Martin Westermann, Heiko Leutbecher, H. Meyer,
Tópico(s): Erythrocyte Function and Pathophysiology
1999 - Springer Science+Business Media | Histochemistry and Cell Biology
Marius Bohnen, Jan Minners, Martin Eichenlaub, Reinhold Weber, Hans-Jürgen Allgeier, Amir Jadidi, Franz‐Josef Neumann, Dirk Westermann, Thomas Arentz, Heiko Lehrmann,
Transseptal puncture (TP) for left-sided catheter ablation procedures is routinely performed under fluoroscopic or echocardiographic guidance [transoesophageal echocardiography (TEE) or intracardiac echocardiography (ICE)], although three-dimensional (3D) mapping systems are readily available in most electrophysiology laboratories. Here, we sought to assess the feasibility and safety of a right atrial (RA) 3D map-guided TP.In 104 patients, 3D RA mapping was performed to identify the fossa ovalis (FO) using ...
Tópico(s): Cardiac Imaging and Diagnostics
2023 - Oxford University Press | EP Europace
Matthias Englert, Heiko Röglin, Matthias Westermann,
Tópico(s): Algorithms and Data Compression
2006 - Springer Science+Business Media | Lecture notes in computer science
Udo Bavendiek, Anika Großhennig, Johannes Schwab, Dominik Berliner, Xiaofei Liu, Lars S. Maier, Thomas Gaspar, Andreas Rieth, Sebastian Philipp, Rainer Hambrecht, Ralf Westenfeld, Thomas Münzel, Sebastian Winkler, Martin Hülsmann, Dirk Westermann, Marja Zdravkovic, Ralf Lichtinghagen, Heiko von der Leyen, Silke Zimmermann, Christian Veltmann, Michael Böhm, Stefan Störk, Armin Koch, Johann Bauersachs,
The present study aimed to develop a simple dosing score when starting the cardiac glycoside digitoxin in heart failure with reduced ejection fraction (HFrEF) employing first data from the randomized, double-blinded DIGIT-HF trial.In DIGIT-HF, digitoxin was started with a dose of 0.07 mg once daily (o.d.) in all patients. For score derivation, 317 patients were analyzed who had been randomized to digitoxin. In these patients, after scheduled determination of serum levels at study week 6, the digitoxin ...
Tópico(s): Cardiovascular Function and Risk Factors
2023 - Springer Science+Business Media | Clinical Research in Cardiology
Felicitas Escher, Ganna Aleshcheva, Heiko Pietsch, Christian Baumeier, Ulrich Groß, Benedikt Schrage, Dirk Westermann, C.‐Thomas Bock, Heinz‐Peter Schultheiß,
Parvovirus B19 (B19V) is the predominant cardiotropic virus currently found in endomyocardial biopsies (EMBs). However, direct evidence showing a causal relationship between B19V and progression of inflammatory cardiomyopathy are still missing. The aim of this study was to analyze the impact of transcriptionally active cardiotropic B19V infection determined by viral RNA expression upon long-term outcomes in a large cohort of adult patients with non-ischemic cardiomyopathy in a retrospective analysis ...
Tópico(s): Cardiac Structural Anomalies and Repair
2021 - Multidisciplinary Digital Publishing Institute | Biomedicines
Johannes Steinfurt, Pietro Bernardo Dall’Aglio, Jannik Hugenschmidt, Judith Stuplich, Markus Jäckel, Eike Jordan, Heiko Lehrmann, Thomas Faber, Alexander Gressler, Amir Jadidi, Dirk Westermann, Thomas Arentz, Luca Trolese,
The Octaray (Biosense Webster) is a novel, multispline mapping catheter with 48 closely spaced microelectrodes enabling high-resolution electroanatomical mapping.This study sought to report the initial clinical mapping experience with this novel catheter in a variety of cardiac arrhythmias and to compare the mapping performance with the 5-spline Pentaray.Fifty consecutive procedures among 46 patients were retrospectively analyzed regarding safety, efficacy, and acute procedural success defined as ...
Tópico(s): Cardiac pacing and defibrillation studies
2022 - Elsevier BV | JACC. Clinical electrophysiology
Xiaoshu Tang, Dalial Freitak, Heiko Vogel, Liyan Ping, Yongqi Shao, Erika Arias Cordero, Gary L. Andersen, Martin Westermann, David G. Heckel, Wilhelm Boland,
Background The gut of most insects harbours nonpathogenic microorganisms. Recent work suggests that gut microbiota not only provide nutrients, but also involve in the development and maintenance of the host immune system. However, the complexity, dynamics and types of interactions between the insect hosts and their gut microbiota are far from being well understood. Methods/Principal Findings To determine the composition of the gut microbiota of two lepidopteran pests, Spodoptera littoralis and Helicoverpa ...
