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Artigo Revisado por pares

Mathias Bruyand, François Dabis, M.A. Vandenhende, Estibaliz Lazaro, D. Neau, Olivier Leleux, S. Geffard, Philippe Morlat, Geneviève Chêne, Fabrice Bonnet,

... co-infected patients are at high risk for hepatocarcinoma. The contribution of immunodeficiency is not well documented. ... at estimating the relationship between the occurrence of hepatocarcinoma and both types of measures of immunodeficiency, current ... entry were used to estimate the risk of hepatocarcinoma. Exposure to a CD4+ <350 or <500 cells/ ... were fixed-effect variables. Results Sixteen cases of hepatocarcinoma were diagnosed among the 2864 eligible patients, the ... was independently associated with a higher risk of hepatocarcinoma (Hazard Ratio [HR]: 5.0, CI 1.5– ...

Tópico(s): Hepatitis B Virus Studies

2011 - Elsevier BV | Journal of Hepatology

Artigo Acesso aberto

Jun Lü, Xing-Zhizi Wang, Tianqi Zhang, Xiaoying Huang, Jin‐Guang Yao, Chao Wang, Zhonghong Wei, Yun Ma, Xue-Min Wu, Chunying Luo, Qiang Xia, Xi‐Dai Long,

... Dai Long, email: sjtulongxd@263.net Keywords: XRCC4, hepatocarcinoma, prognosis, TACE Received: May 01, 2017 Accepted: August ... 4 (XRCC4) may be involved in hepatocellular carcinoma (hepatocarcinoma) tumorigenesis. This study aimed to investigate the possible prognostic significance of XRCC4 expression for hepatocarcinoma patients and possible value for the selection of ... conducted a hospital-based retrospective analysis (including 421 hepatocarcinoma cases) to analyze the effects of XRCC4 on hepatocarcinoma prognosis and TACE. The levels of XRCC4 expression ...

Tópico(s): Ubiquitin and proteasome pathways

2017 - Impact Journals LLC | Oncotarget

Artigo Acesso aberto Revisado por pares

Mario Serradilla Martín, José Ramón Oliver Guillén, Ana Palomares Cano, José Manuel Ramia,

... metabolicos con la aparicion y el desarrollo de hepatocarcinoma. En este contexto, es primordial determinar si los ... deben de seguir un protocolo de cribado de hepatocarcinoma. Hasta la fecha, la incidencia mundial publicada de hepatocarcinoma en pacientes con enfermedad hepatica grasa no alcoholica ... a los diez anos. Aunque el screening de hepatocarcinoma en pacientes con enfermedad hepatica grasa no alcoholica y cirrosis es obligatorio, la baja incidencia de hepatocarcinoma en pacientes sin cirrosis no justifica la vigilancia ...

Tópico(s): Alcohol Consumption and Health Effects

2020 - Arán Ediciones | Revista Española de Enfermedades Digestivas

Artigo Acesso aberto Revisado por pares

Joanne Ho, Eftihia Cocolakis, Víctor Dumas, Barry I. Posner, Stéphane A. Laporte, Jean‐Jacques Lebrun,

... induces cell growth arrest and apoptosis in human hepatocarcinoma cells Human hepatocellular carcinoma (HuH7) and hepatoblastoma (HepG2) ... activin/TGFβ regulates cell growth of these two hepatocarcinoma cell lines by inhibiting cell proliferation (G1 arrest) ... Activin/TGFβ selectively induces GRK2 expression in human hepatocarcinoma cells To identify novel activin/TGFβ target genes ... microarray experiments using activin or TGFβ-treated human hepatocarcinoma (HuH7) cells. From our microarray experiments, we found ...

Tópico(s): NF-κB Signaling Pathways

2005 - Springer Nature | The EMBO Journal

Artigo Acesso aberto Revisado por pares

Shaobo Hu, Liyu Wang, Xi Zhang, Yongzhong Wu, Jing Yang, Jun Li,

Abstract Autophagy promotes invasion of hepatocarcinoma cells through transforming growth factor (TGF)‐β‐dependent epithelial‐mesenchymal transition (EMT). This study investigated the mechanism by which autophagy induces TGF ‐β‐triggered EMT and invasion of hepatocarcinoma cells. Autophagy was induced in HepG2 and BEL ... increased cAMP response element binding ( CREB ) phosphorylation in hepatocarcinoma cells. Autophagy‐induced activation of cAMP / PKA / CREB ... the expression of mesenchymal markers, accelerating invasion of hepatocarcinoma cells. Inhibition of autophagy by Atg3 and Atg7 ...

