Matthew E. Falagas, Ioannis A. Bliziotis, J. Kosmidis, G. K. Daikos,
... epidemics of infections. Hace unos 2.500 años, Hipócrates realizó notables observaciones sobre la influencia del clima ... ciudades con diferencias climáticas podían padecer distintas enfermedades. Hipócrates observó también que los cambios climáticos bruscos o ... nervioso central. Creemos que las observaciones científicas de Hipócrates constituyen importantes ejemplos históricos que indican a los ...
Tópico(s): Climate Change and Health Impacts
2010 - Elsevier BV | Enfermedades Infecciosas y Microbiología Clínica
MD, FACS (Hon), MACC (Hon)*Se cree que Hipocrates nacio en 460 a.C. en la islade ... del paciente, sento las bases de laciencia medica. Hipocrates cristalizo el disperso co-nocimiento de las escuelas ... reconoce como “El Pa-dre de la Medicina”.Hipocrates fue un errante asklepiada, del linajedirecto de Asclepios ( ...
Tópico(s): Ethics and bioethics in healthcare
2005 - | Revista Colombiana de Cirugía
Paolo Ricci A, Rodrigo Lema C, Vicente Solá D, Jack Pardo S, Enrique Guiloff F,
... treatments by means of endoscope were made by Hipocrates. Soon through history the precursors, pioneers and so ...
Tópico(s): Abdominal Surgery and Complications
2008 - Sociedad Chilena de Obstetricia y Ginecología | Revista chilena de obstetricia y ginecología
Produção Nacional
Revisado por pares
Leijiane F. Sousa, Matthew L. Holding, Tiago H. M. Del-Rei, Marisa Maria Teixeira da Rocha, Rosa Helena Veras Mourão, Hipócrates de Menezes Chalkidis, Benedito C. Prezoto, H. Lisle Gibbs, Ana Maria Moura‐da‐Silva,
Differences in snake venom composition occur across all taxonomic levels and it has been argued that this variation represents an adaptation that has evolved to facilitate the capture and digestion of prey and evasion of predators. Bothrops atrox is a terrestrial pitviper that is distributed across the Amazon region, where it occupies different habitats. Using statistical analyses and functional assays that incorporate individual variation, we analyzed the individual venom variability in B. atrox ...
Tópico(s): Rabies epidemiology and control
2021 - Multidisciplinary Digital Publishing Institute | Toxins
Produção Nacional
Revisado por pares
Diana R. Amazonas, Luciana Aparecida Freitas-de-Sousa, Daniele Pereira Orefice, Leijiane F. Sousa, Melissa Gaste Martinez, Rosa Helena Veras Mourão, Hipócrates de Menezes Chalkidis, Plínio Barbosa de Camargo, Ana Maria Moura‐da‐Silva,
Variability in snake venom composition has been frequently reported and correlated to the adaptability of snakes to environmental conditions. Previous studies report plasticity for the venom phenotype. However, these observations are not conclusive, as the results were based on pooled venoms, which present high individual variability. Here we tested the hypothesis of plasticity by influence of confinement and single diet type in the venom composition of 13 adult specimens of Bothrops atrox snakes, ...
Tópico(s): Amphibian and Reptile Biology
2019 - Multidisciplinary Digital Publishing Institute | Toxins
Produção Nacional
Revisado por pares
Tiago H. M. Del-Rei, Leijiane F. Sousa, Marisa Maria Teixeira da Rocha, Luciana Aparecida Freitas-de-Sousa, Silvia Regina Travaglia-Cardoso, Kathleen Fernandes Grego, Sávio Stefanini Sant’Anna, Hipócrates de Menezes Chalkidis, Ana Maria Moura‐da‐Silva,
Variability in the composition of snake venoms occurs in different taxa and is usually correlated to snake fitness. Here, we compared B. atrox venoms from three different geographic regions across the Brazilian Amazon and found remarkable functional differences particularly between venoms from two populations separated by the Amazon River, in specimens born, raised and maintained under the same conditions at Instituto Butantan serpentary. Venom from Presidente Figueiredo snakes induced stronger ...
