Yukitaka Ushio, Norio Arita, Tōru Hayakawa, H Mogami, Hiroshi Hasegawa, S Bitoh, Yuzuru Oku, Hiroya Ikeda, Nobuhiro Kanai, Mitsuaki Kanoh, Katsuhito Akagi, Hidemitsu Nakagawa,
Abstract A controlled randomized study was carried out to evaluate the effects of chemotherapy in patients with brain metastases from lung carcinoma. One hundred patients were randomly divided into three groups at the time of diagnosis or after surgery for metastases. Group A received radiotherapy alone; Group B received radiotherapy and chloroethylnitrosoureas (methyl-CCNU, 100-120 mg/m2, or ACNU 80-100 mg/m2, every 6-8 weeks), and Group C received radiotherapy and a combination of chloroethylnitrosoureas ...
Tópico(s): Lung Cancer Research Studies
1991 - Lippincott Williams & Wilkins | Neurosurgery
Tetsuya Yasuda, Keiko Oku, Hiroya Higuchi, Shinji Shigehisa, Yasuyo Okutani-Akamatsu, Tomonari Watanabe, Akihiro Takahashi, Wataru Sugeno, Miyoshi Yamashita, Takehiko Fukumoto, Fumiaki Mochizuki,
Three components, hexyl butyrate (=butanoate) (6:nBu), (E)-4-oxohex-2-enal (E2O4-6:Ald) and (E)-hex-2-en-1-yl butyrate (E2-6:nBu), were identified as sex attractant pheromone components of the sorghum plant bug Stenotus rubrovittatus (Matsumura) (Heteroptera: Miridae) in a previous study. The optimum ratio and amount of the three components loaded into rubber septa for male attraction were investigated. A 5:10:1 blend of 6:nBu, E2O4-6:Ald and E2-6:nBu at 64 μg per rubber septum was most effective for male ...
Tópico(s): Seed Germination and Physiology
2009 - Springer Science+Business Media | Applied Entomology and Zoology
Tetsuya Yasuda, Keiko Oku, Hiroya Higuchi, Tomotaka Suzuki, Joji Kashin, Toshinori Kichishima, Tomonari Watanabe, Ai Takeda, Mika Yasuda, Ken Tabuchi, Akihiro Takahashi, Miyoshi Yamashita, Takehiko Fukumoto, Fumiaki Mochizuki,
Two mirid bugs, Stenotus rubrovittatus (Matsumura) and Trigonotylus caelestialium (Kirkaldy) (Heteroptera: Miridae), are sympatric pests that infest rice in many regions of Japan. Three components, hexyl butyrate, (E)-4-oxohex-2-enal and (E)-hex-2-en-1-yl butyrate, in S. rubrovittatus and three other components, hexyl hexanoate, (E)-hex-2-en-1-yl hexanoate and octyl butyrate, in T. caelestialium, were identified as sex attractant pheromone components in these species. The synthetic pheromone lures for ...
Tópico(s): Entomopathogenic Microorganisms in Pest Control
2010 - Springer Science+Business Media | Applied Entomology and Zoology
Hirotaka Fukuoka, Takato Kawase, Masahide Oku, Hiroya Yurimoto, Yasuyoshi Sakai, T. Hayakawa, Tomoyuki Nakagawa,
In this work, we analyzed several genes participating in the rearrangement pathway for xylulose 5-phosphate (Xu5P) in the methylotrophic yeast Pichia pastoris (syn. Komagataella phaffii). P. pastoris has two set of genes for fructose-1,6-bisphosphate aldolase (FBA1 and FBA2) and transaldolase (TAL1 and TAL2), although there are single-copy genes for fructose-1,6-bisphosphatase (FBP1) and transketolase (TKL1), respectively. Expressions of FBP1 and TAL2 were upregulated by non-fermentative carbon sources, ...
