... 457.https://doi.org/10.1071/MF03200Gloria Martı́nez, Hernán Pérez Effect of different temperature regimes on reproductive conditioning ...
Tópico(s): Marine Biology and Environmental Chemistry
1968 - University of Chicago Press | Physiological Zoology
Tópico(s): Medieval Architecture and Archaeology
1972 - Spanish National Research Council | Trabajos de Prehistoria
Rubén Soto‐Moyano, Alejandro Hernández, Hernán Pérez, Samuel Ruíz, Gabriela Dı́az-Véliz, Jorge Belmar,
The influence of early protein-energy malnutrition on the induced release of noradrenaline in the rat prefrontal cortex was studied: (i) by evaluating in vivo the release of the neurotransmitter as revealed by changes in the ability of pyramidal cells to integrate transient transmembrane currents generated by discrete packets of noradrenaline released by repetitive electrical stimulation of the locus coeruleus; and (ii) by measuring in vitro the potassium-induced release of 3H-noradrenaline in slices ...
Tópico(s): Diet and metabolism studies
1987 - Taylor & Francis | International Journal of Neuroscience
Hernán Pérez, Alejandro Hernández, C. Robert Almli,
Field-evoked potentials from the main olfactory bulb in response to stimulation of the olfactory nerve and lateral olfactory tract were measured without and with conditioning stimulation of the locus coeruleus noradrenergic system. The locus coeruleus conditioning stimulus suppressed or inhibited the late components of the olfactory bulb potential evoked by orthodromic olfactory nerve stimulation; this inhibitory effect was suppressed by the microinjection of the alpha-adrenergic blocker prazosin ...
Tópico(s): Biochemical Analysis and Sensing Techniques
1987 - Elsevier BV | Brain Research Bulletin
Hernán Pérez, Katherina Brokordt, Gloria Martı́nez, Helga Guderley,
Tópico(s): Marine Biology and Environmental Chemistry
2009 - Springer Science+Business Media | Marine Biology
Gloria Martı́nez, Hernán Pérez,
Adult Argopecten purpuratus were conditioned under four different temperature regimes and their gonadal development and quality of the resulting offspring evaluated. Biochemical composition of muscle and gonad, during laboratory conditioning at the different treatments, was also examined. Spawned-out individuals were obtained from commercial culture centers for experimentation. Test groups of scallops were independently maintained at: (a) 15 °C, (b) 19 °C, (c) 15 °C in the first stage, raised to 19 °C ...
Tópico(s): Marine Biology and Environmental Chemistry
2003 - Elsevier BV | Aquaculture
Hernán Pérez, Xavier Janssoone, Helga Guderley,
To escape from starfish predators, giant scallops, Placopecten magellanicus, swim using series of strong phasic contractions interrupted by tonic contractions. To investigate whether these tonic contractions allow metabolic recuperation of the adductor muscle, we sampled scallops at rest (Control), after an initial series of phasic contractions (Phasic) and after 1 min of tonic contraction following their initial phasic contractions (Phasic + Tonic) and compared muscle levels of phosphoarginine, adenylate ...
Tópico(s): Ocean Acidification Effects and Responses
2008 - Elsevier BV | Journal of Experimental Marine Biology and Ecology
Alejandro Hernández, Héctor Burgos, Mauricio Mondaca, Rafael Barra, Héctor Núñez, Hernán Pérez, Rubén Soto‐Moyano, Walter Sierralta, Víctor Fernández Salinas, Ricardo Olivares, Luis Valladares,
Reduction of the protein content from 25 to 8% casein in the diet of pregnant rats results in impaired neocortical long-term potentiation (LTP) of the offspring together with lower visuospatial memory performance. The present study was aimed to investigate whether this type of maternal malnutrition could result in modification of plastic capabilities of the entorhinal cortex (EC) in the adult progeny. Unlike normal eutrophic controls, 55–60-day-old prenatally malnourished rats were unable to develop ...