Tópico(s): Mosquito-borne diseases and control
2012 - Public Library of Science | PLoS ONE
Tai‐Yuan Huang, Juan Chen, Björn Müller‐Edenborn, Louisa Mayer, Martin Eichenlaub, Zoraida Moreno Weidmann, Juergen Allgeier, Marius Bohnen, Heiko Lehrmann, Dietmar Trenk, Simon Schoechlin, Dirk Westermann, Thomas Arentz, Amir Jadidi,
Background Low-voltage-substrate (LVS)-guided ablation for persistent atrial fibrillation (AF) has been described either in sinus rhythm (SR) or AF. Prolonged fractionated potentials (PFPs) may represent arrhythmogenic slow conduction substrate and potentially co-localize with LVS. We assess the spatial correlation of PFP identified in AF (PFP-AF) to those mapped in SR (PFP-SR). We further report the relationship between LVS and PFPs when mapped in AF or SR. Materials and methods Thirty-eight patients ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2022 - Frontiers Media | Frontiers in Cardiovascular Medicine
Deborah Nairn, Martin Eichenlaub, Björn Müller‐Edenborn, Taiyuan Huang, Heiko Lehrmann, Claudia Nagel, Luca Azzolin, Giorgio Luongo, R. Ventura, Barbara Rubio Forcada, Anna Vallès Colomer, Dirk Westermann, Thomas Arentz, Olaf Dössel, Axel Loewe, Amir Jadidi,
Electro-anatomical voltage, conduction velocity (CV) mapping, and late gadolinium enhancement (LGE) magnetic resonance imaging (MRI) have been correlated with atrial cardiomyopathy (ACM). However, the comparability between these modalities remains unclear. This study aims to (i) compare pathological substrate extent and location between current modalities, (ii) establish spatial histograms in a cohort, (iii) develop a new estimated optimized image intensity threshold (EOIIT) for LGE-MRI identifying patients ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2023 - Oxford University Press | EP Europace
Matthias Englert, Heiko Röglin, Matthias Westermann,
A sequence of objects that are characterized by their color has to be processed. Their processing order influences how efficiently they can be processed: Each color change between two consecutive objects produces costs. A reordering buffer, which is a random access buffer with storage capacity for k objects, can be used to rearrange this sequence online in such a way that the total costs are reduced. This concept is useful for many applications in computer science and economics. The strategy with ...
Tópico(s): Algorithms and Data Compression
2009 - Association for Computing Machinery | ACM Journal of Experimental Algorithmics
Felicitas Escher, Heiko Pietsch, Ganna Aleshcheva, Philip Wenzel, Friedrich Fruhwald, Christian Stumpf, Dirk Westermann, Johann Bauersachs, Frank Enseleit, Frank Ruschitzka, Herbert Nägele, Karl‐Ludwig Laugwitz, Hendrik Haake, Norbert Frey, Johannes Brachmann, Kurt Huber, Ruediger C. Braun‐Dullaeus, Martin Bergmann, Jörg Strotmann, Gerian Grönefeld, J. Krülls-Münch, Ralf Westenfeld, Carsten Skurk, Ulf Landmesser, Burkert Pieske, Ulrich Groß, Lars Morawietz, Heinz‐Peter Schultheiß,
Aims: The diagnostic approach to idiopathic giant-cell myocarditis (IGCM) is based on identifying various patterns of inflammatory cell infiltration and multinucleated giant cells (GCs) in histologic sections taken from endomyocardial biopsies (EMBs). The sampling error for detecting focally located GCs by histopathology is high, however. The aim of this study was to demonstrate the feasibility of gene profiling as a new diagnostic method in clinical practice, namely in a large cohort of patients suffering ...
Tópico(s): Whipple's Disease and Interleukins
2020 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Eike M. Wülfers, Robin Moss, Heiko Lehrmann, Thomas Arentz, Dirk Westermann, Gunnar Seemann, Katja E. Odening, Johannes Steinfurt,
Brugada syndrome (BrS) is characterized by dynamic ST-elevations in right precordial leads and increased risk of ventricular fibrillation and sudden cardiac death. As the mechanism underlying ST-elevation and malignant arrhythmias is controversial computational modeling can aid in exploring the disease mechanism. Thus we aim to test the main competing hypotheses ('delayed depolarization' vs. 'early repolarization') of BrS in a whole-heart computational model.
Tópico(s): ECG Monitoring and Analysis
2024 - Elsevier BV | IJC Heart & Vasculature
Anna-Katharina Wirth, Lucas E. Wange, Sebastian Vosberg, Kai‐Oliver Henrich, Christian Rausch, Erbey Ziya Özdemir, Christina Zeller, Daniel Richter, Tobias Feuchtinger, Markus Kaller, Heiko Hermeking, Philipp A. Greif, Daniela Senft, Vindi Jurinović, Ehsan Bahrami, Ashok Kumar Jayavelu, Frank Westermann, Matthias Mann, Wolfgang Enard, Tobias Herold, Irmela Jeremias,
Abstract Resistance towards cancer treatment represents a major clinical obstacle, preventing cure of cancer patients. To gain mechanistic insights, we developed a model for acquired resistance to chemotherapy by treating mice carrying patient derived xenografts (PDX) of acute lymphoblastic leukemia with widely-used cytotoxic drugs for 18 consecutive weeks. In two distinct PDX samples, tumors initially responded to treatment, until stable disease and eventually tumor re-growth evolved under therapy, ...
Tópico(s): Cancer Genomics and Diagnostics
2022 - Springer Nature | Leukemia
Thomas Burmeister, Aeint-Steffen Ströh, Britta Kehden, Heiko Trautmann, Claus Meyer, Rolf Marschalek, Patrizia Larghero, Stefan Schwartz, Björn Steffen, Bernd M. Spriewald, Thomas Heinicke, Nadja Jäkel, Jörg Westermann, Kathrin Nachtkamp, Andreas Viardot, Max S. Topp, Martín Neumann, Claudia D. Baldus, Nicola Gökbuget, Monika Brüggemann,
In adult ALL, 5-10% of patients show KMT2A translocations (KMT2A rearrangements) with only a few secondary alterations, implicating it as a leukemia-initiating factor [1,2].Approximately 95% of all fusions in adult ALL are KMT2A::AFF1 or KMT2A::MLLT1 [3].KMT2A-rearranged adult ALL patients are generally considered high-risk and are treated with intensified therapy, including allogeneic hematopoietic stem cell transplantation (SCT) [4].Current ALL treatment protocols are often guided by measurable residual ...
