Christine Heim, Ulrike Ehlert, Jost E. Rexhausen, J. P. Hanker, Dirk H. Hellhammer,
... GermanySearch for more papers by this authorDIRK H. HELLHAMMER, DIRK H. HELLHAMMER Center for Psychobiological and Psychosomatic Research University of ... GermanySearch for more papers by this authorDIRK H. HELLHAMMER, DIRK H. HELLHAMMER Center for Psychobiological and Psychosomatic Research University of ... C., U. Ehlert, J. P. Hanker & D. H. Hellhammer Submitted for publication. 7 Dhabhar, F. S., A. ...
Tópico(s): Dermatology and Skin Diseases
1997 - Wiley | Annals of the New York Academy of Sciences
Friedemann Gerhards, Rachel Yehuda, Moran Shoham, Dirk H. Hellhammer,
... GermanySearch for more papers by this authorDIRK H. HELLHAMMER, Corresponding Author DIRK H. HELLHAMMER Center for Psychobiological and Psychosomatic Research University of ... GermanySearch for more papers by this authorDIRK H. HELLHAMMER, Corresponding Author DIRK H. HELLHAMMER Center for Psychobiological and Psychosomatic Research University of ...
Tópico(s): Migraine and Headache Studies
1997 - Wiley | Annals of the New York Academy of Sciences
Akira Tsuda, Masatoshi Tanaka,
... animals. In Neurobiological Approaches to Human Disease. D. Hellhammer, I. Florin & H. Weiner, Eds.: 335–343. Hans ... 287–290. 13 Rea, M. A. & D. H. Hellhammer. 1984. Activity wheel stress: Changes in brain norepinephrine ... N.Y. Acad. Sci. 575: 561–563. 30 Hellhammer, D. H., M. A. Rea, M. Bell & L. ...
Tópico(s): Stress Responses and Cortisol
1990 - Wiley | Annals of the New York Academy of Sciences
... 26Bohmelt A.H. Nater U.M. Franke S. Hellhammer D.H. Ehlert U. Basal and stimulated hypothalamic- ... 26Bohmelt A.H. Nater U.M. Franke S. Hellhammer D.H. Ehlert U. Basal and stimulated hypothalamic- ... 26Bohmelt A.H. Nater U.M. Franke S. Hellhammer D.H. Ehlert U. Basal and stimulated hypothalamic- ...
Tópico(s): Child Nutrition and Feeding Issues
2006 - Elsevier BV | Gastroenterology
John L. Gerlach, Bruce S. McEwen, Donald W. Pfaff, Sheila Moskovitz, Michael Ferin, Peter W. Carmel, Earl A. Zimmerman,
Dirk Hellhammer and his colleagues have played a major role in creating the field of psychoneuroendocrinology from their roots ... how they converged with the contributions from Dirk Hellhammer and his colleagues.
Tópico(s): Stress Responses and Cortisol
1976 - Elsevier BV | Brain Research
Anne Hirsch, Stephen M. Hirsch,
... consistent with the findings of other studies. Hubert, Hellhammer, and Freischem failed to find any evidence of ... Psychological impact of infertility. 1985Google Scholar, 25Hubert W. Hellhammer D.H. Freischem C.W. Psychobiological profiles in ...
Tópico(s): Family Dynamics and Relationships
1989 - Elsevier BV | JOGN Nursing
Dirk H. Hellhammer, Dirk H. Hellhammer,
for each drug for any change in indications and dosage and for added warnings and precautions.This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Tópico(s): COVID-19 and Mental Health
2008 - Karger Publishers | Key issues in mental health (Online)/Key issues in mental health (Print)
Ping‐Chang Yang, Jennifer Jury, Johan D. Söderholm, Philip M. Sherman, Derek M. McKay, Mary H. Perdue,
... PubMed Scopus (16) Google Scholar, 12Buske-Kirschbaum A Hellhammer DH Endocrine and immune responses to stress in ... PubMed Scopus (16) Google Scholar, 12Buske-Kirschbaum A Hellhammer DH Endocrine and immune responses to stress in ...