Tópico(s): Anesthesia and Neurotoxicity Research
2008 - Hindawi Publishing Corporation | Neural Plasticity
Héctor Núñez, Samuel Ruíz, Rubén Soto‐Moyano, Mario Navarrete, Luis Valladares, Allan White, Hernán Pérez,
Prenatal undernutrition induces a variety of cardiovascular alterations in mammals when adults, including hypertension and hypercortisolism, which are thought to be caused by decreased glucocorticoid feedback control of the hypothalamus-pituitary-adrenal (HPA) axis programmed during fetal life. Hypothalamic CRH seems to be involved in blood pressure elevation of spontaneously hypertensive rats and in primary hypertension of humans, but the influence of prenatal undernutrition on CRH expression has ...
Tópico(s): Diet and metabolism studies
2008 - Elsevier BV | Neuroscience Letters
Helga Guderley, Xavier Janssoone, Madeleine Nadeau, Mélanie Bourgeois, Hernán Pérez Cortés,
Handling stress coupled with air exposure reduced the contractile performance during escape responses of 2+ scallops, Placopecten magellanicus, modifying maximal and mean phasic force production, the number of phasic contractions and the minimal interval between phasic contractions as well as reducing maximal tonic force production and increasing the reliance upon tonic contractions. The impact of handling stress was mitigated in scallops studied in the fall (late October) relative to the summer ( ...
Tópico(s): Cephalopods and Marine Biology
2008 - Elsevier BV | Journal of Experimental Marine Biology and Ecology
Hernán Pérez, Xavier Janssoone, Madeleine Nadeau, Helga Guderley,
Scallops are quite vulnerable to handling and transport because they cannot completely close their valves. We examined how handling stress changed force production during escape responses of juvenile giant scallops, Placopecten magellanicus and compared these changes to those of adenylate energy charge (AEC) and phosphoarginine levels in the adductor muscle. We characterised force production 1) after the scallops were transported by boat in pearl nets from the culture site to the sorting area; 2) ...
Tópico(s): Calcium Carbonate Crystallization and Inhibition
2008 - Elsevier BV | Aquaculture
Alessia Ligresti, Luciano De Petrocellis, Dolores Hernán Pérez de la Ossa, M.R. Aberturas, Luigia Cristino, Aniello Schiano Moriello, Andrea Fińizio, María Esther Gil-Alegre, Ana Isabel Torres‐Suárez, Jesús Molpeceres, Vincenzo Di Marzo,
Background Considerable efforts have been made to characterize the pathways regulating the extracellular levels of the endocannabinoid anandamide. However, none of such pathways has been so argued as the existence of a carrier-mediated transport of anandamide across the membrane. Apart from the lack of molecular evidence for such a carrier, the main reasons of this controversy lie in the methodologies currently used to study anandamide cellular uptake. Furthermore, the main evidence in favor of ...
Tópico(s): Sleep and Wakefulness Research
2010 - Public Library of Science | PLoS ONE
... nanomedicinesFalk Ehmann, Kumiko Sakai-Kato, Ruth Duncan, Dolores Hernán Pérez de la Ossa, Ruben Pita, Jean-Marc Vidal, ...
Tópico(s): Nanoparticles: synthesis and applications
2007 - Future Medicine | Nanomedicine
Daniza Ivanovic, María del Pilar Rodríguez, Hernán Pérez, J Alvear, Natalia Díaz‐Valdivia, Bárbara Leyton, Atilio F. Almagià, Triana D. Toro, Marı́a Soledad C. Urrutia, R Ivanović,
Tópico(s): Health and Lifestyle Studies
2007 - Springer Nature | European Journal of Clinical Nutrition
Jeffrey Lopez‐Rojas, William Almaguer, Hernán Pérez, Julietta U. Frey, Jorge A. Bergado,
Hippocampal long-term potentiation (LTP) is a long-lasting increase in synaptic efficacy which is considered a cellular correlate of learning and memory. It has been shown that both, stimuli with emotional/motivational content and the electrical stimulation the basolateral amygdala, can modulate hippocampal LTP. The nucleus accumbens is part of the ventral striatum and is composed of two main regions: core and shell. Core and shell share a similar cellular composition, but differ in their connectivity ...
