Wakako Himeno, Teiji Akagi, Jun Furui, Yasuki Maeno, Masahiro Ishii, K Kosai, Toyoaki Murohara, Hiroki Kato,
Tópico(s): Congenital Heart Disease Studies
2003 - Springer Science+Business Media | Pediatric Cardiology
Akira Tanaka, Masafumi Seki, Shinya Yamahira, Hiroki Noguchi, Kosuke Kosai, M. Toba, Y. Morinaga, Taeko Miyazaki, K. Izumikawa, Hiroshi Kakeya, Y. Yamamoto, Katsunori Yanagihara, Takayoshi Tashiro, Noriyuki Kohda, Shigekatsu Kohno,
Aims: Oral administration of probiotics has been known to improve inflammatory responses against infectious diseases. Here, we describe the inhibitory effect of oral intake of heat-killed Lactobacillus pentosus strain b240 (b240) on pneumococcal pneumonia in a murine experimental model. Method and Results: The mice treated with oral b240 for 21 days before Streptococcus pneumoniae infection exhibited prolonged survival time and less body weight loss, compared with saline-treated control mice. Mild ...
Tópico(s): Immune Response and Inflammation
2011 - Oxford University Press | Letters in Applied Microbiology
Keisuke Nagai, Keigo Osuga, Eiji Kashiwagi, Shinya Kosai, Hidenari Hongyo, Kaishu Tanaka, Yusuke Ono, Hiroki Higashihara, Noriyuki Tomiyama,
To investigate and compare venous sac and feeding artery embolization (VFE) with feeding artery embolization (FAE) alone for treatment of pulmonary arteriovenous malformations (PAVMs), based on difference in outcomes in decrease of the size of the draining vein.Twenty-six patients (7 male and 19 female; median age [interquartile range], 58 years [46-65 years]) with 42 simple PAVMs treated with coil embolization between August 2005 and December 2018 were retrospectively evaluated. Twenty PAVMs were treated ...
Tópico(s): Vascular Malformations and Hemangiomas
2021 - Elsevier BV | Journal of Vascular and Interventional Radiology
Shoki Kosai, Hiroki Noguchi, Masaaki Fuse, Eiji Yamasue,
A sound understanding of transport energy efficiency is of paramount importance. It has been widely accepted that a higher level of urban density is associated with a more significant amount of energy consumption in long-distance travel, including international trips. Meanwhile, its negative correlation with domestic long-distance travel was reported in only a few studies. In addition, the analysis of domestic long-distance travel and its transport energy efficiency has yet to be thoroughly conducted. ...
Tópico(s): Urban and Freight Transport Logistics
2021 - SAGE Publishing | Transportation Research Record Journal of the Transportation Research Board
Takaaki Masuda, Miwa Noda, Akihiro Kitagawa, Qingjiang Hu, Atsushi Fujii, Shuhei Ito, Keisuke Kosai, Yukio Ando, Yoshihiro Matsumoto, Hajime Ohtsu, Hiroki Uchida, Shinji Ohno, Koshi Mimori,
Background/Aim: Programmed death-ligand 1 (PD-L1/CD274) elicits T-cell anergy, leading to immune suppression. We aimed to determine the prognostic relevance of PD-L1 expression in the blood of breast cancer (BC) patients. Materials and Methods: We measured PD-L1 mRNA expression in blood and tumor tissues of BC patients using RT-qPCR and a dataset from The Cancer Genome Atlas, and performed a survival analysis of PD-L1 expression in the blood of 330 BC patients. Flow cytometric analysis was performed ...
