Monal Patel, Dan Predescu, Cristina Bardita, Jiwang Chen, Niranjan Jeganathan, Melanie Pritchard, Salvatore DiBartolo, Roberto F. Machado, Sanda Predescu,
... Pogoriler J. Bhorade S. Wang M. Comhair S. Hemnes A.R. Chen J. Machado R. Husain A. ... Pogoriler J. Bhorade S. Wang M. Comhair S. Hemnes A.R. Chen J. Machado R. Husain A. ... Pogoriler J. Bhorade S. Wang M. Comhair S. Hemnes A.R. Chen J. Machado R. Husain A. ... Pogoriler J. Bhorade S. Wang M. Comhair S. Hemnes A.R. Chen J. Machado R. Husain A. ... Pogoriler J. Bhorade S. Wang M. Comhair S. Hemnes A.R. Chen J. Machado R. Husain A. ... Pogoriler J. Bhorade S. Wang M. Comhair S. Hemnes A.R. Chen J. Machado R. Husain A. ...
Tópico(s): Cardiomyopathy and Myosin Studies
2017 - Elsevier BV | American Journal Of Pathology
Anna R. Hemnes, Evan L. Brittain,
... Arterial HypertensionTime to Rest and Digest Anna R. Hemnes, MD and Evan L. Brittain, MD, MSCI Anna R. HemnesAnna R. Hemnes Division of Allergy, Pulmonary, and Critical Care Medicine ( ... primum non nocere (first do no harm).DisclosuresDr Hemnes received grant funding from the National Institutes of ... American Heart Association.http://circ.ahajournals.orgAnna R. Hemnes, MD, Division of Allergy, Pulmonary, and Critical Care ... Robbins IM, Loyd JE, Newman JH, Austin ED, Hemnes AR. Prostanoids but not oral therapies improve right ...
Tópico(s): Heart rate and cardiovascular health
2018 - Lippincott Williams & Wilkins | Circulation
... 2013; 127:55–62.LinkGoogle Scholar8. Robbins IM, Hemnes AR, Pugh ME, Brittain EL, Zhao DX, Piana ... Assad T, Robbins I, Newman J, Pugh M, Hemnes A and Brittain E (2019) Echocardiographic Detection of ... Noordegraaf A, Chin K, Haddad F, Hassoun P, Hemnes A, Hopkins S, Kawut S, Langleben D, Lumens ... Geraci M, Gillies H, Gladwin M, Gray M, Hemnes A, Herbst R, Hernandez A, Hill N, Horn ...
Tópico(s): Cardiac Valve Diseases and Treatments
2014 - Lippincott Williams & Wilkins | Circulation Heart Failure
Anna R. Hemnes, Gerald J. Beck, John H. Newman, Aiden Abidov, Micheala A. Aldred, John Barnard, Erika B. Rosenzweig, Barry A. Borlaug, Wendy K. Chung, Suzy Comhair, Serpil C. Erzurum, Robert P. Frantz, Michael P. Gray, Gabriele Grünig, Paul M. Hassoun, Nicholas S. Hill, Evelyn M. Horn, Bo Hu, Jason K. Lempel, Bradley A. Maron, Stephen C. Mathai, Mitchell A. Olman, Franz Rischard, David M. Systrom, W.H. Wilson Tang, Aaron B. Waxman, Lei Xiao, Jason X.‐J. Yuan, Jane A. Leopold,
... of Pulmonary Vascular Disease Through Phenomics Anna R. Hemnes, Gerald J. Beck, John H. Newman, Aiden Abidov, ... Leopoldthe PVDOMICS Study Group Anna R. HemnesAnna R. Hemnes From the Vanderbilt University, Nashville, TN (A.R. ...
