Produção Nacional
Revisado por pares
Shirley Braga Lima Gamonal, Nathália Couri Vieira Marques, Heitor Motta Bini Pereira, Aloísio Gamonal,
... more papers by this authorHeitor Motta Bini Pereira, Heitor Motta Bini Pereira orcid.org/0000-0001-9845-4876 Department of ... more papers by this authorHeitor Motta Bini Pereira, Heitor Motta Bini Pereira orcid.org/0000-0001-9845-4876 Department of ...
Tópico(s): Skin Diseases and Diabetes
2022 - Wiley | Dermatologic Therapy
Produção Nacional
Revisado por pares
Jocksam G. De Matos, Carla K. De M. Marques, Carlos Heitor Pereira Liberalino,
Technological advancement has required ever more computing resources. In this context the cloud computing emerges as a new paradigm to meet this demand, though its resources are physically limited due to the growing data traffic that the system may be subject. The task scheduling aims to distribute tasks in order to make them more efficient in the use of computing resources. Thus, this paper aims to propose a solution to the task scheduling problem in cloud computing to reduce the processing time ...
Tópico(s): Distributed and Parallel Computing Systems
2019 - | International Journal of Cloud Computing
Produção Nacional
Revisado por pares
Danielle A. S. Rodrigues, Elisa Beatriz Prestes, Andreza Moreira Gama, Leandro S. Silva, Ana Acácia S. Pinheiro, José M. C. Ribeiro, Raquel Maria Pereira Campos, Pedro M. Pimentel‐Coelho, Heitor Siffert Pereira de Souza, Alassane Dicko, Patrick E. Duffy, Michal Fried, Ivo M.B. Francischetti, Elvira M. Saraiva, Heitor A. Paula-Neto, Marcelo T. Bozza,
Neutrophil extracellular traps (NETs) evolved as a unique effector mechanism contributing to resistance against infection that can also promote tissue damage in inflammatory conditions. Malaria infection can trigger NET release, but the mechanisms and consequences of NET formation in this context remain poorly characterized. Here we show that patients suffering from severe malaria had increased amounts of circulating DNA and increased neutrophil elastase (NE) levels in plasma. We used cultured erythrocytes ...
Tópico(s): Immune cells in cancer
2020 - Public Library of Science | PLoS Pathogens
Produção Nacional
Revisado por pares
Sílvia Rodrigues Jardim, Lucila Marieta Perrotta de Souza, Heitor Siffert Pereira de Souza,
The overall burden of cancer is rapidly increasing worldwide, reflecting not only population growth and aging, but also the prevalence and spread of risk factors. Gastrointestinal (GI) cancers, including stomach, liver, esophageal, pancreatic, and colorectal cancers, represent more than a quarter of all cancers. While smoking and alcohol use are the risk factors most commonly associated with cancer development, a growing consensus also includes dietary habits as relevant risk factors for GI cancers. ...
Tópico(s): Diet and metabolism studies
2023 - Multidisciplinary Digital Publishing Institute | International Journal of Environmental Research and Public Health
Produção Nacional
Revisado por pares
Lígia Moriguchi Watanabe, Heitor Bernardes Pereira Delfino, Marcela Augusta de Souza Pinhel, Natália Yumi Noronha, Luísa Maria Diani, Lucca Cintra do Prado Assumpção, Carolina Ferreira Nicoletti, Carla Barbosa Nonino,
“Nutrition transition” describes the shifts in dietary consumption and energy expenditure influenced by economic, demographic, and epidemiological changes at a population level. This phenomenon has been associated with rising obesity rates worldwide, especially in developed countries. In Brazil, the historical analysis of temporal trends between malnutrition and obesity characterized the nutrition transition in the country and interweaved it with the formulation and implementation of public food ...
