Hideo Murata, Hirokazu Takahashi, Hideto MATSUMOTO,
Four castrated Holstein calves, four to six months old, were transported by road for 4 h. Blood samples collected before and after the transportation were examined for total and differential leucocyte counts, lymphocyte subpopulations, lymphocyte blastogenesis, Nitroblue tetrazolium (NBT) reduction activity of neutrophils, and for plasma cortisol concentrations. The animals showed a leucocytosis with neutrophilia, a decrease of T-lymphocyte population, a suppression of lymphocyte blastogenesis and ...
Tópico(s): Immune Response and Inflammation
1987 - Elsevier BV | British Veterinary Journal
Hideo Murata, Hideyuki Takahashi, Hideto MATSUMOTO,
Effects of 1 hour transportation by a truck on cellular immune function were investigated in Holstein castrated calves of 6 months of age. Mitogen-induced blastogenesis of lymphocytes and Nitroblue tetrazolium (NBT) reduction activity of phagocytes in peripheral blood were determined before and 6 and 24 hours after the transportation and compared with those of control animals. Increases were observed in both of the activities 6 hours after the transportation. The increments returned to the initial ...
Tópico(s): T-cell and Retrovirus Studies
1985 - Japanese Society of Veterinary Science | The Japanese Journal of Veterinary Science
Hideyuki Takahashi, Hideo Murata, Hideto Matsumoto,
Secretory responses of plasma insulin, glucagon, cortical and glucose to heat exposure (33°C, 60% RH) were investigated using Holstein calves. Plasma gluagon concentration had a significant increase, but plasma insulin, cortisol and glucose had significant decreases within 24 h following heat exposure. Concerning subsequent responses to heat exposure, plasma glucagon level maintained increased concentrations for 8 days of heat exposure. Plasma insulin level increased on and after day 4 of heat exposure. ...
Tópico(s): Effects of Environmental Stressors on Livestock
1986 - Japanese Society of Veterinary Science | The Japanese Journal of Veterinary Science
Chika Ogami, Yasuhiro Tsuji, Hiroto Seki, Hideaki Kawano, Hideto To, Yoshiaki Matsumoto, Hiroyuki Hosono,
We developed a method to apply artificial neural networks (ANNs) for predicting time-series pharmacokinetics (PKs), and an interpretable the ANN-PK model, which can explain the evidence of prediction by applying Shapley additive explanations (SHAP). A previous population PK (PopPK) model of cyclosporin A was used as the comparison model. The patients' data were used for the ANN-PK model input, and the output by ANN was the clearance (CL). The estimated CL value from the ANN were substituted into the ...
Tópico(s): Explainable Artificial Intelligence (XAI)
2021 - Nature Portfolio | CPT Pharmacometrics & Systems Pharmacology
Ippei Ohnishi, Yuji Iwashita, Yuto Matsushita, Shunsuke Ohtsuka, Takashi Yamashita, Keisuke Inaba, A. Fukazawa, Hideto Ochiai, Keigo Matsumoto, Nobuhito Kurono, Yoshitaka Matsushima, Hiroki Mori, Shioto Suzuki, Shohachi Suzuki, Fumihiko Tanioka, Haruhiko Sugimura,
Abstract Background A comprehensive understanding of DNA adducts, one of the most plausible origins of cancer mutations, is still elusive, especially in human tissues in clinical settings. Recent technological developments have facilitated the identification of multiple DNA adducts in a single experiment. Only a few attempts toward this “DNA adductome approach” in human tissues have been reported. Geospatial information on DNA adducts in human organs has been scarce. Aim Mass spectrometry of human ...