Tópico(s): Immunotherapy and Immune Responses
2020 - International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts | Anticancer Research
Hidenari Hongyo, Hiroki Higashihara, Keigo Osuga, Eiji Kashiwagi, Shinya Kosai, Keisuke Nagai, Kaishu Tanaka, Yusuke Ono, Takeshi Ujike, Motohide Uemura, Ryoichi Imamura, Norio Nonomura, Noriyuki Tomiyama,
Transcatheter arterial embolization (TAE) has been widely performed for renal angiomyolipomas (AMLs) as prophylaxis or emergency treatment. On the other hand, mammalian target of rapamycin (mTOR) inhibitors have recently been used for tuberous sclerosis (TSC)-related AMLs, and no comparison between the effectiveness of mTOR inhibitors versus prophylactic selective TAE has yet been performed. Therefore, the purpose of this study was to evaluate the efficacy of TAE for AML tumor volume reduction and predictors ...
Tópico(s): Vascular Tumors and Angiosarcomas
2020 - Springer Nature | CVIR Endovascular
Akihiro Kitagawa, Tsuyoshi Osawa, Miwa Noda, Yuta Kobayashi, Sho Aki, Yusuke Nakano, Tomoko Saito, Dai Shimizu, Hisateru Komatsu, Maki Sugaya, Junichi Takahashi, Keisuke Kosai, Seiichiro Takao, Yushi Motomura, Kuniaki Sato, Qingjiang Hu, Atsushi Fujii, Hiroaki Wakiyama, Taro Tobo, Hiroki Uchida, K Sugimachi, Kohei Shibata, Tohru Utsunomiya, Shogo Kobayashi, Hideshi Ishii, Takanori Hasegawa, Takaaki Masuda, Yusuke Matsui, Atsushi Niida, Tomoyoshi Soga, Yutaka Suzuki, Satoru Miyano, Hiroyuki Aburatani, Yuichiro� Doki, Hidetoshi Eguchi, Masaki Mori, Keiichi I. Nakayama, Teppei Shimamura, Tatsuhiro Shibata, Koshi Mimori,
Abstract Background Driver alterations may represent novel candidates for driver gene-guided therapy; however, intrahepatic cholangiocarcinoma (ICC) with multiple genomic aberrations makes them intractable. Therefore, the pathogenesis and metabolic changes of ICC need to be understood to develop new treatment strategies. We aimed to unravel the evolution of ICC and identify ICC-specific metabolic characteristics to investigate the metabolic pathway associated with ICC development using multiregional ...
Tópico(s): Cancer-related molecular mechanisms research
2023 - Springer Nature | British Journal of Cancer
Abdelatif Toufik, Guessoum Amir Nidhal, Amar Makhlouf, Irbah Abadi, Mario Aguero, E. M. ALONSO, María Victoria, Aquilano Roberto, Oscar L. Arnal, Marcelo Azcarate, Ismael Bagala, Liria Bajaja, Esteban Barba, Rodolfo Bassino, Lilia Beauge, Christian Benaglia, Paula Benvenuto, O. J.H. Bosch, Brandi Elisande, Estela Dr Branham, Richard Calderon, Jesus Cappa De Nicolau, Cristina Carpintero, Daniel Carranza, Gustavo Dr Castagnino, Mario Cellone, Sergio Cidale, Lydia Sonia, Cincotta Pablo, Miguel Claria, Juan Colomb, Fernando Combi, Jorge Ariel, Cora Sofia, Alejandra Costa, Andrea Cruzado, Alicia De Biasi, Maria Donzelli, Carlos Dubner, Gloria Dr Feinstein, Vigen Melik-Alaverdian, Yu Melikian, Norair Mickaelian, A. De La Llave Martin, Mnatsakanian Mamikon, A. G. Nikoghossian, Arthur Abies, John Ashley, Michael