Tópico(s): Nutritional Studies and Diet
2022 - Multidisciplinary Digital Publishing Institute | Nutrients
Produção Nacional
Revisado por pares
Cláudio Bernardazzi, Morgana T. Castelo-Branco, Beatriz Pêgo, Beatriz Elias Ribeiro, Siane Lopes Bittencourt Rosas, Patrícia Teixeira Santana, João Carlos Machado, Camille V. Leal, Fabiano L. Thompson, Robson Coutinho‐Silva, Heitor Siffert Pereira de Souza,
Background: Given the role of the P2X7 receptor (P2X7R) in inflammatory bowel diseases (IBD), we investigated its role in the development and progression of colitis-associated colorectal cancer (CA-CRC). Methods: CA-CRC was induced in P2X7R+/+ and P2X7R-/- mice with azoxymethane (AOM) combined with dextran sodium sulfate (DSS). In a therapeutic protocol, P2X7R+/+ mice were treated with a P2X7R-selective inhibitor (A740003). Mice were evaluated with follow-up video endoscopy with endoluminal ultrasound ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2022 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Produção Nacional
Revisado por pares
Patrícia Teixeira Santana, Siane Lopes Bittencourt Rosas, Beatriz Elias Ribeiro, Ygor Marinho, Heitor Siffert Pereira de Souza,
Microbe–host communication is essential to maintain vital functions of a healthy host, and its disruption has been associated with several diseases, including Crohn’s disease and ulcerative colitis, the two major forms of inflammatory bowel disease (IBD). Although individual members of the intestinal microbiota have been associated with experimental IBD, identifying microorganisms that affect disease susceptibility and phenotypes in humans remains a considerable challenge. Currently, the lack of ...
Tópico(s): Fibromyalgia and Chronic Fatigue Syndrome Research
2022 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Produção Nacional
Revisado por pares
Ludimilla dos Reis Malvão, Kalil Madi, Barbara C. Esberard, Renata Fernandes de Amorim, Kelly Dos Santos Silva, Katia Farias e Silva, Heitor Siffert Pereira de Souza, Ana Teresa Pugas Carvalho,
Abstract Mucosal healing (MH) has become a major target in the management of ulcerative colitis (UC). Because repeat endoscopy is expensive and invasive, we aimed to evaluate fecal calprotectin (FC) as an alternative marker to predict MH in UC. Eighty patients with UC in clinical remission were consecutively included in a prospective observational study. FC was measured using a quantitative enzyme-linked immunosorbent assay. The colonic mucosa was assessed for endoscopic and histological measures of ...
Tópico(s): Helicobacter pylori-related gastroenterology studies
2021 - Wolters Kluwer | Medicine
Produção Nacional
Revisado por pares
Ana Grinman, Maria das Graças Coelho de Souza, Eliete Bouskela, Ana Teresa Pugas Carvalho, Heitor Siffert Pereira de Souza,
Abstract Monitoring anti-TNF agents in inflammatory bowel disease (IBD) patients may be helpful in optimizing outcomes. We aimed to evaluate potential correlations among demographic, clinical, laboratory, or imaging parameters, as well as serum levels of infliximab (IFX) and adalimumab (ADA) and their respective antibodies, in the clinical management of IBD patients. A cross-sectional study of 95 patients with Crohn's disease (CD) or ulcerative colitis (UC) in maintenance therapy with infliximab or adalimumab ...
Tópico(s): Celiac Disease Research and Management
2020 - Wolters Kluwer | Medicine
Produção Nacional
Revisado por pares
Carolina Ferreira Nicoletti, Heitor Bernardes Pereira Delfino, Flávia Campos Ferreira, Marcela Augusta de Souza Pinhel, Carla Barbosa Nonino,
Tópico(s): Biochemical Analysis and Sensing Techniques
2019 - Springer Science+Business Media | Reviews in Endocrine and Metabolic Disorders
Produção Nacional
Revisado por pares
Fernando Castro, Heitor Siffert Pereira de Souza,
Dramatic changes in the environment and human lifestyle have been associated with the rise of various chronic complex diseases, such as inflammatory bowel disease (IBD). A dysbiotic gut microbiota has been proposed as a crucial pathogenic element, contributing to immune imbalances and fostering a proinflammatory milieu, which may be associated with disease relapses or even the initiation of IBD. In addition to representing important regulators of the mucosal immunity and the composition of the gut ...
Tópico(s): Dietary Effects on Health
2019 - Multidisciplinary Digital Publishing Institute | Nutrients
Produção Nacional
Revisado por pares
Heitor Antônio Pereira da Silva, Rodrigo Nicoletti,
The dynamic characteristics of tilting-pad journal bearings (TPJBs) are strongly related to their geometric parameters, most importantly the bearing clearance. In turn, the bearing clearance in TPJBs is strongly dependent on the machining tolerances of the bearing parts and their assembling. Considering that, the machining tolerances of the pads can be of the same magnitude order of the oil film thickness in the bearing, it is uncertain that the TPJB will have the originally designed geometry after ...