Tópico(s): Chronic Lymphocytic Leukemia Research
2024 - Springer Nature | Leukemia
Gilberto Pastorello, Carlo Trotta, Eleonora Canfora, Housen Chu, Danielle Christianson, You-Wei Cheah, C. Poindexter, Jiquan Chen, Abdelrahman Elbashandy, Marty Humphrey, Peter Isaac, Diego Polidori, Markus Reichstein, Alessio Ribeca, Catharine van Ingen, Nicolas Vuichard, Leiming Zhang, B. D. Amiro, Christof Ammann, M. Altaf Arain, Jonas Ardö, Timothy J. Arkebauer, Stefan K. Arndt, Nicola Arriga, Marc Aubinet, Mika Aurela, Dennis Baldocchi, Alan Barr, Eric Beamesderfer, Luca Belelli Marchesini, Onil Bergeron, Jason Beringer, Christian Bernhofer, Daniel Berveiller, D. P. Billesbach, T. Andrew Black, Peter D. Blanken, Gil Bohrer, Julia Boike, Paul V. Bolstad, Damien Bonal, Jean-Marc Bonnefond, D. R. Bowling, Rosvel Bracho, Jason Brodeur, Christian Brümmer, Nina Buchmann, Benoît Burban, Sean P. Burns, Pauline Buysse, Peter Cale, M. Cavagna, Pierre Cellier, Shiping Chen, Isaac Chini, Torben R. Christensen, James Cleverly, Alessio Collalti, Claudia Consalvo, Bruce D. Cook, David Cook, Carole Coursolle, Edoardo Cremonese, Peter S. Curtis, Ettore D’Andrea, Humberto da Rocha, Xiaoqin Dai, K. J. Davis, Bruno De Cinti, A. de Grandcourt, Anne De Ligne, Raimundo Cosme de Oliveira, Nicolas Delpierre, Ankur R. Desai, Carlos Marcelo Di Bella, Paul Di Tommasi, A. J. Dolman, Francisco Domingo, Gang Dong, Sabina Dore, Pierpaolo Duce, Éric Dufrêne, Allison L. Dunn, Jiří Dušek, Derek Eamus, Uwe Eichelmann, Hatim Abdalla M. ElKhidir, Werner Eugster, Cäcilia Ewenz, B. E. Ewers, D. Famulari, Silvano Fares, Iris Feigenwinter, Andrew Feitz, Rasmus Fensholt, Gianluca Filippa, M. L. Fischer, J. M. Frank, Marta Galvagno, Mana Gharun, Damiano Gianelle, Bert Gielen, Beniamino Gioli, Anatoly A. Gitelson, Ignacio Goded, Mathias Goeckede, A. H. Goldstein, Christopher M. Gough, Michael L. Goulden, Alexander Graf, Anne Griebel, Carsten Gruening, Thomas Grünwald, Albin Hammerle, Shijie Han, Xingguo Han, Birger Ulf Hansen, Chad Hanson, Juha Hatakka, Yongtao He, Markus Hehn, Bernard Heinesch, Nina Hinko‐Najera, Lukas Hörtnagl, Lindsay B. Hutley, Andreas Ibrom, Hiroki Ikawa, M. Jackowicz-Korczyński, Dalibor Janouš, W.W.P. Jans, Rachhpal S. Jassal, Shicheng Jiang, Tomomichi Kato, Myroslava Khomik, Janina Klatt, Alexander Knohl, Sara Knox, Hideki Kobayashi, Georgia R. Koerber, Olaf Kolle, Yoshiko Kosugi, Ayumi Kotani, Andrew S. Kowalski, Bart Kruijt, Julia Kurbatova, Werner L. Kutsch, Hyojung Kwon, Samuli Launiainen, Tuomas Laurila, B. E. Law, R. Leuning, Yingnian Li, Michael J. Liddell, Jean‐Marc Limousin, Marryanna Lion, Adam Liska, Annalea Lohila, Ana López‐Ballesteros, Efrén López‐Blanco, Benjamin Loubet, Denis Loustau, Antje Lucas-Moffat, Johannes Lüers, Siyan Ma, Craig Macfarlane, Vincenzo Magliulo, Regine Maier, Ivan Mammarella, Giovanni Manca, Barbara Marcolla, Hank A. Margolis, Serena Marras, W. J. Massman, Mikhail Mastepanov, Roser Matamala, Jaclyn Hatala Matthes, Francesco Mazzenga, Harry McCaughey, Ian McHugh, Andrew M. S. McMillan, Lutz Merbold, Wayne S. Meyer, Tilden Meyers, S. D. Miller, Stefano Minerbi, Uta Moderow, Russell K. Monson, Leonardo Montagnani, Caitlin E. Moore, Eddy Moors, Virginie Moreaux, Christine Moureaux, J. William Munger, T. Nakai, Johan Neirynck, Zoran Nesic, Giacomo Nicolini, Asko Noormets, Matthew Northwood, Marcelo D. Nosetto, Yann Nouvellon, Kimberly A. Novick, Walter C. Oechel, Jørgen E. Olesen, Jean‐Marc Ourcival, S. A. Papuga, Frans‐Jan W. Parmentier, Eugénie Paul‐Limoges, Marian Pavelka, Matthias Peichl, Elise Pendall, Richard P. Phillips, Kim Pilegaard, Norbert Pirk, Gabriela Posse, Thomas L. Powell, Heiko Prasse, Suzanne M. Prober, Serge Rambal, Üllar Rannik, Naama Raz‐Yaseef, Corinna Rebmann, David E. Reed, Víctor Resco de Dios, Natalia Restrepo‐Coupé, Borja Ruiz Reverter, Marilyn Roland, Simone Sabbatini, Torsten Sachs, S. R. Saleska, Enrique P. Sánchez‐Cañete, Zulia M. Sánchez‐Mejía, Hans Peter Schmid, Marius Schmidt, Karl Schneider, Frederik Schrader, Ivan Schroder, Russell L. Scott, Pavel Sedlák, Penélope Serrano‐Ortiz, Changliang Shao, Peili