Bailey, J D BALDRY, Ivan Ball, Lewis Barnes, Graham Batty, Michael Bedding, Timothy Bersier, David Bessell, Michael Dr Bicknell, Geoffrey Biggs, J.R. Birch, Peter Hunter Blair, D. Gerald, Jonathan Boyle, Brian Bray, Robert A. Bridges, Terry Brouw, Wendy J. Brown, Ronald S. Burton, Cally Paul, S Campbell-Wilson Duncan, Cane Hilary, Vivien Cannon, Carter Bradley, Darren Carver, J Caswell, James Chapman, Jessica Christiansen, Wilbur Clay, Roger Cogan, Bruce Cole, Trevor William, Colless Matthew Costa, M. Couch, W. Alec Cram, Lawrence Cramer, Neil Da, Costa Gary, Stewart Davis, John Dawe, John Nikoloff, Ivan Norris, John M. Norris, Raymond Nulsen, Paul M. O’Byrne, John O', Mara Bernard, J Orchiston, W R B L O O, Sullivan John, David Page, Arthur Perdrix, John Peterson, Bruce Piddington, Jack Res, Fel Pols, Onno Pongracic, Helen Prentice, Andrew Protheroe, Raymond Reber Grote, Rees David, Elwyn Reynolds, John Robertson, James Gordon, Robinson Brian, Jo Robinson, Garry Ross, R Kenneth, Veronique Dejaiffe, Rene Dejonghe, Herwig Delbouille, Luc Denis, Carlo Dommanget, Jessy Elst, Eric Eyer, Gabriel Laurent, Maurice Gerard, C Gonze, Roger Goossens, Marcel Goriely, Stephane Gosset, Eric Grevesse, Nicolas Henrard, Jacques Hensberge, Herman Heynderickx, Daniel Houziaux, Leo Hutsemekers, Damien Huygen, Eric Jamar, Claude Jorissen, Alain Lampens, Patricia Lausberg, Andre Lemaire, Joseph E. Jablonski, Janot-Pacheco Eduardo, Jatenco-Pereira Vera, Jayanthi Udaya, Berwind P. Kaufmann, Pierre Kepler, S Kotanyi, Christophe Lazzaro, Daniela Leister, Nelson Vani, Leite Scheid, Paulo Lepine, Jacques Lima, Botti Luiz, C. Coelhio Lima, José Luiz de Souza Lopes, Dalton De Faria Maciel, Walter Magalhaes, Antonio Mario, Maia Marcio, Ana Catarina Maia, Graciete Marques, Dos Santos, Martin Inacio, Malmonge Matsuura, Oscar Medina, Tanco Gustavo, Audrey Ben Méliani, A Peterson Chris, Alexander Murray, Elaine Argyle, P Auman, Avery Lome, Bartel Norbert, Harald Dr Bastien, Pierre Basu, Dipak Batten, Alan Beaudet, Gilles Bell, Morley Bishop, Roy Bochonko, Richard Bohlender, David R. Bolton, Thomas Bond, J Richard, Bona Ermanno, Brandie George-Milford, W Brassard, Pierre Brooks, Randall Brosterhus, F Broten, Norman Burke, James C. Anthony, Caldwell John, James Cannon, Wayne Carignan, Claude Carlberg, Raymond Gary, Clark Thomas, Alan Clarke, Thomas Clement, Maurice Climenhaga, J. CLUTTON-BROCK, Martin Colombi, Stephane Couchman, Hugh Courteau, Stephane Coutts-Clement, Christine Covington, Arthur B. Crabtree, Dennis Crampton, David Davidge, Timothy Dawson, Peter De, R Michael, Mélanie Demers, Serge Dewdney, Peter C. Doherty, Lome Dougherty, Pengfei Chen, Xiaozhong Chen, Chen Yang, Chen Yongjun, Чен Жен, Zhencheng Chen, Cheng Fu-hua, Cheng Fu-zhen, Abada-Simon Meil, Abgrall Aboudarham, Jean Acker, Agnes Aime, Claude Alecian, Georges Alimi, J.F. Allard, Nicole Allegre, Claude Aly, Jean-Jacques Amari, Tahar Amram, Philippe Andrillat, Yvette Arduini-Malinovsky, Monique Arenou, F. Arias, Elisa