Kotohiro Nomura, Srisuda Patamma, Hideshi Matsuda, Shohei Katao, Ken Tsutsumi, Hiroya Fukuda,
Cp*TiCl 2 [1,3-(2,6-Me 2 C 6 H 3 ) 2 (CH 2 N) 2 CN] showed remarkable catalytic activities for ethylene/1-hexene copolymerisation with efficient comonomer incorporation (ex. activity 1 750 000 kg-polymer per mol-Ti per h).
Tópico(s): Carbon dioxide utilization in catalysis
2015 - Royal Society of Chemistry | RSC Advances
Kotohiro Nomura, Hiroya Fukuda, Hideshi Matsuda, Shohei Katao, Srisuda Patamma,
A series of half-titanocenes containing 1,3-imidazolidin-2-iminato ligands of type, (tert-BuC5H4)TiCl2[1,3-R2(CH2N)2CN] [R = tBu (2a), cyclohexyl (Cy, 2b), C6H5 (2c), 2,6-Me2C6H3 (2d), 2,6-iPr2C6H3 (2e)] have been prepared and structures of 2a–d have been determined by X-ray crystallography. Complex 2a showed higher catalytic activity than the Cp analogue (1a) for ethylene polymerization but showed low catalytic activity in ethylene/1-hexene copolymerization under the similar conditions; the 2,6-Me2C6H3 analogue ( ...
Tópico(s): Carbon dioxide utilization in catalysis
2015 - Elsevier BV | Journal of Organometallic Chemistry
Hisato Iriki, Takahiro ADACHI, Hideshi Matsuda, Katsuya Chinen, Hiroki Arakawa, Jun Yamagami, Wataru Nishie, Mariko Yokouchi,
... JapanSearch for more papers by this authorHideshi Matsuda, Hideshi Matsuda Department of , Internal Medicine, Nerima General Hospital, Tokyo, ... JapanSearch for more papers by this authorHideshi Matsuda, Hideshi Matsuda Department of , Internal Medicine, Nerima General Hospital, Tokyo, ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2020 - Wiley | The Journal of Dermatology
Katsumi Harimaya, Kazuhiro Tanaka, Yoshihiro Matsumoto, Hideshi Sato, Shuichi Matsuda, Yukihide Iwamoto,
Tópico(s): Bioactive natural compounds
2000 - Springer Science+Business Media | Clinical & Experimental Metastasis
Akira Matsuda, Hideshi Hattori, Motohiro Tanaka, Takuma Sasaki,
1-(3-C-Ethynyl-β-d-ribo-pentofuranosyl)uracil (EUrd) has been designed as a potential multifunctional antitumor nucleoside antimetabolite. EUrd was synthesized by condensation of 1-O-acetyl-2,3,5-tri-O-benzoyl-3-C-ethynyl-α,β-d-ribo-pentofuranose (6) and bis(trimethylsilyl)uracil in the presence of trimethylsilyl triflate in CH3CN in good yield, followed by debenzoylation with NH3/MeOH. In vitro tumor cell growth inhibitory activity of EUrd against 14 human solid tumor cell lines was compared with ...
Tópico(s): RNA modifications and cancer
1996 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Hideshi Miura, Mitsuhiro Matsuda,
Metal Injection molding (MIM) process is an advanced powder processing technique because of net shaping with shape complexity at low processing energy and 100% material utilization. This study has been performed to clarify and to optimize the relationship between the mechanical properties and the microstructures for the superhigh strengthening sintered low alloy steels (Fe–Ni system) by using MIM process. A 6 mass%Ni MIM steel showed excellent properties of 2000 MPa tensile strength, 5% elongation ...