Tópico(s): Chronic Obstructive Pulmonary Disease (COPD) Research
2017 - Lippincott Williams & Wilkins | Circulation Research
David Langleben, Stylianos E. Orfanos, Michele Giovinazzo, Robert Schlesinger, Andrew M. Hirsch, Fay Blenkhorn, Lyda Lesenko, Apostolos Armaganidis, John D. Catravas,
... New Disease? Evan L. Brittain and Anna R. Hemnes Vasodilator-Responsive Idiopathic Pulmonary Arterial Hypertension: Evidence for ... New Disease? Evan L. Brittain and Anna R. Hemnes Metrics Cited byEndothelial Damage in Acute Respiratory Distress ... Evan L. Brittain, MD, MSCI and Anna R. Hemnes, MDResearch Reviews: Vasoreactivity in PAH 20 January 2015Volume ...
Tópico(s): Heart Failure Treatment and Management
2015 - American College of Physicians | Annals of Internal Medicine
... 1672–1678.LinkGoogle Scholar4. Austin ED, Hamid R, Hemnes AR, Loyd JE, Blackwell T, Yu C, Phillips ... Parker C, Colglazier E, Nawaytou H, Leary P, Hemnes A, Teitel D and Fineman J (2020) Novel ...
Tópico(s): Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
2019 - Lippincott Williams & Wilkins | Circulation Research
Brian A. Houston, Ryan J. Tedford,
... 1161/CIRCHEARTFAILURE.117.004082.LinkGoogle Scholar13. Assad TR, Hemnes AR, Larkin EK, Glazer AM, Xu M, Wells ... 1-10), Online publication date: 1-Jan-2019. Hemnes A, Opotowsky A, Assad T, Xu M, Doss ...
Tópico(s): Congenital Heart Disease Studies
2017 - Lippincott Williams & Wilkins | Circulation Heart Failure
Harry Karmouty‐Quintana, Hongyan Zhong, Luis Acero, Tingting Weng, Ernestina Melicoff, James West, Anna R. Hemnes, Almut Grenz, Holger K. Eltzschig, Timothy S. Blackwell, Yang Xia, Richard A. Johnston, Dewan Zeng, Luiz Belardinelli, Michael R. Blackburn,
... L., Weng, T., Melicoff, E., West, J. D., Hemnes, A., Grenz, A., Eltzschig, H. K., Blackwell, T. ...
Tópico(s): Cardiac Arrhythmias and Treatments
2012 - Wiley | The FASEB Journal
... LinkGoogle Scholar6. Robbins IM, Newman JH, Johnson RF, Hemnes AR, Fremont RD, Piana RN, Zhao DX, Byrne ... PR, Fisher MR, Mathai SC, Housten-Harris T, Hemnes AR, Borlaug BA, Chamera E, Corretti MC, Champion ...
Tópico(s): Congenital Heart Disease Studies
2011 - Lippincott Williams & Wilkins | Circulation Heart Failure
... Gumperz was carried out in the village of Hemnes in Northern Norway, and the focus of the ... equivalent roles in the verbal repertoire of the Hemnes population, they are kept completely separate by the ...
Tópico(s): Linguistic and Sociocultural Studies
1996 - Elsevier BV | Journal of Pragmatics
Evan L. Brittain, Anna R. Hemnes,
... Evan L. Brittain, MD, MSCI and Anna R. Hemnes, MDEvan L. Brittain, MD, MSCIFrom Vanderbilt University Medical Center, Nashville, Tennessee. and Anna R. Hemnes, MDFrom Vanderbilt University Medical Center, Nashville, Tennessee.Author, ... 1987;76:135-41. [PMID: 2954725] CrossrefMedlineGoogle Scholar8. Hemnes AR, Trammell AW, Archer SL, Rich S, Yu ... InformationAuthors: Evan L. Brittain, MD, MSCI; Anna R. Hemnes, MDAffiliations: From Vanderbilt University Medical Center, Nashville, Tennessee. ... do?msNum=M14-2700.Corresponding Author: Anna R. Hemnes, MD, Division of Pulmonary and Critical Care Medicine, ...