Tópico(s): Carcinogens and Genotoxicity Assessment
2021 - BioMed Central | Genes and Environment
Haruko Miyazaki, Naoko Midorikawa, Saki Fujimoto, Natsumi Miyoshi, Hideto Yoshida, Tetsuya Matsumoto,
Objectives: Methicillin-resistant Staphylococcus aureus (MRSA) is an important health care-associated and community-associated pathogen and causes a large number of infections worldwide. For the purpose of application to topical treatment of MRSA infection, we examined the antimicrobial effects of lysophosphatidylcholine (LPC) on MRSA strains. We also investigated the combination effect of LPC and gentamicin on MRSA growth. Methods: The LPC minimum inhibitory concentrations (MIC) for Gram-positive ( ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
2017 - SAGE Publishing | Therapeutic Advances in Infectious Disease
Daichi Ishimaru, Norío Sugiura, Haruhiko Akiyama, Hideto Watanabe, Kazu Matsumoto,
Summary Objective To determine whether the structure of chondroitin sulfate (CS) in cartilage is reflected by the degree of cartilage degeneration in patients with osteoarthritis (OA) of the knee and to determine how CS biosynthesis affects cartilage degeneration. Design Two osteoarthritic cartilage samples were obtained from medial femoral condyle (MFC) and lateral femoral condyle (LFC) of 24 knees with end-stage OA. The samples were assigned to two groups as follows: lesion and remote cartilage were adjacent ...
Tópico(s): Tendon Structure and Treatment
2013 - Elsevier BV | Osteoarthritis and Cartilage
Sheng Ying Qin, Norihito Kawasaki, Dan Hu, Hideto Tozawa, Naoki Matsumoto, Kazuhiko Yamamoto,
Newly synthesized glycoproteins destined for secretion are transported from the endoplasmic reticulum (ER), through the Golgi and toward the cell surface. In this secretion pathway, several intracellular ER- or Golgi-resident transmembrane proteins serve as cargo receptors. ER–Golgi intermediate compartment (ERGIC)-53, VIP36 and VIPL, which have an L-type lectin domain within the luminal portion, participate in the vectorial transport of glycoproteins via sugar–protein interactions. To understand ...
Tópico(s): RNA regulation and disease
2012 - Oxford University Press | Glycobiology
Hideto Imai, Masashi Matsumoto, Takashi Miyazaki, Kazúo Kato, Hajime Tanida, Tomoya Uruga,
The dynamical oxidation processes of Pt-skin layers on Pt(3)Co were investigated in situ and in real-time by time-resolved X-ray absorption spectroscopy combined with electrochemical measurements. Growth limit behaviors and the suppression of higher-order formation of surface oxides were observed, and these might explain the highly durable nature of Pt-skin layers.
Tópico(s): Advanced Memory and Neural Computing
2011 - Royal Society of Chemistry | Chemical Communications
Hideto Imai, Masashi Matsumoto, Takashi Miyazaki, Shinji Fujieda, Akimitsu Ishihara, Motoko Tamura, Ken-ichiro Ota,
We analyzed the local structure of the surface Ta-oxide phase of TaCN/Ta2O5 core-shell particles that have a high oxygen reduction activity by using surface-sensitive conversion-electron-yield x-ray absorption spectroscopy, suppressing the contribution from the TaCN cores. The radial structure analysis revealed that the catalytically-active Ta2O5 phase in the TaCN/Ta2O5 particle surface contains oxygen-vacancy defects with shorter Ta–O bonds leading to the slight expansion of the first Ta–O shell. ...
Tópico(s): Electrocatalysts for Energy Conversion
2010 - American Institute of Physics | Applied Physics Letters
Hideto Chono, Kazuya Matsumoto, Hiroshi Tsuda, Naoki Saito, Karim Lee, Sujeong Kim, Hiroaki Shibata, Naohide Ageyama, Keiji Terao, Yasuhiro Yasutomi, Junichi Mineno, Sunyoung Kim, Masayori Inouye, Ikunoshin Kato,
Transcriptional activation of gene expression directed by the long terminal repeat (LTR) of HIV-1 requires both the transactivation response element (TAR) and Tat protein. HIV-1 mutants lacking a functional tat gene are not able to proliferate. Here we take a genetic approach to suppress HIV-1 replication based on Tat-dependent production of MazF, an ACA-specific endoribonuclease (mRNA interferase) from Escherichia coli. When induced, MazF is known to cause Bak- and NBK-dependent apoptotic cell death ...