Tópico(s): Neural dynamics and brain function
2007 - Elsevier BV | Neuroscience
Mario Navarrete, Héctor Núñez, Samuel Ruíz, Rubén Soto‐Moyano, Luis Valladares, Allan White, Hernán Pérez,
Prenatal undernutrition is known to disturb the hypothalamo-pituitary-adrenal (HPA) axis, possibly through the programming of decreased expression of hypothalamic and pituitary glucocorticoid receptors. To test this hypothesis, we examined the corticosterone response to moderate subcutaneous (100 μg/kg) and intra-paraventricular (50 pmol, bilaterally) dexamethasone (DEX) challenges in normal eutrophic and prenatally undernourished young rats. Undernutrition was induced during fetal life by restricting ...
Tópico(s): Diet and metabolism studies
2007 - Elsevier BV | Neuroscience Letters
Guillermo Jiménez‐Ferrer, Hernán Pérez-López, Lorena Soto‐Pinto, José Nahed-Toral, Lorenzo Hernández-López, Jesús Rivas Carmona,
SUMMARY The purpose of the present study was to characterize the livestock system and to identify nutritional potential and local knowledge of fodder trees and shrubs in two localities of Chiapas, Mexico. The study included participatory rural evaluation techniques, semi-structured interviews, laboratory analysis and a palatability essay with “Pelibuey” sheep. The latter was carried out through a random design. The livestock system was classified as agrosilvopastoral, characterized by its access ...
Tópico(s): Seed and Plant Biochemistry
2007 - Associação Interciencia | Interciencia
Osvaldo Flores, Hernán Pérez, Luis Valladares, Carlos Morgan, Arnaldo Gatica, Héctor Burgos, Ricardo Olivares, Alejandro Hernández,
Moderate reduction in the protein content of the mother's diet (hidden malnutrition) does not alter body and brain weights of rat pups at birth, but leads to dysfunction of neocortical noradrenaline systems together with impaired long-term potentiation and visuo-spatial memory performance. As β₁-adrenoceptors and downstream protein kinase signaling are critically involved in synaptic long-term potentiation and memory formation, we evaluated the β₁-adrenoceptor density and the expression of cyclic- ...
Tópico(s): Neuroscience and Neuropharmacology Research
2011 - Wiley | Journal of Neurochemistry
Rubén Soto‐Moyano, Héctor Burgos, Francisco Flores, Luis Valladares, Walter Sierralta, Valeria Herrera Fernández, Hernán Pérez, Pablo Hernández, Alejandro Hernández,
Melatonin has been shown to inhibit long-term potentiation (LTP) in hippocampal slices of rats. Since LTP may be one of the main mechanisms by which memory traces are encoded and stored in the central nervous system, it is possible that melatonin could modulate cognitive performance by interfering with the cellular and/or molecular mechanisms involved in LTP. We investigated in rats the effects of intraperitoneally-administered melatonin (0.1, 1 and 10 mg/kg), its saline-ethanol solvent, or saline ...
Tópico(s): Stress Responses and Cortisol
2006 - Elsevier BV | Pharmacology Biochemistry and Behavior
Hernán Pérez, Samuel Ruíz, Héctor Núñez, Allan White, Martín Gotteland, Alejandro Hernández,
Abstract Rats submitted to fetal growth retardation by in utero malnutrition develop hypertension when adult, showing increased hypothalamic mRNA expression for corticotropin‐releasing hormone (CRH) and increased central noradrenergic activity. As hypothalamic CRH serves as an excitatory neurotransmitter within the locus coeruleus (LC) and coerulear norepinephrine plays a similar role within the paraventricular nucleus (PVN) of the hypothalamus, we studied, in both normal and prenatally undernourished ...