Shi, Ivan Shironya, Lukas Siebicke, Ladislav Šigut, Richard Silberstein, Costantino Sirca, Donatella Spano, R. Steinbrecher, Robert M. Stevens, Cove Sturtevant, Andy Suyker, Torbern Tagesson, Satoru Takanashi, Yanhong Tang, Nigel Tapper, Jonathan E. Thom, Michele Tomassucci, Juha‐Pekka Tuovinen, S. P. Urbanski, Riccardo Valentini, M. K. van der Molen, Eva van Gorsel, J. van Huissteden, Andrej Varlagin, Joseph Verfaillie, Timo Vesala, Caroline Vincke, Domenico Vitale, N. N. Vygodskaya, Jeffrey P. Walker, Elizabeth A. Walter‐Shea, Huimin Wang, R. J. Weber, Sebastian Westermann, Christian Wille, Steven C. Wofsy, Georg Wohlfahrt, Sebastian Wolf, William Woodgate, Yuelin Li, Roberto Zampedri, Junhui Zhang, Guoyi Zhou, Donatella Zona, D. Agarwal, Sébastien Biraud, Margaret Torn, Dario Papale,
Abstract The FLUXNET2015 dataset provides ecosystem-scale data on CO 2 , water, and energy exchange between the biosphere and the atmosphere, and other meteorological and biological measurements, from 212 sites around the globe (over 1500 site-years, up to and including year 2014). These sites, independently managed and operated, voluntarily contributed their data to create global datasets. Data were quality controlled and processed using uniform methods, to improve consistency and intercomparability ...
Nature Portfolio
Gilberto Pastorello, Carlo Trotta, Eleonora Canfora, Housen Chu, Danielle Christianson, You-Wei Cheah, C. Poindexter, Jiquan Chen, Abdelrahman Elbashandy, Marty Humphrey, Peter Isaac, Diego Polidori, Markus Reichstein, Alessio Ribeca, Catharine van Ingen, Nicolas Vuichard, Leiming Zhang, B. D. Amiro, Christof Ammann, M. Altaf Arain, Jonas Ardö, Timothy J. Arkebauer, Stefan K. Arndt, Nicola Arriga, Marc Aubinet, Mika Aurela, Dennis Baldocchi, Alan Barr, Eric Beamesderfer, Luca Belelli Marchesini, Onil Bergeron, Jason Beringer, Christian Bernhofer, Daniel Berveiller, D. P. Billesbach, T. Andrew Black, Peter D. Blanken, Gil Bohrer, Julia Boike, Paul V. Bolstad, Damien Bonal, Jean-Marc Bonnefond, D. R. Bowling, Rosvel Bracho, Jason Brodeur, Christian Brümmer, Nina Buchmann, Benoît Burban, Sean P. Burns, Pauline Buysse, Peter Cale, M. Cavagna, Pierre Cellier, Shiping Chen, Isaac Chini, Torben R. Christensen, James Cleverly, Alessio Collalti, Claudia Consalvo, Bruce D. Cook, David Cook, Carole Coursolle, Edoardo Cremonese, Peter S. Curtis, Ettore D’Andrea, Humberto da Rocha, Xiaoqin Dai, K. J. Davis, Bruno De Cinti, A. de Grandcourt, Anne De Ligne, Raimundo Cosme de Oliveira, Nicolas Delpierre, Ankur R. Desai, Carlos Marcelo Di Bella, Paul Di Tommasi, A. J. Dolman, Francisco Domingo, Gang Dong, Sabina Dore, Pierpaolo Duce, Éric Dufrêne, Allison L. Dunn, Jiří Dušek, Derek Eamus, Uwe Eichelmann, Hatim Abdalla M. ElKhidir, Werner Eugster, Cäcilia Ewenz, B. E. Ewers, D. Famulari, Silvano Fares, Iris Feigenwinter, Andrew Feitz, Rasmus Fensholt, Gianluca Filippa, M. L. Fischer, J. M. Frank, Marta Galvagno, Mana Gharun, Damiano Gianelle, Bert Gielen, Beniamino Gioli, Anatoly A. Gitelson, Ignacio Goded, Mathias Goeckede, A. H. Goldstein, Christopher M. Gough, Michael L. Goulden, Alexander Graf, Anne Griebel, Carsten Gruening, Thomas Grünwald, Albin Hammerle, Shijie Han, Xingguo Han, Birger Ulf Hansen, Chad Hanson, Juha Hatakka, Yongtao He, Markus Hehn, Bernard Heinesch, Nina Hinko‐Najera, Lukas Hörtnagl, Lindsay B. Hutley, Andreas Ibrom, Hiroki Ikawa, M. Jackowicz-Korczyński, Dalibor Janouš, W.W.P. Jans, Rachhpal S. Jassal, Shicheng Jiang, Tomomichi Kato, Myroslava Khomik, Janina Klatt, Alexander Knohl, Sara Knox, Hideki Kobayashi, Georgia R. Koerber, Olaf Kolle, Yoshiko Kosugi, Ayumi Kotani, Andrew S. Kowalski, Bart Kruijt, Julia Kurbatova, Werner L. Kutsch, Hyojung Kwon, Samuli Launiainen, Tuomas Laurila, B. E. Law, R. Leuning, Yingnian Li, Michael J. Liddell, Jean‐Marc Limousin, Marryanna Lion, Adam Liska, Annalea Lohila, Ana López‐Ballesteros, Efrén López‐Blanco, Benjamin Loubet, Denis Loustau, Antje Lucas-Moffat, Johannes Lüers, Siyan Ma, Craig Macfarlane, Vincenzo Magliulo, Regine Maier, Ivan Mammarella, Giovanni Manca, Barbara