Koichi Ohno, Shoji Fujisawa, Hideki Mutoh, Yoshiya Harada,
... Penning ionization in substituted anilinesKoichi Ohno, Shoji Fujisawa, Hideki Mutoh, and Yoshiya HaradaCite this: J. Phys. Chem. 1982, ...
Tópico(s): Electron and X-Ray Spectroscopy Techniques
1982 - American Chemical Society | The Journal of Physical Chemistry
Koichi Ohno, Hideki Mutoh, Yoshiya Harada,
... molecular orbitals by Penning ionization electron spectroscopyKoichi Ohno, Hideki Mutoh, and Yoshiya HaradaCite this: J. Am. Chem. Soc. ...
Tópico(s): Various Chemistry Research Topics
1983 - American Chemical Society | Journal of the American Chemical Society
Yasuhisa Tochigi, Katsuhiko Hanzawa, Yuri Kato, Rihito Kuroda, Hideki Mutoh, Ryuta Hirose, Hideki Tominaga, Kenji Takubo, Yasushi Kondo, Shigetoshi Sugawa,
A 400 H ×256 V pixels global-shutter high-speed CMOS image sensor including 128 on-chip memories/pixel has been fabricated in a 0.18-μm 2P4M CMOS with pinned photodiode process. The key technologies of this image sensor are as follows: multiple on-chip memories for each pixel, spatial separation of pixel and on-chip memory regions, multiple pixel output wires for each column, in-pixel noise reduction circuits, in-pixel source-follower current-sources and flexibly selectable on-chip memories. This ...
Tópico(s): Advanced Memory and Neural Computing
2012 - Institute of Electrical and Electronics Engineers | IEEE Journal of Solid-State Circuits
Kiichiro Uchino, Takeharu Koga, Katsunori Muraoka, Mitsuo Maeda, Masanori Akazaki, S. Sudo, O. Motojima, Fumimichi Sano, Motoyasu Sato, Takashi Mutoh, Hideki Zushi, Y. Takeiri, A. Iiyoshi, K. Uo,
Measurements of atomic hydrogen density profiles in Heliotron E plasmas were performed, where attention was focussed on the anisotropy of the profiles in the poloidal cross section. Obtained penetration profiles of atomic hydrogen agreed well with the Monte Carlo code calculations of the penetration of Franck-Condon neutrals when averaged electron densities \bar n e are larger than 10 19 m -3 . For \bar n e <10 19 m -3 , however, experimental profiles decreased steeper than calculated ones. Degree of the ...
Tópico(s): Ionosphere and magnetosphere dynamics
1988 - Physical Society of Japan | Journal of the Physical Society of Japan
Tadashi Konoshita, Kyoko Miyagi, Tamehito Onoe, Kenichi Katano, Hisao Mutoh, Hideki Nomura, Ichiro Koni, Isamu Miyamori, Hiroshi Mabuchi,
Polycystic kidney disease (PKD) is one of the most common genetic disorders and a major cause of renal death or end-stage renal disease (ESRD) requiring regular hemodialysis. The responsible genes recently have been cloned; however, genetic factors influencing the rate of progression to ESRD in patients with PKD have yet to be defined. Several studies have shown increased activity of the renin-angiotensin system (RAS) in patients with PKD. In addition, genetic polymorphisms of the RAS have been associated ...
Tópico(s): Renin-Angiotensin System Studies
2001 - Elsevier BV | American Journal of Kidney Diseases
Tamotsu Hashizume, Kengo Ikeya, Morimichi Mutoh, Hideki Hasegawa,
GaAs surfaces were successfully passivated by utilizing an ultrathin Si3N4/Si interface control layer (ICL) formed by molecular beam epitaxy (MBE) and in situ electron-cyclotron-resonance (ECR) plasma-assisted nitridation. Detailed X-ray photoelectron spectroscopy (XPS) analysis showed that optimization of the ECR plasma process led to the realization of well-defined Si3N4/Si double-layer structure without change in chemical status of GaAs surface. As compared with the clean MBE surface, surface Fermi ...