Tópico(s): Diet and metabolism studies
2006 - Wiley | European Journal of Neuroscience
Marco Bragagni, Cristina Beneitez, Cristina Muñoz‐San Martín, Dolores Hernán Pérez de la Ossa, P. Mura, María Esther Gil-Alegre,
The use of injectable local anaesthetics for the treatment of severe postoperative pain is limited by the short duration of the painkilling effect. Pre-formulation studies were carried out for the development of an injectable microparticle formulation for controlled release of prilocaine, an amino-amide type local anaesthetic suitable for intravenous, subcutaneous and intramuscular administration. To the best of our knowledge, the encapsulation of prilocaine into microparticles has not been investigated ...
Tópico(s): Advancements in Transdermal Drug Delivery
2012 - Elsevier BV | International Journal of Pharmaceutics
Dolores Hernán Pérez de la Ossa, Alessia Ligresti, María Esther Gil-Alegre, M.R. Aberturas, Jesús Molpeceres, Vincenzo Di Marzo, Ana Isabel Torres‐Suárez,
Cannabinoids show promise for the treatment of various medical conditions such as emesis, anorexia, pain, cancer, multiple sclerosis, Parkinson's disease and glaucoma. However, their high lipohilicity and instability complicate their handling and dosing, and restrict their use as pharmaceuticals. The objective of the present work was to assess the feasibility of developing cannabinoid loaded poly-ε-caprolactone (PCL) microparticles prepared by the oil-in-water emulsion–solvent evaporation technique ...
Tópico(s): Pancreatic function and diabetes
2012 - Elsevier BV | Journal of Controlled Release
Rubén Soto‐Moyano, Alejandro Hernández, Hernán Pérez, Samuel Ruíz, P. Carreño, Jorge Belmar,
It is known that nutritional restriction during gestation affects the growth of the corpus callosum. The present study was designed to evaluate whether prenatal malnutrition may alter, in the rat, the normal pattern of functional callosal interhemispheric connections of the visual cortex. Since callosal development has been associated with brain lateralization, the effect of malnutrition during gestation on the normal asymmetry of visual cortical evoked responses was also studied. Prenatal malnutrition ...
Tópico(s): Mitochondrial Function and Pathology
1993 - Elsevier BV | Experimental Neurology
Rubén Soto‐Moyano, Luis Valladares, Walter Sierralta, Hernán Pérez, Mauricio Mondaca, Víctor Manuel Fernández, Héctor Burgos, Alejandro Hernández,
Abstract Mild reduction in the protein content of the mother's diet from 25 to 8% casein, calorically compensated by carbohydrates, does not alter body and brain weights of rat pups at birth, but leads to significant enhancements in the concentration and release of cortical noradrenaline during early postnatal life. Since central noradrenaline and some of its receptors are critically involved in long‐term potentiation (LTP) and memory formation, this study evaluated the effect of mild prenatal protein ...
Tópico(s): Birth, Development, and Health
2005 - Wiley | Journal of Neurochemistry
Mauricio Mondaca, Alejandro Hernández, Hernán Pérez, Luis Valladares, Walter Sierralta, Víctor Manuel Fernández, Rubén Soto‐Moyano,
Pretreatment with the alpha(2)-adrenoceptor agonist clonidine (31.25, 62.5, or 125 microg/kg, i.p.) dose-dependently reduced long-term potentiation (LTP) elicited in vivo in the occipital cortex of anesthetized rats, whereas pretreatment with the alpha(2)-adrenoceptor antagonist yohimbine (0.133, 0.4, or 1.2 mg/kg, i.p.) increased neocortical LTP in a dose-dependent fashion. These effects could be related to the reported disruptive and facilitatory actions induced on memory formation by pretreatment ...