Marcolla, Hank A. Margolis, Serena Marras, W. J. Massman, Mikhail Mastepanov, Roser Matamala, Jaclyn Hatala Matthes, Francesco Mazzenga, Harry McCaughey, Ian McHugh, Andrew M. S. McMillan, Lutz Merbold, Wayne S. Meyer, Tilden Meyers, S. D. Miller, Stefano Minerbi, Uta Moderow, Russell K. Monson, Leonardo Montagnani, Caitlin E. Moore, Eddy Moors, Virginie Moreaux, Christine Moureaux, J. William Munger, T. Nakai, Johan Neirynck, Zoran Nesic, Giacomo Nicolini, Asko Noormets, Matthew Northwood, Marcelo D. Nosetto, Yann Nouvellon, Kimberly A. Novick, Walter C. Oechel, Jørgen E. Olesen, Jean‐Marc Ourcival, S. A. Papuga, Frans‐Jan W. Parmentier, Eugénie Paul‐Limoges, Marian Pavelka, Matthias Peichl, Elise Pendall, Richard P. Phillips, Kim Pilegaard, Norbert Pirk, Gabriela Posse, Thomas L. Powell, Heiko Prasse, Suzanne M. Prober, Serge Rambal, Üllar Rannik, Naama Raz‐Yaseef, Corinna Rebmann, David E. Reed, Víctor Resco de Dios, Natalia Restrepo‐Coupé, Borja Ruiz Reverter, Marilyn Roland, Simone Sabbatini, Torsten Sachs, S. R. Saleska, Enrique P. Sánchez‐Cañete, Zulia M. Sánchez‐Mejía, Hans Peter Schmid, Marius Schmidt, Karl Schneider, Frederik Schrader, Ivan Schroder, Russell L. Scott, Pavel Sedlák, Penélope Serrano‐Ortiz, Changliang Shao, Peili Shi, Ivan Shironya, Lukas Siebicke, Ladislav Šigut, Richard Silberstein, Costantino Sirca, Donatella Spano, R. Steinbrecher, Robert M. Stevens, Cove Sturtevant, Andy Suyker, Torbern Tagesson, Satoru Takanashi, Yanhong Tang, Nigel Tapper, Jonathan E. Thom, Michele Tomassucci, Juha‐Pekka Tuovinen, S. P. Urbanski, Riccardo Valentini, M. K. van der Molen, Eva van Gorsel, J. van Huissteden, Andrej Varlagin, Joseph Verfaillie, Timo Vesala, Caroline Vincke, Domenico Vitale, N. N. Vygodskaya, Jeffrey P. Walker, Elizabeth A. Walter‐Shea, Huimin Wang, R. J. Weber, Sebastian Westermann, Christian Wille, Steven C. Wofsy, Georg Wohlfahrt, Sebastian Wolf, William Woodgate, Yuelin Li, Roberto Zampedri, Junhui Zhang, Guoyi Zhou, Donatella Zona, D. Agarwal, Sébastien Biraud, Margaret Torn, Dario Papale,
A Correction to this paper has been published: https://doi.org/10.1038/s41597-021-00851-9.
Nature Portfolio
Hauke Horstmann, Nathaly Anto Michel, Xia Sheng, Sophie Hansen, Alexandra Lindau, Katharina Pfeil, Marbely C. Fernández, Timoteo Marchini, Holger Winkels, Lucía Sol Mitre, Tijani Abogunloko, Xiaowei Li, Timothy Mwinyella, Mark Colin Gissler, Heiko Bugger, Timo Heidt, Konrad Buscher, Ingo Hilgendorf, Peter Stachon, Sven M. Piepenburg, Nicolas Verheyen, Thomas Rathner, Teresa Gerhardt, Patrick M. Siegel, Wolfgang Oswald, Tina Cohnert, Alma Zernecke, Josef Madl, Peter Köhl, Amanda C. Foks, C Von Zur Muehlen, Dirk Westermann, Andreas Zirlik, Dennis Wolf,
Abstract Aims The distinct functions of immune cells in atherosclerosis have been mostly defined by pre-clinical mouse studies. Contrastingly, the immune cell composition of human atherosclerotic plaques and their contribution to disease progression are only poorly understood. It remains uncertain whether genetic animal models allow for valuable translational approaches. Methods and results Single-cell RNA-sequencing (scRNA-seq) was performed to define the immune cell landscape in human carotid atherosclerotic ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2024 - Oxford University Press | Cardiovascular Research
Johannes Steinfurt, Alexander Gressler, Judith Stuplich, Eike Jordan, Markus Jäckel, Diona Gjermeni, Martin Eichenlaub, Marius Bohnen, Armin Luik, Amir Jadidi, Thomas Faber, Brigitte Stiller, Dirk Westermann, Thomas Arentz, Heiko Lehrmann, D. Yu. Fedorov,
It is currently unknown whether high-resolution 3D-mapping and micro-electrodes add meaningful benefits in catheter ablation of Wolff-Parkinson-White (WPW) syndrome and challenging, e.g. para-Hisian accessory pathways (APs). To compare the mapping resolution, acute success and complication rates in patients with WPW syndrome undergoing a first-time catheter ablation using only a contact force-sensing ablation catheter for mapping or a multi-electrode high-resolution mapping catheter. Fifty consecutive ...
