... studiert am Fall der geladenen skalaren Theorie Helmut Jahn, Helmut Jahn Institut für Theoretische Physik der Universität HamburgSearch for more papers by this author Helmut Jahn, Helmut Jahn Institut für Theoretische Physik der Universität HamburgSearch for ...
Tópico(s): Quantum chaos and dynamical systems
1959 - Wiley | Fortschritte der Physik
Verena Jahn, Helmut Breuninger, Claus Garbe, Matthias Moehrle,
Background The ear's specific anatomical and lymphatic characteristics impose special requirements on the treatment of melanoma of the ear. Objectives The aim of this prospective study was to define prognostic factors for melanoma of the ear and to evaluate surgical strategies for excision margins, histological evaluation and sentinel lymph node biopsy (SLNB) in order to achieve better cosmetic and functional results. Patients and methods One-hundred and sixty-one patients with stage I/II melanoma ...
Tópico(s): Nonmelanoma Skin Cancer Studies
2006 - Oxford University Press | British Journal of Dermatology
Verena Jahn, Helmut Breuninger, Claus Garbe, Marcus M. Maassen, Matthias Moehrle,
Abstract Objectives: The prominent position of the nose in the face accounts for its constant exposure to sunlight and thus its high incidence of malignant involvement. The aim of this prospective study was to define prognostic factors for nasal melanomas and to evaluate surgical strategies. Methods: Forty‐five patients with stage I/II melanoma were included. Malignant melanomas of the nose represented 0.8% of stage I/II cutaneous melanoma and 5.3% of head and neck melanoma (1983–2004). The median ...
Tópico(s): Cutaneous Melanoma Detection and Management
2006 - Wiley | The Laryngoscope
Reinhard Jahn, Helmut Grubmüller,
Fusion of biological membranes is governed by physical principles but it is unclear whether the transition states are primarily determined by lipid physics or by protein-lipid interactions. Recent advances in the field include the physical description of bilayer fusion, particularly new models beyond continuum models and the role of the SNARE proteins. Despite substantial progress, an integrated concept for protein-mediated membrane fusion is not yet available, and many open questions remain to ...
Tópico(s): RNA and protein synthesis mechanisms
2002 - Elsevier BV | Current Opinion in Cell Biology
Roland Jahns, Christian Siegmund, Valérie Jahns, Helmut Reiländer, Armin Maidhof, Werner Müller‐Esterl, Martin J. Lohse, Fritz Boege,
In order to generate antibodies suitable for immunological studies on beta-adrenoceptors constitutively expressed at low levels in cells or tissues we have produced fusion proteins of the amino- and carboxy-terminus, and the second extracellular loop of the human beta 1- or beta 2-adrenoceptors with bacterial glutathione-S-transferase in E. coli. Rabbit antibodies raised against these fusion proteins strongly reacted with intact human beta 1- or beta 2-adrenoceptors in a subtype- and domain-specific ...
Tópico(s): Neuroscience and Neuropharmacology Research
1996 - Elsevier BV | European Journal of Pharmacology
D. Oertel, D. Spänkuch, H. Jahn, Helmut Becker-Roß, W. Stadthaus, J. Nopirakowski, W. Döhler, Klaus Schäfer, J. Güldner, R. Dubois, В. І. Мороз, V. M. Linkin, V. V. Kerzhanovich, I.A. Matsgorin, A. N. Lipatov, A. A. Shurupov, L. V. Zasova, E. A. Ustinov,
Fourier spectrometers for the investigation of infrared spectra of Venus were installed on the recent Soviet orbiters “Venera-15” and “Venera-16”. Many spectra with reliable absolute calibration were obtained in the 280–1500 cm−1 region with a spectral resolution of 5 cm−1 (ground based processing) and about 7 cm−1 (preoprocessed on board) and a spatial resolution of about 100 km at the Venusian cloud top level. Bands of CO2, H2O, H2SO4 and SO2 are identified. The 15 μm-CO2- fundamental band was used ...
Tópico(s): Atmospheric and Environmental Gas Dynamics
1985 - Elsevier BV | Advances in Space Research
Simone C. Tauber, Sandra Ribes, Sandra Ebert, Torsten Joseph Heinz, Volker Fingerle, Stephanie Bunkowski, Dominik Kugelstadt, Annette Spreer, Olaf Jahn, Helmut Eiffert, Roland Nau,
Lyme neuroborreliosis (LNB) is the most frequent tick-borne infectious disease of the central nervous system. In acute LNB and the rare chronic state of infection, patients can experience cognitive deficits such as attention and memory disturbances. During LNB, single compounds of Borrelia burgdorferi sensu lato are released into the subarachnoid space.