Tópico(s): Virus-based gene therapy research
2010 - Mary Ann Liebert, Inc. | Human Gene Therapy
Takeshi Matsui, Kazutoshi Nakashima, Takaaki Ohyama, John Kobayashi, Yuzo Arima, Tadamitsu Kishimoto, Motohiko Ogawa, Yong-rong Cai, Sadashi Shiga, Shuji Ando, Ichiro Kurane, Kenji Tabara, A Itagaki, N Nitta, Hideto Fukushi, Akira Matsumoto, N. Okabe,
SUMMARY An outbreak of psittacosis related to a bird park occurred in Matsue City, Shimane Prefecture, Japan, during winter 2001. Seventeen cases of psittacosis (12 visitors, three staff, and two student interns) were confirmed. A cohort study was conducted among the park staff and students to determine the risk factors for the development of acute serologically confirmed psittacosis (SCP) infection. Being ‘bird staff’ had an increased risk of SCP infection (RR 3·96, 95% CI 1·48–10·58). Entering the ...
Tópico(s): Allergic Rhinitis and Sensitization
2007 - Cambridge University Press | Epidemiology and Infection
Daisuke Yamaguchi, Norihito Kawasaki, Ichiro Matsuo, Kiichiro Totani, Hideto Tozawa, Naoki Matsumoto, Yukishige Ito, Kazuo Yamamoto,
VIP36-like protein (VIPL) was identified as an endoplasmic reticulum (ER) resident protein with homology to VIP36, a cargo receptor involved in the transport of glycoproteins within cells. Although VIPL is structurally similar to VIP36, VIPL is thought not to be a lectin, because its sugar-binding activity has not been detected in several experiments. Here, recombinant soluble VIPL proteins (sVIPL) were expressed in Escherichia coli, biotinylated with biotin ligase and oligomerized with R-phycoerythrin ( ...
Tópico(s): Galectins and Cancer Biology
2007 - Oxford University Press | Glycobiology
Mamoru Kawakami, Hiroshi Hashizume, Hideto Nishi, Takuji Matsumoto, Tetsuya Tamaki, Koichi Kuribayashi,
Abstract We studied whether applying nucleus pulposus tissue, obtained from tail intervertebral discs that had been subjected to chronic mechanical compression, to the lumbar nerve roots produces hyperalgesia, which is thought to be a pain‐related behavior in the rat. An Ilizarov‐type apparatus was used for immobilization and chronically applied compression of the rat tail for eight weeks. Three weeks after application of extracted nucleus pulposus tissue on the lumbar nerve roots, motor function, ...
Tópico(s): Musculoskeletal pain and rehabilitation
2003 - Wiley | Journal of Orthopaedic Research®
Emi H. Kato, Hideto Yamada, Yoshinori Matsumoto, Satoshi Hattori, S. Makinoda, Seiichiro Fujimoto,
In order to better understand the effect of obstetric management on the prognosis of very low birth weight (VLBW) fetuses, we retrospectively studied perinatal factors and the outcome of two hundred twenty-eight VLBW infants without major anomaly excluding cases of multiple pregnancy. The frequency of malpresentation were significantly high in the early neonatal death group (p < 0.05) and in the cerebral palsy/mental retardation (CP/MR) group (p < 0.01). A stepwise regression analysis for the CP/MR detected ...
Tópico(s): Pregnancy and preeclampsia studies
1996 - De Gruyter | Journal of Perinatal Medicine
Hideyuki Yamato, Yumiko Nagai, Daisuke Inoue, Yasuyuki Ohnishi, Yoshito Ueyama, Hideto Ohno, Toshio Matsumoto, Etsuro Ogata, Kyoji Ikeda,
The present study was undertaken to clarify in vivo the temporal profile of parathyroid hormone-related peptide (PTHRP) gene expression as well as bone histomorphometric features as a function of tumor growth, using an athymic rat model associated with humoral hypercalcemia of malignancy (HHM). Tumor-bearing animals exhibited hypercalcemia, hypophosphatemia, and increased circulating levels of PTHRP, and died within 3 weeks. Steady-state PTHRP mRNA levels and the transcription rate of PTHRP gene in ...