Tópico(s): Atrial Fibrillation Management and Outcomes
2024 - Elsevier BV | IJC Heart & Vasculature
Tai‐Yuan Huang, PATRICK SCHURR, Bjoern Muller-Edenborn, Nicolas Pilia, Louisa Mayer, Martin Eichenlaub, Juergen Allgeier, Marie Heidenreich, Christoph Ahlgrim, Marius Bohnen, Heiko Lehrmann, Dietmar Trenk, Franz‐Josef Neumann, Dirk Westermann, Thomas Arentz, Amir Jadidi,
Aim This study sought to develop and validate diagnostic models to identify individuals with atrial fibrillation (AF) using amplified sinus-p-wave analysis. Methods A total of 1,492 patients (491 healthy controls, 499 with paroxysmal AF and 502 with persistent AF) underwent digital 12-lead-ECG recording during sinus rhythm. The patient cohort was divided into training and validation set in a 3:2 ratio. P-wave indices (PWI) including duration of standard p-wave (standard PWD; scale at 10 mm/mV, sweep ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2023 - Frontiers Media | Frontiers in Cardiovascular Medicine
Stéphanie Becker, Lisa Langdon Koch, Andrija Bošnjak, M Biedermann, Daniel Engler, Heiko Lehrmann, A Krishna, Amir Jadidi, Stefan Blankenberg, Dirk Westermann, Timea Keller, Thomas Arentz, Renate B. Schnabel, Axel Loewe, Martin Eichenlaub,
Tópico(s): Cardiac electrophysiology and arrhythmias
2025 - Oxford University Press | EP Europace
Tsai-Sang Dederichs, Christina Ehlert, Heiko Becker, Donna Wolf, Martin Czerny, Siddhartha Jaiswal, Dirk Westermann, Ingo Hilgendorf,
Abstract Background Clonal hematopoiesis of indeterminate potential (CHIP) is an acquired, genetic cardiovascular (CV) risk factor affecting about 10% of the general population at the age of 70 years. Most CHIP-driver mutations affect the epigenetic regulator gene DNMT3A. Experimental studies suggest a causal link between CHIP and inflammation-driven atherosclerosis, but the underlying mechanisms of how few mutant clones provoke adverse clinical outcomes in patients remain obscure. Methods Single ...
Tópico(s): Lung Cancer Research Studies
2024 - Oxford University Press | European Heart Journal
Carolin A. Ehlert, Tsai-Sang Dederichs, Heiko Becker, Christoph Bode, Dennis Wolf, Klaus Kaier, Dirk Westermann, Ingo Hilgendorf,
Background and Aims: CHIP is a mutation-driven clonal hematopoiesis in the absence of overt hematologic disease. In the general population CHIP-carriers are twice as likely to suffer from CHD as non-carriers (Jaiswal et al.). However prevalence of CHIP and its association with risk factors and extent CAD in patients undergoing coronary-angiography are unknown. Aim: To determine whether CHIP mutations are associated with the extend of CAD independent of comorbidities and to investigate possible associations. ...
Tópico(s): Hemoglobinopathies and Related Disorders
2023 - Elsevier BV | Atherosclerosis
Amir Jadidi, B Mueller-Edenborn, Martin Eichenlaub, Heiko Lehrmann, Juergen Allgeier, Dietmar Trenk, Franz‐Josef Neumann, Dirk Westermann, Thomas Arentz,
Abstract Funding Acknowledgements Type of funding sources: Private company. Main funding source(s): Abbott Introduction Novel catheter ablation technologies (e.g. RF with contiguous lesions) for pulmonary vein isolation (PVI) achieve high (80-85%) arrhythmia freedom rates at 12 months in both paroxysmal and persistent AF. However, success rates are importantly reduced (45-50%) in persistent AF patients presenting atrial cardiomyopathy with additional low voltage areas in the left atrial body. Aim SOLVE- ...
Tópico(s): Cardiac pacing and defibrillation studies
2023 - Oxford University Press | EP Europace
Deborah Nairn, Martin Eichenlaub, Heiko Lehrmann, Björn Müller‐Edenborn, Juan Chen, Tai‐Yuan Huang, Claudia Nagel, Jorge Sánchez, Giorgio Luongo, Dirk Westermann, Thomas Arentz, Olaf Dössel, Amir Jadidi, Axel Loewe,
Abstract Introduction Improved sinus rhythm (SR) maintenance rates have been achieved in patients with persistent atrial fibrillation (AF) undergoing pulmonary vein isolation plus additional ablation of low voltage substrate (LVS) during SR. However, voltage mapping during SR may be hindered in persistent and long‐persistent AF patients by immediate AF recurrence after electrical cardioversion. We assess correlations between LVS extent and location during SR and AF, aiming to identify regional voltage ...