Tópico(s): Microbial metabolism and enzyme function
2019 - Elsevier BV | Journal of Bioscience and Bioengineering
Hirosuke Oku, Shigeyuki Baba, Hiroya Koga, Kensaku Takara, Hironori Iwasaki,
Tópico(s): Coastal wetland ecosystem dynamics
2003 - Springer Science+Business Media | Journal of Plant Research
Shin Ohsawa, Susumu Nishida, Masahide Oku, Yasuyoshi Sakai, Hiroya Yurimoto,
Abstract In methylotrophic yeasts, the expression of methanol-inducible genes is repressed by ethanol even in the presence of methanol, a phenomenon called ethanol repression. The mechanism of ethanol repression in Komagataella phaffii ( Pichia pastoris ) was studied, and acetyl-CoA synthesis from ethanol by sequential reactions of alcohol dehydrogenase, aldehyde dehydrogenase and acetyl-CoA synthetase (ACS) was involved in ethanol repression. Molecular analysis of the ACS-encoding gene product KpAcs1 ...
Tópico(s): Fermentation and Sensory Analysis
2018 - Nature Portfolio | Scientific Reports
Shin Ohsawa, Koichi Inoue, Takahiro Isoda, Masahide Oku, Hiroya Yurimoto, Yasuyoshi Sakai,
In nature, methanol is produced during the hydrolysis of pectin in plant cell walls. Methanol on plant leaves shows circadian dynamics, to which methanol-utilizing phyllosphere microorganisms adapt. In the methylotrophic yeast Komagataella phaffii (Kp; also known as Pichia pastoris), the plasma membrane protein KpWsc1 senses environmental methanol concentrations and transmits this information to induce the expression of genes for methanol metabolism and the formation of huge peroxisomes. In this ...
Tópico(s): Lipid metabolism and biosynthesis
2021 - The Company of Biologists | Journal of Cell Science
Shin Ohsawa, Masahide Oku, Hiroya Yurimoto, Yasuyoshi Sakai,
The methylotrophic yeast Komagataella phaffii (synoym Pichia pastoris) can grow on methanol with an associated proliferation of peroxisomes, which are subsequently degraded by pexophagy upon depletion of methanol. Two cell wall integrity and stress response component (WSC) family proteins (Wsc1 and Wsc3) sense the extracellular methanol concentration and transmit the methanol signal to Rom2. This stimulates the activation of transcription factors (Mxr1, Trm1, and Mit1 etc.), leading to the induction ...
Tópico(s): Autophagy in Disease and Therapy
2022 - Frontiers Media | Frontiers in Cell and Developmental Biology
Chika Nishizaki, Makiya Nishikawa, Tomoya Yata, Toshiyuki Yamada, Yuki Takahashi, Masahide Oku, Hiroya Yurimoto, Yasuyoshi Sakai, Kenji Nakanishi, Yoshinobu Takakura,
Surgical trauma, which is inevitably associated with the surgical removal of cancer, has been reported to accelerate tumor metastasis.The close association of reactive oxygen species with the trauma and tumor metastasis supports the possibility of using antioxidants for the inhibition of metastasis.To inhibit surgical trauma-enhanced peritoneal dissemination, human catalase (hCAT) derivatives, i.e., hCAT-nona-arginine peptide (hCAT-R9) and hCAT-albumin binding peptide (hCAT-ABP), were designed to increase ...
Tópico(s): Cardiac, Anesthesia and Surgical Outcomes
2011 - Elsevier BV | Free Radical Biology and Medicine
Taisuke Yano, Masahide Oku, Natsuko Akeyama, Akinori Itoyama, Hiroya Yurimoto, Shusuke Kuge, Yukio Fujiki, Yasuyoshi Sakai,
Reactive oxygen species are generated within peroxisomes during peroxisomal metabolism. However, due to technological difficulties, the intraperoxisomal redox state remain elusive, and the effect of peroxisome deficiency on the intracellular redox state is controversial. A newly developed, genetically encoded fluorescence resonance energy transfer (FRET) probe, Redoxfluor, senses the physiological redox state via its internal disulfide bonds, resulting in a change in the conformation of the protein ...