Tópico(s): Cardiovascular Issues in Pregnancy
2015 - American College of Physicians | Annals of Internal Medicine
Megan M. Lowery, Nicholas S. Hill, Lu Wang, Erika B. Rosenzweig, Mamatha Bhat, Serpil C. Erzurum, J. Emanuel Finet, Christine Jellis, Sunjeet Kaur, Deborah Kwon, R Nawabit, Milena Radeva, Gerald J. Beck, Robert P. Frantz, Paul M. Hassoun, Anna R. Hemnes, Evelyn M. Horn, Jane A. Leopold, Franz Rischard, Reena Mehra, Nicholas S. Hill, Lei Xiao, Yongping Fu, Lisa Postow, Barry Schmetter, K. Stanton, Xuefei Tian, Michael P. Gray, Banny S. Wong, Jane A. Leopold, Aaron B. Waxman, Marcelo F. DiCarli, Laurie Lawler, Bradley A. Maron, Sergio A. Segrera, David M. Systrom, Peng Yu, Erika B. Rosenzweig, Selim M. Arcasoy, David J. Brady, Wendy K. Chung, David A. Payne, Gabriele Grünig, Jennifer Haythe, U. Krishnan, Evelyn M. Horn, Kemal M. Akat, Alain Borczuk, Richard B. Devereux, J. B. Gordon, Robert J. Kaner, Maria Karas, Jeff Min, Nupoor Narula, Michelle L. Ricketts, I. Sobol, Robert Spiera, Harsimran Singh, Thomas Tuschl, Jonathan W. Weinsaft, Paul M. Hassoun, Stephen C. Mathai, Kathleen C. Barnes, R.L. Damico, Blessing Enobun, Lei Gao, Marc K. Halushka, David A. Kass, Todd M. Kolb, Lin Tian, Ryan J. Tedford, Stefan L. Zimmerman, Robert P. Frantz, Atta Behfar, Linda Block, Barry A. Borlaug, Louise A. Durst, Thomas A. Foley, Thomas Hammer, Bruce D. Johnson, Geoffrey B. Johnson, Garvan C. Kane, Michael J. Krowka, Annette McNallan, Thomas P. Olson, Margaret M. Redfield, Kristi Rohwer, André Terzic, Eric E. Williamson, Franz Rischard, Jason X.‐J. Yuan, Aiden Abidov, Joe G. N. Garcia, Arlette G. Cordery, Ankit A. Desai, H. Erickson, Lene Hansen, Zain Khalpey, Kenneth S. Knox, Yves A. Lussier, Marc A. Simon, Rebecca Vanderpool, Anna R. Hemnes, Jamie E. Newman, Eric D. Austin, Evan L. Brittain, James M. Cunningham, Catherine Larochelle, Meredith E. Pugh, Ivan M. Robbins, L. Wheeler, Gerald J. Beck, Serpil C. Erzurum, Micheala A. Aldred, Kewal Asosingh, J. Barnard, C. Collart, S. Comhair, Frank P. DiFilippo, Jeanne K. Drinko, Raed A. Dweik, Aisling M. Flinn, M Geraci, Bo Hu, Wael A. Jaber, Miriam Jacob, Christine Jellis, Satish C. Kalhan, K. Kassimatis, Jennifer Kirsop, M. Koo, Deborah Kwon, Brett Larive, Jason K. Lempel, M. Li, J. MacKrell, Brittany Matuska, Kevin McCarthy, Reena Mehra, D. Neumann, R Nawabit, Mitchell A. Olman, M. Park, Milena Radeva, Jacqueline Sharp, Stefan Sherer, W.H. Wilson Tang, Jason Thomas, Kerri L. Wiggins, Belinda Willard, Sharon Rounds, Raymond L. Benza, Todd Bull, John B. Cadigan, James C. Fang, Mardi Gomberg‐Maitland, Grier P. Page,
Group 1 pulmonary arterial hypertension (PAH) is a progressive fatal condition characterized by right ventricular (RV) failure with worse outcomes in connective tissue disease (CTD). Obstructive sleep apnea and sleep-related hypoxia may contribute to RV dysfunction, though the relationship remains unclear. The aim of this study was to prospectively evaluate the association of the apnea-hypopnea index (AHI) and sleep-related hypoxia with RV function and survival. Pulmonary Vascular Disease Phenomics ( ...
