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Artigo Acesso aberto Revisado por pares

Nelli Muradyan, Harutyun Gyulasaryan, Avetik A. Arzumanyan, Maria Badalyan, Marine Kalantaryan, Yeghiazar V. Vardanyan, D. Laroze, Aram Manukyan, M.G. Barseghyan,

In this work, multi-walled carbon nanotubes (MWCNTs) have been synthesized using a modified method of solid-phase pyrolysis. The MWCNTs are effectively dispersed using a simple and facile method such as ultrasonic energy without and with surfactant for two different sonication times (15 min and 40 min). In the present study, the effect of MWCNT concentration (0.001, 0.01, 0.05, 0.1 wt.%) on the compressive strengths of cement mortars has been investigated. Compressive tests were carried out on an automatic ...

Tópico(s): Concrete and Cement Materials Research

2022 - Multidisciplinary Digital Publishing Institute | Coatings

Artigo Acesso aberto Revisado por pares

Astghik Abrahamyan, Jodene Eldstrom, Harutyun Sahakyan, Nare Karagulyan, L. S. Mkrtchyan, Tatev Karapetyan, Ernest Sargsyan, Matthias Kneussel, Karen Nazaryan, Jürgen R. Schwarz, David Fedida, Vitya Vardanyan,

KCNQ1 voltage-gated K+ channels are involved in a wide variety of fundamental physiological processes and exhibit the unique feature of being markedly inhibited by external K+. Despite the potential role of this regulatory mechanism in distinct physiological and pathological processes, its exact underpinnings are not well understood. In this study, using extensive mutagenesis, molecular dynamics simulations, and single-channel recordings, we delineate the molecular mechanism of KCNQ1 modulation ...

Tópico(s): Neuroscience and Neuropharmacology Research

2023 - Rockefeller University Press | The Journal of General Physiology

Artigo Revisado por pares

Magnus Chan, Marc Pourrier, Jodene Eldstrom, Sahakyan Harutyun, Vitya A. Vardanyan, David Fedida,

Tópico(s): Pharmacological Effects of Natural Compounds

2025 - Elsevier BV | Biophysical Journal

Artigo Acesso aberto Revisado por pares

Magnus Chan, Marc Pourrier, Jodene Eldstrom, Harutyun Sahakyan, Vitya Vardanyan, David Fedida,

Mutations in both KCNQ1 and KCNE1, which together form the cardiac I

Tópico(s): Neuroscience and Neuropharmacology Research

2024 - Wiley | British Journal of Pharmacology

Artigo Acesso aberto Revisado por pares

Magnus Chan, Harutyun Sahakyan, Jodene Eldstrom, Daniel Sastre, Yundi Wang, Ying Dou, Marc Pourrier, Vitya Vardanyan, David Fedida,

The cardiac IKs ion channel comprises KCNQ1, calmodulin, and KCNE1 in a dodecameric complex which provides a repolarizing current reserve at higher heart rates and protects from arrhythmia syndromes that cause fainting and sudden death. Pharmacological activators of IKs are therefore of interest both scientifically and therapeutically for treatment of IKs loss-of-function disorders. One group of chemical activators are only active in the presence of the accessory KCNE1 subunit and here we investigate ...

Tópico(s): Neuroscience and Neural Engineering

2023 - eLife Sciences Publications Ltd | eLife

Artigo Revisado por pares

H. S. Harutyunyan, S. Grigoryan, Harutyun Alaverdyan, G. S. Vardanyan, M. I. Aghajanov,

Tópico(s): Pain Management and Placebo Effect

2017 - Pleiades Publishing | Neurochemical Journal

Artigo Acesso aberto Revisado por pares

Magnus Chan, Harutyun Sahakyan, Yundi Wang, Jodene Eldstrom, Marc Pourrier, Vitya A. Vardanyan, David Fedida,

Tópico(s): Ion channel regulation and function

2023 - Elsevier BV | Biophysical Journal

Artigo Acesso aberto Revisado por pares

Magnus Chan, Harutyun Sahakyan, Jodene Eldstrom, Daniel Sastre, Yundi Wang, Ying Dou, Marc Pourrier, Vitya Vardanyan, David Fedida,

The cardiac I Ks ion channel comprises KCNQ1, calmodulin, and KCNE1 in a dodecameric complex which provides a repolarizing current reserve at higher heart rates and protects from arrhythmia syndromes that cause fainting and sudden death. Pharmacological activators of I Ks are therefore of interest both scientifically and therapeutically for treatment of I Ks loss-of-function disorders. One group of chemical activators are only active in the presence of the accessory KCNE1 subunit and here we investigate ...

Tópico(s): Electrostatic Discharge in Electronics

2023 - eLife Sciences Publications Ltd | eLife

Artigo Acesso aberto Revisado por pares

L. S. Mkrtchyan, Harutyun Sahakyan, Jodene Eldstrom, Tatev Karapetyan, Astghik Abrahamyan, Karen Nazaryan, Jürgen R. Schwarz, Matthias Kneussel, David Fedida, Vitya Vardanyan,

KCNQ1 potassium channels play a pivotal role in the physiology and pathophysiology of several human excitable and epithelial tissues. The latest cryo-electron microscopy (cryo-EM) structures provide unique insights into channel function and pharmacology, opening avenues for different therapeutic strategies against human diseases associated with KCNQ1 mutations. However, these structures also raise fundamental questions about the mechanisms of ion permeation. Cryo-EM structures thought to represent ...

Tópico(s): Microfluidic and Capillary Electrophoresis Applications

2024 - National Academy of Sciences | Proceedings of the National Academy of Sciences