Tópico(s): Adipose Tissue and Metabolism
2010 - Taylor & Francis | Molecular and Cellular Biology
Kosuke Shiraishi, Masahide Oku, Kosuke Kawaguchi, Daichi Uchida, Hiroya Yurimoto, Yasuyoshi Sakai,
Abstract Recently, microbe-plant interactions at the above-ground parts have attracted great attention. Here we describe nitrogen metabolism and regulation of autophagy in the methylotrophic yeast Candida boidinii , proliferating and surviving on the leaves of Arabidopsis thaliana. After quantitative analyses of yeast growth on the leaves of A. thaliana with the wild-type and several mutant yeast strains, we showed that on young leaves, nitrate reductase (Ynr1) was necessary for yeast proliferation ...
Tópico(s): Nematode management and characterization studies
2015 - Nature Portfolio | Scientific Reports
Tomoya Yata, Makiya Nishikawa, Chika Nishizaki, Masahide Oku, Hiroya Yurimoto, Yasuyoshi Sakai, Yoshinobu Takakura,
Hypoxia-induced reactive oxygen species (ROS)-mediated expression of a variety of genes in endothelial cells has been suggested to be involved in abnormal cell adhesion. To prevent this by accelerated binding of catalase to endothelial cells, human catalase (hCAT), an enzyme catalyzing the decomposition of hydrogen peroxide, was fused with three repeats of arginine-glycine-aspartic acid peptide or nona arginine peptide at the C-terminal to obtain hCAT-(RGD)3 and hCAT-R9, respectively. Human CAT and ...
Tópico(s): Pancreatic function and diabetes
2009 - Elsevier BV | Free Radical Biology and Medicine
Hiroya Yurimoto, Masahide Oku, Yasuyoshi Sakai,
Eukaryotic methylotrophs, which are able to obtain all the carbon and energy needed for growth from methanol, are restricted to a limited number of yeast species. When these yeasts are grown on methanol as the sole carbon and energy source, the enzymes involved in methanol metabolism are strongly induced, and the membrane-bound organelles, peroxisomes, which contain key enzymes of methanol metabolism, proliferate massively. These features have made methylotrophic yeasts attractive hosts for the ...
Tópico(s): Polyamine Metabolism and Applications
2011 - Hindawi Publishing Corporation | International Journal of Microbiology
Kosuke Kawaguchi, Hiroya Yurimoto, Masahide Oku, Yasuyoshi Sakai,
The yeast Candida boidinii capable of growth on methanol proliferates and survives on the leaves of Arabidopsis thaliana. The local methanol concentration at the phyllosphere of growing A. thaliana exhibited daily periodicity, and yeast cells responded by altering both the expression of methanol-inducible genes and peroxisome proliferation. Even under these dynamically changing environmental conditions, yeast cells proliferated 3 to 4 times in 11 days. Among the C1-metabolic enzymes, enzymes in ...
Tópico(s): Polyamine Metabolism and Applications
2011 - Public Library of Science | PLoS ONE
Ryosuke Sakemi, Suketo So, Yosuke Morimitsu, Hajime Imada, Hiroshi Ishihara, Kenjiro Kuhara, Yuichiro Oku, Hiroya Terabe, Masahiro Kishi, Ei Sasaki, Miyuki Sakemi, Masayuki Shimokobe,
Tópico(s): Colorectal and Anal Carcinomas
2014 - Springer Science+Business Media | Clinical Journal of Gastroenterology
Kosuke Shiraishi, Masahide Oku, Daichi Uchida, Hiroya Yurimoto, Yasuyoshi Sakai,
The methylotrophic yeast Candida boidinii, which is capable of growth on methanol as a sole carbon source, can proliferate on the leaf surface of Arabidopsis thaliana. Previously, we demonstrated that adaptation to a change in the major available nitrogen source from nitrate to methylamine during the host plant aging was crucial for yeast survival on the leaf environment. In this report, we investigated the regulatory profile of nitrate and methylamine metabolism in the presence of multiple nitrogen ...