Tópico(s): Epigenetics and DNA Methylation

2018 - Wiley | Journal of Cellular and Molecular Medicine

Artigo Acesso aberto Revisado por pares

Xiaona Li, Hong Yang, Tao Yang,

... we investigated the role of miR-122 in hepatocarcinoma progression and explored the mechanism. In hepatocarcinoma tissues and cells, we used qRT-PCR to ... inhibition effect of miR-122 ASO therapy against hepatocarcinoma. miR-122 was reduced in hepatocarcinoma tissues compared to the paracarcinoma tissues, which was relatively low or high in hepatocarcinoma cell line SMMC7721 or Hep3B, and overexpressed miR-122 inhibited proliferation, migration, and invasion in hepatocarcinoma cells. Additionally, some reports showed that LMNB2 was ...

Tópico(s): RNA Research and Splicing

2019 - Cognizant Communication Corporation | Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics

Artigo Acesso aberto Revisado por pares

Chunmei Guo, Nannan Li, Chengyong Dong, Liming Wang, Zhaopeng Li, Qinlong Liu, Qinglai Ma, Frederick T. Greenaway, Yuxiang Tian, Lihong Hao, Shuqing Liu, Ming‐Zhong Sun,

... and regulation mechanism of 33-kDa ANXA3 in hepatocarcinoma.The expressions of ANXA3, CRKL, Rac1, c-Myc and pAkt were analyzed in hepatocarcinoma specimens by Western blotting. The biological function of ... in the growth, metastasis, apoptosis, angiogenesis, chemoresistance of hepatocarcinoma cells with the underlying molecular mechanism were investigated ... tissues compared with corresponding normal liver tissues of hepatocarcinoma patients. Its stable knockdown decreased the in vivo tumor growing velocity and malignancy of hepatocarcinoma HepG2 cells transplanted in nude mice. The in ...

Tópico(s): Cell death mechanisms and regulation

2020 - Elsevier BV | Journal of Advanced Research

Artigo Acesso aberto Revisado por pares

Paola Dongiovanni, Anna Ludovica Fracanzani, Gaetano Cairo, C. Megazzini, Stefano Gatti, Raffaela Rametta, Silvia Fargion, Luca Valenti,

Iron overload is a risk factor for hepatocarcinoma, but the pathways involved are poorly characterized. Gene expression analysis in immortalized mouse hepatocytes exposed to iron or the iron chelator deferoxamine revealed ... p53 activity, was associated with higher risk of hepatocarcinoma in cirrhotic patients with hemochromatosis, and with HFE mutations in patients with hepatocarcinoma without hemochromatosis, suggesting an interaction between MDM2 and iron in the pathogenesis of hepatocarcinoma. In conclusion, iron status influences p53 activity and ...

Tópico(s): Iron Metabolism and Disorders

2009 - Elsevier BV | American Journal Of Pathology

Carta Acesso aberto Revisado por pares

Helen S. Sanderson, Paul R. Clarke,

... Kocher T. Wilm M. Mattaj I.W. HURP (Hepatocarcinoma-Upregulated) is part of a Ran-dependent complex ... Scopus (208) Google Scholar] show that another oncoprotein, hepatocarcinoma-upregulated protein (HURP), is under the direct regulatory ... Kocher T. Wilm M. Mattaj I.W. HURP (Hepatocarcinoma-Upregulated) is part of a Ran-dependent complex ... Kocher T. Wilm M. Mattaj I.W. HURP (Hepatocarcinoma-Upregulated) is part of a Ran-dependent complex ... Kocher T. Wilm M. Mattaj I.W. HURP (Hepatocarcinoma-Upregulated) is part of a Ran-dependent complex ...

Tópico(s): Nuclear Structure and Function

2006 - Elsevier BV | Current Biology

Artigo Acesso aberto Revisado por pares

Bing Hu, Hong‐Mei An, Ke-Ping Shen, Haiyan Song, Shan Deng,

... Huzhang) is a frequently used Chinese herb in hepatocarcinoma. In present study, we evaluated the effects of Polygonum cuspidatum extract (PCE) in hepatocarcinoma cells in suspension. The results showed that PCE inhibited the proliferation of hepatocarcinoma cells in suspension in a dose- and time- ... manner. PCE also inhibited anchorage-independent growth of hepatocarcinoma cells in soft agar. PCE induced anoikis in human hepatocarcinoma Bel-7402 cells accompanied by caspase-3 and ... suspension growth and induce caspase-mediated anoikis in hepatocarcinoma cells and may relate to ROS generation and ...