Arlot, Jean-Eudes Arnaud, J.P. Arnaud, Monique Artru, Marie-Christine Artzner, Guy Asseo, Estelle Assus, Pierre Athanassoula, Evangelia Aubier, Monique Audouze, Jean Augarde, Renee Auriere, M. Auvergne, Michel Avignon, C. Burkhart, Robert Burnage, S. Cabrit, Odile Calame, H. Camichel, N. Capitaine, James Caplan, Jean-Michel Carquillat, F. Casoli, Michel Cassé, A. Castets, Claude Català, V. Cayatte, R. Cayrel, G. Cayrel de Strobel, Anny Cazenave, L. M. Celnikier, A. Chalabaev, P. Chamaraux, G. Chambe, J. Chapront, Michelle Chapront‐Touzé, C. Charbonnel, Patrick Chariot, Stephane Chariot, Éric Chassefière, Bertrand Chauvineau, C. Chevalier, Serge Chevrel, Fernand Chollet, Marguerite Chopinet, J. Clairemidi, J. Colin, S. Collin-Souffrin, P. Colom, F. Combes, M. Combes, Georges Comte, Janine Connes, P. Connes,
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Cambridge University Press
Shinya Kosai, Hiroki Higashihara, Hiroki Yano, Eiji Kashiwagi, Keisuke Nagai, Kaishu Tanaka, Yusuke Ono, Tatsuya Miyake, Noriyuki Tomiyama,
To identify risk factors for clinical failure of uterine artery embolization (UAE) for postpartum hemorrhage (PPH), with particular attention to the uterine artery diameter.This retrospective study included 47 patients who underwent UAE for PPH between January 1, 2010, and January 31, 2021. Technical success was defined as the completion of embolization of the arteries thought to be the cause of the bleeding. Clinical success was defined as no recurrent bleeding or need for additional therapeutic ...
Tópico(s): Uterine Myomas and Treatments
2022 - Elsevier BV | Journal of Vascular and Interventional Radiology
Shinsuke Suzuki, Hiroki Kofune, Kimiharu Uozumi, Makoto Yoshimitsu, Naomichi Arima, Kenji Ishitsuka, Shinichi Ueno, Ken-ichiro Kosai,
Adult T-cell leukemia/lymphoma (ATL) is a peripheral T-cell malignancy caused by long-term human T-cell leukemia virus type I (HTLV-1) infection. Survivin-responsive, conditionally replicating adenoviruses regulated by multiple tumor-specific factors (Surv.m-CRAs), in which the expression of the adenoviral early region 1A gene is regulated by the survivin (BIRC5) promoter, can be used to treat several cancers. As survivin is overexpressed in ATL, we examined the effects of Surv.m-CRAs on ATL-selective ...
Tópico(s): Vector-Borne Animal Diseases
2019 - BioMed Central | BMC Cancer
Eiji Kashiwagi, Yusuke Ono, Hiroki Yano, Shinya Kosai, Keisuke Nagai, Kaishu Tanaka, Hiroki Higashihara, Noriyuki Tomiyama,
Lymphoceles can result from disruption of lymphatic vessels after surgical procedures in areas with extensive lymphatic networks. Percutaneous catheter drainage with sclerotherapy can be performed for the treatment of lymphoceles. OK-432 has been used to treat benign cysts, such as lymphangioma and ranula. Therefore, we aimed to report the efficacy and safety of sclerotherapy using OK-432 for postoperative lymphoceles. This study retrospectively analyzed 16 patients who underwent sclerotherapy using ...