Tópico(s): Semiconductor materials and devices
1998 - Elsevier BV | Applied Surface Science
Yuichiro Hirayama, Yuta Tsunematsu, Yuko Yoshikawa, Ryota Tamafune, Nobuo Matsuzaki, Yuji Iwashita, Ippei Ohnishi, Fumihiko Tanioka, Michio Sato, Noriyuki Miyoshi, Michihiro Mutoh, Hideki Ishikawa, Haruhiko Sugimura, Keiji Wakabayashi, Kenji Watanabe,
While high-colibactin-producing Escherichia coli is thought to be associated with colorectal oncogenesis, this study is complicated part due to an inability to isolate colibactin adequately. Here, we created fluorescent probes activated by ClbP, the colibactin-maturing peptidase, to identify high-colibactin-producing strains. Our probe served as a valuable clinical diagnostic tool that allowed simple high-throughput diagnostic screening of clinical samples. Furthermore, the probe also allowed identification ...
Tópico(s): Genomics and Phylogenetic Studies
2019 - American Chemical Society | Organic Letters
Yuko Yoshikawa, Yuta Tsunematsu, Nobuo Matsuzaki, Yuichiro Hirayama, Fumi Higashiguchi, Michio Sato, Yuji Iwashita, Noriyuki Miyoshi, Michihiro Mutoh, Hideki Ishikawa, Haruhiko Sugimura, Keiji Wakabayashi, Kenji Watanabe,
We investigated the relationship between colibactin-producing (clb+) Escherichia coli and colorectal adenocarcinoma. In total, 729 E. coli colonies were isolated from tumor and surrounding non-tumor regions in resected specimens from 34 Japanese patients; 450 colonies were from the tumor regions and 279 from the non-tumor regions. clb+ bacteria were found in tumor regions of 11 patients (11/34, 32.4%) and they were also detected in the non-tumor regions of 7 out of these 11 patients (7/34, 20.6%). ...
Tópico(s): Clostridium difficile and Clostridium perfringens research
2020 - National Institute of Infectious Diseases | Japanese Journal of Infectious Diseases
Yuta Tsunematsu, Koji Hosomi, Jun Kunisawa, Michio Sato, Noriko Shibuya, Emiko Saito, Haruka Murakami, Yuko Yoshikawa, Yuji Iwashita, Noriyuki Miyoshi, Michihiro Mutoh, Hideki Ishikawa, Haruhiko Sugimura, Motohiko Miyachi, Keiji Wakabayashi, Kenji Watanabe,
The Escherichia coli strain that is known to produce the genotoxic secondary metabolite colibactin is linked to colorectal oncogenesis. Therefore, understanding the properties of such colibactin-positive E. coli and the molecular mechanism of oncogenesis by colibactin may provide us with opportunities for early diagnosis or prevention of colorectal oncogenesis. While there have been major advances in the characterization of colibactin-positive E. coli and the toxin it produces, the infection route ...
Tópico(s): Breastfeeding Practices and Influences
2021 - BioMed Central | BMC Microbiology
Tao Zhou, Yuichiro Hirayama, Yuta Tsunematsu, Nanami Suzuki, Seiji Tanaka, Nahoko Uchiyama, Yukihiro Goda, Yuko Yoshikawa, Yuji Iwashita, Michio Sato, Noriyuki Miyoshi, Michihiro Mutoh, Hideki Ishikawa, Haruhiko Sugimura, Keiji Wakabayashi, Kenji Watanabe,
Colibactin is a polyketide-nonribosomal peptide hybrid secondary metabolite that can form interstrand cross-links in double-stranded DNA. Colibactin-producing Escherichia coli has also been linked to colorectal oncogenesis. Thus, there is a strong interest in understanding the role colibactin may play in oncogenesis. Here, using the high-colibactin-producing wild-type E. coli strain we isolated from a clinical sample with the activity-based fluorescent probe we developed earlier, we were able to ...
Tópico(s): DNA Repair Mechanisms
2021 - American Chemical Society | Journal of the American Chemical Society
S. Sudo, Katsumi Kondo, Takashi Mutoh, Hideki Zushi, A. Iiyoshi, K. Uo,
A Thomson scattering system for simultaneous measurements of the electron temperature and density at ten different positions at two times during a single plasma shot has been developed for Heliotron E. The apparatus consists of two ruby lasers, each delivering two pulses whose temporal separation is typically 100 ms; light collection optics including automatic positioning mechanisms; 80 detectors; and a data processing system. We have obtained spatial profiles of T e (0.05–1.3 keV) and n e (0.2-9. ...
