracoccidioidomycosis (PCM), a serious disease of multiple organs. The large number of tissues colonized by this fungus suggests the presence of a variety of surface molecules involved in adhesion. A surprising finding is that the majority of enzymes in the glycolytic pathway, tricarboxylic acid (TCA) cycle and glyoxylate cycle in Paracoccidioides spp. has adhesive properties that aid in the interaction with the host extracellular ...
Tópico(s): Plant-Microbe Interactions and Immunity
2014 - Frontiers Media | Frontiers in Microbiology