... St. Tomé de Guyana [f. 86] e yendo hera del Reyno del Valle de romegas o seguna ... que mentia el dicho indio Cristova que no hera mestizo sono indio puno ye ansi no le ...
0000 - Gale Group | SASII
Lakshminarayan M. Iyer, Kira S. Makarova, Eugene V. Koonin, L. Aravind,
... shown that a predicted P-loop ATPase (the HerA or MlaA protein), which is highly conserved in ... the TrwB ATPase. In this study, the FtsK–HerA superfamily of P-loop ATPases, in which the HerA clade comprises one of the major branches, is ... show that, in addition to the FtsK and HerA clades, this superfamily includes several families of characterized ... stranded DNA viruses also belong to the FtsK–HerA superfamily. The FtsK protein is the essential bacterial ... cell division. The structural and evolutionary relationship between HerA and FtsK and the nearly perfect complementarity of ...
Tópico(s): RNA and protein synthesis mechanisms
2004 - Oxford University Press | Nucleic Acids Research
Springer Link
... St. Tomé de Guyana [f. 86] e yendo hera del Reyno del Valle de romegas o seguna ... que mentia el dicho indio Cristova que no hera mestizo sono indio puno ye ansi no le ...
0000 - Gale Group | SASII
Qihong Huang, Linlin Liu, Junfeng Liu, Jinfeng Ni, Qunxin She, Yulong Shen,
... the in vivo functions of the ATPase/helicase HerA, the nuclease NurA, and their associated proteins Mre11 ... four genes in the same operon, mre11, rad50, herA, and nurA, are essential for cell viability by ... biochemical characterization demonstrating that the ATPase activity of HerA, the interaction between HerA and NurA, and the efficient 5'-3' DNA end resection activity of the HerA-NurA complex are essential for cell viability. NurA ... co-purified with a chromosomally encoded N-His-HerA in vivo. The interactions of HerA with the ...
Tópico(s): Enzyme Structure and Function
2015 - Springer Science+Business Media | BMC Molecular Biology
... St. Tomé de Guyana [f. 86] e yendo hera del Reyno del Valle de romegas o seguna ... que mentia el dicho indio Cristova que no hera mestizo sono indio puno ye ansi no le ...
0000 - Gale Group | SASII
C. W. de Jager, Tjeerd Ketel, P. J. Mulders, J.E.J. Oberski, M. Oskam-Tamboezer,
... Spin in the Nucleon Physics with a Polarized HERA Collider Spin and Weak Interactions in Atoms and ... Polarized Structure Functions in Charged Current Processes at HERA The Twist-3 Induced Asymmetries in p↑p → ... Quark Mass The HERMES Polarised Proton Target at HERA Spin Effects in Diffractive Deep Inelastic Scattering x- ... from a Polarized 3He Target Polarized Protons in HERA Large Spin-Polarized Solid HD Targets for Photonuclear ... Spin Structure Function Single Spin Asymmetry Measurements with HERA- Mechanisms of Two-Body Breakup of Polarized 3He ...
1997 - World Scientific | SPIN
... St. Tomé de Guyana [f. 86] e yendo hera del Reyno del Valle de romegas o seguna ... que mentia el dicho indio Cristova que no hera mestizo sono indio puno ye ansi no le ...
0000 - Gale Group | SASII
S. Morlang, Wolfgang Weglöhner, F. Franceschi,
... crystallization of the first thermophilic DEAD box protein, Hera (heat-resistant RNA-dependent ATPase) from Thermus thermophilus HB8. The molecular mass of the deduced Hera protein sequence (510 amino acid residues) is 55.95 kDa. Hera possesses all of the conserved motifs found among ... at its C-terminal region (residues 372–386). Hera appears to be non-specific with respect to ... P protein motif significantly reduces the ability of Hera to hydrolyze ATP in the presence of RNase P RNA. Hera has a specific ATPase activity of 480 units/ ...
Tópico(s): RNA modifications and cancer
1999 - Elsevier BV | Journal of Molecular Biology
... St. Tomé de Guyana [f. 86] e yendo hera del Reyno del Valle de romegas o seguna ... que mentia el dicho indio Cristova que no hera mestizo sono indio puno ye ansi no le ...
0000 - Gale Group | SASII
Tie-Jiun Hou, Sayipjamal Dulat, Jun Gao, Marco Guzzi, J. Huston, Pavel Nadolsky, Jon Pumplin, Carl R. Schmidt, Daniel R. Stump, C.–P. Yuan,
We analyze the impact of the recent HERA Run $\mathrm{I}+\mathrm{II}$ combination of inclusive deep inelastic scattering cross-section data on the CT14 global analysis of parton distribution functions ( ... to-leading order, called ${\mathrm{CT}14}_{\mathrm{HERA}2}$, are obtained by a refit of the CT14 data ensembles, in which the HERA Run I combined measurements are replaced by the new HERA Run $\mathrm{I}+\mathrm{II}$ combination. The CT14 ... the same parametrization for ${\mathrm{CT}14}_{\mathrm{HERA}2}$ but with an additional shape parameter for ...