Tópico(s): Bone health and osteoporosis research
1995 - Oxford University Press | Journal of Bone and Mineral Research
Yoshinobu Nakamura, Shouichi Uenishi, Tatsuo Kunishi, Kyosuke Miki, H. Tabata, Kenji Kuwada, Hideto SUZUKI, Takuya Matsumoto,
lnternal stress, as a result of temperature cycle testing (TCT), causes package cracking, passivation film cracking, aluminum pattern deformation, etc. This is particularly evident in IC's and LSI devices with large-size chips and larger memory capacity. Greater reduction of internal stress imparted by resin encapsulants is required to address these problems. To reduce the internal stress, it was previously determined that it is effective to introduce very small sized silicone domains into the epoxy ...
Tópico(s): Electrostatic Discharge in Electronics
1987 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Components Hybrids and Manufacturing Technology
Daisuke Takimoto, Shino Toma, Yuya Suda, Tomoki Shirokura, Y. Tokura, Katsutoshi Fukuda, Masashi Matsumoto, Hideto Imai, Wataru Sugimoto,
Increasing the performance of Pt-based electrocatalysts for the oxygen reduction reaction (ORR) is essential for the widespread commercialization of polymer electrolyte fuel cells. Here we show the synthesis of double-layer Pt nanosheets with a thickness of 0.5 nm via the topotactic reduction of 0.9 nm-thick single-layer PtOx nanosheets, which are exfoliated from a layered platinic acid (HyPtOx). The ORR activity of the Pt nanosheets is two times greater than that of conventionally used state-of-the- ...
Tópico(s): Supercapacitor Materials and Fabrication
2023 - Nature Portfolio | Nature Communications
Xiao Gao, Kentaro Yamamoto, Tomoyasu Hirai, Tomoki Uchiyama, Noboru Ohta, Naoki Takao, Masashi Matsumoto, Hideto Imai, Seiho Sugawara, Kazuhiko Shinohara, Yoshiharu Uchimoto,
The morphological changes of Nafion thin films with thicknesses from 10 to 200 nm on Pt substrate with various annealing histories (unannealed to 240 °C) were systematically investigated using grazing incidence small-angle X-ray scattering (GISAXS) and grazing incidence wide-angle X-ray scattering (GIWAXS). The results revealed that the hydrophilic ionic domain and hydrophobic backbone in Nafion thin films changed significantly when the annealing treatment exceeded the cluster transition temperature, ...
Tópico(s): Advancements in Solid Oxide Fuel Cells
2020 - American Chemical Society | Langmuir
Katsuyoshi Kakinuma, Kohei Suda, Ryo Kobayashi, Tetsuro Tano, Chisato Arata, Isao Amemiya, Sumitaka Watanabe, Masashi Matsumoto, Hideto Imai, Akihiro Iiyama, Makoto Uchida,
Semiconducting oxide nanoparticles are strongly influenced by surface-adsorbed molecules and tend to generate an insulating depletion layer. The interface between a noble metal and a semiconducting oxide constructs a Schottky barrier, interrupting the electron transport. In the case of a Pt catalyst supported on the semiconducting oxide Nb-doped SnO2 with a fused-aggregate network structure (Pt/Nb-SnO2) for polymer electrolyte fuel cells, the electronic conductivity increased abruptly with increasing ...
Tópico(s): Conducting polymers and applications
2019 - American Chemical Society | ACS Applied Materials & Interfaces
Akimitsu Ishihara, Makoto Hamazaki, Masazumi Arao, Masashi Matsumoto, Hideto Imai, Yuji Kohno, Koichi Matsuzawa, Shigenori Mitsushima, Kunio Ota,
The development of non-platinum electrocatalysts for oxygen reduction reactions (ORR) is required for the commercialization of polymer electrolyte fuel cells. We focused on highly stable group 4 and 5 metal oxide-based compounds in acidic media. In this study, we proposed precious-metal- and carbon-free cathodes based on oxides and demonstrated the superior durability of oxide-based cathodes by preparing titanium-niobium oxides mixed with Ti4O7 (TixNbyOz + Ti4O7). The ORR activity of the TixNbyOz + Ti4O7 ...