Tópico(s): Amphibian and Reptile Biology
2019 - Elsevier BV | Toxicon
Produção Nacional
Revisado por pares
Leijiane F. Sousa, Christina N. Zdenek, James Dobson, Bianca op den Brouw, Francisco C. P. Coimbra, Amber Gillett, Tiago H. M. Del-Rei, Hipócrates de Menezes Chalkidis, Sávio Stefanini Sant’Anna, Marisa M. Teixeira-da-Rocha, Kathleen Fernandes Grego, Silvia Regina Travaglia‐Cardoso, Ana Maria Moura‐da‐Silva, Bryan G. Fry,
Lancehead pit-vipers (Bothrops genus) are an extremely diverse and medically important group responsible for the greatest number of snakebite envenomations and deaths in South America. Bothrops atrox (common lancehead), responsible for majority of snakebites and related deaths within the Brazilian Amazon, is a highly adaptable and widely distributed species, whose venom variability has been related to several factors, including geographical distribution and habitat type. This study examined venoms ...
Tópico(s): Rabies epidemiology and control
2018 - Multidisciplinary Digital Publishing Institute | Toxins
Hipócrates Nolasco‐Cancino, Jorge A. Santiago‐Urbina, Carmen Wacher, Francisco Ruíz‐Terán,
Artisanal mezcal is produced by the natural fermentation of maguey juice, which frequently results in a process that becomes stuck or is sluggish. Using selected indigenous starter inoculums of Saccharomyces and non-Saccharomyces yeasts is considered beneficial in overcoming these problems and thereby preserving the essence of the artisanal process. In this work, three hundred and four yeast isolates were recovered from 17 distilleries and then grouped by the ARDRA analysis, their restriction profiles ...
Tópico(s): Botanical Research and Applications
2018 - Frontiers Media | Frontiers in Microbiology
Produção Nacional
Revisado por pares
Diana R. Amazonas, José A. Portes-Junior, Milton Yutaka Nishiyama, Carolina Alves Nicolau, Hipócrates de Menezes Chalkidis, Rosa Helena Veras Mourão, Felipe G. Grazziotin, Darin R. Rokyta, H. Lisle Gibbs, Richard H. Valente, Inácio L.M. Junqueira-de-Azevedo, Ana Maria Moura‐da‐Silva,
Elucidating the molecular mechanisms underlying snake venom variability provides important clues for understanding how the biological functions of this powerful toxic arsenal evolve. We analyzed in detail individual transcripts and venom protein isoforms produced by five specimens of a venomous snake (Bothrops atrox) from two nearby but genetically distinct populations from the Brazilian Amazon rainforest which show functional similarities in venom properties. Individual variation was observed among ...
Tópico(s): Amphibian and Reptile Biology
2018 - Elsevier BV | Journal of Proteomics
Francisco Ruíz‐Terán, Paulina N. Martínez-Zepeda, Sara Y. Geyer-de la Merced, Hipócrates Nolasco‐Cancino, Jorge A. Santiago‐Urbina,
In this study, 19 indigenous mezcal Saccharomyces cerevisiae strains were screened for their tolerance to grow under different stress conditions and their potential use in fermentation. All strains were able to tolerate pH value of 3, significant levels of glucose (30%), ethanol (12% v/v), and temperature of 37 °C. Eleven of them were able to grow in presence of 15% of ethanol, but only CH7 and PA18 strains grew at 42 °C. Both were selected for evaluation of their fermentative abilities in maguey juice ...
Tópico(s): Biochemical and biochemical processes
2018 - Springer Science+Business Media | Food Science and Biotechnology
Jazmin M Sanchez-Salvatierra, Alvaro Taype‐Rondán,
El medico griego Hipocrates (aprox. 460 a.C.) es considerado el fundador de la Escuela Hipocratica en Cos, a la cual se le ...