Tópico(s): Cardiovascular Function and Risk Factors
2023 - Elsevier BV | Journal of the American College of Cardiology
Kelly Chin, Murali M. Chakinala, Anna R. Hemnes, Harrison W. Farber, Vallerie V. McLaughlin, Nick Kim, Carol Zhao, VEENA NARAYAN, Kristin B. Highland,
... 1001 - $5000 Added 04/14/2020 by Anna Hemnes, source=Web Response, value=Consulting fee Advisory Committee ... 1-$1000 Added 04/14/2020 by Anna Hemnes, source=Web Response, value=Consulting fee Advisory Committee ... 1001 - $5000 Added 04/14/2020 by Anna Hemnes, source=Web Response, value=Consulting fee Advisory Committee ... 1001 - $5000 Added 04/14/2020 by Anna Hemnes, source=Web Response, value=Consulting fee Scientific Medical ... 1-$1000 Added 04/14/2020 by Anna Hemnes, source=Web Response, value=Ownership interest Speaker/Speaker' ...
Tópico(s): Pulmonary Hypertension Research and Treatments
2020 - Elsevier BV | CHEST Journal
Lawrence Rudski, Nowell M. Fine,
... PR, Fisher MR, Mathai SC, Housten-Harris T, Hemnes AR, Borlaug BA, Chamera E, Corretti MC, Champion ... 1161/CIRCULATIONAHA.113.001458.LinkGoogle Scholar17. Tedford RJ, Hemnes AR, Russell SD, Wittstein IS, Mahmud M, Zaiman ...
Tópico(s): Cardiac Imaging and Diagnostics
2018 - Lippincott Williams & Wilkins | Circulation Cardiovascular Imaging
... Sivarajan L Wang L Robbins IM Newman JH Hemnes AR Causes of pulmonary hypertension in the elderly. ... MD, FCCP; Mary G. George, MD; Anna R. Hemnes, MD,
Tópico(s): Heart Failure Treatment and Management
2014 - Elsevier BV | CHEST Journal
Robert P. Frantz, Vallerie V. McLaughlin, Sandeep Sahay, Pilar Escribano Subías, R. Zolty, Raymond L. Benza, Richard N. Channick, Kelly Chin, Anna R. Hemnes, Luke Howard, Olivier Sitbon, Jean‐Luc Vachiéry, Roham T. Zamanian, Matt Cravets, Robert F. Roscigno, David Mottola, Robin Osterhout, Jean‐Marie Bruey, Erin Elman, Cindy‐ann Tompkins, Ed Parsley, Richard Aranda, Lawrence S. Zisman, Hossein A. Ghofrani, Yochai Adir, T. Baillie, David Baratz, Charles Burger, Murali M. Chakinala, Jose Ales Martinez, Marion Delcroix, Nathan Dwyer, Jean Elwing, Micah R. Fisher, Verónica Franco, Ekkehard Grünig, Kristin B. Highland, Nicholas S. Hill, Naushad Hirani, Marius M. Hoeper, P Jansa, Anne Keogh, J.F. Kingrey, Manuel López‐Meseguer, John W. McConnell, Sanjay Mehta, Lana Melendres‐Groves, Christian Opitz, Joanna Pepke‐Żaba, Priya Pillutla, Franck Rahaghi, Amresh Raina, Yael Raviv, Jeffrey C. Robinson, John Ryan, Jeffrey S. Sager, Shelley Shapiro, Marc A. Simon, Kerri Smith, I. Sobol, Namita Sood, Leslie Spikes, Stefan Stadler, Wendy B.C. Stevens, Roxana Sulica, R. James White,
Background Morbidity and mortality in pulmonary arterial hypertension (PAH) remain high. Activation of platelet-derived growth factor receptor, colony stimulating factor 1 receptor, and mast or stem cell growth factor receptor kinases stimulates inflammatory, proliferative, and fibrotic pathways driving pulmonary vascular remodelling in PAH. Seralutinib, an inhaled kinase inhibitor, targets these pathways. We aimed to evaluate the efficacy and safety of seralutinib in patients with PAH receiving ...
