Hironori Aoki, Eiichiro Yamamoto, Akira Takasawa, Takeshi Niinuma, Hiro‐o Yamano, Taku Harada, Hiro‐o Matsushita, Kenjiro Yoshikawa, Ryo Takagi, Eiji Harada, Yoshihito Tanaka, Yuko Yoshida, Tomoyuki Aoyama, Makoto Eizuka, Akira Yorozu, Hiroshi Kitajima, Masahiro Kai, Norimasa Sawada, Tamotsu Sugai, Hiroshi Nakase, Hiromu Suzuki,
... 1 , Hiro-O Yamano 2 , Taku Harada 1 , Hiro-O Matsushita 4 , Kenjiro Yoshikawa 4 , Ryo Takagi 4 , Eiji ...
Tópico(s): Cholangiocarcinoma and Gallbladder Cancer Studies
2017 - Impact Journals LLC | Oncotarget
Yoshiki Kajiwara, Shiro Oka, Shinji Tanaka, Takahiro Nakamura, Shôichi Saito, Yosuke Fukunaga, Manabu Takamatsu, Hiroshi Kawachi, Kinichi Hotta, Hiroaki Ikematsu, Motohiro Kojima, Yutaka Saito, Masayoshi Yamada, Yukihide Kanemitsu, Shigeki Sekine, Shinji Nagata, Kazutaka Yamada, Nozomu Kobayashi, Soichiro Ishihara, Yusuke Saitoh, Kenji Matsuda, Kazutomo Togashi, Koji Komori, Megumi Ishiguro, Toshio Kuwai, Takashi Okuyama, Akihiro Ohuchi, Shinobu Ohnuma, Kazuhiro Sakamoto, Tamotsu Sugai, Kenji Katsumata, Hiro‐o Matsushita, Hiro‐o Yamano, Hirotsugu Eda, Toshio Uraoka, Naohiko Akimoto, Hirotoshi Kobayashi, Yoichi Ajioka, Kenichi Sugihara, Hideki Ueno,
Since 2009, the Japanese Society for Cancer of the Colon and Rectum guidelines have recommended that tumor budding and submucosal invasion depth, in addition to lymphovascular invasion and tumor grade, be included as risk factors for lymph node metastasis (LNM) in patients with T1 colorectal cancer (CRC). In this study, a novel nomogram was developed and validated by usirge-scale, real-world data, including the Japanese Society for Cancer of the Colon and Rectum risk factors, to accurately evaluate ...
Tópico(s): Colorectal Cancer Surgical Treatments
2023 - Elsevier BV | Gastrointestinal Endoscopy
Tamotsu Sugai, Mitsunori Tsukahara, Masaki Endoh, Yoshihiro Shioi, Noriko Takebe, Yoshiharu Mue, Hiro‐o Matsushita, Minoru Toyota, Kazuyuki Suzuki,
Abnormalities of cell cycle regulators are common features in human cancers, and several of these factors are associated with the early development of gastric cancers. However, recent studies have shown that gastric cancer tumorigenesis was characterized by mucin expression. Thus, expression patterns of cell cycle-related proteins were investigated in the early phase of differentiated-type gastric cancers to ascertain any mechanistic relationships with mucin phenotypes. Immunostaining for Cyclins ...
Tópico(s): Genetic factors in colorectal cancer
2010 - BioMed Central | BMC Gastroenterology
Sadahiro Amemori, Hiro‐o Yamano, Yoshihito Tanaka, Kenjiro Yoshikawa, Hiro‐o Matsushita, Ryo Takagi, Eiji Harada, Yuko Yoshida, Kazunori Tsuda, Kato Bun'ichiro, Eri Tamura, Makoto Eizuka, Tamotsu Sugai, Yasushi Adachi, Eiichiro Yamamoto, Hiromu Suzuki, Hiroshi Nakase,
Based on the concept of the adenoma‐carcinoma sequence, most colorectal cancers are considered to arise from conventional adenomas. However, recent studies suggested that a subset of colorectal cancers develop through the serrated neoplastic pathway. It has also been documented that serrated polyps can rapidly transform into invasive cancers even when they are small in size. We now describe a case of a sessile serrated adenoma/polyp which had been followed up for 4 years but eventually showed rapid ...