Tópico(s): Advanced machining processes and optimization
2002 - | MATERIALS TRANSACTIONS
Mitsuhiro Matsuda, Hideshi Miura,
Tópico(s): Injection Molding Process and Properties
2003 - Springer Science+Business Media | Metals and Materials International
Takateru Akiyama, Yoko Eto, Hideshi Matsuda, Yuko Kimura, Tatsuo Yanagawa,
Tópico(s): Diabetes, Cardiovascular Risks, and Lipoproteins
2013 - Springer Science+Business Media | Diabetology International
Hideshi Matsuda, Katsuya Chinen,
(A) A blue fringe along the surface epithelium of the colonic mucosa on hematoxylin-eosin staining, a characteristic histology of intestinal spirochetosis. (B) Numerous spirochetes highlighted on Warthin-Starry silver staining.
Tópico(s): Clostridium difficile and Clostridium perfringens research
2018 - Wiley | Journal of General and Family Medicine
Kazuhiko Nara, M. Kurokawa, S. Chiba, Hideshi Yoshikawa, Satoshi Tsukikawa, Takahide Matsuda, Noboru Suzuki,
Summary The involvement of excessive T helper 1 (Th1) cell functions in the pathogenesis of Behçet's disease (BD) has been reported. We therefore studied Toll-like receptor (TLR)-expressing cells, which play important roles in innate immunity in patients with BD. Peripheral blood mononuclear cells (PBMC) of BD and healthy controls, and tissue specimens of intestinal BD and Crohn's disease (CD) were analysed for messenger RNA (mRNA) and protein expressions by reverse transcription–polymerase chain reaction ...
Tópico(s): Inflammasome and immune disorders
2008 - Oxford University Press | Clinical & Experimental Immunology
Yoshinori Kagawa, Shinji Matsumoto, Yuji Kamioka, Koshi Mimori, Yoko Naito, Taeko Ishii, Daisuke Okuzaki, Naohiro Nishida, Sakae Maeda, Atsushi Naito, Junichi Kikuta, Keizo Nishikawa, Junichi Nishimura, Naotsugu Haraguchi, Ichiro Takemasa, Tsunekazu Mizushima, Masataka Ikeda, Hirofumi Yamamoto, Mitsugu Sekimoto, Hideshi Ishii, Yuichiro� Doki, Michiyuki Matsuda, Akira Kikuchi, Masaki Mori, Masaru Ishii,
The mechanism behind the spatiotemporal control of cancer cell dynamics and its possible association with cell proliferation has not been well established. By exploiting the intravital imaging technique, we found that cancer cell motility and invasive properties were closely associated with the cell cycle. In vivo inoculation of human colon cancer cells bearing fluorescence ubiquitination-based cell cycle indicator (Fucci) demonstrated an unexpected phenomenon: S/G2/M cells were more motile and invasive ...
Tópico(s): Microtubule and mitosis dynamics
2013 - Public Library of Science | PLoS ONE
Toshiyuki Saito, Yoichi Matsuda, Hideshi Ishii, Fumiaki Watanabe, Masahiko Mori, Akiko Hayashi, Ryoko Araki, Akira Fujimori, Ryutaro Fukumura, Mitsuoki Morimyo, Koichi Tatsumi, Tada-aki Hori, Masumi Abe,
Tópico(s): Genetics and Neurodevelopmental Disorders
1998 - Springer Science+Business Media | Mammalian Genome
Hideshi Yanase, Dai Sato, Keiko Yamamoto, Saori Matsuda, Sho Yamamoto, Kenji Okamoto,
Its metabolic characteristics suggest that Zymobacter palmae gen. nov., sp. nov. could serve as a useful new ethanol-fermenting bacterium, but its biotechnological exploitation will require certain genetic modifications. We therefore engineered Z. palmae so as to broaden the range of its fermentable sugar substrates to include the pentose sugar xylose. The Escherichia coli genes encoding the xylose catabolic enzymes xylose isomerase, xylulokinase, transaldolase, and transketolase were introduced ...
Tópico(s): Enzyme Catalysis and Immobilization
2007 - American Society for Microbiology | Applied and Environmental Microbiology
Hideshi Tomita, Shigeto Fuse, Kazuo Ikeda, Kazuko Matsuda, Shunzo Chiba,
Abstract We report a 3‐month‐old girl with Costelio syndrome complicating fatal hypertrophic obstructive cardio‐myopathy. She had typical findings of this syndrome, slight dyspnea and persistent wheezing. Doppler echocardiography revealed asymmetric septal hypertrophy and systolic anterior movement of the anterior mitral leaflet. There was grade 1 mitral regurgitation. Although once her heart failure had been controlled medically, she died suddenly following deterioration of her heart condition. ...