Tópico(s): Dermatological diseases and infestations
2011 - Oxford University Press | Journal of Neuropathology & Experimental Neurology
Mardjan Arvand, Thomas Schneider, H Jahn, Helmut Hahn,
Streptococcal toxic shock syndrome (strepTSS) has been associated with various streptococcal soft-tissue infections including cellulitis, necrotizing fasciitis, and peritonitis in adults. We describe a 40-year-old patient with pharyngitis and strepTSS. Throat swab cultures yielded a strain of Streptococcus pyogenes that produced large amounts of erythrogenic toxin A. Fluorescence-activated cell sorter analysis of the patient's peripheral blood lymphocytes revealed generally enhanced expression of ...
Tópico(s): Botulinum Toxin and Related Neurological Disorders
1996 - Oxford University Press | Clinical Infectious Diseases
Marlene Remely, Eva Aumueller, Daniel Jahn, Berit Hippe, Helmut Brath, Alexander G. Haslberger,
Metabolic syndrome is associated with alterations in the structure of the gut microbiota leading to low-grade inflammatory responses. An increased penetration of the impaired gut membrane by bacterial components is believed to induce this inflammation, possibly involving epigenetic alteration of inflammatory molecules such as Toll-like receptors (TLRs). We evaluated changes of the gut microbiota and epigenetic DNA methylation of TLR2 and TLR4 in three groups of subjects: type 2 diabetics under glucagon- ...
Tópico(s): Diet and metabolism studies
2014 - | Beneficial Microbes
Stefan Wolfart, Frauke Müller, Joachim Gerß, G. Heyedcke, Birgit Marré, K. Böning, Bernd Wöstmann, Matthias Kern, Torsten Mündt, Wolfgang Hannak, Julia Brückner, Nicole Passia, F. Jahn, Sinsa Hartmann, Helmut Stark, Elisabeth Richter, W Gernet, Ralph G. Luthardt, Michael H. Walter,
Tópico(s): Dental materials and restorations
2013 - Springer Nature | Clinical Oral Investigations
Falk Kiefer, Holger Jahn, Christian Otte, Helmut Nakovics, Klaus Wiedemann,
Tópico(s): Pain Mechanisms and Treatments
2006 - Elsevier BV | Neuroscience Letters
... and the Philharmonie, one sees the scaffolding of Helmut Jahn’s eleven-storey Sony Center, which, in its ...
Tópico(s): Architecture, Modernity, and Design
2000 - The MIT Press | PAJ A Journal of Performance and Art
Georg Martius, Luisa Jahn, Helmut Häuser, Verena V. Hafner,
One of the long-term goals of artificial life research is to create autonomous, self-motivated, and intelligent animats. We study an intrinsic motivation system for behavioral self-exploration based on the maximization of the predictive information using the Stumpy robot, which is the first evaluation of the algorithm on a real robot. The control is organized in a closed-loop fashion with a reactive controller that is subject to fast synaptic dynamics. Even though the available sensors of the robot ...
Tópico(s): Reinforcement Learning in Robotics
2014 - Springer Science+Business Media | Lecture notes in computer science
... de Groot4, Dietmar Riedel1, Sirkka Keränen5, Hans Ronne6, Helmut Grubmüller4 and Reinhard Jahn 1 1Department of Neurobiology, Max-Planck-Institute for ...
Tópico(s): Lipid Membrane Structure and Behavior
2000 - Springer Nature | The EMBO Journal
... Sektion Mathematik Ernst-Moritz-Arndt-Universität Friedrich-Ludwig-Jahn-Str. 15 DDR - Greifswald 2200Search for more papers by this author Helmut Boseck, Helmut Boseck Sektion Mathematik Ernst-Moritz-Arndt-Universität Friedrich-Ludwig-Jahn-Str. 15 DDR - Greifswald 2200Search for more papers ...
Tópico(s): Nonlinear Waves and Solitons
1990 - Wiley | Mathematische Nachrichten
... Sektion Mathematik Ernst-Moritz-Arndt-Universität Friedrich-Ludwig-Jahn-Straße 15a DDR-Greifswald 2200Search for more papers by this author Helmut Boseck, Helmut Boseck Sektion Mathematik Ernst-Moritz-Arndt-Universität Friedrich-Ludwig-Jahn-Straße 15a DDR-Greifswald 2200Search for more papers ...