Tópico(s): Lubricants and Their Additives
2018 - ASM International | Journal of Tribology
Produção Nacional
Revisado por pares
Heitor Siffert Pereira de Souza, Claudio Fiocchi,
Despite unquestionable progress in the management of inflammatory bowel disease (IBD) and the much improved clinical results achievable today in Crohn's disease (CD) and ulcerative colitis (UC) patients, the overall therapeutic outcome remains far from optimal. The main reason of this partial success is that all current medications only block individual components of a highly complex disease process that results from the integration of multiple and incompletely identified pathogenic components. Thus, ...
Tópico(s): Gut microbiota and health
2018 - Oxford University Press | Inflammatory Bowel Diseases
Produção Nacional
Hayandra F. Nanini, Cláudio Bernardazzi, Fernando Castro, Heitor Siffert Pereira de Souza,
The chronic inflammatory process underlying inflammatory bowel disease (IBD), comprising Crohn's disease and ulcerative colitis, derives from the interplay of several components in a genetically susceptible host. These components include environmental elements and gut microbiota a dysbiosis. For decades, immune abnormalities have been investigated as critically important in IBD pathogenesis, and attempts to develop effective therapies have predominantly targeted the immune system. Nevertheless, immune ...
Tópico(s): Inflammasome and immune disorders
2018 - Baishideng Publishing Group | World Journal of Gastroenterology
Produção Nacional
Revisado por pares
Lucila Marieta Perrotta de Souza, Jéssica Pronestino de Lima Moreira, Homero Soares Fogaça, Ronir Raggio Luiz, Heitor Siffert Pereira de Souza,
Objectives To describe incidence and lethality time trends rates of pancreatic cancer (PC) in Brazil. Methods Data from Brazilian Health National Public System (SUS) were retrospectively collected with regard to PC from January 2005 to December 2012. Pancreatic cancer incidence and lethality rates were estimated from SUS hospitalizations and in-hospital PC deaths and adjusted to total available hospital beds. Results From 2005 to 2012, a total of 36,332 admissions for PC were registered in Brazil. ...
Tópico(s): Childhood Cancer Survivors' Quality of Life
2017 - Lippincott Williams & Wilkins | Pancreas
Produção Nacional
Revisado por pares
Renata de Sá Brito Fróes, Ana Teresa Pugas Carvalho, Antônio José Carneiro, Adriana Maria Hilu de Barros Moreira, Jéssica Pronestino de Lima Moreira, Ronir Raggio Luiz, Heitor Siffert Pereira de Souza,
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2017 - Springer Science+Business Media | The European Journal of Health Economics
Produção Nacional
Revisado por pares
Vanessa Ribeiro Figliuolo, Luiz Eduardo Baggio Savio, Hanaa Safya, Hayandra F. Nanini, Cláudio Bernardazzi, Alessandra Abalo, Heitor Siffert Pereira de Souza, Jean Kanellopoulos, Pierre Bobé, Cláudia Mara Lara Melo Coutinho, Robson Coutinho‐Silva,
P2X7 receptor activation contributes to inflammation development in different pathologies. We previously reported that the P2X7 receptor is over-expressed in the gut mucosa of patients with inflammatory bowel disease, and that P2X7 inhibition protects against chemically induced colitis. Here, we investigated in detail the role of the P2X7 receptor in inflammatory bowel disease development, by treating P2X7 knockout (KO) and WT mice with two different (and established) colitis inductors. P2X7 KO mice ...
Tópico(s): Eosinophilic Esophagitis
2017 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Produção Nacional
Revisado por pares
Heitor Siffert Pereira de Souza,
Purpose of review Crohn's disease and ulcerative colitis, the two major forms of inflammatory bowel disease (IBD), represent chronic diseases of unknown cause, and they are regarded as prototypical complex diseases. Despite all the recent advances, a complete appreciation of the pathogenesis of IBD is still limited. In this review, we present recent information contributing to a better understanding of mechanisms underlying IBD. Recent findings Here, we attempt to highlight novel environmental triggers, ...