Tópico(s): Congenital Heart Disease Studies
1998 - Wiley | Pediatrics International
Tetsuo Takanashi, Masayuki Matsuda, Masahide Yazaki, Hideshi Yamazaki, Masashi Nawata, Yoshiki Katagiri, Shu‐ichi Ikeda,
To investigate histological features of deposited amyloid in the synovial tissue and its clinical significance in knee joint osteoarthritis (OA) patients.We prospectively enrolled 232 consecutive patients who underwent arthroplasty or total replacement of the knee joint for treatment of OA. Congo red staining and immunohistochemistry were performed in the synovial tissue obtained at surgery. When transthyretin (TTR)-derived amyloid was positive, we analyzed all 4 exons of the TTR gene using the direct ...
Tópico(s): Peptidase Inhibition and Analysis
2013 - Taylor & Francis | Amyloid
Mitsuhiro Matsuda, Hideshi Miura,
In our previous studies on the 4600 steels produced by Metal Injection Molding (MIM) process using mixed elemental powder, the fine heterogeneous microstructure caused by the agglomeration of Ni powders was reported to be significantly effective for the improvement of mechanical properties. This study has been performed to clarify and optimize the relationship between the mechanical properties and the heterogeneous microstructure for ultrahigh strengthening the sintered low alloy steels (4600grade, ...
Tópico(s): Advanced materials and composites
2000 - | Journal of the Japan Society of Powder and Powder Metallurgy
Hideshi Hattori, Motohiro Tanaka, Masakazu Fukushima, Takuma Sasaki, Akira Matsuda,
We previously designed 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)uracil (EUrd) as a potential multifunctional antitumor nucleoside antimetabolite. It showed a potent and broad spectrum of antitumor activity against various human tumor cells in vitro and in vivo. To determine the structure-activity relationship, various nucleobase analogues of EUrd, such as 5-fluorouracil, thymine, cytosine, 5-fluorocytosine, adenine, and guanine derivatives, were synthesized by condensation of 1-O-acetyl-2,3,5-tri- ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
1996 - American Chemical Society | Journal of Medicinal Chemistry
Sumiko Furuto-Kato, Akira Shimatsu, Hideshi Kuzuya, KIMISHT MATSUDA, Kazuwa Nakao, Hiroo Imura,
We treated a diabetic patient with familial multiple endocrine neoplasia type 1 (MEN 1) who had undergone total pancreatoduodenectomy. The patient received insulin and showed signs of symptomatic primary hyperparathyroidism (PHPT). The insulin requirement to control blood glucose before and after parathyroidectomy was compared by using an artificial pancreas. The insulin infusion rate during the day and at night was reduced to about one-third and half, respectively, after parathyroidectomy with autotransplantation ...
Tópico(s): Pancreatic function and diabetes
1994 - Japan Endocrine Society | Endocrine Journal
Akira Matsuda, Hideshi Hattori, Masahiro Tanaka, T. Sasaki,
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Tópico(s): N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
1996 - Wiley | ChemInform
Yosuke Nagata, Hideshi Kobayashi, Masato Umeda, Naoshi Ohta, Seiichiro Kawashima, Peter S. Zammit, Ryoichi Matsuda,
Satellite cells are responsible for postnatal growth, hypertrophy, and regeneration of skeletal muscle. They are normally quiescent, and must be activated to fulfill these functions, yet little is known of how this is regulated. As a first step in determining the role of lipids in this process, we examined the dynamics of sphingomyelin in the plasma membrane. Sphingomyelin contributes to caveolae/lipid rafts, which act to concentrate signaling molecules, and is also a precursor of several bioactive ...