Tópico(s): Nonlinear Waves and Solitons
1989 - Wiley | Mathematische Nachrichten
Werner Sobek, Lucio Blandini, Annette Krtscha,
... sogenannte Mansueto Library, erweitert. Dieser vom Chicagoer Architekten Helmut Jahn entworfene Anbau wird durch eine weitspannende Stahlgitterschale überdacht, ... eine Gitterschale aus Stahlrohren, aufgeständert ist. Die von Helmut Jahn in enger Zusammenarbeit mit Werner Sobek entworfene transparente ... called Mansueto Library – designed by Chicago‐based architect Helmut Jahn – is covered by an all but dematerialized glazed ...
Tópico(s): Archaeological Research and Protection
2011 - Wiley | Stahlbau
Wael Al Zoughbi, Martin Pichler, Gregor Gorkiewicz, Barbara Guertl‐Lackner, Johannes Haybaeck, Stephan Jahn, Carolin Lackner, Bernadette Liegl‐Atzwanger, Helmut Popper, Silvia Schauer, Elisa Nusshold, Alida Kindt, Zlatko Trajanoski, Michael R. Speicher, Guenter Haemmerle, Robert Zimmermann, Rudolf Zechner, Paul Vesely, Gerald Höefler,
Metabolic reprogramming is a hallmark of cancer. Understanding cancer metabolism is instrumental to devise innovative therapeutic approaches. Anabolic metabolism, including the induction of lipogenic enzymes, is a key feature of proliferating cells. Here, we report a novel tumor suppressive function for adipose triglyceride lipase (ATGL), the rate limiting enzyme in the triglyceride hydrolysis cascade.In immunohistochemical analysis, non-small cell lung cancers, pancreatic adenocarcinoma as well ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2016 - Impact Journals LLC | Oncotarget
Agata Witkowska, Leonard P. Heinz, Helmut Grubmüller, Reinhard Jahn,
Abstract Membrane fusion is fundamental to biological processes as diverse as membrane trafficking or viral infection. Proteins catalyzing membrane fusion need to overcome energy barriers to induce intermediate steps in which the integrity of bilayers is lost. Here, we investigate the structural features of tightly docked intermediates preceding hemifusion. Using lipid vesicles in which progression to hemifusion is arrested, we show that the metastable intermediate does not require but is enhanced ...
Tópico(s): Force Microscopy Techniques and Applications
2021 - Nature Portfolio | Nature Communications
Patricia Bassereau, Rui Jin, Tobias Baumgart, Markus Deserno, Rumiana Dimova, Vadim A. Frolov, Pavel V. Bashkirov, Helmut Grubmüller, Reinhard Jahn, Herre Jelger Risselada, Ludger Johannes, Michael M. Kozlov, Reinhard Lipowsky, Thomas J. Pucadyil, Wade F. Zeno, Jeanne C. Stachowiak, Dimitrios Stamou, Artù Breuer, Line Lauritsen, Camille Simon, Cécile Sykes, Gregory A. Voth, Thomas R. Weikl,
The importance of curvature as a structural feature of biological membranes has been recognized for many years and has fascinated scientists from a wide range of different backgrounds. On the one hand, changes in membrane morphology are involved in a plethora of phenomena involving the plasma membrane of eukaryotic cells, including endo- and exocytosis, phagocytosis and filopodia formation. On the other hand, a multitude of intracellular processes at the level of organelles rely on generation, modulation, ...
Tópico(s): Cellular transport and secretion
2018 - Institute of Physics | Journal of Physics D Applied Physics
Geert van den Bogaart, Shashi Thutupalli, Jelger H Risselada, Karsten Meyenberg, Matthew G. Holt, Dietmar Riedel, Ulf Diederichsen, Stephan Herminghaus, Helmut Grubmüller, Reinhard Jahn,
Synaptotagmin-1 triggers Ca(2+)-sensitive, rapid neurotransmitter release by promoting interactions between SNARE proteins on synaptic vesicles and the plasma membrane. How synaptotagmin-1 promotes this interaction is unclear, and the massive increase in membrane fusion efficiency of Ca(2+)-bound synaptotagmin-1 has not been reproduced in vitro. However, previous experiments have been performed at relatively high salt concentrations, screening potentially important electrostatic interactions. Using ...
Tópico(s): Erythrocyte Function and Pathophysiology
2011 - Nature Portfolio | Nature Structural & Molecular Biology
Martin Margittai, Jerker Widengren, Enno Schweinberger, Gunnar F. Schröder, Suren Felekyan, Elke Haustein, Marcelle König, Dirk Fasshauer, Helmut Grubmüller, Reinhard Jahn, Claus A. M. Seidel,
Protein conformational transitions form the molecular basis of many cellular processes, such as signal transduction and membrane traffic. However, in many cases, little is known about their structural dynamics. Here we have used dynamic single-molecule fluorescence to study at high time resolution, conformational transitions of syntaxin 1, a soluble N -ethylmaleimide-sensitive factor attachment protein receptors protein essential for exocytotic membrane fusion. Sets of syntaxin double mutants were ...