Tópico(s): Atomic and Molecular Physics
1983 - Institute of Physics | Japanese Journal of Applied Physics
Masanobu Kawanishi, Yuuta Hisatomi, Yoshimitsu Oda, Chiaki Shimohara, Yuta Tsunematsu, Michio Sato, Yuichiro Hirayama, Noriyuki Miyoshi, Yuji Iwashita, Yuko Yoshikawa, Haruhiko Sugimura, Michihiro Mutoh, Hideki Ishikawa, Keiji Wakabayashi, Takashi Yagi, Kenji Watanabe,
Colibactin is a polyketide-peptide genotoxin produced by enteric bacteria such as E. coli, and is considered to contribute to the development of colorectal cancer. We previously isolated E. coli strains from Japanese colorectal cancer patients, and in the present study we investigated the genotoxic potency of the colibactin-producing (clb+) E. coli strains that carry the polyketide synthases "pks" gene cluster (pks+) and an isogenic clb- mutant in which the colibactin-producing ability is impaired. ...
Tópico(s): Enterobacteriaceae and Cronobacter Research
2019 - Japanese Society of Toxicological Sciences | The Journal of Toxicological Sciences
Masanobu Kawanishi, Chiaki Shimohara, Yoshimitsu Oda, Yuuta Hisatomi, Yuta Tsunematsu, Michio Sato, Yuichiro Hirayama, Noriyuki Miyoshi, Yuji Iwashita, Yuko Yoshikawa, Haruhiko Sugimura, Michihiro Mutoh, Hideki Ishikawa, Keiji Wakabayashi, Takashi Yagi, Kenji Watanabe,
Abstract Introduction Colibactin is a small genotoxic molecule produced by enteric bacteria, including certain Escherichia coli ( E. coli ) strains harbored in the human large intestine. This polyketide-peptide genotoxin is considered to contribute to the development of colorectal cancer. The colibactin-producing ( clb + ) microorganisms possess a 54-kilobase genomic island ( clb gene cluster). In the present study, to assess the distribution of the clb gene cluster, genotyping analysis was carried out among ...
Tópico(s): DNA Repair Mechanisms
2020 - BioMed Central | Genes and Environment
Koichi Ohno, Hideki Mutoh, Yoshiya Harada,
Photooxidation reactions on the solid films of naphthacene and rubrene were studied by Penning ionization electron spectroscopy (PIES) and UV photoelectron spectroscopy (UPS). PIES was found to reveal the processes of the surface reaction within the first layer selectively. On the other hand, the UPS result showed that the photooxidation reaction proceeded into the inner layers as oxygen molecules diffused into the solid. The present study indicates that the reaction process from the surface to the ...
Tópico(s): Surface Chemistry and Catalysis
1982 - Elsevier BV | Surface Science
Yoshihisa Harada, Koichi Ohno, Hideki Mutoh,
The He* Penning ionization electron spectra (PIES) and He I UV photoelectron spectra (UPS) of CO and Fe(CO)5 were measured. The relative intensity of the bands in PIES was shown to give information on the spatial electron distribution of individual molecular orbitals. On the basis of the information together with the results of the population analysis, most of the bands in the UPS of Fe(CO)5 were assigned. The usefulness of PIES in the study of stereochemistry was indicated.
Tópico(s): Catalytic Processes in Materials Science
1983 - American Institute of Physics | The Journal of Chemical Physics
Penning ionization electron spectra resulting from thermal collisions of He*(1s2s, 23S) metastable atoms with gaseous metallocenes, M(C5H5)2 (M = V, Cr, Mn, Fe, Co, Ni, Ru, and Os), were measured to directly probe the spatial electron distribution of the metal d-derived orbitals. Owing to the strong antibonding d–π interactions the metallic e1″ orbitals in Mn(C5H5)2, Ni(C5H5)2, and especially Co(C5H5)2, show rather diffuse electron distributions. In contrast, the Cp π-derived e1″ orbitals exhibit compact ...
Tópico(s): Electron and X-Ray Spectroscopy Techniques
2002 - Royal Society of Chemistry | Journal of the Chemical Society Dalton Transactions
Takeharu ETOH, Dirk Poggemann, G. Kreider, Hideki Mutoh, Albert Theuwissen, Arno Ruckelshausen, Yasushi Kondo, Hiromasa Maruno, Kenji Takubo, H. Soya, Kohsei Takehara, Tomoo Okinaka, Yasuhide TAKANO,
An image sensor for a video camera of 1000000 frames per second (fps) was developed. The specifications of the developed sensor are as follows: 1) frame rate: 1000000 fps; 2) pixel count: 81 120 (=312/spl times/260) pixels; 3) total number of successive frames: 103 frames; 4) gray levels: 10 b; and 5) open area of each pixel (fill factor): 580 square micrometers (13%). The overwriting function is installed for synchronization of image capturing with occurrence of the target event. Sensitivity is significantly ...