Tópico(s): Nuclear Structure and Function
2006 - SAGE Publishing | Journal of Histochemistry & Cytochemistry
Takeshi Usui, Yuji Ikeda, Tetsuya Tagami, Ken‐ichi Matsuda, Kenji Moriyama, Kazuki Yamada, Hideshi Kuzuya, Satomi Kohno, Akira Shimatsu,
Some plant compounds or herb mixtures are popular alternatives to conventional therapies and contain organic compounds that bind to some nuclear receptors, such as the estrogen receptor (ER), to exert various biological effects. We studied the effect of various herbal extracts on ERalpha and ERbeta isoforms. One herbal extract, Rhei rhizoma (rhubarb), acts as an agonist to both ERalpha and ERbeta. The phytochemical lindleyin, a major component of rhubarb, might contribute to this estrogenic activity ...
Tópico(s): Hops Chemistry and Applications
2002 - Bioscientifica | Journal of Endocrinology
Mitsunobu Takeda, Jun Koseki, Hidekazu Takahashi, Norikatsu Miyoshi, Naohiro Nishida, Junichi Nishimura, Taishi Hata, Chu Matsuda, Tsunekazu Mizushima, Hirofumi Yamamoto, Hideshi Ishii, Yuichiro� Doki, Masaki Mori, Naotsugu Haraguchi,
Given that cancer stem cells (CSC) play a key role in drug resistance and relapse, targeting CSCs remains promising in cancer therapy. Here we show that RAB5/7, which are involved in the endolysosomal pathway, play key roles in the maintenance of CSC survival via regulation of the mitophagic pathway. Inhibition of RAB5/7 efficiently eliminated colorectal CSCs and disrupted cancer foci. In addition, we identified mefloquine hydrochloride, an antimalarial drug, as a novel RAB5/7 inhibitor and promising ...
Tópico(s): Lysosomal Storage Disorders Research
2019 - American Association for Cancer Research | Cancer Research
Mitsuhiro Nakamura, Yuichi Oba, Tatsuya Mori, Kazuki Sato, Yukisato Ishida, Tsukasa Matsuda, Hideshi Nakamura,
μ-Conotoxin GIIIA, one of the strong peptide toxins in the cone shell, preferentially blocks the skeletal muscle-type sodium channels in vertebrates. The toxicity of μ-conotoxin GIIIA is nearly equal to that of tetrodotoxin. The generation of an antibody for the native toxins is analytically useful, but practically difficult due to its high toxicity to animals. In this study, we generated the polyclonal antibody for μ-conotoxin GIIIA using a specific conjugation method in which the immunogen was ...
Tópico(s): Receptor Mechanisms and Signaling
2002 - Elsevier BV | Biochemical and Biophysical Research Communications
Mitsuhiro Matsuda, Hideshi Miura,
In the previous report on the sintered low alloy steels (4600grade, 0.4mass%C) produced by MIM process varying Ni content from 0 to 8 mass%, the mechanical properties were improved significantly with increasing Ni content to 6mass%. This was attributed to the solution strengthening and the mezzo-heterogeneous microstructure which were consisted of Ni rich martensite surrounded by a network of tempered martensite. However, the tensile and fatigue strength of the steel added 8 mass% Ni were dropped ...
Tópico(s): Injection Molding Process and Properties
2001 - | Journal of the Japan Society of Powder and Powder Metallurgy
Toshinori Matsuoka, Miwako Yamasaki, Manabu Abe, Yukiko Matsuda, Hiroyuki Morino, Hideshi Kawakami, Kenji Sakimura, Masahiko Watanabe, Kouichi Hashimoto,
Key points Some ion channels are known to behave as inductors and make up the parallel resonant circuit in the plasma membrane of neurons, which enables neurons to respond to current inputs with a specific frequency (so‐called ‘resonant properties’). Here, we report that heterologous expression of mouse Kv11 voltage‐dependent K + channels generate resonance and oscillation at depolarized membrane potentials in HEK293 cells; expressions of individual Kv11 subtypes generate resonance and oscillation with ...