Tópico(s): Colorectal Cancer Treatments and Studies
2019 - Wiley | Digestive Endoscopy
Hiro‐o Yamano, Hiro‐o Matsushita, Seiko Yanagiwara,
The plasma concentration of rabeprazole in patients treated for gastroesophageal reflux disease (GERD) has not been reported, although the concentration in healthy volunteers has been reported previously. Here, CYP2C19 genotype effects of rabeprazole on the area under the plasma concentration-time curve (AUC) and the pH elevation were studied in GERD patients.Rabeprazole 10 mg/day was administrated for 8 weeks. AUC of rabeprazole in 18 Helicobacter pylori-negative GERD subjects (five CYP2C19 homozygous ...
Tópico(s): Potassium and Related Disorders
2007 - Wiley | Journal of Gastroenterology and Hepatology
Masau Sekiguchi, Kinichi Hotta, Yoji Takeuchi, Shinji Tanaka, Hironori Yamamoto, Kensuke Shinmura, Keita Harada, Toshio Uraoka, Takashi Hisabe, Yasushi Sano, Hitoshi Kondo, Takahiro Horimatsu, Hidezumi Kikuchi, Takuji Kawamura, Shinji Nagata, Katsumi Yamamoto, Masahiro Tajika, Shigetsugu Tsuji, Toshihiro Kusaka, Yusuke Okuyama, Naohisa Yoshida, Tomohiko Moriyama, Aki Hasebe, Suketo So, Hideki Kobara, Hiroshi Kashida, Ryoichi Miyanaga, Sosuke Kato, Yoshito Hayashi, Miwa Sada, Masakatsu Fukuzawa, Hiroyuki Kato, Tetsuji Takayama, Jun Konishi, Hiro‐o Matsushita, Toshiaki Narasaka, Ken Ohata, Kazutomo Togashi, Hisashi Nakamura, Kentaro Moriichi, Yasushi Oda, Naoki Kanda, Toshio Kuwai, Shuji Terai, Makoto Sanomura, Shinji Kitamura, Hayato Miyamoto, Shinsuke Kiriyama, Chiemi Mizuno, Yutaka Saito, Shigeki Sekine, Sayo Ito, Hiroko Nakahira, Shiro Oka, Yoshikazu Hayashi, Kenichi Yoshimura, Hideki Ishikawa, Takahisa Matsuda,
Tópico(s): Neuroblastoma Research and Treatments
2022 - Springer Science+Business Media | Journal of Gastroenterology
Hiro‐o Yamano, Hiro‐o Matsushita, Kousei Yamanaka, Satoshi Maeda, Masaru Nakazato, Kentaro Sato, Kazuhiko Fujita, Shinya Satake,
ABSTRACT There are various types of snares for endoscopic mucosal resection (EMR). Some endoscopists may choose the snare according to their feeling, but we supposed that there were some physical reasons behind each choice. In this paper, we raise the questions, ‘What is the best snare chosen for EMR?’, and ‘Why do we have to do it?’. From the theory of dynamics, we thought that the most important element was vertical force, which we could add against mucosa through the snare. First, we made two situations; ...
Tópico(s): Gastrointestinal Tumor Research and Treatment
2004 - Wiley | Digestive Endoscopy
Takeshi Sawada, Eiichiro Yamamoto, Hiro‐o Yamano, Masanori Nojima, Taku Harada, Reo Maruyama, Masami Ashida, Hironori Aoki, Hiro‐o Matsushita, Kenjiro Yoshikawa, Eiji Harada, Yoshihito Tanaka, Shigenori Wakita, Takeshi Niinuma, Masahiro Kai, Makoto Eizuka, Tamotsu Sugai, Hiromu Suzuki,
To clarify the molecular and clinicopathological characteristics of colorectal serrated lesions, we assessed the DNA methylation of cancer-associated genes in a cohort of BRAF-mutant precancerous lesions from 94 individuals. We then compared those results with the lesions' clinicopathological features, especially colorectal subsites. The lesions included hyperplastic polyps (n = 16), traditional serrated adenomas (TSAs) (n = 15), TSAs with sessile serrated adenomas (SSAs) (n = 6), SSAs (n = 49) and SSAs with ...