Tópico(s): Plant nutrient uptake and metabolism
2015 - Oxford University Press | FEMS Yeast Research
Shun‐ichi Yamashita, Hiroya Yurimoto, Dai MURAKAMI, M. Yoshikawa, Masahide Oku, Yasuyoshi Sakai,
When microbes sense environmental changes, they often temporarily attenuate cell growth to adapt to the new situations, showing a lag phase. In this study, we report that the methylotrophic yeast, Pichia pastoris, induced autophagy during the lag phase after the cells were shifted from glucose to methanol medium. Through the autophagic process at least two proteins, aminopeptidase I precursor and cytosolic aldehyde dehydrogenase, were found to be transported into the vacuole, which was dependent ...
Tópico(s): Endoplasmic Reticulum Stress and Disease
2009 - Wiley | Genes to Cells
Yoh Kasahara, Hiroya Umemura, Takeshi Kuyama, Hidetaka Oku,
Tópico(s): Pediatric Hepatobiliary Diseases and Treatments
1978 - Springer Science+Business Media | World Journal of Surgery
Mitsuhiko Iwamoto, Ayana Ikari, Tomo Tominaga, Saki Maezawa, Junna Sakane, Hiroyo Oku, Katsuhide Yoshidome, Takashi Morimoto, Hiroya Fujioka, Seita Hagihara, Toshikatsu Nitta, Ayumi Matsutani, Kosei Kimura,
e12594 Background: Anthracycline and Taxane have been widely used and studied in neoadjuvant setting for treatment of locally advanced breast cancer. Various regimens have explored the addition of newer agents to determine safety and efficacy, and pathological complete response(pCR) has been demonstrated to be associated with favorable overall survival in primary breast cancer. Pertuzumab increases the rate of pathological complete response in the preoperative context and increases overall survival ...
Tópico(s): Breast Cancer Treatment Studies
2023 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Koshiro Kanaoka, Kenji Onoue, Satoshi Terasaki, Tomoya Nakano, Michikazu Nakai, Yoko Sumita, Kinta Hatakeyama, Fumio Terasaki, Rika Kawakami, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Yoshihiko Saito, Satoshi Yuda, Masaya Tanno, Toru Takahashi, Hisashi Yokoshiki, Masahiro Toba, Toshihisa Anzai, Toshiyuki Nagai, Takuma Sato, Takashi Takenaka, Seiji Yamazaki, Yuki Katagiri, Toshiharu Takeuchi, Kazuya Sugitatsu, Shigeo Kakinoki, Tomoaki Matsumoto, Kazushi Urasawa, Michinao Tan, Ichizo Tsujino, Mitsunori Kamigaki, Hirofumi Tomita, Kenji Hanada, Motoi Kushibiki, Akihiro Nakamura, Yoshihiro Morino, Takahito Nasu, Satoshi Yasuda, Hideaki Suzuki, Kaoru Iwabuchi, Kanako Tsuji, Shigeto Namiuchi, Tatsuya Komaru, Masahiro Yagi, Shoko Uematsu, Toshiaki Takahashi, Satoru Takeda, Toru Nakanishi, Masafumi Watanabe, Masahiro Wanezaki, Motoyuki Matsui, Shigeo