Tópico(s): Quantum Chromodynamics and Particle Interactions
2017 - American Physical Society | Physical review. D/Physical review. D.
... St. Tomé de Guyana [f. 86] e yendo hera del Reyno del Valle de romegas o seguna ... que mentia el dicho indio Cristova que no hera mestizo sono indio puno ye ansi no le ...
0000 - Gale Group | SASII
David R. DeBoer, Aaron R. Parsons, James E. Aguirre, Paul Alexander, Zaki S. Ali, Adam P. Beardsley, G. Bernardi, Judd D. Bowman, Richard F. Bradley, C. L. Carilli, Carina Cheng, Eloy de Lera Acedo, Joshua S. Dillon, Aaron Ewall‐Wice, Gcobisa Fadana, Nicolas Fagnoni, Randall Fritz, Steve R. Furlanetto, Brian Glendenning, Bradley Greig, Jasper Grobbelaar, B. J. Hazelton, Jacqueline N. Hewitt, J. Hickish, Daniel Jacobs, Austin Julius, MacCalvin Kariseb, Saul A. Kohn, Telalo Lekalake, Adrian Liu, Anita Loots, David H. E. MacMahon, Lourence Malan, Cresshim Malgas, Matthys Maree, Zachary E. Martinot, Nathan Mathison, Eunice Matsetela, Andrei Mesinger, M. F. Morales, Abraham R. Neben, Nipanjana Patra, Samantha Pieterse, Jonathan C. Pober, N. Razavi‐Ghods, Jon Ringuette, James Robnett, Kathryn Rosie, Raddwine Sell, Craig Smith, Angelo Syce, Max Tegmark, Nithyanandan Thyagarajan, Peter K. G. Williams, Haoxuan Zheng,
The Hydrogen Epoch of Reionization Array (HERA) is a staged experiment to measure 21 cm emission from the primordial intergalactic medium (IGM) throughout cosmic reionization ($z=6-12$), and ... the IGM, introducing fluctuations in 21 cm emission. HERA is designed to characterize the evolution of the ... and the early sources of heating. The full HERA instrument will be a 350-element interferometer in ... site and the next 18 are under construction. HERA has been designated as an SKA Precursor instrument. In this paper, we summarize HERA's scientific context and provide forecasts for its ...
Tópico(s): Radio Wave Propagation Studies
2017 - Institute of Physics | Publications of the Astronomical Society of the Pacific
... St. Tomé de Guyana [f. 86] e yendo hera del Reyno del Valle de romegas o seguna ... que mentia el dicho indio Cristova que no hera mestizo sono indio puno ye ansi no le ...
0000 - Gale Group | SASII
Zainab Ahdash, Andy M. Lau, Robert T. Byrne, Katja Lammens, Alexandra Stüetzer, Henning Urlaub, Paula J. Booth, Eamonn Reading, Karl‐Peter Hopfner, Argyris Politis,
The HerA-NurA helicase-nuclease complex cooperates with Mre11 and Rad50 to coordinate the repair of double-stranded DNA ... about the assembly mechanism and activation of the HerA-NurA. By combining hybrid mass spectrometry with cryo- ... biochemical data, we investigate the oligomeric formation of HerA and detail the mechanism of nucleotide binding to the HerA-NurA complex from thermophilic archaea. We reveal that ATP-free HerA and HerA-DNA complexes predominantly exist in solution as a ... of either NurA or ATP stabilizes the hexameric HerA, indicating that HerA-NurA is activated by substrates ...
Tópico(s): Bacterial Genetics and Biotechnology
2017 - Oxford University Press | Nucleic Acids Research
... St. Tomé de Guyana [f. 86] e yendo hera del Reyno del Valle de romegas o seguna ... que mentia el dicho indio Cristova que no hera mestizo sono indio puno ye ansi no le ...
0000 - Gale Group | SASII
Jarkko Johansson, Alireza Salami, Anders Lundquist, Anders Wåhlin, Micael Andersson, Lars Nyberg,
The HERA (Hemispheric Encoding/Retrieval Asymmetry) model captures hemispheric lateralization of prefrontal cortex (PFC) brain activity during memory encoding and retrieval. Reduced HERA has been observed in cross-sectional aging studies, ... to our knowledge, on age-related changes in HERA and whether maintained or reduced HERA relates to well-preserved memory functioning. In the present study we set out to explore HERA in a longitudinal neuroimaging sample from the Betula ... face-name paired-associates task to derive a HERA index. In support of the HERA model, the ...
Tópico(s): Functional Brain Connectivity Studies
2019 - Elsevier BV | Neuropsychologia
... St. Tomé de Guyana [f. 86] e yendo hera del Reyno del Valle de romegas o seguna ... que mentia el dicho indio Cristova que no hera mestizo sono indio puno ye ansi no le ...