Tópico(s): Microtubule and mitosis dynamics

2012 - Hindawi Publishing Corporation | Evidence-based Complementary and Alternative Medicine

Artigo Acesso aberto Revisado por pares

Sung-Koo Kang, Tae‐Wook Chung, Ji-Young Lee, Young-Choon Lee, Richard E. Morton, Cheorl‐Ho Kim,

... cells appeared to be higher than that of hepatocarcinoma cells as well as GnT-III-transfected cells, ... cells appeared to be higher than that of hepatocarcinoma cells as well as GnT-III-transfected cells, ... GnT-III mRNA and Protein in Normal Cells, Hepatocarcinoma Cells, and Our Transfected Cells—To compare the ... carried out using normal liver Chang cells, the hepatocarcinoma cell line (HepG2), and our transfected cells as ... Fig. 4B) because HepG2 is well known as hepatocarcinoma cell line, which is not integrated with hepatitis ...

Tópico(s): Glycosylation and Glycoproteins Research

2004 - Elsevier BV | Journal of Biological Chemistry

Artigo Acesso aberto Revisado por pares

Nicolas Charette, Christine De Saeger, Yves Horsmans, Isabelle Leclercq, Peter Stärkel,

Ras activation is a frequent event in human hepatocarcinoma that may contribute to resistance towards apoptosis. Salirasib ... that induces a pro-apoptotic phenotype in human hepatocarcinoma cell lines. In this work, we evaluate whether ... results show that pretreatment with salirasib sensitized human hepatocarcinoma cell lines, but not normal human hepatocytes, to ... in this process and was sufficient to sensitize hepatocarcinoma cells to apoptosis. Furthermore, TRAIL-induced apoptosis in ... death receptor (DR) 5. In conclusion, salirasib sensitizes hepatocarcinoma cells to TRAIL-induced apoptosis by a mechanism ...

Tópico(s): Endoplasmic Reticulum Stress and Disease

2013 - Springer Nature | Cell Death and Disease

Artigo Acesso aberto Revisado por pares

Ping He, Hongxia Zhang, Changyu Sun, Chun-yong Chen, He-qing Jiang,

... of SASH1 in the invasion and metastasis of hepatocarcinoma are largely unknown. In this study, we investigated ... of SASH1 in the invasion and metastasis of hepatocarcinoma. Our results showed that SASH1 was lowly expressed in hepatocarcinoma cell lines. The in vitro experiments showed that ... SASH1 inhibited the proliferation and migration/invasion of hepatocarcinoma cells, as well as the epithelial‐mesenchymal transition ( ... well as Smo, Ptc, and Gli-1 in hepatocarcinoma cells. Taken together, these results suggest that overexpression ...

Tópico(s): MicroRNA in disease regulation

2016 - Cognizant Communication Corporation | Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics

Artigo Acesso aberto Revisado por pares

Bao‐Dong Tang, Xin Xia, Xiao‐Fei Lv, Beixin Yu, Jia‐Ni Yuan, Xiao‐Yi Mai, Jin‐Yan Shang, Jia‐Guo Zhou, Si‐Jia Liang, Rui‐Ping Pang,

... we aim to investigate whether 5-FU induces hepatocarcinoma cell death through regulating Ca2+ -dependent autophagy. [Ca2+ ] ... 5-FU) induced autophagic cell death in HepG2 hepatocarcinoma cells by inhibiting PI3K/AKT/mTOR pathway. Orai1 expression was obviously elevated in hepatocarcinoma tissues. 5-FU treatment decreased SOCE and Orai1 ... to show that Orai1 expression is increased in hepatocarcinoma tissues. 5-FU can induce autophagic cell death in HepG2 hepatocarcinoma cells through inhibition of SOCE via decreasing Orai1 ...

Tópico(s): Bioactive Compounds and Antitumor Agents

2016 - Wiley | Journal of Cellular and Molecular Medicine

Artigo Revisado por pares

Pau Sancho‐Bru, E. Juez, Montserrat Moreno, Valeria K Khurdayan, Manuel Morales‐Ruiz, Jordi Colmenero, Vicente Arroyo, David A. Brenner, Pere Ginà ̈s, Ramón Bataller,

... found around hepatocellular carcinoma. It is unknown whether hepatocarcinoma cells regulate the biological functions of HSC. Aims: ... study aimed to investigate the paracrine effects of hepatocarcinoma cells on human HSC using a co-culture system. Methods: Huh7 or HepG2 cells, human hepatocarcinoma cell lines, were co-cultured with primary human ... virus (HCV) infection is a major cause of hepatocarcinoma, we next investigated whether these effects are regulated by the expression of HCV in hepatocarcinoma cells. Expression of a subgenomic replicon expressing HCV ...