Tópico(s): Vascular Anomalies and Treatments
2024 - Elsevier BV | The Lancet Respiratory Medicine
Anna R. Hemnes, David S Celermajer, Michele D’Alto, François Haddad, Paul M. Hassoun, Kurt W. Prins, Robert Naeije, Anton Vonk Noordegraaf,
The right ventricle and its stress response is perhaps the most important arbiter of survival in patients with pulmonary hypertension of many causes. The physiology of the cardiopulmonary unit and definition of right heart failure proposed in the 2018 World Symposium on Pulmonary Hypertension have proven useful constructs in subsequent years. Here, we review updated knowledge of basic mechanisms that drive right ventricular function in health and disease, and which may be useful for therapeutic ...
Tópico(s): Cardiovascular Effects of Exercise
2024 - European Respiratory Society | European Respiratory Journal
Pieter Martens, Shilin Yu, Brett Larive, Barry A. Borlaug, Serpil C. Erzurum, Samar Farha, J. Emanuel Finet, Gabriele Grünig, Anna R. Hemnes, Nicholas S. Hill, Evelyn M. Horn, Miriam Jacob, Deborah Kwon, Margaret Park, Franz Rischard, Erika B. Rosenzweig, Jennifer Wilcox, W.H. Wilson Tang,
Iron deficiency is common in pulmonary hypertension, but its clinical significance and optimal definition remain unclear.
Tópico(s): Erythropoietin and Anemia Treatment
2023 - Oxford University Press | European Heart Journal
Vineet Agrawal, Jonathan A. Kropski, Jason J. Gokey, Elizabeth Kobeck, Matthew B. Murphy, Katherine T. Murray, Niki Fortune, Christy Moore, David F. Meoli, Ken Monahan, Y. Su, Thomas W. Blackwell, Deepak K. Gupta, Megha Talati, Santhi Gladson, Erica J. Carrier, James West, Anna R. Hemnes,
Pulmonary hypertension (PH) in heart failure with preserved ejection fraction (HFpEF) is a common and highly morbid syndrome, but mechanisms driving PH-HFpEF are poorly understood. We sought to determine whether a well-accepted murine model of HFpEF also displays features of PH, and we sought to identify pathways that might drive early remodeling of the pulmonary vasculature in HFpEF.
Tópico(s): MicroRNA in disease regulation
2023 - Lippincott Williams & Wilkins | Circulation Research
Charles D Smart, Daniel J. Fehrenbach, Jean W Wassenaar, Vineet Agrawal, Niki Fortune, Debra Dixon, Matthew A. Cottam, Alyssa H. Hasty, Anna R. Hemnes, Amanda C. Doran, Deepak K. Gupta, Meena S. Madhur,
Abstract Aims Heart failure with preserved ejection fraction (HFpEF) is characterized by diastolic dysfunction, microvascular dysfunction, and myocardial fibrosis with recent evidence implicating the immune system in orchestrating cardiac remodelling. Methods and results Here, we show the mouse model of deoxycorticosterone acetate (DOCA)-salt hypertension induces key elements of HFpEF, including diastolic dysfunction, exercise intolerance, and pulmonary congestion in the setting of preserved ejection ...