Tópico(s): Stress Responses and Cortisol
2006 - Elsevier BV | American Journal Of Pathology
Eva Fries, Dirk H. Hellhammer, Dirk H. Hellhammer,
Tópico(s): Tryptophan and brain disorders
2006 - Elsevier BV | Psychoneuroendocrinology
Dirk H. Hellhammer, Torsten Hero, Friedemann Gerhards, Dirk H. Hellhammer,
Translational research is most prominently represented by the search for biomarkers and preclinical research. Aside from generating such new measures and methodologies, translational research additionally refers to translation of integrated knowledge. This strategy involves synthesis, exchange, and dissemination of available knowledge, with the goal of improving health services and health care systems. For stress-related disorders, such as depression and anxiety disorders, this strategy meets numerous ...
Tópico(s): Tryptophan and brain disorders
2012 - Informa | Stress
... method is extensively used in psychoneuroendocrinological research (Kirschbaum & Hellhammer, 1994). For example, studies of naturalistic life events ... see: Hanrahan, 2006; Jessop & Turner-Cobb, 2006; Kirschbaum & Hellhammer, 1994; and Schmidt, 1997.
Tópico(s): Neuroendocrine regulation and behavior
2012 - Elsevier BV | Journal of Pediatric Nursing
Eva Fries, Judith Hesse, Dirk H. Hellhammer, Dirk H. Hellhammer,
Low cortisol levels have been observed in patients with different stress-related disorders such as chronic fatigue syndrome, fibromyalgia, and post-traumatic stress disorder. Data suggest that these disorders are characterized by a symptom triad of enhanced stress sensitivity, pain, and fatigue. This overview will present data on the development, mechanisms and consequences of hypocortisolism on different bodily systems. We propose that the phenomenon of hypocortisolism may occur after a prolonged ...
Tópico(s): Fibromyalgia and Chronic Fatigue Syndrome Research
2005 - Elsevier BV | Psychoneuroendocrinology
Wolff Schlotz, Peter J. Schulz, Dirk H. Hellhammer, Arthur A. Stone, Dirk H. Hellhammer,
Stress and negative affective states are associated with cortisol in everyday life. However, it remains unclear what types of stressors and which affective states yield these associations, and the effect of trait anxiety is unknown. This study investigates the associations of specific task-related stressors and negative affective states in everyday life with salivary cortisol, and explores the mediating and moderating role of state negative affect and trait anxiety, respectively. Salivary cortisol, ...
Tópico(s): Health, psychology, and well-being
2005 - Elsevier BV | Psychoneuroendocrinology
Dirk H. Hellhammer, Eva Fries, Claudia Buß, Veronika Engert, A. Tuch, David Rutenberg, Dirk H. Hellhammer,
Phosphatidylserine, derived from cow brains, has been shown previously to dampen the ACTH and cortisol response to physical stress. Further research investigated the influence of soy lecithin phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor. In this study, we investigated the effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) supplementation on pituitary adrenal reactivity (ACTH, cortisol) and on the psychological response (Spielberger ...
Tópico(s): Tryptophan and brain disorders
2004 - Informa | Stress
Dirk H. Hellhammer, Wolff Schlotz, Arthur A. Stone, Karl‐Martin Pirke, Dirk H. Hellhammer,
A bstract : Overactivity of the hypothalamus‐pituitary‐adrenal axis (HPAA) has been observed in the presence of acute stress and, under chronic conditions, in disorders such as depression and anorexia nervosa as well as in cardiovascular and metabolic disorders. However, there may be other stress‐related disorders (fatigue, pain, etc) that seem to be associated with mild hypocortisolism. This suggests that two major subtypes of the HPAA response to stress need to be discriminated. In this study, we ...
Tópico(s): Fibromyalgia and Chronic Fatigue Syndrome Research
2004 - Wiley | Annals of the New York Academy of Sciences
J. Caroline Dekkers, Rinie Geenen, Guido L. R. Godaert, Lorenz J.P. van Doornen, J. W. J. Bijlsma,
... Biol 1992; 43: 683–92. 4 Kirschbaum C, Hellhammer DH. Salivary cortisol in psychological research: an overview. ... 150–69. 5 Schmidt-Reinwald A, Pruessner JC, Hellhammer DH, Federenko I, Rohleder N, Schurmeyer TH, et ...