Tópico(s): Gut microbiota and health
2017 - Lippincott Williams & Wilkins | Current Opinion in Gastroenterology
Produção Nacional
Revisado por pares
Vanessa Ribeiro Figliuolo, Liliane Martins dos Santos, Alessandra Abalo, Hayandra F. Nanini, A. B. G. Santos, Nilda M. Brittes, Cláudio Bernardazzi, Heitor Siffert Pereira de Souza, Leda Quércia Vieira, Robson Coutinho‐Silva, Cláudia Mara Lara Melo Coutinho,
The intestinal microbiota is critical for mammalian immune system development and homeostasis. Sulfate-reducing bacteria (SRB) are part of the normal gut microbiota, but their increased levels may contribute to colitis development, likely in association with hydrogen sulfide (H2S) production. Here, we investigated the effects of SRB in the gut immune response in germ-free mice, and in experimental colitis. After 7days of colonization with Desulfovibrio indonesiensis or with a human SRB consortium ( ...
Tópico(s): IL-33, ST2, and ILC Pathways
2017 - Elsevier BV | Life Sciences
Produção Nacional
Revisado por pares
Marcelo A. Savi, Francisco Heitor I. Pereira-Pinto, Flavio M. Viola, Aline Souza de Paula, Davide Bernardini, Grzegorz Litak, Giuseppe Rega,
Shape Memory Alloy (SMA) dynamical systems may exhibit a rich response that can include periodic, quasi-periodic, chaotic and hyperchaotic behaviors. In this regard, diagnostic tools are important in order to identify the different types of behaviors. This paper aims to analyze systems with SMA elements through a nonlinear dynamics perspective with a specific focus on the use of 0–1 test to quantify the chaoticity of the dynamical response of SMA oscillators. The investigation includes different ...
Tópico(s): Chaos control and synchronization
2017 - Elsevier BV | Chaos Solitons & Fractals
Produção Nacional
Davy Rapozo, Cláudio Bernardazzi, Heitor Siffert Pereira de Souza,
Core tip
Tópico(s): Dietary Effects on Health
2017 - Baishideng Publishing Group | World Journal of Gastroenterology
Produção Nacional
Revisado por pares
Heitor Siffert Pereira de Souza, Claudio Fiocchi, Dimitrios Iliopoulos,
Tópico(s): Tuberculosis Research and Epidemiology
2017 - Nature Portfolio | Nature Reviews Gastroenterology & Hepatology
Produção Nacional
Revisado por pares
Cláudio Bernardazzi, Beatriz Pêgo, Heitor Siffert Pereira de Souza,
Intestinal immunity is finely regulated by several concomitant and overlapping mechanisms, in order to efficiently sense external stimuli and mount an adequate response of either tolerance or defense. In this context, a complex interplay between immune and nonimmune cells is responsible for the maintenance of normal homeostasis. However, in certain conditions, the disruption of such an intricate network may result in intestinal inflammation, including inflammatory bowel disease (IBD). IBD is believed ...
Tópico(s): Infant Health and Development
2016 - Hindawi Publishing Corporation | Mediators of Inflammation
Produção Nacional
Revisado por pares
Heitor Siffert Pereira de Souza, Claudio Fiocchi,
Tópico(s): Immune Cell Function and Interaction
2015 - Nature Portfolio | Nature Reviews Gastroenterology & Hepatology
Produção Nacional
Revisado por pares
Heitor Siffert Pereira de Souza, C A Tortori, Letícia Lintomen, Rodrigo T. Figueiredo, Cláudio Bernardazzi, Lin Leng, Richard Bucala, Kalil Madi, Fernanda Buongusto, Celeste C. Elia, Morgana T. Castelo-Branco, Marcelo T. Bozza,
Abstract Macrophage migration inhibitory factor (MIF) is involved in eosinophil biology and in type 2 inflammation, contributing to allergic and helminthic diseases. We hypothesized that MIF participates in the pathogenesis of eosinophilic esophagitis (EoE), an allergic condition characterized by esophageal eosinophilic inflammation. MIF is highly expressed in esophageal mucosa of patients with EoE, compared with gastro-esophageal reflux disease and control patients, where it co-localizes predominantly with ...