Tópico(s): Ethics and bioethics in healthcare
2018 - Q16635223 | Revista médica de Chile
Produção Nacional
Revisado por pares
Úrsula Castro de Oliveira, Milton Yutaka Nishiyama, Maria Beatriz Viana dos Santos, Andria de Paula Santos-da-Silva, Hipócrates de Menezes Chalkidis, Andréia Souza-Imberg, Denise Maria Cândido, Norma Yamanouye, Valquíria Abrão Coronado Dorce, Inácio L.M. Junqueira-de-Azevedo,
Background Except for the northern region, where the Amazonian black scorpion, T. obscurus, represents the predominant and most medically relevant scorpion species, Tityus serrulatus, the Brazilian yellow scorpion, is widely distributed throughout Brazil, causing most envenoming and fatalities due to scorpion sting. In order to evaluate and compare the diversity of venom components of Tityus obscurus and T. serrulatus, we performed a transcriptomic investigation of the telsons (venom glands) corroborated ...
Tópico(s): Ion channel regulation and function
2018 - Public Library of Science | PLoS ONE
Jerónimo J. González‐Bernal, Raquel de la Fuente Anuncibay,
... encontrado el camino más seguro hacia la salud.” (Hipócrates 460-380 AC). Desde tiempos inmemoriables, el envejecimiento ...
Tópico(s): Aging and Gerontology Research
2017 - | International Journal of Developmental and Educational Psychology Revista INFAD de psicología
Produção Nacional
Revisado por pares
H. Lisle Gibbs, Michael G. Sovic, Diana R. Amazonas, Hipócrates de Menezes Chalkidis, David Salazar‐Valenzuela, Ana Maria Moura‐da‐Silva,
Identifying the evolutionary and ecological mechanisms that drive lineage diversification in the species-rich tropics is of broad interest to evolutionary biologists. Here, we use phylogeographical and demographic analyses of genome-scale RADseq data to assess the impact of a large geographical feature, the Amazon River, on lineage formation in a venomous pitviper, Bothrops atrox. We compared genetic differentiation in samples from four sites near Santarem, Brazil, that spanned the Amazon and represented ...
Tópico(s): Genetic diversity and population structure
2017 - Oxford University Press | Biological Journal of the Linnean Society
Produção Nacional
Revisado por pares
Leijiane F. Sousa, José A. Portes-Junior, Carolina Alves Nicolau, Juliana L. Bernardoni, Milton Yutaka Nishiyama, Diana R. Amazonas, Luciana Aparecida Freitas-de-Sousa, Rosa HV Mourão, Hipócrates de Menezes Chalkidis, Richard H. Valente, Ana Maria Moura‐da‐Silva,
Venom variability is commonly reported for venomous snakes including Bothrops atrox. Here, we compared the composition of venoms from B. atrox snakes collected at Amazonian conserved habitats (terra-firme upland forest and várzea) and human modified areas (pasture and degraded areas). Venom samples were submitted to shotgun proteomic analysis as a whole or compared after fractionation by reversed-phase chromatography. Whole venom proteomes revealed a similar composition among the venoms with predominance ...
Tópico(s): Marine Invertebrate Physiology and Ecology
2017 - Elsevier BV | Journal of Proteomics
Produção Nacional
Revisado por pares
Gabriella Neves Leal Santos Barreto, Sâmella Silva de Oliveira, Isabelle Valle dos Anjos, Hipócrates de Menezes Chalkidis, Rosa Helena Veras Mourão, Ana Maria Moura‐da‐Silva, Ida S. Sano‐Martins, Luís Roberto C. Gonçalves,
Bothrops atrox snakes are the leading cause of snake bites in Northern Brazil. The venom of this snake is not included in the antigen pool used to obtain the Bothrops antivenom. There are discrepancies in reports on the effectiveness of this antivenom to treat victims bitten by B. atrox snakes. However, these studies were performed using a pre-incubation of the venom with the antivenom and, thus, did not simulate a true case of envenomation treatment. In addition, the local lesions induced by Bothrops ...