Tópico(s): ECG Monitoring and Analysis
2023 - Wiley | Journal of Cardiovascular Electrophysiology
P. Mendes-Ferreira, C. Maia-Rocha, Rui Adão, Ana Paula Lourenço, Clícia Grazielly de Lima Moura, Sirlaine de Pinho, J. C. Areias, Gilles W. De Keulenaer, Adelino Leite‐Moreira, C. Bras-Silva, Luise Holzhauser, D. Lindner, Anika Jenke, Heinz‐Peter Schultheiß, Diedrich Westermann, Carsten Skurk, T. Misaka, S. Suzuki, M Miyata, Akio Kobayashi, S. Saitoh, Yasuchika Takeishi, M. Czolbe, V. Pekarek, Trevor Williams, F. Panther, J. Strassen, Oliver Ritter, Stefan Voß, Holger Nef, S. Szardien, C. Troidl, B. Kojonazarov, D. Visser, J Hoffmann, M. Willmer, C. Hamm, H. Moellmann, Suzana Ljubojević, S. Sedej, M. Sacherer, G. Leitinger, J. Kockskaemper, Burkert Pieske, N. M. Vorobyeva, A. B. Dobrovolsky, E. V. Titaeva, A. I. Kirienko, Е. П. Панченко, R. Nakamura, Yuya Matsue, Akiko Mizukami, M. Ohno, M. Suzuki, Akira Matsumura, Yasuhiro Hashimoto, M. Rosiak, Marek Postuła, Agnieszka Kapłon‐Cieślicka, E. Trzepla, A. Czlonkowski, Krzysztof J. Filipiak, Grzegorz Opolski, Dariusz A. Kosior, Tommy Andersson, Pola Nagy, Maha Niazi, S. Nylander, Lars Wallentin, Joshua T. Mendell, Lee J Johnson, Glyneva Bradley Ridout, Longtao He, S. Chen, M. Petrkova, P. Schneiderova, E. Kriegova, Zdeněk Kolář, Miloš Táborský, Martin Petřek, N. Khuseyinova, Renate B. Schnabel, Thomas Zeller, Tommaso Gori, A. Schulz, Christine Espinola‐Klein, K Lackner, Stefan Blankenberg, T. Muenzel, P. S. Wild, Nicolas Amabile, SiMin Cheng, M. G. Larson, A. Ghorbani, E. Mc Cabe, G. Griffin, K. S. Cohen, A. Tedgui, Carole Boulanger, T. J. Wang, Marish I.F.J. Oerlemans, A. Mosterd, Mireille Dekker, E. A. De Vrey, Annette H M van der Helm–van Mil, Gerard Pasterkamp, Pieter A. Doevendans, A. W. Hoes, Joost P. G. Sluijter, C. Besler, Raisa Laaksonen, K. Ekroos, K. Tarasov, R. Hurme, T. F. Luescher, Arnold von Eckardstein, Ulf Landmesser, M. Ohno, Shaw Watanabe, Y. Hiraoka, Tatsuomi Matsuoka, Kazuhiko Nishi, Shigeru Saijo, Tomoko Kita, E. Nishi, T. Kimura, Keith Robertson, Jing Hu, R. A. Mcdonald, Keith G. Oldroyd, Stephanie Jessica Wan, Andrew H. Baker, Diane Jones, Krishnaraj S. Rathod, John Howard, Stuart Gallagher, A. K. Jain, Charles H. Knight, Sam Mohiddin, A. Mathur, Erin Smith, A. Wragg, Marije M. Vis, Marcel A.M. Beijk, Maik J. Grundeken, Janneke Baan, Klaus Koch, Joanna J. Wykrzykowska, J. G. P. Tijssen, Robbert J. de Winter, Jan J. Piek, José P.S. Henriques, T. Bauer, R Schiele, R. Zahn, S. Schneider, Bernhard Rauch, G. Sabin, Gunnar Steineck, J. Senges, Uwe Zeymer, Étienne Puymirat, E. Durand, K. Khalife, B. De Breyne, Vanda M. Lucke, Gillian H. Levy, Yves Cottin, J. Ferrrieres, Trevor W. Simon, Nicolas Danchin, Y. M. Lopatin, O. V. Ilyukhin, M. V. Ilyukhina, E. L. Kalganova, D. L. Tarasov, V. Ivanenko, Yves Devaux, Naser Ahmed Razvi, M. Vausort, Ged McCann, Dorothy H. Kelly, L. Zhang, Lavrova Ng, David R. Wagner, Iain Squire, Y. Ozaki, Aiko Tanaka, Kanji Ishibashi, T Tanimoto, Toshinao Yamano, Y. Ino, T. Yamaguchi, Takeshi Kubo, T. Imanishi, T Akasaka, Masahiko Takahata, Takeshi Kubo, T. Wada, Masahiro Orii, Toshinao Yamano, T Tanimoto, Y. Ino, T. Yamaguchi, T. Imanishi, T Akasaka, F. Imola, M. T. Mallus, V. Ramazzotti, M. Manzoli, Andrea A. Pappalardo, M. Occhipinti, L. Di Vito, Francesco Prati, Terue Okamura, Junichi Yamada, T. Nao, T. Suetomi, T Maeda, A. Hino, Takako Nakashima, Oda T, Tetsuji Miura, Masayo Matsuzaki, S Umemura, H. Kamihata, Shuji Nakamura, T. Sugiura, Tadashi Seno, K. Manabe, Saburo Tsujimoto, Miura Motohiro, T Iwasaka, Kenya Kusunose, A. Dahiya, M. Chadi Alraies, Diana Kwon, T. Marwick, Abbie Klein, T. Butz, L. Penfield Faber, Crystal Piper, G. Plehn, Dieter Horstkotte, H.-J. Trappe, R. M. Jimenez, J. M. Serrano, C Cristóbal, Pablo Talavera, P. Awanleh, Catherine Graupner, Antonio Curcio, J. J. Alonso Martin, A. Cresti, E. Capati, G. Guerrieri, Sauro Severi, C. Mornos, A. Ionac, D. Cozma, A. Mornos, S. Pescariu, S. Petrescu, S. Rekhraj, B. Szwejkowski, Adnan Nadir, S. Gandy, Jill George, Chim C. Lang, Allan D. Struthers, T. Yingchoncharoen, Sangita Agarwal, T. Marwick, Kiyohiro Takigiku, Masao Takeuchi, S. Nakatani, Chisato Izumi, S. Yuda, Kenji Sakata, N. Ohte, Kumiko Tanabe, Kohei Kaku, Masao Takeuchi, Kiyohiro Takigiku, S. Yasukouchi, Victor Mor‐Avi, Robin Lang, Y. Otsuji, S. A. Kleijn, Natesa G. Pandian, Leopoldo Pérez de Isla, O. Kamp, Michel Züber, P. Nyhoyannopoulos, Tim Forster, H. J. Nesser,
Oxford University Press
Till Althoff, Martin Eichenlaub, David Padilla-Cueto, Heiko Lehrmann, Paz Garre, Simon Schoechlin, Elisenda Ferró, Eric Invers-Rubio, Philipp Ruile, Manuel Hein, Christopher L. Schlett, R. Ventura, Susanna Prat‐González, B Mueller-Edenborn, Marius Bohnen, Andreu Porta‐Sánchez, José Marı́a Tolosana, Eduard Guasch, Ivo Roca‐Luque, Elena Arbelo, Franz‐Josef Neumann, Dirk Westermann, Marta Sitges, Josép Brugada, Thomas Arentz, Lluı́s Mont, Amir Jadidi,
With recurrence rates up to 50% after pulmonary vein isolation (PVI) in persistent atrial fibrillation (AF), predictive tools to improve patient selection are needed. Patient selection based on left atrial late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) has been proposed previously (UTAH-classification). However, this approach has not been widely established, in part owed to the lack of standardization of the LGE quantification method. We have recently established a standardized ...