Tópico(s): Multiple Sclerosis Research Studies
2000 - Wiley | Arthritis & Rheumatism
... 171. Heim C. Ehlert U. Hanker J.P. Hellhammer D. Abuse-related posttraumatic stress disorder and alterations ... 60 1998 309– 318. Heim C. Ehlert U. Hellhammer D.H. The potential role of hypocortisolism in ...
Tópico(s): Stress Responses and Cortisol
2000 - Wiley | European Journal of Pain
Ken A. Rose, Adrian K. Allan, Stephan D. Gauldie, Genevieve Stapleton, Lorraine Dobbie, Karin Dott, Cécile Martin, Ling Wang, Eva Hedlund, Jonathan R. Seckl, Jan-Ακε Gustafsson, Richard Lathe,
... 787) Google Scholar,17Wolf O.T. Neumann O. Hellhammer D.H. Geiben A.C. Strasburger C.J. ... 242) Google Scholar, 18Wolf O.T. Naumann E. Hellhammer D.H. Kirschbaum C. J. Gerontol. A Biol. ...
Tópico(s): Pharmacogenetics and Drug Metabolism
2001 - Elsevier BV | Journal of Biological Chemistry
Brigitte M. Kudielka, Dirk H. Hellhammer, Dirk H. Hellhammer, Oliver T. Wolf, Karl-Martin Pirke, Enikő Váradi, Jürgen Pilz, Clemens Kirschbaum,
Evidence from animal as well as human studies has suggested that significant sex differences exist in hypothalamus-pituitary-adrenal axis (HPA) activity. As gonadal steroids could be important modulators of HPA sex differences, stress responses were investigated in subjects of advanced age after dehydroepiandrosterone (DHEA) or placebo treatment. After a 2-week treatment with 50 mg DHEA daily or placebo, 75 men and women (mean age, 67.6 yr) were exposed to the Trier Social Stress Test (TSST). The TSST ...
Tópico(s): Hormonal and reproductive studies
1998 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
Oliver T. Wolf, Brigitte M. Kudielka, Dirk H. Hellhammer, Dirk H. Hellhammer, Clemens Kirschbaum,
Aging is accompanied by a continuous decline of the adrenal steroid hormone DHEA and its ester DHEAS. Results from studies in rodents have demonstrated that DHEA(S) administration can enhance memory in several test paradigms. However studies from this laboratory did not find positive effects of DHEA treatment on cognitive performance in young and elderly humans. With respect to a possible mechanism of DHEA activity, effects on several neurotransmitter receptors as well as a possible antiglucocorticoid ...
Tópico(s): Hormonal Regulation and Hypertension
1998 - Elsevier BV | Psychoneuroendocrinology
Dirk Hellhammer and his colleagues have played a major role in creating the field of psychoneuroendocrinology from their roots ... how they converged with the contributions from Dirk Hellhammer and his colleagues.
Tópico(s): Hormonal Regulation and Hypertension
2018 - Elsevier BV | Psychoneuroendocrinology
Gregor Domes, Christian Frings,
... was developed almost 30 years ago (Kirschbaum, Pirke, & Hellhammer, 1993). The TSST has been shown to induce ... in articleLink, Google ScholarKirschbaum, C., Pirke, K.-M., & Hellhammer, D. H. (1993). The 'Trier social stress test' – ...
Tópico(s): Health, psychology, and well-being
2020 - Hogrefe Verlag | Experimental Psychology (formerly Zeitschrift für Experimentelle Psychologie)
H. Schmalbruch, U. Hellhammer,
The number and the size of different populations of nuclei were studied in skeletal muscles and in the diaphragm of male Wistar rats of 200-250 g weight. Nuclei on cross-sections were counted and classified by electron microscopy, their incidence was corrected for their different lengths, and the number of nuclei per mm3 of muscle was determined by light microscopy. The total number of nuclei per mm3 was 5-10(4) in the superficial part of the anterior tibial muscle, it was 10-10(4) in the soleus, ...