Tópico(s): Neuroscience and Neuropharmacology Research
2020 - Wiley | The Journal of Physiology
Yoshinori Imamura, M. Kurokawa, Hideshi Yoshikawa, Kazuhiko Nara, E. Takada, Chieko Masuda, Satoshi Tsukikawa, S Ozaki, Takahide Matsuda, Noboru Suzuki,
Summary Involvement of excessive Th1 cell functions and heat shock protein expression in the pathogenesis of Behçet's disease (BD) has been reported. In this study we have characterized immune responses in intestinal lesions of BD. Peripheral blood lymphocytes (PBL) of BD and healthy controls (HC) and tissue specimens of intestinal Behçet's disease (intestinal BD), Crohn's disease (CD) and ulcerative colitis (UC) were analysed for mRNA and protein expression by reverse transcriptase-polymerase chain reaction ( ...
Tópico(s): Systemic Lupus Erythematosus Research
2004 - Oxford University Press | Clinical & Experimental Immunology
Min-Jue Xie, Yasuyuki Ishikawa, Hideshi Yagi, Tokuichi Iguchi, Y. Oka, Kazuki Kuroda, Keiko Iwata, Hiroshi Kiyonari, Shinji Matsuda, Hideo Matsuzaki, Michisuke Yuzaki, Yugo Fukazawa, Makoto Sato,
Abstract The essential involvement of phosphoinositides in synaptic plasticity is well-established, but incomplete knowledge of the downstream molecular entities prevents us from understanding their signalling cascades completely. Here, we determined that Phldb2, of which pleckstrin-homology domain is highly sensitive to PIP 3 , functions as a phosphoinositide-signalling mediator for synaptic plasticity. BDNF application caused Phldb2 recruitment toward postsynaptic membrane in dendritic spines, whereas ...
Tópico(s): Ion channel regulation and function
2019 - Nature Portfolio | Scientific Reports
Yujiro Nishizawa, Masamitsu Konno, Ayumu Asai, Jun Koseki, Koichi Kawamoto, Norikatsu Miyoshi, Hidekazu Takahashi, Naohiro Nishida, Naotsugu Haraguchi, Daisuke Sakai, Toshihiro Kudo, Taishi Hata, Chu Matsuda, Tsunekazu Mizushima, Taroh Satoh, Yuichiro� Doki, Masaki Mori, Hideshi Ishii,
... 2 , Toshihiro Kudo 2 , Taishi Hata 1 , Chu Matsuda 1 , Tsunekazu Mizushima 1, 4 , Taroh Satoh 2 , Yuichiro Doki 1 , Masaki Mori 1 and Hideshi Ishii 2, 3 1 Department of Gastroenterological Surgery, ...
Tópico(s): Cancer-related molecular mechanisms research
2017 - Impact Journals LLC | Oncotarget
Tatsuhiko Sato, Koji Niita, Vyacheslav Shurshakov, E. N. Yarmanova, I. B. Nikolaev, Hiroshi Iwase, L. Sihver, Davide Mancusi, Akira Endo, Norihiro Matsuda, Yosuke Iwamoto, Hiroshi Nakashima, Yukio Sakamoto, Hideshi YASUDA, Masashi Takada, T. Nakamura,
Tópico(s): Radiation Effects in Electronics
2011 - Pleiades Publishing | Cosmic Research
Shuichi Matsuda, Kazuhiro Tanaka, Katsumi Harimaya, Yoshihiro Matsumoto, Hideshi Sato, Yukihide Iwamoto,
Two cases of pregnancy associated with myxoid liposarcoma are presented. Both patients were treated with hyperthermoradiotherapy after the induced delivery of healthy infants and by surgical excision of the tumor 5 to 7 weeks after delivery. No local recurrence or distant metastasis occurred; the children have progressed normally for 4 and 5 years, respectively, after surgery. Because coexistence of pregnancy and sarcoma is rare, it is difficult for the clinician to develop an appropriate approach ...
Tópico(s): Soft tissue tumor case studies
2000 - Lippincott Williams & Wilkins | Clinical Orthopaedics and Related Research