Tópico(s): Colorectal Cancer Treatments and Studies
2016 - Impact Journals LLC | Oncotarget
Hirokazu Takahara, Hiro‐o Matsushita, Erika Inui, Masashi Ochiai, Masahiko Hashimoto,
A novel microfluidic cartridge eliminates the need for careful and time-consuming manual droplet handling using a micropipette, which is usually necessary for the transfer of droplets between the three discrete steps of droplet PCR.
Tópico(s): Electrowetting and Microfluidic Technologies
2021 - Royal Society of Chemistry | Analytical Methods
Hironori Aoki, Eiichiro Yamamoto, Hiro‐o Yamano, Tamotsu Sugai, Tomoaki Kimura, Yoshihito Tanaka, Hiro‐o Matsushita, Kenjiro Yoshikawa, Ryo Takagi, Eiji Harada, Michiko Nakaoka, Yuko Yoshida, Taku Harada, Gota Sudo, Makoto Eizuka, Akira Yorozu, Hiroshi Kitajima, Takeshi Niinuma, Masahiro Kai, Masanori Nojima, Hiromu Suzuki, Hiroshi Nakase,
Tópico(s): Gastric Cancer Management and Outcomes
2018 - Springer Science+Business Media | Digestive Diseases and Sciences
Tianshu Chu, Xin Liu, Takayanagi Shigemi, Tomoko Matsushita, Hiro Kishimoto,
Abstract Objectives Impaired mental health status tends to be associated with poor academic performance, but few prospective studies have examined the association between mental health and academic performance among undergraduates while considering the interacting roles of multiple lifestyle behaviors. Participants and Methods A total of 1823 Japanese undergraduate students (67% men) were followed up for 4 years. Their mental health status was measured by the six‐item Kessler Psychological Distress ...
Tópico(s): COVID-19 and Mental Health
2022 - Wiley | International Journal of Methods in Psychiatric Research
Akira Ouchi, Koji Komori, Masahiro Tajika, Kazuhiro Toriyama, Yoshiki Kajiwara, Shiro Oka, Yosuke Fukunaga, Kinichi Hotta, Hiroaki Ikematsu, Shunsuke Tsukamoto, Shinji Nagata, Kazutaka Yamada, Maki Konno, Soichiro Ishihara, Yusuke Saitoh, Kenji Matsuda, Kazutomo Togashi, Megumi Ishiguro, Toshio Kuwai, Takashi Okuyama, Akihiro Ohuchi, Shinobu Ohnuma, Kazuhiro Sakamoto, Tamotsu Sugai, Kenji Katsumata, Hiro‐o Matsushita, Keisuke Nakai, Toshio Uraoka, Naohiko Akimoto, Hirotoshi Kobayashi, Yoichi Ajioka, Kenichi Sugihara, Hideki Ueno,
Objective: To investigate how omitting additional surgery after local excision (LE) affects patient outcomes in high-risk T1 colorectal cancer (CRC). Summary Background Data: It is debatable whether additional surgery should be performed for all patients with high-risk T1 CRC regardless of the tolerability of invasive procedures. Methods: Patients who had received LE for T1 CRC at the Japanese Society for Cancer of the Colon and Rectum (JSCCR) institutions between 2009 and 2016 were analyzed. Those ...