Tópico(s): Anesthesia and Neurotoxicity Research
2004 - Elsevier BV | Brain Research
Christian Pedemonte, Hernán Pérez Gutiérrez, Edgardo González, Ilich Vargas, Diego Lazo,
Post-traumatic oromandibular dystonia (PTOD) is a disorder whose symptoms can include bruxism, muscle pain, and involuntary muscle contraction, among others. The use of onabotulinumtoxinA (ObT-A) is helpful in controlling the symptoms of patients with PTOD. The aim of this study was to evaluate the use of ObT-A in the treatment of PTOD.In this prospective case-series study, the population consisted exclusively of patients diagnosed with PTOD, without distinction by age or gender, from January 2007 ...
Tópico(s): Ophthalmology and Eye Disorders
2014 - Elsevier BV | Journal of Oral and Maxillofacial Surgery
Cristina González, Jorge Martín‐Gutiérrez, Melchor García Domínguez, Alejandra Sanjuán Hernán-Pérez, Carmen Mato Carrodeguas,
In this work we present the results obtained from an experience performed with freshmen students of the Industrial Engineering degree at Las Palmas de Gran Canaria University aiming for improvement of their spatial abilities.The work linked to spatial abilities show a great lack of uniformity according to the adopted terminology as a consequence of different approaches, researchers' field of study and the research's scale.But all research agree on the relationship between a high level of spatial ...
Tópico(s): Geography Education and Pedagogy
2013 - Elsevier BV | Procedia Computer Science
Dolores Hernán Pérez de la Ossa, Mar Lorente, María Esther Gil-Alegre, Sofía Torres, Elena García-Taboada, M.R. Aberturas, Jesús Molpeceres, Guillermo Velasco, Ana Isabel Torres‐Suárez,
Cannabinoids, the active components of marijuana and their derivatives, are currently investigated due to their potential therapeutic application for the management of many different diseases, including cancer. Specifically, Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD) – the two major ingredients of marijuana – have been shown to inhibit tumor growth in a number of animal models of cancer, including glioma. Although there are several pharmaceutical preparations that permit the oral administration ...
Tópico(s): Sleep and Wakefulness Research
2013 - Public Library of Science | PLoS ONE
Dolores Hernán Pérez de la Ossa, María Esther Gil-Alegre, Alessia Ligresti, M.R. Aberturas, Jesús Molpeceres, Ana Isabel Torres‐Suárez, Vincenzo Di Marzo,
Cannabinoids present an interesting therapeutic potential as antiemetics, appetite stimulants in debilitating diseases (cancer, AIDS and multiple sclerosis), analgesics, and in the treatment of multiple sclerosis and cancer, among other conditions. However, despite their high clinical potential, only few dosage forms are available to date.In this paper, the development of Δ9-tetrahydrocannabinol (THC) biodegradable microspheres as an alternative delivery system for cannabinoid parenteral administration ...
Tópico(s): Biochemical effects in animals
2013 - Taylor & Francis | Journal of drug targeting
Falk Ehmann, Kumiko Sakai‐Kato, Ruth Duncan, Dolores Hernán Pérez de la Ossa, Ruben Pita, Jean-Marc Vidal, Ashish Kohli, László Tóthfalusi, Alan Sanh, Sandrine A. Tinton, Jean-Louis Robert, Beatriz Silva Lima, M. Papaluca Amati,
Over the last three decades many first-generation nanomedicines have successfully entered routine clinical use and it is now important for medicines regulatory agencies to consider the mechanisms needed to ensure safe introduction of 'follow-on' nanomedicine products, 'nanosimilars'. Moreover, drug regulators need to ensure that 'next'-generation nanomedicines enter clinical development and consequently the market in a safe and timely way for the benefit of public health. Here we review recent European ...
Tópico(s): Graphene and Nanomaterials Applications
2013 - Future Medicine | Nanomedicine