Tópico(s): Marine Invertebrate Physiology and Ecology
2017 - Public Library of Science | PLoS neglected tropical diseases
Produção Nacional
Revisado por pares
Nathalia Baptista Días, Bibiana Monson de Souza, Fernando Kamimura Cocchi, Hipócrates de Menezes Chalkidis, Valquíria Abrão Coronado Dorce, Mário Sérgio Palma,
Many scorpion accidents occur in the Brazilian Amazonian region and are frequently caused by Tityus obscurus. Approximately 5% of the crude venom of this species is composed of short linear, non-disulfide-bridged peptides, which have not been intensively investigated. As a consequence, only a few of these peptides have been structurally and functionally characterized to date. In the present paper, the peptide fraction of the venom was subjected to peptide profiling using an LCMS-IT-TOF/MS and MSn ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
2017 - Elsevier BV | Journal of Proteomics
A Residência Pediátrica (RP) é uma revista eletrônica trimestral, em publicação contínua, da Sociedade Brasileira de Pediatria (SBP), disponível em português e inglês, destinada aos médicos residentes de nossa especialidade, áreas afins e aos pediatras. O conteúdo da revista pode ser acessado livremente. A missão da RP é contribuir para a formação acadêmica dos residentes e incentivá-los a uma participação ativa na produção científica sobre temas pediátricos e relacionados à adolescência.
Tópico(s): Ethics and bioethics in healthcare
2016 - | Residência Pediátrica
Produção Nacional
Revisado por pares
Patrik F. Viana, Leila Braga Ribeiro, George Myller Souza, Hipócrates de Menezes Chalkidis, Maria Cláudia Gross, Eliana Feldberg,
Boids are primitive snakes from a basal lineage that is widely distributed in Neotropical region. Many of these species are both morphologically and biogeographically divergent, and the relationship among some species remains uncertain even with evolutionary and phylogenetic studies being proposed for the group. For a better understanding of the evolutionary relationship between these snakes, we cytogenetically analysed 7 species and 3 subspecies of Neotropical snakes from the Boidae family using ...
Tópico(s): Plant Virus Research Studies
2016 - Public Library of Science | PLoS ONE
Elena Cabeza, Sebastià March, Carmen Cabezas, Andreu Segura,
This article argues for the need to implement community healthcare promotion initiatives in medical practice. Some of the community initiatives introduced in primary care, as well as scientific evidence and associated implementation factors are described. The need for effective coordination between primary care and public health services, working with the community, is underlined. Two specific coordination initiatives are explained by way of example. The first is a project to develop healthcare ...
Tópico(s): Public Health and Social Inequalities
2016 - Elsevier BV | Gaceta Sanitaria
Produção Nacional
Revisado por pares
Andria de Paula Santos-da-Silva, Denise Maria Cândido, Ana Leonor Abrahão Nencioni, Louise F. Kimura, José Pedro Prezotto-Neto, Kátia Cristina Barbaro, Hipócrates de Menezes Chalkidis, Valquíria Abrão Coronado Dorce,
There are a great number of studies about Brazilian scorpions. However, little is known about the venom of scorpions of northern Brazil, mainly about Tityus obscurus, which is responsible for the most number of accidents in the Amazon. Thus, this study aimed to evaluate some pharmacological effects of T. obscurus venom in rats and mice. In rats, the venom (10 mg/kg i.p.) caused hemorrhagic patches in the lung parenchyma but did not lead to pulmonary edema. There was a decrease in general activity, ...
Tópico(s): Healthcare and Venom Research
2016 - Elsevier BV | Toxicon
... de autores tan reconocidos como Platón, Aristóteles, Herodoto, Hipócrates y Cicerón, quienes vertieron estas ideas y concepciones ...
Tópico(s): Language, Linguistics, Cultural Analysis
2015 - | INTERdisciplina
Alon Eisen, Dorit Leshem‐Lev, Hagai Yavin, Katia Orvin, Aviv Mager, Eldad Rechavia, Tamir Bental, Oshrat Dadush, Alexander Battler, Ran Kornowski, Eli I. Lev,
Tópico(s): Cardiac and Coronary Surgery Techniques
2015 - Springer Science+Business Media | Cardiovascular Drugs and Therapy
Produção Nacional
Revisado por pares
Luciana Aparecida Freitas-de-Sousa, Diana R. Amazonas, Leijiane F. Sousa, Sávio Stefanini Sant’Anna, Milton Yutaka Nishiyama, Solange M.T. Serrano, Inácio L.M. Junqueira-de-Azevedo, Hipócrates de Menezes Chalkidis, Ana Maria Moura‐da‐Silva, Rosa Helena Veras Mourão,
Comparisons between venoms from snakes kept under captivity or collected at the natural environment are of fundamental importance in order to obtain effective antivenoms to treat human victims of snakebites. In this study, we compared composition and biological activities of Bothrops atrox venom from snakes collected at Tapajós National Forest (Pará State, Brazil) or maintained for more than 10 years under captivity at Instituto Butantan herpetarium after have been collected mostly at Maranhão State, ...