Tópico(s): Conducting polymers and applications
2016 - Institute of Physics | Journal of The Electrochemical Society
Mitsuharu Chisaka, Akimitsu Ishihara, Naoki Uehara, Masashi Matsumoto, Hideto Imai, Kunio Ota,
Nano-TaO x N y oxygen reduction reaction catalysts with a new active site, slightly oxidized-Ta 3 N 5 , were synthesized for use in acidic media.
Tópico(s): Catalysis and Hydrodesulfurization Studies
2015 - Royal Society of Chemistry | Journal of Materials Chemistry A
Naoki Uehara, Akimitsu Ishihara, Masashi Matsumoto, Hideto Imai, Yuji Kohno, Koichi Matsuzawa, Shigenori Mitsushima, Kunio Ota,
The development of non-platinum-based cathodes is required in order to commercialize polymer electrolyte fuel cells. We have previously investigated group 4 and 5 transition metal oxides because they exhibit high chemical stability under cathode conditions and are less costly than platinum. In this paper, tantalum oxide-based cathodes were prepared from oxy-tantalum phthalocyanines by heat treatment under low oxygen partial pressures. We successfully obtained nano-sized tantalum oxide-based particles ...
Tópico(s): Advanced battery technologies research
2015 - Elsevier BV | Electrochimica Acta
Eiichiro Mori, Yasuhiro Akai, Takeshi Matsumoto, Hideto Kawaratani, Masahiro Horii, Masayuki Iwano, Shiro Uemura, Akitaka Nonomura, Hiroshi Fukui, Yoshihiko Saito,
Simple hepatic cysts are usually asymptomatic and are not associated with impaired hepatic function. However, complications, such as obstructive jaundice, rupture, intracystic haemorrhage and infection, can occur. The authors describe the case of a 82-year-old man with fever and elevated C-reactive protein. A repeat contrast-enhanced abdominal CT scan revealed enlargement with peripheral enhancement in the left lateral segment of the liver. A diagnosis of infected hepatic cyst was made, and percutaneous ...
Tópico(s): Urological Disorders and Treatments
2012 - BMJ | BMJ Case Reports
Yoshiro Ohgi, Akimitsu Ishihara, Koichi Matsuzawa, Shigenori Mitsushima, Ken-ichiro Ota, Masashi Matsumoto, Hideto Imai,
To obtain insights into the roles of carbon and nitrogen contained in the starting materials in partially oxidized tantalum carbonitride (TaCxNy) oxygen-reduction electrocatalysts, we studied oxygen-reduction-reaction (ORR) behaviors and structural properties of tantalum-oxide-based catalysts prepared by partial oxidation of tantalum carbides (TaC) and nitrides (TaN) under low oxygen pressure with 2%H2/N2 based gas at 1000 °C. The surface tantalum-oxide phase obtained from TaC were β-Ta2O5 in whole degree ...
Tópico(s): Catalytic Processes in Materials Science
2012 - Elsevier BV | Electrochimica Acta
Yoshiro Ohgi, Akimitsu Ishihara, Koichi Matsuzawa, Shigenori Mitsushima, Ken-ichiro Ota, Masashi Matsumoto, Hideto Imai,
Partially oxidized zirconium carbonitrides (Zr-CNO) were evaluated as a non-precious-metal cathode used for polymer electrolyte fuel cells. The zirconium-oxide-based catalysts were prepared from zirconium carbonitrides under controlled oxygen partial pressures from 10−2 to 10−18 atm at 1000°C. The ORR activity of Zr-CNO showed a volcano-like tendency against the degree of oxidation (DOO). We found a significant lattice-parameter decrease for highly active Zr-CNOs, and this could be ascribed for the ...
