Roland Kocijan, Matthias Englbrecht, Judith Haschka, David Simón, Arnd Kleyer, Stephanie Finzel, Sebastian Kraus, Heinrich Resch, Christian Muschitz, Klaus Engelke, Michael Sticherling, Jürgen Rech, Georg Schett,
Psoriatic arthritis (PsA) is a chronic inflammatory disease characterized by periarticular bone loss and new bone formation. Current data regarding systemic bone loss and bone mineral density (BMD) in PsA are conflicting. The aim of this study was to evaluate bone microstructure and volumetric BMD (vBMD) in patients with PsA and psoriasis. We performed HR-pQCT scans at the ultradistal and periarticular radius in 50 PsA patients, 30 psoriasis patients, and 70 healthy, age- and sex-related controls assessing ...
Tópico(s): Rheumatoid Arthritis Research and Therapies
2015 - Oxford University Press | Journal of Bone and Mineral Research
David Simón, Judith Haschka, Christian Muschitz, Annemarie Kocijan, Andreas Baierl, Arnd Kleyer, Georg Schett, S. Kapiotis, Heinrich Resch, Michael Sticherling, Jürgen Rech, Roland Kocijan,
Tópico(s): Inflammatory Myopathies and Dermatomyositis
2020 - Springer Science+Business Media | Osteoporosis International
Anna Neumann, Judith Haschka, Arnd Kleyer, Louis Schuster, Matthias Englbrecht, Andreas Berlin, Camille Pinto Figueiredo, David Simón, Christian Muschitz, Roland Kocijan, Heinrich Resch, Jürgen Rech, Georg Schett,
In the present study, we investigated bone geometry, microstructure, and volumetric bone mineral density (vBMD) in a cohort of patients with nonradiographic axial spondyloarthritis (nr-axSpA) in order to define the early bone changes occurring in axial spondyloarthritis (axSpA) and to define potential factors for deterioration of bone microstructure.Patients with axSpA (n = 107) and healthy control subjects (n = 50) of similar age and sex were assessed for geometric, volumetric, and microstructural parameters ...
Tópico(s): Bone health and osteoporosis research
2018 - BioMed Central | Arthritis Research & Therapy
Produção Nacional
Revisado por pares
Judith Haschka, Simon Hirschmann, Arnd Kleyer, Matthias Englbrecht, Francesca Faustini, David Simón, Camille Pinto Figueiredo, Louis Schuster, Christian Muschitz, Roland Kocijan, Heinrich Resch, Raja Atreya, Jürgen Rech, Markus F. Neurath, Georg Schett,
Background and Aims: To investigate the macro- and microstructural changes of bone in patients with inflammatory bowel disease [IBD] and to define the factors associated with bone loss in IBD. Methods: A total of 148 subjects, 59 with Crohn's disease [CD], 39 with ulcerative colitis [UC], and 50 healthy controls were assessed for the geometric, volumetric and microstructural properties of bone using high-resolution peripheral quantitative computed tomography. In addition, demographic and disease-specific ...
Tópico(s): Bone health and osteoporosis research
2016 - Oxford University Press | Journal of Crohn s and Colitis
Judith Haschka, David Simón, Sara Bayat, Zora Messner, Eleni Kampylafka, Filippo Fagni, Susanna Skalicky, Matthias Hackl, Heinrich Resch, Jochen Zwerina, Arnd Kleyer, Alexander Cavallaro, Michael Sticherling, Goerg Schett, Roland Kocijan, Jürgen Rech,
miRNAs are small non-coding RNAs that control gene expression. Specific intra- and extracellular miRNA signatures have been identified in various diseases. Whether certain miRNA signatures are associated with psoriasis (PsO) and PsA is currently unknown. We aimed to search for circulating miRNA signatures associated with PsO and PsA patients.Expression of miRNAs was analysed by reverse transcription quantitative real-time PCR (RT-qPCR) in the serum of PsA, PsO patients and healthy controls. Demographic ...
Tópico(s): Cytokine Signaling Pathways and Interactions
2023 - Oxford University Press | Lara D. Veeken
Simon Heinrich, Johannes Michaelis, Isabella Reiher, Birte Coppers, Markus Lohmayer, E. Fleischmann, Arnd Kleyer, Georg Schett, Ann‐Sophie De Craemer, Dirk Elewaut, Sigrid Leyendecker, Anna‐Maria Liphardt,
We investigate the accuracy of different calibration methods for the CyberGlove III for objective hand function assessments. The accuracy is evaluated by means of root-mean-squared errors (RMSE) between ground truth and angles estimated by the glove. Additionally, we propose two improvements. The first increases standardization capabilities for the measurement of pure thumb carpometacarpal joint flexion. The second increases the accuracy by extending an existing calibration method to all thumb and ...
Tópico(s): Optical measurement and interference techniques
2024 - IEEE Sensors Council | IEEE Sensors Journal
Birte Coppers, Simon Heinrich, Koray Taşçılar, Uday Phutane, Arnd Kleyer, David Simón, Johanna Bräunig, Johann Penner, Martin Vossiek, Verena Schönau, Sara Bayat, Georg Schett, Sigrid Leyendecker, Anna‐Maria Liphardt,
Tópico(s): Autoimmune and Inflammatory Disorders Research
2025 - Nature Portfolio | Scientific Reports
B. Coppers, Sebastian Heinrich, Sara Bayat, Koray Taşçılar, A. Kleyer, David Simón, Ioanna Minopoulou, Giulia Corte, Filippo Fagni, V. Schönau, Daniela Bohr, S. Leyendecker, G. Schett, A. M. Liphardt,
Background: Measuring disease activity in patients with inflammatory arthritis remains challenging and is mainly based on physician-dependent assessments, subjective measures and just one blood biomarker of inflammation with no indication of the subclinical or functional state of the patients [1, 2]. Patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA) present with impaired hand function compared to healthy controls [3, 4]. While hand function is well studied in RA patients [5], data is sparse ...