Tópico(s): Hepatitis B Virus Studies

2009 - Wiley | Liver International

Artigo Acesso aberto

Yi Feng,

AIM:To investigate the protein profile of human hepatocarcinoma cell line SMMC-7721, to analyze the specific ... of abundant expressed proteins in the processes of hepatocarcinoma genesis, growth and metastasis, to identify the hepatocarcinoma-specific biomarkers for the early prediction in diagnosis, ... liver cancer therapy. METHODS:Total proteins from human hepatocarcinoma cell line SMMC-7721 were separated by two- ... searching. RESULTS:We obtained protein profile of human hepatocarcinoma cell line SMMC-7721.Among the twenty-one ...

Tópico(s): Enzyme Structure and Function

2007 - Baishideng Publishing Group | World Journal of Gastroenterology

Artigo Acesso aberto Revisado por pares

Susanne Schuster, Melanie Penke, Theresa Gorski, Rolf Gebhardt, Thomas S. Weiß, Wieland Kieß, Antje Garten,

... its specific inhibitor FK866 on the viability of hepatocarcinoma cells and analyzed the effects of FK866 on ... markedly decreased NAMPT activity and NAD content in hepatocarcinoma cells (Huh7 cells, Hep3B cells) and led to ... a dysregulation of the AMPK/mTOR pathway in hepatocarcinoma cells compared to non-cancerous hepatocytes with a ... of mTOR and a lower AMPKα activation in hepatocarcinoma cells. We found that NAMPT inhibition by FK866 ... downstream targets p70S6 kinase and 4E-BP1 in hepatocarcinoma cells. Non-cancerous hepatocytes were less sensitive to ...

Tópico(s): Calcium signaling and nucleotide metabolism

2015 - Elsevier BV | Biochemical and Biophysical Research Communications

Artigo Acesso aberto Revisado por pares

Ingeborg Dreher, Tatjana Jakobs, Josef Köhrle,

... start site of selenoprotein P in human HepG2 hepatocarcinoma cells was mapped to bp −70 by 5′- ... gene. They exhibited functional promoter activity in HepG2 hepatocarcinoma and Caco2 colon carcinoma cells in transient transfection ... start site of selenoprotein P in human HepG2 hepatocarcinoma cells was mapped to bp −70 by 5′- ... gene. They exhibited functional promoter activity in HepG2 hepatocarcinoma and Caco2 colon carcinoma cells in transient transfection ... SeP gene. In transient transfection experiments of cultured hepatocarcinoma and colon carcinoma cells, the activity of this ...

Tópico(s): Sperm and Testicular Function

1997 - Elsevier BV | Journal of Biological Chemistry

Artigo Acesso aberto

Yanxia Gong, Jie Zhang, Xiang Wu, Tao Wang, Jia Zhao, Zhi Yao, Qingyu Zhang, Xi Liu, Jian Xu,

... and transport activity of PEPT1 both in human hepatocarcinoma tissues and cell lines. Western blotting and an ... the high level of PEPT1 protein expression in hepatocarcinoma Bel‑7402, SMMC‑7721, HepG2, HEP3B, SK‑HEP‑ ... HEP‑1 cells. High level PEPT1 expression in hepatocarcinoma patient samples were observed by Immunohistology and showed ... a substrate of peptide transporter) in above five hepatocarcinoma cell lines. The uptake tests performed by fluorescent ... transport both D‑Ala‑Lys‑AMCA into the hepatocarcinoma cells and the uptake can be competitively inhibited ...

Tópico(s): Sulfur Compounds in Biology

2017 - Spandidos Publishing | Oncology Letters

Artigo Acesso aberto Revisado por pares

Chen Zong, Hangjie Zhang, Xue Yang, Lu Gao, Jing Hou, Fei Ye, Jinghua Jiang, Yang Yang, Rong Li, Zhipeng Han, Lixin Wei,

... Therefore, we investigated the effect of MSCs on hepatocarcinoma and whether the role of MSCs depends on ... rats to N -diethylnitrosamine (DEN) was employed as hepatocarcinoma model. And to evaluate the effect of MSCs on hepatocarcinoma, the animals were divided into three groups: rats ... or progressive stage (DEN + MSC (Ps) group) of hepatocarcinoma, respectively. Rats injected with PBS were used as ... a tumor-suppressive effect in the Is of hepatocarcinoma, yet a tumor-promotive effect in the Ps. ... new light on the role of MSCs in hepatocarcinoma and cautions the therapeutic application of MSCs for ...