Tópico(s): Colorectal Cancer Treatments and Studies
2023 - Lippincott Williams & Wilkins | Annals of Surgery
Katsunori Iijima, Tamotsu Matsuhashi, Yosuke Shimodaira, Tatsuya Mikami, Tetsuro Yoshimura, Shunichi Yanai, Norihiko Kudara, Tsuyotoshi Tsuji, Hiro‐o Matsushita, Hiroyuki Watanabe, Tomoyuki Koike, Katsuaki Kato, Yasuhiko Abe, Nakao Shirahata, Takuto Hikichi, Kyoko Katakura, Koji Kono, Hirotake Sakuraba, Yoshiyuki Ueno, Hiromasa Ohira, Atsushi Masamune, Takayuki Matsumoto, Shinsaku Fukuda,
The whole picture of the disturbance in endoscopy performance caused by the coronavirus disease 2019 (COVID-19) pandemic in Japan remains to be clarified. Therefore, the Japan Gastroenterological Endoscopy Society-Tohoku conducted this questionnaire survey in Tohoku region of Japan.A questionnaire on the number of diagnostic endoscopy procedures and resulting diagnosed cancers in 2019 and 2020 was sent to all guidance/guidance cooperation hospitals in the Japan Gastroenterological Endoscopy Society ...
Tópico(s): Colorectal Cancer Screening and Detection
2023 - Wiley | DEN Open
Shiro Oka, Shinji Tanaka, Yoshiki Kajiwara, Shôichi Saito, Yosuke Fukunaga, Manabu Takamatsu, Hiroshi Kawachi, Kinichi Hotta, Hiroaki Ikematsu, Motohiro Kojima, Yutaka Saito, Masayoshi Yamada, Yukihide Kanemitsu, Shigeki Sekine, Shinji Nagata, Kazutaka Yamada, Nozomu Kobayashi, Soichiro Ishihara, Yusuke Saitoh, Kenji Matsuda, Kazutomo Togashi, Koji Komori, Megumi Ishiguro, Toshio Kuwai, Takashi Okuyama, Akihiro Ohuchi, Shinobu Ohnuma, Kazuhiro Sakamoto, Tamotsu Sugai, Kenji Katsumata, Hiro‐o Matsushita, Hiro‐o Yamano, Hirotsugu Eda, Toshio Uraoka, Naohiko Akimoto, Hirotoshi Kobayashi, Kenichi Sugihara, Hideki Ueno,
To verify the value of the pathological criteria for additional treatment in locally resected pT1 colorectal carcinoma (CRC) which have been used in the Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines since 2009.
Tópico(s): Colorectal and Anal Carcinomas
2024 - Lippincott Williams & Wilkins | The American Journal of Gastroenterology
Katsunori Iijima, Yosuke Shimodaira, Kenta Watanabe, Shigeto Koizumi, Tamotsu Matsuhashi, Mario Jin, Masahito Miura, Kengo Onochi, Kiyonori Yamai, Yuko Fujishima, Takuma Ajimine, Hidehiko Tsuda, Tsuyotoshi Tsuji, Hiro‐o Matsushita, Yohei Horikawa, Takahiro Dohmen, Hiroyuki Shibata,
We recently reported the decrease in the number of gastrointestinal (GI) cancer diagnoses in 2020 due to disturbance of the healthcare system by the coronavirus disease 2019 (COVID-19) pandemic, using a hospital-based cancer registration system in Akita prefecture, Japan. In this study, we extended the research by showing the latest data (2021) on the number of cancers and examinations. Information on the occurrence and stage of esophageal, gastric, and colorectal cancers was collected from the same ...
Tópico(s): Colorectal Cancer Screening and Detection
2023 - Tohoku University | The Tohoku Journal of Experimental Medicine
Takahisa Matsuda, Shiro Oka, Hiroaki Ikematsu, Hiro‐o Matsushita, Yuichi Mori, Yoji Takeuchi, Naoto Tamai, Takuji Kawamura, Akiko Chino, Bora Keum, Supakij Khomvilai, Toshio Uraoka,
Serrated lesions, especially sessile serrated adenoma/polyps (SSA/P) are considered one of the most important precursors of colorectal cancers. However, it is still difficult to endoscopically differentiate SSA/P from hyperplastic polyps. In the present review, we mainly focus on the current status and future perspectives of endoscopic diagnosis of colorectal serrated lesions based on the results of a questionnaire survey and report from the Endoscopic Forum Japan (EFJ) 2015 held in Tokyo in August ...