Tópico(s): Lipid Membrane Structure and Behavior
2003 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Thorsten Lang, Martin Margittai, Helmut Hölzler, Reinhard Jahn,
During neuronal exocytosis, the vesicle-bound soluble NSF attachment protein (SNAP) receptor (SNARE) synaptobrevin 2 forms complexes with the plasma membrane–bound SNAREs syntaxin 1A and SNAP25 to initiate the fusion reaction. However, it is not known whether in the native membrane SNAREs are constitutively active or whether they are unable to enter SNARE complexes unless activated before membrane fusion. Here we used binding of labeled recombinant SNAREs to inside-out carrier supported plasma membrane ...
Tópico(s): Endoplasmic Reticulum Stress and Disease
2002 - Rockefeller University Press | The Journal of Cell Biology
Ralph G. Luthardt, Birgit Marré, Achim Heinecke, Joachim Gerß, Hans Aggstaller, E. Busche, Paul Dressler, I Gitt, Wolfgang Hannak, Sinsa Hartmann, Guido Heydecke, F. Jahn, Matthias Kern, Torsten Mündt, Peter Pospiech, Helmut Stark, Bernd Wöstmann, Michael H. Walter,
Various treatment options for the prosthetic treatment of jaws where all molars are lost are under discussion. Besides the placement of implants, two main treatment types can be distinguished: replacement of the missing molars with removable dental prostheses and non-replacement of the molars, i.e. preservation of the shortened dental arch. Evidence is lacking regarding the long-term outcome and the clinical performance of these approaches. High treatment costs and the long time required for the ...
Tópico(s): Orthodontics and Dentofacial Orthopedics
2010 - Springer Science+Business Media | Trials
V. Kempe, D. Oertel, R. Schuster, Helmut Becker-Roß, H. Jahn,
Abstract It is well known that temperature- and watervapour-profiles, ozone concentration, other atmospheric constituents and the surface-radiation of the Earth can be determined by remote sensing in the IR radiation range with the aid of a satellite. The narrow-band radiation measurements for remote sensing of the atmosphere and the Earth-surface can be realized either by various radiometers working in selected frequency channels or, continuously in a given frequency range, by spectrometers with ...
Tópico(s): Spacecraft Design and Technology
1980 - Elsevier BV | Acta Astronautica
Hannes Alessandrini, Daniel Oberladstätter, Helmut Trimmel, Beate Jahn, Michael Baubin,
Tópico(s): Sepsis Diagnosis and Treatment
2010 - Springer Science+Business Media | Notfall + Rettungsmedizin
Stefanie Tietz, Sujith Puthiyaveetil, Heather M. Enlow, Robert Yarbrough, Magnus Wood, Dmitry A. Semchonok, Troy W. Lowry, Zhirong Li, Peter Jahns, Egbert J. Boekema, Steven Lenhert, Krishna Niyogi, Helmut Kirchhoff,
The structural organization of proteins in biological membranes can affect their function. Photosynthetic thylakoid membranes in chloroplasts have the remarkable ability to change their supramolecular organization between disordered and semicrystalline states. Although the change to the semicrystalline state is known to be triggered by abiotic factors, the functional significance of this protein organization has not yet been understood. Taking advantage of an Arabidopsis thaliana fatty acid desaturase ...
Tópico(s): Mitochondrial Function and Pathology
2015 - Elsevier BV | Journal of Biological Chemistry
Theodor Wieland, Heinz Faulstich, Werner Jahn, M. Variath Govindan, H. Puchinger, Z Kopitar, Helmut Schmaus, Alwine Schmitz,
Tópico(s): Ecology, Conservation, and Geographical Studies
1972 - De Gruyter | Hoppe-Seyler´s Zeitschrift für physiologische Chemie
Tópico(s): European history and politics
1980 - | Design Quarterly
Ahmad Zia, Berkley J. Walker, Hui Min Olivia Oung, Dana Charuvi, Peter Jahns, Asaph B. Cousins, Jill M. Farrant, Ziv Reich, Helmut Kirchhoff,
Summary The group of homoiochlorophyllous resurrection plants evolved the unique capability to survive severe drought stress without dismantling the photosynthetic machinery. This implies that they developed efficient strategies to protect the leaves from reactive oxygen species ( ROS ) generated by photosynthetic side reactions. These strategies, however, are poorly understood. Here, we performed a detailed study of the photosynthetic machinery in the homoiochlorophyllous resurrection plant Craterostigma ...
Tópico(s): Plant responses to water stress
2016 - Wiley | The Plant Journal