Tópico(s): Advancements in Solid Oxide Fuel Cells
2012 - Institute of Physics | Journal of The Electrochemical Society
Kyung-Don Nam, Akimitsu Ishihara, Koichi Matsuzawa, Shigenori Mitsushima, Ken-ichiro Ota, Masashi Matsumoto, Hideto Imai,
Partially oxidized NbC0.5N0.5 has been evaluated as a non-platinum catalyst for the reduction of oxygen in acidic medium. NbC0.5N0.5 powder was partially oxidized in N2 gas containing O2 of 10−4 atm at the temperature range of 700–1000 °C. Partially oxidized NbC0.5N0.5 had a definite oxygen reduction reaction (ORR) activity, while as-prepared NbC0.5N0.5 and completely oxidized Nb2O5 had a poor catalytic activity for ORR. The onset potential of the partially oxidized NbC0.5N0.5 for the ORR achieved ...
Tópico(s): Semiconductor materials and devices
2010 - Elsevier BV | Electrochimica Acta
Naoki Banno, Toshitsugu Sakamoto, Noriyuki Iguchi, Masashi Matsumoto, Hideto Imai, Toshinari Ichihashi, Shinji Fujieda, Kazuhiko Tanaka, Satoshi Watanabe, Shu Yamaguchi, Tsuyoshi Hasegawa, Masakazu Aono,
Diffusivity of Cu in amorphous (a-) Ta2O5 is increased by low temperature annealing above 350 °C but the increase is suppressed by adding SiO2 to Ta2O5. To clarify the reasons, we investigated the structural difference between a-Ta2O5 and a-SiO2–Ta2O5. The results show that the low temperature annealing does not cause polycrystallization of Ta2O5 but purges weakly bonded oxygen atoms from the bulk and decreases the film density. Adding SiO2 to Ta2O5 is shown to increase the coordination number of ...
Tópico(s): Semiconductor materials and devices
2010 - American Institute of Physics | Applied Physics Letters
Shigeru Sasaki, Hiroyuki Yamamoto, Hiroyuki Kaneto, Itaru Ozeki, Yasuyo Adachi, Hideyasu Takagi, Takeshi Matsumoto, Hideto Itoh, Tatsuya Nagakawa, Hiroyuki Miyakawa, Shunji Muraoka, Akira Fujinaga, Toshihiro Suga, Masaaki Satoh, Fumio Itoh, Takao Endo, Kohzoh Imai,
Intraductal papillary-mucinous tumors (IPMTs) of the pancreas are characterized by dilated pancreatic ducts and ductules that are lined by tall columnar mucin-producing neoplastic epithelial cells. IPMTs have been suggested to be distinct neoplasms with a less aggressive phenotype than that of conventional ductal adenocarcinomas of the pancreas. Molecular mechanisms underlying tumorigenesis of IPMTs are beginning to be characterized. Allelic losses have frequently been detected at 9p, 17p, and 18q, ...
Tópico(s): Neuroendocrine Tumor Research Advances
2003 - Elsevier BV | Oncology Reports
Takahiro Yamada, Kohzoh Mitsuya, Tomohiko Kayashima, Kentaro Yamasaki, Tohru Ohta, Koh-ichiro Yoshiura, Naomichi Matsumoto, Hideto Yamada, Hisanori Minakami, Mitsuo Oshimura, Norio Niikawa, Tatsuya Kishino,
MEST is one of the imprinted genes in human. With the assistance of our integration map and the complete sequence in the registry, we mapped a total of 16 genes/transcripts at the 1.5-Mb MEST-flanking region at 7q32. This region has been suggested to form an imprinted gene cluster, because MEST and its three flanking genes/transcripts (MESTIT1, CPA4, and COPG2IT1) were reported to be imprinted, although two (TSGA14 and COPG2) were shown to escape imprinting. In this study, 10 other genes/transcripts ...
Tópico(s): Prenatal Screening and Diagnostics
2003 - Elsevier BV | Genomics