Tópico(s): Fibromyalgia and Chronic Fatigue Syndrome Research
2024 - BMJ | Annals of the Rheumatic Diseases
Helena Port, Birte Coppers, Sonja Tragl, Eva Manger, Lisa M Niemiec, Sara Bayat, David Simón, Filippo Fagni, Giulia Corte, Anne‐Christine Bay‐Jensen, Koray Taşçılar, Axel J. Hueber, Katja Schmidt, Verena Schönau, Michael Sticherling, Simon Heinrich, Sigrid Leyendecker, Daniela Bohr, Georg Schett, Arnd Kleyer, Signe Holm Nielsen, Anna‐Maria Liphardt,
Tópico(s): Spondyloarthritis Studies and Treatments
2025 - Nature Portfolio | Scientific Reports
B. Coppers, Sebastian Heinrich, U. Phutane, D. Berisha, K. Tascilar, A. Kleyer, D. Simon, J. Bräunig, J. Penner, M. Vossiek, V. Schönau, S. Bayat, G. Schett, S. Leyendecker, A. M. Liphardt,
Background Physical function is an important factor determining disease burden in arthritis. Monitoring function in rheumatoid arthritis (RA) patients is essential for effective treatment [1]. The currently used tools to assess physical function (e.g. patient reported outcomes) have limitations with respect to sensitivity and specificity to measure functional impairment in RA [2,3]. A marker-based optoelectronic measurement of hand function enables detailed analysis of hand movements such as spatial- ...
Tópico(s): Rheumatoid Arthritis Research and Therapies
2022 - BMJ | Annals of the Rheumatic Diseases
J. Haschka, David Nils Simon, S. Bayat, Zora Messner, E. Kampylafka, F. Fagni, S. Skalicky, M. Hackl, Heinrich Resch, Jochen Zwerina, A. Kleyer, M. Sticherling, G. Schett, Roland Kocijan, J. Rech,
Background MicroRNAs (miRNAs) are small non-coding RNAs that control gene expression. Specific miRNA signatures have been identified in numerous diseases and may serve as potential biomarkers or new drug targets. Whether certain miRNA signatures are associated with psoriatic joint disease is currently unknown. Objectives To search for circulating miRNA signatures in psoriasis patients with subclinical joint disease and in patients with psoriatic arthritis (PsA). Methods Analyses of serum miRNA were ...
Tópico(s): Cytokine Signaling Pathways and Interactions
2022 - BMJ | Annals of the Rheumatic Diseases
Produção Nacional
Revisado por pares
Judith Haschka, Anna Neumann, Arnd Kleyer, Louis Schuster, Matthias Englbrecht, Cláudia P. Figueiredo, Christian Muschitz, Roland Kocijan, Heinrich Resch, Jürgen Rech, Georg Schett,
Background Systemic bone loss is a well-known and severe consequence in axial spondyloarthritis (axSpA). To date deterioration of bone microstructure has only been described in patients with long-standing ankylosing spondylitis while bone microstructure has not been assessed in axSpA. Objectives The aim of the present study was to investigate bone microstructure, geometry and volumetric bone mineral density (vBMD) using high resolution peripheral quantitative CT (HR-pQCT) in a cohort of axSpA patients at an ...
Tópico(s): Bone health and osteoporosis research
2017 - BMJ | Annals of the Rheumatic Diseases
Produção Nacional
Revisado por pares
Valério D. Pillar, Meelis Pärtel, Jodi N. Price, Milan Chytrý,
... Kikvidze Tania Kim Adam Kimberley Kevin Kirkman Michael Kleyer Keito Kobayashi Johannes Kollmann Buntarou Kusumoto Charles Kwit ...
Tópico(s): Forest Ecology and Biodiversity Studies
2022 - Wiley | Journal of Vegetation Science
Judith Haschka, Simon Hirschmann, Arnd Kleyer, Matthias Englbrecht, Janin Zimmermann, Francesca Faustini, David Simón, Cláudia P. Figueiredo, A. Cavallaro, Christian Muschitz, Roland Kocijan, Heinrich Resch, Raja Atreya, Jürgen Rech, MF Neurath, Georg Schett,
Background Musculoskeletal symptoms are considered as one of the most frequent extra-intestinal manifestation in Inflammatory Bowel Disease (IBD) patients with a prevalence of up to 40% involving axial and/or peripheral joints. Data on the prevalence of musculoskeletal disease, in particular of SpA are limited and vary considerably due to different criteria the studies have used to define musculoskeletal disease in IBD patients. Objectives To define the prevalence of axial and peripheral spondyloarthritis ( ...
Tópico(s): Rheumatoid Arthritis Research and Therapies
2017 - BMJ | Annals of the Rheumatic Diseases
Dimitrios L. Wagner, Lennard Ostendorf,
... Wilhelm A. Aigner M. Völkl S. Simon D. Kleyer A. Munoz L. et al.Anti-CD19 CAR ... L. Burns M. Durek P. Heinz G.A. Heinrich F. Garantziotis P. Enghard P. Richter U. Biesen ...
Tópico(s): T-cell and B-cell Immunology
2023 - Cell Press | Molecular Therapy — Methods & Clinical Development