Tópico(s): Lymphatic System and Diseases
2022 - Springer Nature | CVIR Endovascular
Naotaka Haraguchi, Shoki Kosai, Shunsuke Kashiwakura, Eiji Yamasue, Hiroki Tanikawa,
Tópico(s): Urban and Freight Transport Logistics
2025 - Multidisciplinary Digital Publishing Institute | Sustainability
Kaishu Tanaka, Keigo Osuga, Hiroki Higashihara, Shinya Kosai, Eiji Kashiwagi, Keisuke Nagai, Hidenari Hongyo, Yasushi Kimura, Yusuke Ono, Noriyuki Tomiyama,
Tópico(s): Abdominal vascular conditions and treatments
2021 - Springer Science+Business Media | CardioVascular and Interventional Radiology
Keisuke Nagai, Keigo Osuga, Eiji Kashiwagi, Shinya Kosai, Hidenari Hongyo, Kaishu Tanaka, Yusuke Ono, Hiroki Higashihara, Noriyuki Tomiyama,
The purpose of this study was to investigate the difference in the shrinkage rates of the draining vein between feeding artery embolization (FAE) and venous sac and feeding artery embolization (VFE) for pulmonary arteriovenous malformations (PAVMs). Between August 2005 and December 2018, 26 patients (M:F = 7:19; mean age, 51.0 y) with 42 PAVMs underwent successful coil embolization defined by complete blood flow cessation of each PAVM on DSA. Twenty PAVMs were treated with FAE (FAE group), while 22 PAVMs ...
Tópico(s): Pulmonary Hypertension Research and Treatments
2020 - Elsevier BV | Journal of Vascular and Interventional Radiology
Wataru Shibata, Kenichiro Uchida, Daiki Ozawa, Haruka Imai, Shiro Endo, Yuji Watanabe, Kosuke Kosai, Yasuhide Kawamoto, Hirotsugu Uehara, Norihiko Sugimoto, Hiroki Namikawa, Yasumitsu Mizobata, Keiji Kanemitsu, Hisakazu Yano, Mitsuo Kaku, Masafumi Seki, Katsunori Yanagihara, Hiroshi Kakeya,
Blood culture, a method for identifying causative agents of bacterial sepsis, requires several days. The combination of cell-direct polymerase chain reaction and nucleic acid lateral flow immunoassay (cdPCR-NALFIA) is a simple and sensitive detection method for identifying pathogenic bacteria. Furthermore, this assay, when applied directly to blood samples yields results within 4.5 h, without requiring culture. This study was performed at five hospitals in Japan between 2013 and 2016. Blood samples ...
Tópico(s): Antibiotic Resistance in Bacteria
2022 - Elsevier BV | Journal of Microbiological Methods
Shigeyoshi Yamanaga, Keita Shimata, Satoko Ohfuji, Mikiko Yoshikawa, Yoichiro Natori, Taizo Hibi, Kenji Yuzawa, Hiroto Egawa, Kohei Unagami, Hideki Ishida, Kazuya Omoto, Mureo Kasahara, Hajime Uchida, Seisuke Sakamoto, Kenta Futamura, Kenta Nishikawa, Ryoichi Imamura, Shigeaki Nakazawa, Etsuro Hatano, T. Ito, Yuki Masano, Morikuni Nishihira, Yuta Hirata, Yasunaru Sakuma, Yasuharu Onishi, Naoki Yokoyama, S. Yamamoto, Yusuke Yamada, Yasuhiro Ogura, N. Kurata, Junji Uchida, Kazuya Kabei, Hitoshi Iwamoto, Chie Ikeda, Kazunobu Shinoda, Miki Yoshiike, Kiyohiko Hotta, Yuji Hidaka, Daiki Iwami, Yasuo Ishíi, Manabu Kamiyama, Tomoharu Yoshizumi, Yukiko Kosai‐Fujimoto, Takaaki Kobayashi, Kentaro Motoyama, Megumi Yamamoto, Toshihiro Asai, Masayuki