Tópico(s): Gastroesophageal reflux and treatments
2015 - Elsevier BV | Mucosal Immunology
Produção Nacional
Revisado por pares
Marcelo Soares Neves, Marlei Gomes da Silva, Grasiella M. Ventura, Patrícia Barbur Côrtes, Rafael Silva Duarte, Heitor Siffert Pereira de Souza,
Background and Aims Attention to patient safety has increased recently due to outbreaks of nosocomial infections associated with GI endoscopy. The aim of this study was to evaluate current cleaning and disinfection procedures of endoscope channels with high bioburden and biofilm analysis, including the use of resistant mycobacteria associated with postsurgical infections in Brazil. Methods Twenty-seven original endoscope channels were contaminated with organic soil containing 10 8 colony-forming units/mL ...
Tópico(s): Healthcare and Environmental Waste Management
2015 - Elsevier BV | Gastrointestinal Endoscopy
Produção Nacional
Revisado por pares
Paula P. Elia, Yolanda F. Tolentino, Cláudio Bernardazzi, Heitor Siffert Pereira de Souza,
Innate immunity constitutes the first line of defense, fundamental for the recognition and the initiation of an inflammatory response against microorganisms. The innate immune response relies on the sensing of microbial-associated molecular patterns through specialized structures such as toll-like receptors (TLRs) and the nucleotide oligomerization domain- (NOD-) like receptors (NLRs). In the gut, these tasks are performed by the epithelial barrier and the presence of adaptive and innate immune mechanisms. ...
Tópico(s): IL-33, ST2, and ILC Pathways
2015 - Hindawi Publishing Corporation | Mediators of Inflammation
Produção Nacional
Revisado por pares
Tiago Nunes, Cláudio Bernardazzi, Heitor Siffert Pereira de Souza,
Interleukin- (IL-) 33 is a widely expressed cytokine present in different cell types, such as epithelial, mesenchymal, and inflammatory cells, supporting a predominant role in innate immunity. IL-33 can function as a proinflammatory cytokine inducing Th2 type of immune response being involved with the defense against parasitic infections of the gastrointestinal tract. In addition, it has been proposed that IL-33 can act as a signaling molecule alerting the immune system of danger or tissue damage. ...
Tópico(s): Immune Cell Function and Interaction
2014 - Hindawi Publishing Corporation | Mediators of Inflammation
Produção Nacional
Revisado por pares
Adriane R. Neves, Morgana T. Castelo-Branco, Vanessa Ribeiro Figliuolo, Cláudio Bernardazzi, Fernanda Buongusto, Agnes N. Yoshimoto, Hayandra F. Nanini, Cláudia Mara Lara Melo Coutinho, Antonio José V. Carneiro, Robson Coutinho‐Silva, Heitor Siffert Pereira de Souza,
Extracellular nucleotides released in conditions of cell stress alert the immune system from tissue injury or inflammation. We hypothesized that the P2X7 receptor (P2X7-R) could regulate key elements in inflammatory bowel disease pathogenesis. Colonoscopy samples obtained from patients with Crohn's disease (CD), ulcerative colitis, and controls were used to analyze P2X7-R expression by RT and real-time PCR, immunohistochemistry, and confocal microscopy. Inflammatory response was determined by the ...
Tópico(s): Eosinophilic Esophagitis
2014 - Oxford University Press | Inflammatory Bowel Diseases
Ivan J. Fuss, Bharat Joshi, Zhiqiong Yang, Heba Degheidy, Stefan Fichtner‐Feigl, Heitor Siffert Pereira de Souza, Florian Rieder, Franco Scaldaferri, Anja Schirbel, Melania Scarpa, Gail West, Chuli Yi, Lili Xu, Pamela Leland, Michael Yao, Peter Mannon, Raj K. Puri, Claudio Fiocchi, Warren Strober,
Objective Previous studies have shown that ulcerative colitis (UC) is associated with the presence of lamina propria non-invariant (Type II) NKT cells producing IL-13 and mediating epithelial cell cytotoxicity. Here we sought to define the antigen(s) stimulating the NKT cells and to quantitate these cells in the UC lamina propria. Design Detection of Type II NKT cells in UC lamina propria mononuclear cells (LPMC) with lyso-sulfatide loaded tetramer and quantum dot-based flow cytometry and staining. ...
Tópico(s): Pharmacological Effects of Natural Compounds
2014 - BMJ | Gut