Tópico(s): Cardiac Imaging and Diagnostics
2022 - Oxford University Press | European Heart Journal Open
Martin Eichenlaub, Heiko Lehrmann, Jan Minners, Simon Schoechlin, B Mueller-Edenborn, Nikolaus Jander, Martin Allgeier, Juergen Allgeier, Marius Bohnen, Franz‐Josef Neumann, Dietmar Trenk, Dirk Westermann, Thomas Arentz, Amir Jadidi,
Abstract Funding Acknowledgements Type of funding sources: Private company. Main funding source(s): Medtronic Background Atrial cardiomyopathy (ACM) is associated with an increased risk for new-onset atrial fibrillation (AF), progression from paroxysmal to persistent AF-forms and higher arrhythmia recurrence rates after PVI. Therefore, the current ESC guidelines on AF recommend to characterize the underlying ACM to better inform and treat AF patients. Over the past decade, various diagnostic tools ...
Tópico(s): Cardiac pacing and defibrillation studies
2023 - Oxford University Press | EP Europace
Carolin A. Ehlert, Tsai-Sang Dederichs, Assel Yerdenova, Hauke Horstmann, Tamara Vico, Simone Nübling, Rémi Peyronnet, Heiko Becker, Dietmar Pfeifer, Christoph Niemoeller, Nathaly Anto-Michel, Andreas Zirlik, Christoph Bode, Constantin von zur Mühlen, Dennis Wolf, Sebastian Preißl, Ingo Hilgendorf, Dirk Westermann,
Tópico(s): Blood properties and coagulation
2024 - Elsevier BV | Atherosclerosis
Tsai-Sang Dederichs, Carolin A. Ehlert, Heiko Becker, Dietmar Pfeifer, Christoph Niemoeller, Nathaly Anto-Michel, Andreas Zirlik, Christoph Bode, Dennis Wolf, Constantin von zur Mühlen, Klaus Kaier, Sebastian Preißl, Timo Heidt, Dirk Westermann, Ingo Hilgendorf,
Background and Aims: The study aimed to identify phenotypical changes directly attributed to DNMT3A-CHIP driver mutations in blood and bone marrow myeloid cells from patients with coronary artery disease risk. Methods: We conducted a prospective, observational study to screen CHIP-driver mutations in patients who were admitted for percutaneous coronary intervention. We established a single-cell DNA/RNA parallel sequencing method to acquire whole transcriptome and DNMT3A genotype of the same single ...
Tópico(s): Blood disorders and treatments
2023 - Elsevier BV | Atherosclerosis
Robert Delsnyder, Gordon Davies, Jacqueline Isaac, John A. Kessler, Claude Cox, J. Harvey, Joseph Kozar, David B. Gowler, Daniel Smith, Leif E. Vaage, John S. Kloppenborg, Grant LeMarquand, Mark Husbands, Steven Muir, Kristen Sweder, John C. Meagher, Douglas Houghton Campbell, Terence L. Donaldson, Gregory Bloomquist, Robert A. Derrenbacker, Wendy Cotter, William E. Arnal, Harry O. Maier, Marion Taylor, Victor Shepherd, Alan Davies, B. J. Fraser, Gordon L. Jensen, John Egan, Pamela Moeller, Lillian Perigoe, R. D. Barnes, Jean-Marc Laporte, Joseph Quinn Raab, Peter Althouse, Daniel J. Donovan, Michael Dempsey, Harold Wells, Dennis Ngien, Sheila Kappler, Gerard Whelan, P.W. Wyatt,
... Hebrew Bible, reviewed by Claude E. Cox Claus Westermann, Roots of Wisdom: The Oldest Proverbs of Israel ... Life and Culture, reviewed by Brian J. Fraser Heiko A. Oberman, The Impact of the Reformation, reviewed by Gordon A. Jensen Heiko A. Oberman, The Reformation: Roots and Ramifications, reviewed ...
Tópico(s): Biblical Studies and Interpretation
1997 - Toronto School of Theology | Toronto Journal of Theology