Tópico(s): Apelin-related biomedical research
2023 - Oxford University Press | Cardiovascular Research
Carrie L. Welch, Micheala A. Aldred, Srimmitha Balachandar, Dennis Dooijes, Christina A. Eichstaedt, Stefan Gräf, Arjan C. Houweling, Rajiv D. Machado, Divya Pandya, Matina Prapa, Memoona Shaukat, Laura Southgate, Jair Tenorio, Emily P. Callejo, Kristina M. Day, Daniela Macaya, Gabriel Maldonado-Velez, Wendy K. Chung, Stephen L. Archer, Kathryn Auckland, Eric D. Austin, Roberto Badagliacca, Joan-Albert Barberà, Catharina Belge, Harm Jan Bogaard, Sébastien Bonnet, Karin A. Boomars, Olivier Boucherat, Murali M. Chakinala, Robin Condliffe, Rachel L. Damico, Marion Delcroix, Ankit A. Desai, Anna Doboszyńska, C. Gregory Elliott, Mélanie Eyries, Pilar Escribano Subías, Henning Gall, Stefano Ghio, Ardeschir-Hossein Ghofrani, Ekkehard Grünig, Rizwan Hamid, Lars Harbaum, Paul M. Hassoun, Anna R. Hemnes, Katrin Hinderhofer, Luke Howard, Marc Humbert, David G. Kiely, David Langleben, Allan Lawrie, James E. Loyd, Shahin Moledina, David Montani, Nichols W. Morrell, William C. Nichols, Andrea Olschewski, Horst Olschewski, Silvia Papa, M. Pauciulo, S. Provencher, Rozenn Quarck, Christopher J. Rhodes, Laura Scelsi, Werner Seeger, Duncan J. Stewart, Andrew J. Sweatt, Emilia M. Swietlik, Carmen Treacy, Richard C. Trembath, Olga Tura-Ceide, Carmine Dario Vizza, Anton Vonk Noordegraaf, Martin R. Wilkins, Roham T. Zamanian, D. A. Zateyshchikov,
Abstract Purpose Pulmonary arterial hypertension (PAH) is a rare, progressive vasculopathy with significant cardiopulmonary morbidity and mortality. Genetic testing is currently recommended for adults diagnosed with heritable, idiopathic, anorexigen-, hereditary hemorrhagic telangiectasia–, and congenital heart disease–associated PAH, PAH with overt features of venous/capillary involvement, and all children diagnosed with PAH. Variants in at least 27 genes have putative evidence for PAH causality. Rigorous ...
Tópico(s): Cardiovascular Function and Risk Factors
2023 - Elsevier BV | Genetics in Medicine
Dana McGlothlin, John Granton, Walter Klepetko, Maurice Beghetti, Erika B. Rosenzweig, Paul A. Corris, Evelyn M. Horn, Manreet Kanwar, Karen McRae, Antonio Román, Ryan J. Tedford, Roberto Badagliacca, Sonja Bartolome, Raymond L. Benza, Marco Caccamo, Rebecca Cogswell, Céline Dewachter, Laura Donahoe, Élie Fadel, Harrison W. Farber, Jeffrey A. Feinstein, Verónica Franco, Robert P. Frantz, Michael Gatzoulis, Choon Hwa Goh, Marco Guazzi, Georg Hansmann, Stuart Hastings, Paul M. Heerdt, Anna R. Hemnes, Antoine Herpain, Chih‐Hsin Hsu, Kim M. Kerr, Nicholas A. Kolaitis, Jasleen Kukreja, Michael M. Madani, Stuart A. McCluskey, Michael A. McCulloch, Bernhard Moser, Manchula Navaratnam, Göran Rådegran, Cara Reimer, Laurent Savale, Oksana A. Shlobin, Jana Svetlichnaya, Keith M. Swetz, Jessica A. Tashjian, Thenappan Thenappan, Carmine Dario Vizza, Shawn C. West, Warren A. Zuckerman, Andreas Zuckermann, Teresa De Marco,
Pulmonary hypertension (PH) is a risk factor for morbidity and mortality in patients undergoing surgery and anesthesia. This document represents the first international consensus statement for the perioperative management of patients with pulmonary hypertension and right heart failure. It includes recommendations for managing patients with PH being considered for surgery, including preoperative risk assessment, planning, intra- and postoperative monitoring and management strategies that can improve ...