Tópico(s): Esophageal Cancer Research and Treatment
2016 - Wiley | Digestive Endoscopy
Taku Harada, Eiichiro Yamamoto, Hiro‐o Yamano, Hironori Aoki, Hiro‐o Matsushita, Kenjiro Yoshikawa, Ryo Takagi, Eiji Harada, Yoshihito Tanaka, Yuko Yoshida, Makoto Eizuka, Akira Yorozu, Gota Sudo, Hiroshi Kitajima, Takeshi Niinuma, Masahiro Kai, Yasushi Sasaki, Takashi Tokino, Tamotsu Sugai, Hiroshi Nakase, Hiromu Suzuki,
Tópico(s): Cancer Genomics and Diagnostics
2018 - Springer Science+Business Media | Journal of Gastroenterology
Yuzuru Tamaru, Toshio Kuwai, Yoshiki Kajiwara, Shiro Oka, Shôichi Saito, Yosuke Fukunaga, Hiroshi Kawachi, Manabu Takamatsu, Kinichi Hotta, Hiroaki Ikematsu, Motohiro Kojima, Yutaka Saito, Yukihide Kanemitsu, Masayoshi Yamada, Shigeki Sekine, Shinji Tanaka, Shinji Nagata, Takahiro Nakamura, Kazutaka Yamada, Maki Konno, Soichiro Ishihara, Yusuke Saitoh, Kenji Matsuda, Kazutomo Togashi, Koji Komori, Megumi Ishiguro, Takashi Okuyama, Akihiro Ohuchi, Shinobu Ohnuma, Kazuhiro Sakamoto, Tamotsu Sugai, Kenji Katsumata, Hiro‐o Matsushita, Hiro‐o Yamano, Keisuke Nakai, Toshio Uraoka, Naohiko Akimoto, Hirotoshi Kobayashi, Yoichi Ajioka, Kenichi Sugihara, Hideki Ueno,
INTRODUCTION: There is considerable concern about whether endoscopic resection (ER) before additional surgery (AS) for T1 colorectal cancer (CRC) has oncologically potential adverse effects. Therefore, the aim of this study was to compare the long-term outcomes, including overall survival (OS), of patients treated with AS after ER vs primary surgery (PS) for T1 CRC using a propensity score-matched analysis from a large observational study. METHODS: This study investigated 6,105 patients with T1 CRC treated ...
Tópico(s): Colorectal Cancer Screening and Detection
2024 - Lippincott Williams & Wilkins | The American Journal of Gastroenterology
Yasutsugu Shimohara, Yuji Urabe, Shiro Oka, Takashi Hisabe, Atsushi Yamada, Hiro‐o Matsushita, Kato Bun'ichiro, Hirotsugu Sakamoto, Joichiro Horii, Daisuke Watanabe, Hirotsugu Eda, Fumika Nakamura, Akiko Chino, Hironori Yamamoto, Tetsuji Takayama, Takayuki Matsumoto, Hideki Ishikawa, Shinji Tanaka,
Tópico(s): Gastric Cancer Management and Outcomes
2022 - Springer Science+Business Media | Journal of Gastroenterology
N. Ono, Ryo� Saito, Taira Abiru, Yasuhiro Matsushita, Hiro‐o Kamiya,
Haloperidol given intraperitoneally dose-dependently elicited cataleptic behavior, evaluated by high bar and four-cork tests, in mice. The haloperidol-induced cataleptic behavior was reduced dose-dependently after oral treatment with aspirin, a cyclooxygenase inhibitor. The intracerebroventricular administration of prostaglandin F2a produced cataleptic behavior of long duration determined by the high bar test. It is suggested that prostaglandins may participate in the induction of cataleptic behavior ...