Tópico(s): Image Processing Techniques and Applications
2003 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Electron Devices
The optical and electrical characteristics of CMOS image sensors, such as readout, saturation, reset, charge-voltage conversion, and crosstalk characteristics, are analyzed by a three-dimensional (3-D) device simulator SPECTRA and a 3-D optical simulator TOCCATA which were developed for the analysis of CCD image sensors. The model of readout operation for a buried photodiode with potential barrier and dip is discussed with consideration of thermal diffusion. The transient simulation is executed for ...
Tópico(s): Image Processing Techniques and Applications
2003 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Electron Devices
A device simulator, SPECTRA, and an optics simulator, TOCCATA, were developed for three-dimensional (3-D) optical and electrical analysis of a charge-coupled device (CCD). SPECTRA solves Poisson's and time dependent current continuity equations by a novel Gummel's method. Since the basic parameters are potential and exponential functions of the quasi-Fermi level of electrons and holes, the solution can be obtained in a stable and rapid way compared to the conventional method. TOCCATA calculates the ...
Tópico(s): Infrared Target Detection Methodologies
1997 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Electron Devices
Tamás Veszprémi, Yoshiya Harada, Koichi Ohno, Hideki Mutoh,
Tópico(s): DNA and Nucleic Acid Chemistry
1983 - Elsevier BV | Journal of Organometallic Chemistry
For application of a video camera of 1,000,000 fps, developed by the authors in 2001, to electron microscopes and biological microscopes, a next generation ultra-high-speed image sensor with photon-counting sensitivity is proposed. It is based on three key technologies, i.e., (1) ISIS, the In-situ Storage Image Sensor for ultra-high-speed continuous image capturing, invented by the authors, (2) CCM, the Charge Carrier Multiplication by impact ionization, invented by Hynecek, and (3) conventional back- ...
Tópico(s): Medical Imaging Techniques and Applications
2005 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
Atsushi Ishida, Tatsushi Mutoh, Tomoko Ueyama, Hideki Bando, Satoru Masubuchi, Daiichiro Nakahara, Gozoh Tsujimoto, Hitoshi Okamura,
Summary Light is a powerful synchronizer of the circadian rhythms, and bright light therapy is known to improve metabolic and hormonal status of circadian rhythm sleep disorders, although its mechanism is poorly understood. In the present study, we revealed that light induces gene expression in the adrenal gland via the suprachiasmatic nucleus (SCN)-sympathetic nervous system. Moreover, this gene expression accompanies the surge of plasma and brain corticosterone levels without accompanying activation of ...
Tópico(s): Stress Responses and Cortisol
2005 - Cell Press | Cell Metabolism
Hiroshi Takahashi, Toshiyuki Yoshida, Morimichi Mutoh, Takamasa Sakai, Hideki Hasegawa,
Abstract In this paper, the applicability of an ultra-high vacuum (UHV) contactless capacitance-voltage ( C-V ) measurement method is evaluated for use in non-destructive characterization of crystal growth and device processing steps for the compound semiconductor heterostructure microelectronics. The UHV gap length between the sample surface and the field plate was made by an optical measurement using the Goos–Haenchen effect, and its accuracy was discussed by a theoretical calculation. Then, zero-bias ...
Tópico(s): Integrated Circuits and Semiconductor Failure Analysis
1999 - Elsevier BV | Solid-State Electronics
Tamás Veszprémi, Yoshiya Harada, Koichi Ohno, Hideki Mutoh,
Penning ionization electron spectroscopy and CNDO/S calculations have been applied succesfully to the analyses of the UV photoelectron spectra of some phenyl-fluoro- and -chloro-silanes. The relative intensities of the π-type and the lone pair bands are enhanced in the Penning spectra compared with those of the UV photoelectron spectra.
Tópico(s): Organic Chemistry Cycloaddition Reactions
1984 - Elsevier BV | Journal of Organometallic Chemistry
Yusaku Shimamoto, Yoji Takeuchi, Shingo Ishiguro, Shin‐ichi Nakatsuka, Hiroshi Yunokizaki, Yasumasa Ezoe, Takeshi Nakajima, Kumiko Tanaka, Ryu Ishihara, Tetsuji Takayama, Teruhiko Yoshida, Kokichi Sugano, Michihiro Mutoh, Hideki Ishikawa,
Abstract Familial adenomatous polyposis (FAP) patients develop various life‐threatening extracolonic comorbidities that appear individually or within a family. This diversity can be explained by the localization of the adenomatous polyposis coli ( APC ) variant, but few reports provide definitive findings about genotype–phenotype correlations. Therefore, we investigated FAP patients and the association between the severe phenotypes and APC variants. Of 247 FAP patients, 126 patients from 85 families ...