Tópico(s): Cardiovascular Effects of Exercise
1977 - Wiley | The Anatomical Record
H. Schmalbruch, U. Hellhammer,
Abstract The satellite cell population in skeletal muscles of ten normal subjects aged 7 to 73 years was quantitated by electron microscopy. In all 1,414 nuclei were assessed. Satellite cell nuclei comprised 4% (standard deviation 2%) of all nuclei within the fibre basal lamina. The lowest incidence (0.6%) was found in a 73‐year‐old man. The study confirms, that satellite cells are regularly present in human skeletal muscle.
Tópico(s): Nutrition and Health in Aging
1976 - Wiley | The Anatomical Record
Dirk H. Hellhammer, J.N. Hingtgen, Stephen E. Wade, Philip A. Shea, M. H. Aprison,
To study serotonergic involvement in the development of gastric lesions following activity wheel stress, three groups of rats (gastric lesions, no gastric lesions, and home—cage controls) were killed following exposure to the experimental procedures. The brains were dissected into eight specific areas and subjected to analyses for serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) using high performance liquid chromatography with EC detection. Lower levels of 5-HT were found in the midbrain, ...
Tópico(s): Gastrointestinal motility and disorders
1983 - Lippincott Williams & Wilkins | Psychosomatic Medicine
The effects of activity wheel stress on brain regional norepinephrine (NE) and 3-methoxy-4-hydroxyphenylglycol (MHPG) content and on the occurrence of gastric lesions were investigated. Multiple gastric lesions were present in the stomachs of all rats exposed to activity wheel stress (AW). No gastric lesions were observed in any of the food consumption (FC) or untreated (UC) control rats. In AW rats, NE levels were significantly different (p < 0.05) from UC and/or FC rats in the hypothalamus (––25%), striatum (+ ...
Tópico(s): Animal Nutrition and Physiology
1984 - Karger Publishers | Psychotherapy and Psychosomatics
Dirk H. Hellhammer, M.A. Rea, M. E. Bell, L. Belkien, Marius Ludwig,
The effect of the learned helplessness paradigm, a model of depression, on biogenic amines in eight brain regions, and on the serum levels of luteinizing hormone, corticosterone, and testosterone in male rats was determined. Rats which were exposed to uncontrollable and unpredictable shocks (HY-rats) had hormone levels similar to those in appropriate control animals. However, HY-rats had higher levels of 5-H1AA in the pons/medulla oblongata and lower levels of 5-HT in the cortex than rats which could ...
Tópico(s): Child and Adolescent Psychosocial and Emotional Development
1984 - Elsevier BV | Pharmacology Biochemistry and Behavior
D.H. Hellhammer, M.A. Rea, M. E. Bell, L. Belkien,
The study was designed to study the possible role of dopaminergic and serotonergic systems in pituitary gonadal function following activity stress. 3 groups of rats were caged individually. 1 group of rats (AW) was fed for 1 h each day and had free access to a running wheel. The 2nd group (FC) had no access to a running wheel and received exactly the same amount of food as animals of the AW group. The 3rd group (UC) had 24-hour access to food. AW rats showed a gradual increase in running activity which ...
Tópico(s): Tryptophan and brain disorders
1984 - Karger Publishers | Neuropsychobiology
Walter Hubert, Dirk H. Hellhammer, C. W. Freischem,
To investigate the psychosomatic impact in male infertility, we analysed relationships among psychological (life events, personality attitudes) and biological (gonadotrophins, sex steroids, seminal parameters) variables in 101 husbands of barren couples. In patients with subnormal fertility parameters, personality attitudes were not different from those of a reference group of the questionnaire (FAPK) used in this study. However, patients with high scores on test scales such as regression, hypochondria, ...
Tópico(s): Family Dynamics and Relationships
1985 - Elsevier BV | Journal of Psychosomatic Research
Dirk H. Hellhammer, Walter Hubert, C. W. Freischem, Eberhard Nieschlag,
We investigated the relationship between objective psychologic test data and endocrine parameters as well as ejaculate characteristics in 117 husbands in barren couples. Data analysis suggests that test scores indicating high self-confidence, extraversion, and social assertiveness correspond negatively with male fertility parameters. Our results show that levels of gonadotropins and sex steroids, as well as accessory gland functions, are not randomly related to personality attitudes in these patients, ...
Tópico(s): Sexual Differentiation and Disorders
1985 - Lippincott Williams & Wilkins | Psychosomatic Medicine