Tópico(s): Pharmacogenetics and Drug Metabolism
1988 - Elsevier BV | Neuropharmacology
Takafumi Hirata, Masami Kimura, Takumasa Nishimura, Kousei Kawata, Hiro‐o Matsushita, Shigeki Okamura,
症例は44歳，男性．41歳時に繰り返す上行結腸憩室炎に対し，腹腔鏡補助下結腸切除術を行った．術後1年目に腹壁瘢痕ヘルニアを認めたため，腹腔鏡下ヘルニア手術を行った．ヘルニア手術後2年目に，誘引なく手術創に感染を認めた．抗生剤投与による保存的治療およびメッシュ温存処理にて軽快しなかったため，最終的にメッシュ摘出を行った．腹壁瘢痕ヘルニア術後早期のメッシュ感染報告はあるが，本例のように術後2年経過した遅発性感染の報告例は少ないため文献的考察を加え報告する．
Tópico(s): Intestinal and Peritoneal Adhesions
2008 - Japan Surgical Association | Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)
Kei Horino, Masami Kimura, Takumasa Nishimura, Hiro‐o Matsushita, Mitsuhiro Inoue, Yutaka Tsuruta, Kosei Kawata, Kenji Hiromatsu,
症例は53歳の男性で, 右季肋部痛を主訴に近医を受診した. 血液検査で肝機能障害を認めたため精査加療目的で当科紹介となった. 腹部CTおよびMRIで膵頭部に約3cmの腫瘤と腹腔動脈根部リンパ節の腫大を認めた. 腫瘍マーカー(CEA, CA19-9)は陰性であったが, magnetic resonance cholangiopancreatographyで膵内の総胆管に狭窄を認め膵頭部癌が強く疑われたため幽門輪温存膵十二指腸切除術を施行した. 経過は良好で術後第38日に退院となった. 切除標本の病理組織学的検査所見では悪性所見はなく, 好酸球性肉芽腫であったことから寄生虫症が疑われ, アニサキス特異的抗体を利用した血清免疫学的検査が陽性であったため膵アニサキス症が強く疑われた. 消化管外アニサキス症はまれであり剖検例などで偶然発見される場合が多く, 特に膵アニサキス症はほとんど報告されていない. 自験例に若干の文献的考察を加え報告する.
Tópico(s): Leech Biology and Applications
2007 - The Japan Society of Mechanical Engineers | The Japanese Journal of Gastroenterological Surgery
This chapter examines some of the translational features of value co-creation by focusing on such managerial human activity systems as quality improvement, organizational learning, plan-do-check-act cycle, and cross-cultural diffusion of managerial systems of health services. By so doing this work descriptively analyzes some aspects of value co-creation in action research-based learning in health services administration.
Tópico(s): HIV/AIDS Impact and Responses
2014 - Springer Nature | Translational systems sciences
Hiro‐o Yamano, Hiro‐o Matsushita, Kenjiro Yoshikawa, Ryo Takagi, Eiji Harada, Yoshihito Tanaka, Michiko Nakaoka, Ryogo Himori, Yuko Yoshida, Kentarou Satou, Yasushi Imai,
Bowel cleansing is necessary before colonoscopy, but is a burden to patients because of the long cleansing time and large dose volume. A low-volume (2 L) hypertonic polyethylene glycol-ascorbic acid solution (PEG-Asc) has been introduced, but its possible dehydration effects have not been quantitatively studied. We compared the efficacy and safety including the dehydration risk between hypertonic PEG-Asc and isotonic PEG regimens.This was an observer-blinded randomised study. Participants (n=310) were ...
Tópico(s): Abdominal Surgery and Complications
2016 - BMJ | BMJ Open Gastroenterology
Tatsunori Minamide, Hiroaki Ikematsu, Yoshiki Kajiwara, Shiro Oka, Yoichi Ajioka, Hideki Ueno, Kenichi Sugihara, Shôichi Saito, Yusuke Fukunaga, Hiroshi Kawachi, Manabu Takamatsu, Motohiro Kojima, Kinichi Hotta, Masayoshi Yamada, Yukihide Kanemitsu, Yutaka Saito, Shigeki Sekine, Shinji Tanaka, Shinji Nagata, Takahiro Nakamura, Kazutaka Yamada, Maki Konno, Soichiro Ishihara, Yusuke Saitoh, Kenji Matsuda, Kazutomo Togashi, Koji Komori, Megumi Ishiguro, Toshio Kuwai, Takashi Okuyama, Akihiro Ohuchi, Shinobu Ohnuma, Kazuhiro Sakamoto, Tamotsu Sugai, Kenji Katsumata, Hiro‐o Matsushita, Hiro‐o Yamano, Keisuke Nakai, Toshio Uraoka, Naohiko Akimoto, Hirotoshi Kobayashi,
... Sakamoto,25 Tamotsu Sugai,26 Kenji Katsumata,27 Hiro-o Matsushita,28 Hiro-o Yamano,29 Keisuke Nakai,30 Toshio Uraoka, ...