Tópico(s): Cardiac Valve Diseases and Treatments
2022 - Elsevier BV | The Journal of Heart and Lung Transplantation
Mona Alotaibi, Junzhe Shao, Michael W. Pauciulo, William C. Nichols, Anna R. Hemnes, Atul Malhotra, Nick H. Kim, Jason X.‐J. Yuan, Timothy M. Fernandes, Kim M. Kerr, Laith Alshawabkeh, Ankit A. Desai, Andreea M. Bujor, Robert Lafyatis, Jeramie D. Watrous, Tao Long, Susan Cheng, Stephen Y. Chan, Mohit Jain,
Background The prognosis and therapeutic responses are worse for pulmonary arterial hypertension associated with systemic sclerosis (SSc-PAH) compared with idiopathic pulmonary arterial hypertension (IPAH). This discrepancy could be driven by divergence in underlying metabolic determinants of disease. Research Question Are circulating bioactive metabolites differentially altered in SSc-PAH vs IPAH, and can this alteration explain clinical disparity between these PAH subgroups? Study Design and Methods Plasma ...
Tópico(s): Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
2022 - Elsevier BV | CHEST Journal
Luke Howard, Stephan Rosenkranz, Robert P. Frantz, Anna R. Hemnes, Thomas D. Pfister, Shu‐Fang Hsu Schmitz, Hall Skåra, Marc Humbert, Ioana R. Preston,
Reduced daily life physical activity (DLPA) in pulmonary arterial hypertension (PAH) contributes to a poor quality of life.Can actigraphy be used to assess changes in DLPA in patients with PAH receiving selexipag or placebo?Effect of Selexipag on Daily Life Physical Activity of Patients With Pulmonary Arterial Hypertension (TRACE) was a prospective, multicenter, randomized, placebo-controlled, double-blind, exploratory phase 4 study enrolling patients with PAH in World Health Organization functional ...
Tópico(s): Cardiovascular Function and Risk Factors
2022 - Elsevier BV | CHEST Journal
Vineet Agrawal, Anna R. Hemnes, Nicholas J. Shelburne, Niki Fortune, Julio Fuentes, Dan Colvin, M. Wade Calcutt, Megha Talati, Emily Poovey, James West, Evan L. Brittain,
Abstract Pulmonary arterial hypertension (PAH) is a fatal vasculopathy that ultimately leads to elevated pulmonary pressure and death by right ventricular (RV) failure, which occurs in part due to decreased fatty acid oxidation and cytotoxic lipid accumulation. In this study, we tested the hypothesis that decreased fatty acid oxidation and increased lipid accumulation in the failing RV is driven, in part, by a relative carnitine deficiency. We then tested whether supplementation of l ‐carnitine can ...
Tópico(s): Cardiovascular Function and Risk Factors
2022 - SAGE Publishing | Pulmonary Circulation
Dan Predescu, Babak Mokhlesi, Sanda Predescu,
... E.K. Newman J.H. Austin E.D. Hemnes A.R. Wheeler L. Robbins I.M. West ...
Tópico(s): Cardiovascular, Neuropeptides, and Oxidative Stress Research
2022 - Elsevier BV | American Journal Of Pathology
Kevin Y. Chang, Sue Duval, David B. Badesch, Todd M. Bull, Murali M. Chakinala, Teresa De Marco, Robert P. Frantz, Anna R. Hemnes, Stephen C. Mathai, Erika B. Rosenzweig, John Ryan, Thenappan Thenappan, Roblee P. Allen, Sonja Bartolome, Raymond L. Benza, Linda Cadaret, Michael Eggert, Jean Elwing, Jeffrey R. Fineman, Raymond Foley, H. James Ford, Russel Hirsch, James Grinnan, D. Dunbar Ivy, Steven M. Kawut, Jamie L.W. Kennedy, James R. Klinger, Peter J. Leary, Sula Mazimba, Gautam Ramani, Amresh Raina, James Runo, J. Swisher, Nidhy P. Varghese, R.J. White, Timothy Williamson, Delphine Yung, Roham T. Zamanian, Dianne Zwicke,
Background Current mortality data for pulmonary arterial hypertension (PAH) in the United States are based on registries that enrolled patients prior to 2010. We sought to determine mortality in PAH in the modern era using the PHAR (Pulmonary Hypertension Association Registry). Methods and Results We identified all adult patients with PAH enrolled in the PHAR between September 2015 and September 2020 (N=935). We used Kaplan‐Meier survival analysis and Cox proportional hazards models to assess mortality ...