Tópico(s): Fibroblast Growth Factor Research

2018 - Springer Nature | Cell Death and Disease

Artigo Acesso aberto Revisado por pares

A. Sattar, Abbasi Majid, Jinxia Wang, Qinlong Liu, Ming‐Zhong Sun, Shuqing Liu,

... unknown. The present study revealed AFAP1-AS1 mediated hepatocarcinoma progression through targeting CRKL. The bidirectional interaction of ... AS1 was upregulated in surgical tumorous tissues from hepatocarcinoma patients compared with the paired paracancerous non-tumor liver tissues, and in hepatocarcinoma Huh7, HCCLM3 and HepG2 cell lines compared with ... and c-Jun in mediating the invasiveness of hepatocarcinoma cells. Current work demonstrated AFAP1-AS1 to be an applicable progression indicator of hepatocarcinoma. AFAP1-AS1 probably promotes the proliferation, EMT progression ...

Tópico(s): RNA modifications and cancer

2020 - Elsevier BV | Journal of Advanced Research

Artigo Acesso aberto

Shaoshan Wang,

... trioxide (As 2 O 3 ) on rat experimental hepatocarcinoma and its renal cytotoxicity. METHODS:The hepatocarcinoma model was established by diethaylnitrosamine perfusion in stomach ... 14th and 28th day after the treatment, the hepatocarcinoma nodules were obtained and the morphologic changes of hepatocarcinoma cells were observed under light and electron microscopes; ... expression of bcl-2, bax and PCNA in hepatocarcinoma tissues; flow cytometry (TUNEL assay) was used to ...

Tópico(s): Estrogen and related hormone effects

2003 - Baishideng Publishing Group | World Journal of Gastroenterology

Artigo

Wu Minliang, Shuqing Chen, Xiaohong Wu,

... found only in normal livers, hepatic carcinomas, and hepatocarcinoma cell lines. The CYP2C19 mRNA was expressed at ... 0.000). CYP2C19 protein was also detected in hepatocarcinoma tissues, adjacent normal tissues, and the hepatocarcinoma cell lines HepG2, HepGA, and 7721 based on ... RT-PCR.CYP2C19 mRNA expression is highest in hepatocarcinoma tissue, moderate in adjacent normal liver tissue, and ... The significantly elevated expression of CYP2C19 mRNA in hepatocarcinoma indicates an association between the occurrence of hepatocarcinoma ...

Tópico(s): Chemical Reactions and Isotopes

2006 - International Scientific Information Inc. | Medical Science Monitor

Artigo Revisado por pares

Roberto Mazzanti, A Giallombardo, Enrico Mini, Stefania Nobili, B Neri, Umberto Arena, Pietro Pantaleo, Valentina Fabbroni, Mara Ghilardi, Riccardo Gattai, L Bandettini,

Background. Hepatocarcinoma is one of the most common malignant tumours world-wide with poor prognosis. Treatment of locally advanced hepatocarcinoma is still controversial. Transcatheter arterial (chemo-)embolisation of hepatocarcinoma are widely used methods but some aspects regarding ... 5-flurouracil and folinic acid in locally advanced hepatocarcinoma is a viable alternative to existing therapies. Patients. Twenty-four inoperable consecutive patients with locally advanced hepatocarcinoma were enrolled. They all underwent intra-arterial chemotherapy ...

Tópico(s): Cholangiocarcinoma and Gallbladder Cancer Studies

2004 - Elsevier BV | Digestive and Liver Disease

Artigo Acesso aberto Revisado por pares

Susanne Schuster, Melanie Penke, Theresa Gorski, Stefanie Petzold-Quinque, Georg Damm, Rolf Gebhardt, Wieland Kieß, Antje Garten,

... function and asked whether there are differences in hepatocarcinoma cells (HepG2, Hep3B cells) and non-cancerous primary ... lower basal NAMPT mRNA and protein expression in hepatocarcinoma cells compared to primary hepatocytes. In contrast, SIRT1 was significantly higher expressed in hepatocarcinoma cells than in primary hepatocytes. Resveratrol induced cell ... and SIRT1 are differentially regulated by resveratrol in hepatocarcinoma cells and primary hepatocytes and that resveratrol did not act as a SIRT1 activator in hepatocarcinoma cells.