Tópico(s): Gastric Cancer Management and Outcomes
2023 - Elsevier BV | Gastroenterology
Hiro‐o Matsushita, Hiro‐o Yamano,
On the basis of our translational research, we have reported that type II-open pit pattern should be the characteristic finding of magnifying endoscopy of sessile serrated adenoma/polyp (SSA/P).1 We present a case of SSA/P with the typical type II-open pit pattern. A slightly elevated lesion was detected in the ascending colon (Fig. 1). Color of the lesion was almost the same as that of the surrounding mucosa and some mucus was attached to the surface (Fig. 1a). Dark spots and dilated vessels were ...
Tópico(s): Mycobacterium research and diagnosis
2016 - Wiley | Digestive Endoscopy
Susumu Saigusa, Yasuhiro Inoue, Koji Tanaka, Yuji Toiyama, Kohei Matsushita, Mikio Kawamura, Yoshinaga Okugawa, Junichiro Hiro, Keiichi Uchida, Yasuhiko Mohri, Masato Kusunoki,
LGR5, known as a target of Wnt signaling, has been reported as an intestinal stem cell marker. Recent reports showed that LGR5 was associated with carcinogenesis and tumor invasion in colorectal cancer. CD44 is a ubiquitously expressed cell adhesion molecule and also a potential cell surface marker on colon cancer stem cells. Both LGR5 and CD44 have been also reported to be Wnt signal targets. The aim of this study was to investigate the association of these markers with clinical outcome in rectal ...
Tópico(s): Colorectal and Anal Carcinomas
2012 - Spandidos Publishing | International Journal of Oncology
Susumu Saigusa, Koji Tanaka, Yuji Toiyama, Kohei Matsushita, Mikio Kawamura, Yoshinaga Okugawa, Junichiro Hiro, Yasuhiro Inoue, Keiichi Uchida, Yasuhiko Mohri, Masato Kusunoki,
Tumor regression grading (TRG) reportedly has prognostic value in rectal cancer patients after pre-operative chemoradiotherapy (CRT). The aim of this retrospective study was to differentiate gene expression profiles based on TRG in residual cancer cells after CRT. We evaluated pathological response using the criteria of four TRG systems: the Japanese Society for the Cancer of Colon and Rectum (JSCCR), Mandard, Dworak and Rödel. Total RNA was obtained using microdissection from 52 locally advanced rectal ...
Tópico(s): Colorectal Cancer Treatments and Studies
2012 - Elsevier BV | Oncology Reports
Kohei Matsushita, Yuji Toiyama, Koji Tanaka, Susumu Saigusa, Junichiro Hiro, Keiichi Uchida, Yasuhiro Inoue, Masato Kusunoki,
Tópico(s): Peptidase Inhibition and Analysis
2011 - Springer Science+Business Media | Annals of Surgical Oncology
Midori Kumamoto, Hiro Inoue, Masanori Matsushita, Hiroshi Fujiyama,
Electrode structure and size are the most important factors, as much as the operating pressure is, in the generation of low-pressure coaxial electron cyclotron resonance (ECR) microplasmas. The experimental results will be presented showing the influence of these on the generation of low-pressure coaxial ECR microplasmas. The discharge conditions for various magnetic field were investigated in three types of coaxial electrodes when the gap length was fixed to 3.5 mm. With increasing magnetic field, ...
Tópico(s): Plasma Diagnostics and Applications
2004 - Elsevier BV | Thin Solid Films