0000 - Gale Group | SASII
David M. Richards, Viola Marschall, Katharina Billian-Frey, Karl Heinonen, Christian J. Merz, Mauricio Redondo Müller, Julian P. Sefrin, Matthias Schröder, Jaromir Sykora, Harald Fricke, Oliver Hill, Christian Gieffers, Meinolf Thiemann,
... of antibody-based TNFRSF agonists, we have developed HERA-GITRL, a fully human hex avalent TNF r eceptor a gonist (HERA) targeting GITR and mimicking the natural signaling concept. HERA-GITRL is composed of a trivalent but single- ... mouse tumor models. Results For functional characterization of HERA-GITRL in vitro, human immune cells were isolated ... with anti-CD3 antibody in the presence of HERA-GITRL. Consistently, HERA-GITRL increased the activity of T cells, including ... antibody and a trivalent GITRL, only the hexavalent HERA-GITRL showed full biological activity independent of additional ...
Tópico(s): CAR-T cell therapy research
2019 - BMJ | Journal for ImmunoTherapy of Cancer
... St. Tomé de Guyana [f. 86] e yendo hera del Reyno del Valle de romegas o seguna ... que mentia el dicho indio Cristova que no hera mestizo sono indio puno ye ansi no le ...
0000 - Gale Group | SASII
Zhangfei Shen, Qingpeng Lin, Xiaoyuan Yang, Elizabeth Fosuah, Tian‐Min Fu,
SIR2-HerA, a bacterial two-protein anti-phage defense system, induces bacterial death by depleting NAD+ upon phage infection. Biochemical reconstitution of SIR2, HerA, and the SIR2-HerA complex reveals a dynamic assembly process. Unlike other ATPases, HerA can form various oligomers, ranging from dimers to nonamers. When assembled with SIR2, HerA forms a hexamer and converts SIR2 from a ... ATP can inhibit NAD+ hydrolysis by the SIR2-HerA complex. Cryo-EM structures of the SIR2-HerA complex reveal a giant supramolecular assembly up to ...
Tópico(s): Neonatal Health and Biochemistry
2023 - Elsevier BV | Molecular Cell
... St. Tomé de Guyana [f. 86] e yendo hera del Reyno del Valle de romegas o seguna ... que mentia el dicho indio Cristova que no hera mestizo sono indio puno ye ansi no le ...
0000 - Gale Group | SASII
Kara A. Bernstein, Rodney Rothstein,
... and Rad50 genes cluster in an operon with HerA and NurA genes (Constantinesco et al., 2004Constantinesco F. ... of genes encoding the RecBCD complex in eubacteria. HerA is an ATP-dependent DNA helicase and NurA ... DNA substrates, they can act together with purified HerA and NurA to processively degrade double-stranded DNA ... 122) Google Scholar). Therefore, the cooperative activities of HerA, NurA, Mre11, and Rad50 efficiently process DSB ends, ... the observed functional interactions between Mre11-Rad50 and HerA or NurA on DNA, Hopkins and Paull did ...
Tópico(s): Plant Genetic and Mutation Studies
2009 - Cell Press | Cell
... St. Tomé de Guyana [f. 86] e yendo hera del Reyno del Valle de romegas o seguna ... que mentia el dicho indio Cristova que no hera mestizo sono indio puno ye ansi no le ...
0000 - Gale Group | SASII
... catalyze the ATP-dependent destabilization of RNA duplexes. Hera is a DEAD-box helicase from Thermus thermophilus ... binding domain. The combined structural information on individual Hera domains provides a molecular model of the Hera dimer. The modular architecture with flexible connections between ... relative orientations of the RBD relative to the Hera helicase core, and of the two helicase cores ... in RNA unwinding. The in vivo function of Hera is unknown. The Hera RBD recognizes two distinct elements in the RNA ...
Tópico(s): Bacterial Genetics and Biotechnology
2013 - Wiley | Biopolymers
... St. Tomé de Guyana [f. 86] e yendo hera del Reyno del Valle de romegas o seguna ... que mentia el dicho indio Cristova que no hera mestizo sono indio puno ye ansi no le ...
0000 - Gale Group | SASII
Christian J. Merz, Jaromir Sykora, Viola Marschall, David M. Richards, Karl Heinonen, Mauricio Redondo Müller, Meinolf Thiemann, Tim Schnyder, Harald Fricke, Oliver Hill, Christian Gieffers,
... antibodies, we have developed the hexavalent receptor agonist (HERA) Technology. HERA compounds are fusion proteins composed of 3 receptor ... silenced human IgG1 thereby generating a hexavalent molecule. HERA-CD40L provides efficient receptor agonism on CD40-expressing ... was observed upon treatment of B cells with HERA-CD40L. Monocyte treatment with HERA-CD40L promoted differentiation towards the M1 spectrum and ... co-cultures of T and B cells with HERA-CD40L–triggered robust antitumor activation of T cells, ...
Tópico(s): Immunotherapy and Immune Responses
2018 - Lippincott Williams & Wilkins | Journal of Immunotherapy