Tópico(s): Adipose Tissue and Metabolism

2014 - Public Library of Science | PLoS ONE

Artigo Acesso aberto Revisado por pares

Hong‐Mei An, Yongfei Xue, Yanli Shen, Qin Du, Bing Hu,

... valproate (SVP), a known HDAC inhibitor, in human hepatocarcinoma cells. The results showed SVP inhibited the proliferation ... G0/G1 phase cell cycle arrest in human hepatocarcinoma cells. Low dose SVP treatment also increased acetylation ... dose of SVP could induce cell senescence in hepatocarcinoma cells, which might correlate with hyperacetylation of histone ... Since the effective concentration inducing cell senescence in hepatocarcinoma cells is clinically available, whether a clinical dose of SVP could induce cell senescence in clinical hepatocarcinoma is worthy of further study.

Tópico(s): Protein Degradation and Inhibitors

2013 - Multidisciplinary Digital Publishing Institute | Molecules

Revisão Acesso aberto

Bing Hu,

... used in all aspects of integrative therapy in hepatocarcinoma, including surgical resection, liver transplantation, TACE, local ablative ... and even as monotherapy for middle-advanced stage hepatocarcinoma.Clinical practices have confirmed that TCM is effective ... delay tumor progression, and prolong survival time in hepatocarcinoma patients.The effective mechanism of TCM against hepatocarcinoma is related to inducing apoptosis, autophagy, anoikis and ... contribute more to the prevention and treatment of hepatocarcinoma.

Tópico(s): Traditional Chinese Medicine Analysis

2015 - Baishideng Publishing Group | World Journal of Hepatology

Artigo Acesso aberto

Shuqing Liu, Chunmei Guo, Jiasheng Wang, Bo Wang, Houbao Qi, Ming‐Zhong Sun,

... Sun, e-mail: smzlsq@163.com Keywords: Anxa11, hepatocarcinoma, lymphatic metastasis, chemoresistance, c-Jun Received: October 20, ... various cancers. Using a pair of syngeneic murine hepatocarcinoma cells, Hca-P with ~25% and Hca-F ... metastatic (LNM) potentials, we demonstrated Anxa11 involvement in hepatocarcinoma lymphatic metastasis. Here, ANXA11 acted as a suppressor ... pathway. It might play an important role in hepatocarcinoma cell malignancy and be a therapeutic target for hepatocarcinoma.

Tópico(s): Peptidase Inhibition and Analysis

2016 - Impact Journals LLC | Oncotarget

Artigo Acesso aberto Revisado por pares

Chunmei Guo, Chao Gao, Xinxin Lv, Dongting Zhao, Frederick T. Greenaway, Lihong Hao, Yuxiang Tian, Shuqing Liu, Ming‐Zhong Sun,

... the effect of CRKL on glucose metabolism of hepatocarcinoma cells. CRKL and PI3K were found to be overexpressed in both hepatocarcinoma cells and tissues; meanwhile, CRKL up‐regulation was ... glucose uptake, lactate production and glycogen synthesis of hepatocarcinoma cells by up‐regulating glucose transporters 1 (GLUT1), ... GSK3β) expression. Mechanistically, CRKL promoted glucose metabolism of hepatocarcinoma cells via enhancing the CRKL‐PI3K/Akt‐GLUT1/ ... glucose metabolism and offers novel therapeutic strategies for hepatocarcinoma.

Tópico(s): Cancer, Hypoxia, and Metabolism

2021 - Wiley | Journal of Cellular and Molecular Medicine

Artigo Revisado por pares

Wenjuan Li, Shaoping Nie, Qiang Yu, Mingyong Xie,

... gallate (EGCG) on the induction of apoptosis in hepatocarcinoma cell lines in vitro and further examine the ... was observed that EGCG rapidly induced apoptosis in hepatocarcinoma SMMC7721 cells. EGCG-induced apoptosis was in association ... was also shown during EGCG-induced apoptosis of hepatocarcinoma SMMC7721 cells. The antioxidant N-acetyl-l-cysteine ( ... a key role in EGCG-induced apoptosis in hepatocarcinoma SMMC7721 cells. In summary, EGCG-induced apoptosis through ... pathways, and ROS affected EGCG-induced apoptosis in hepatocarcinoma SMMC7721 cells.

Tópico(s): Tannin, Tannase and Anticancer Activities

2009 - American Chemical Society | Journal of Agricultural and Food Chemistry