Tópico(s): Marine Invertebrate Physiology and Ecology
2015 - Elsevier BV | Biochimie
Susana Collado-Vázquez, Jesús María Carrillo,
... especialmente por el estudio de la marcha. Aristóteles, Hipócrates, Galeno, Leonardo Da Vinci u Honoré de Balzac ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
2015 - Elsevier BV | Neurología (English Edition)
Produção Nacional
Revisado por pares
Valéria Mourão de Moura, Adrielle Nara Serra Bezerra, Rosa Helena Veras Mourão, Juliana Luiza Varjão Lameiras, Juliana Divina Almeida Raposo, Rafael Luckwu de Sousa, Antônio Luiz Boechat, Ricardo Bezerra de Oliveira, Hipócrates de Menezes Chalkidis, Maria Cristina Dos‐Santos,
Bellucia dichotoma Cogn. (Melastomataceae) is one of various plant species used in folk medicine in the west of the state of Pará, Brazil, to treat snake bites. Many studies have been carried out to evaluate the effectiveness of anti-snake bite plants, but few of these use the same preparation methods and doses as those traditionally used by the local populations. This study therefore compared inhibition of the main local effects of B. atrox venom (BaV) by aqueous extract of B. dichotoma (AEBd) administered ...
Tópico(s): Rabies epidemiology and control
2014 - Elsevier BV | Toxicon
Ximena Rodríguez Palleres, O. Castillo, Juan Tejo C, Jaime Rozowski N,
... somatotipo se remonta a la antigua Grecia, donde Hipócrates y Galeno utilizaban una clasifi cación la cual ...
Tópico(s): Sports and Physical Education Studies
2014 - | Revista chilena de nutrición
Produção Nacional
Vítor Nagai Yamaki, Renan Kleber Costa Teixeira, João Paulo Santiago de Oliveira, Edson Yuzur Yasojima, José Antônio Cordero da Silva,
... Código de Ética Médica ou o juramento de Hipócrates. Foram entrevistados 207 acadêmicos de medicina, do 1º ...
Tópico(s): Medical Malpractice and Liability Issues
2014 - Conselho Federal de Medicina | Revista Bioética
Produção Nacional
Revisado por pares
Pedro PO Pardal, Edna AY Ishikawa, José LF Vieira, Johne Souza Coelho, Regina CC Dórea, Paulo AM Abati, Mariana MM Quiroga, Hipócrates de Menezes Chalkidis,
Scorpion envenomations are a major public health problem in Brazil, whose most dangerous cases are attributable to the genus Tityus. This study was designed to compare the clinical and demographic features of envenomations by Tityus obscurus in two areas of the state of Pará located in the Amazon basin.Were compared demographic findings, local and systemic signs and symptoms of human envenomations caused by T. obscurus that occurred in western and eastern areas of the state.Forty-eight patients ...
Tópico(s): Marine Invertebrate Physiology and Ecology
2014 - BioMed Central | The Journal of venomous animals and toxins including tropical diseases
Produção Nacional
Revisado por pares
Leijiane F. Sousa, Carolina Alves Nicolau, Pedro S. Peixoto, Juliana L. Bernardoni, Sâmella Silva de Oliveira, José A. Portes-Junior, Rosa Helena Veras Mourão, Isa Lima-dos-Santos, Ida S. Sano‐Martins, Hipócrates de Menezes Chalkidis, Richard H. Valente, Ana Maria Moura‐da‐Silva,
In Latin America, Bothrops snakes account for most snake bites in humans, and the recommended treatment is administration of multispecific Bothrops antivenom (SAB--soro antibotrópico). However, Bothrops snakes are very diverse with regard to their venom composition, which raises the issue of which venoms should be used as immunizing antigens for the production of pan-specific Bothrops antivenoms. In this study, we simultaneously compared the composition and reactivity with SAB of venoms collected ...
Tópico(s): Amphibian and Reptile Biology
2013 - Public Library of Science | PLoS neglected tropical diseases