Tasaki, Takashi Kenmochi, T. Ito, Kazuaki Tokodai, Atsushi Fujio, Yasumasa Tsukamoto, Takuya Watanabe, Nobuhisa Akamatsu, Sachi Yamashina, Daisuke Ishii, Kazuki Kitajima, Yasutoshi Yamada, Akihiko Mitsuke, Takashi Sakaguchi, Michio Nakamura, Yusuke Tomita, Yuki Nakamura, Tatsuro Ishimoto, Hideki Ohdan, Naoki Tanimine, Takuzo Fujiwara, Mitsuki Yanagihara, Shingo Hatakeyama, Manabu Takai, Kazuhiro Nose, Takashi Kikuchi, Yasunori Mori, Motoo Araki, Takanori Sekito, Shingo Nishimura, Tatsu Tanabe, Yuto Igarashi, Sumi Hidaka, Masaaki Watanabe, Yuichi Ariyoshi, Yasushi Hasegawa, Masato Kamiyama, Tatsuo Yoneda, Tomokazu Shimizu, Kouhei Nishikawa, Takumi Fukumoto, K Kuramitsu, Masashi Kato, Mitsuru Saito, M. Shinkai, Hidehito Usui, Masaaki Sato, Hidetoshi Eguchi, Hiroki Imamura, Shogo Kobayashi, Yuji Soejima, Atsuyoshi Mita, Takashi Kobayashi, Kenji Nakamura, Masayuki Ohtsuka, Shinichiro Nakada, Takahito Yagi, Kazuya Yasui, Naoto Matsuno, Chiharu Mizuno, Mikio Sugimoto, Nobufumi Ueda, Yoshinori Okada, Takashi Hirama, Shinichi Toyooka, Seiichiro Sugimoto, Kei Matsubara, Toru Ikegami, Kenei Furukawa, Hiroyuki Nitta, Hirokatsu Katagiri, Toru Onita, Takeshi Shiraishi, Shugo Mizuno, Eisuke Amiya, Yasushi Shintani, Takashi Kanou, Soichiro Funaki, Yoshifumi Miura, Daisuke Nakajima, Taizen Urahashi, Goro Matsumiya, Michiko Watanabe, Yosuke Ebisu, Ryosuke Osawa, Minoru Ono, Hiroshi Sogawa, Harumi Gomi, Toyofumi F. Chen‐Yoshikawa, Kazunari Yoshida, Naoko Ogawa,
The excess mortality of coronavirus disease 2019 (COVID-19) solid organ transplant recipients (SOTRs) throughout the pandemic remains unclear. This prospective cohort study based on the Japanese nationwide registry included 1632 SOTRs diagnosed with COVID-19 between February 1, 2020, and July 31, 2022, categorized based on dominant phases of variants of concern (VOCs): Waves 1 to 3 (Beta), 4 (Alpha), 5 (Delta), 6 (Omicron BA.1/BA.2), and 7 (Omicron BA.5). Excess mortality of COVID-19-affected SOTRs was ...
Tópico(s): SARS-CoV-2 and COVID-19 Research
2024 - Elsevier BV | American Journal of Transplantation
Naoki Iwanaga, Ayaka Ota, Hiroki Ashizawa, Yuya Ito, Tatsuro Hirayama, Masataka Yoshida, Kazuaki Takeda, Shotaro Ide, Masato Tashiro, Naoki Hosogaya, Noriho Sakamoto, Takahiro Takazono, Kosuke Kosai, Mariko Naito, Yoshimasa Tanaka, Kazuhiro Yatera, Koichi Izumikawa, Katsunori Yanagihara, Hiroshi Mukae,
Objectives: In the present study, we aimed to clarify the mechanisms by which periodontal pathogens, particularly Prevotella intermedia, induce severe neutrophilic inflammation. In addition, we aimed to test the efficacy of macrolides, which has not been resolved in the neutrophilic inflammation induced by P. intermedia. Methods: NCl-H292 human airway epithelial cells were pre-incubated with clarithromycin for 2 h before incubation with P. intermedia supernatants. Then, C-X-C motif chemokine ligand ...
Tópico(s): Immune Response and Inflammation
2024 - Multidisciplinary Digital Publishing Institute | Antibiotics