Tópico(s): Liver Disease and Transplantation
2022 - Wiley | Journal of the American Heart Association
Anna R. Hemnes, Jane A. Leopold, Milena Radeva, Gerald J. Beck, Aiden Abidov, Micheala A. Aldred, John Barnard, Erika B. Rosenzweig, Barry A. Borlaug, Wendy K. Chung, Suzy Comhair, Ankit A. Desai, Hilary M. DuBrock, Serpil C. Erzurum, J. Emanuel Finet, Robert P. Frantz, Joe G. N. Garcia, Mark W. Geraci, Michael P. Gray, Gabriele Grünig, Paul M. Hassoun, Kristin B. Highland, Nicholas S. Hill, Bo Hu, Deborah Kwon, Miriam Jacob, Christine Jellis, A. Brett Larive, Jason K. Lempel, Bradley A. Maron, Stephen C. Mathai, Kevin McCarthy, Reena Mehra, R Nawabit, John H. Newman, Mitchell A. Olman, Margaret M. Park, José Ramos, Rahul D. Renapurkar, Franz Rischard, Susan G. Sherer, W.H. Wilson Tang, James D. Thomas, Rebecca Vanderpool, Aaron B. Waxman, Jennifer Wilcox, Jason X.‐J. Yuan, Evelyn M. Horn,
PVDOMICS (Pulmonary Vascular Disease Phenomics) is a precision medicine initiative to characterize pulmonary vascular disease (PVD) using deep phenotyping. PVDOMICS tests the hypothesis that integration of clinical metrics with omic measures will enhance understanding of PVD and facilitate an updated PVD classification. The purpose of this study was to describe clinical characteristics and transplant-free survival in the PVDOMICS cohort. Subjects with World Symposium Pulmonary Hypertension (WSPH) group ...
Tópico(s): Congenital Heart Disease Studies
2022 - Elsevier BV | Journal of the American College of Cardiology
Justyna A. Karolak, Carrie L. Welch, Christian Mosimann, Katarzyna Bzdęga, James West, David Montani, Mélanie Eyries, Mary P. Mullen, Steven H. Abman, Matina Prapa, Stefan Gräf, Nicholas W. Morrell, Anna R. Hemnes, Frédéric Perros, Rizwan Hamid, Malcolm Logan, Jeffrey A. Whitsett, Csaba Galambos, Paweł Stankiewicz, Wendy K. Chung, Eric D. Austin,
Over the past decade, recognition of the profound impact of the
Tópico(s): Congenital Heart Disease Studies
2022 - American Thoracic Society | American Journal of Respiratory and Critical Care Medicine
Nick H. Kim, Anna R. Hemnes, Murali M. Chakinala, Kristin B. Highland, Kelly Chin, Vallerie V. McLaughlin, Carol Zhao, VEENA NARAYAN, Harrison W. Farber,
BACKGROUNDSelexipag is a selective oral prostacyclin receptor agonist indicated for pulmonary arterial hypertension (PAH) treatment. SelexiPag: tHe usErs dRug rEgistry (SPHERE) (NCT03278002) is collecting data from selexipag-treated patients in real-world clinical practice to elucidate and describe the clinical characteristics, outcomes, and dosing/titration regimens of patients treated with selexipag in routine clinical practice.METHODSSPHERE is a United States (US)-based, ongoing, multicenter, prospective ...
Tópico(s): Cardiovascular Issues in Pregnancy
2021 - Elsevier BV | The Journal of Heart and Lung Transplantation