Tópico(s): Colorectal Cancer Treatments and Studies
2023 - Wiley | Cancer Science
Wee Shong Chin, Zhi Ping Xu, Chup Yew Mok, Hsing Hua Huang, Hideki Mutoh, Shigeru Masuda,
He II photoelectron spectra of tetrahydrothiophen-2-one, tetrahydrothiophen-3-one and 2(5H)-thiophenone have been recorded along with the corresponding He I spectra. The relative He I/He II band intensities provide clear evidence for the assignment of the first few bands, which are also assigned on the basis of bandshape and SCF MO calculations. Correlations with IPs of tetrahydrothiophene, 2,5-dihydrothiophene and formaldehyde show that the interaction of the carbonyl group and the ring heteroatom ...
Tópico(s): Advanced Chemical Physics Studies
1998 - Elsevier BV | Journal of Electron Spectroscopy and Related Phenomena
Masahiro Ohsawa, Junpei Mutoh, Shohei Yamamoto, Hideki Ono, Hiroaki Hisa,
Clinical and experimental observations indicated that 3-hydroxy-3-methylglutaryl CoA reductase inhibitor statins have pleiotropic effects. The present study determined the antinociceptive property of centrally administered simvastatin on the formalin-induced nociception in the mouse. Intrathecal administration of simvastatin at doses of 0.5 – 50 nmol dose-dependently attenuated the second, but not the first, phase of the formalin-induced nociception, which was partially reversed by mevalonate (5 μmol). ...
Tópico(s): Healthcare and Venom Research
2012 - Elsevier BV | Journal of Pharmacological Sciences
S. Mutoh, Satoshi Shigematsu, Y. Matsuya, Hideki Fukuda, Takao Kaneko, J. Yamada,
A 1-V power supply low-power and high-speed 16-b fixed-point digital signal processor using a 0.5-/spl mu/m process has been developed for mobile phone applications. A 1-V multithreshold-voltage CMOS (MTCMOS) technology that uses both high-threshold-voltage and low-threshold-voltage transistors is one key to attaining low power consumption, keeping processing throughput high. A maximum operating frequency of 13.2 MHz and an energy consumption of 2.2 mW/MHz were achieved at 1 V. The second key to ...
Tópico(s): Parallel Computing and Optimization Techniques
1996 - Institute of Electrical and Electronics Engineers | IEEE Journal of Solid-State Circuits
Warô Nakanishi, Satoko Hayashi, Yoshiaki Kusuyama, Takeshi Negoro, Shigeru Masuda, Hideki Mutoh,
The PIES and UPS spectra of xanthone (1a), thioxanthone (1b), and selenoxanthone (1c) were measured, together with those of the corresponding xanthene (2a), thioxanthene (2b), and selenoxanthene (2c). Ab initio MO calculations were performed with the 6-311+G(d,p) basis sets at the DFT (B3LYP) level on 1a−c and 2a−c. The results of the measurements and of the MO calculations explained well the striking difference in the reactivity of the compounds, especially for 1c versus 2c. The ionization potentials ( ...
Tópico(s): Advanced Chemical Physics Studies
1998 - American Chemical Society | The Journal of Organic Chemistry
Nguyen Ngo, Anh Quang Nguyen, F. M. Bufler, Yoshinari Kamakura, Hideki Mutoh, Takayoshi Shimura, Takuji Hosoi, Heiji Watanabe, Philippe Matagne, Kazuhiro Shimonomura, Kohsei Takehara, Edoardo Charbon, Takeharu ETOH,
The theoretical temporal resolution limit tT of a silicon photodiode (Si PD) is 11.1 ps. We call "super temporal resolution" the temporal resolution that is shorter than that limit. To achieve this resolution, Germanium is selected as a candidate material for the photodiode (Ge PD) for visible light since the absorption coefficient of Ge for the wavelength is several tens of times higher than that of Si, allowing a very thin PD. On the other hand, the saturation drift velocity of electrons in Ge is ...
Tópico(s): CCD and CMOS Imaging Sensors
2020 - Multidisciplinary Digital Publishing Institute | Sensors