Sugawara, Yasuchika Takeishi, Masayoshi Oikawa, Nobuo Komatsu, Satoshi Suzuki, Hiroaki Okamoto, Noriyuki Takeyasu, Daiki Akiyama, Yutaka Eki, Tsunekazu Kakuta, Tomoyo Sugiyama, Tomomi Koizumi, Koji Ueno, Kazuomi Kario, Mizuri Taki, Yuri Matsumoto, Takanori Yasu, Osamu Nishioka, Shigeto Naito, Makoto Murata, Shoichi Tange, Katsumi Kaneko, Makoto Muto, Hiroshi Inagaki, Shuichi Hasegawa, Eizo Tachibana, Wataru Atsumi, Masahiro Suzuki, Toshihiro Muramatsu, Yoshihiro Yamada, Isao Taguchi, Yoshiaki Fukuda, Akihiro Matsui, Junji Kanda, Koji Hozawa, Akihiko Matsumura, Wataru Shimizu, Takeshi Yamamoto, Issei Komuro, Masaru Hatano, Takanori Ikeda, Shunsuke Kiuchi, Taishiro Chikamori, Yasuyoshi Takei, Kyoko Soejima, Toshinori Minamishima, Hiroyuki Tanaka, Shigeo Shimizu, Masashi Kasao, Tadayuki Kadohira, Tohru Minamino, Kazunori Shimada, Hiroshi Iwata, Yukihiko Momiyama, Takashi Ashikaga, Toshihiro Nozato, Yasumasa Fujiwara, Kenji Inoue, Tetsuo Sasano, Junji Matsuda, Yasuhiro Ishii, Yuichi Ono, Kengo Tanabe, Yu Horiuchi, Toshiro Shinke, Yusuke Kodama, Masao Moroi, Y Yazaki, Taisuke Mizumura, Hiroshi Ohta, Yoshihiro J. Akashi, Nozomi Kotoku, Yuji Ikari, Mitsunori Maruyama, Yasuhiro Sato, Koichi Tamura, Masaaki Konishi, Hiroshi Suzuki, Mio Ebato, Kazuki Fukui, Kazuhiko Yumoto, Takamasa Iwasawa, Takeshi Kashimura, Kazuyoshi Takahashi, Yoshinobu Okada, Bunji Kaku, Kazuo Usuda, Michiro Maruyama, Tomoki Kameyama, Toshinori Higashikata, Akihiko Hodatsu, Kazuo Osato, Yoji Nagata, Koji Maeno, Kazuo Satake, Takao Sawanobori, Noboru Watanabe, Koichiro Kuwahara, Hirohiko Motoki, Hiroshi Kitabayashi, Kyuhachi Otagiri, Tsunesuke Kono, Daisuke Yamagishi, Yoshikazu Yazaki, Toshiyuki Noda, Itsuro Morishima, Naoki Watanabe, Shinichiro Tanaka, Tomoya Onodera, Ryuzo Nawada, Akinori Watanabe, Masaki Matsunaga, Satoru Suwa, Hiroshi Sakamoto, Hiroki Sakamoto, Takeshi Aoyama, Norio Kanamori, Masahiro Muto, Yuichiro Maekawa, Hayato Ohtani, Yukio Ozaki, Kenshin Naruse, Kenji Takemoto, Haruo Kamiya, Takeshi Suzuki, Yasushi Tomita, Susumu Suzuki, Ryosuke Kametani, Hidekazu Aoyama, Hiroyuki Osanai, Ken Harada, Kenji Kada, Tomoaki Saeki, Koichi Kobayashi, Yasuhiro Ogawa, Akihiro Terasawa, Masanori Shinoda, Mitsutoshi Oguri, Kiyokazu Shimizu, Akinori Sawamura, Atsushi Sugiura, Kosuke Hattori, Shinji Mokuno, Kazuhisa Kondo, Kaoru Dohi, Keishi Moriwaki, Atsunobu Kasai, Tetsuya Nakakuki, Kazuaki Kaitani, Toshikazu Jinnai, Takashi Yamamoto, Hiroyuki Kurata, Atsuyuki Wada, Masaharu Akao, Yasuhiro Hamatani, Kazuya Ishibashi, Yoshiki Akakabe, Yasuhide Asaumi, Hideo Matama, Yasushi Sakata, Hidetaka Kioka, Hiroshi Takaishi, Yoshitaka Iwanaga, Toru Takase, Mitsuo Matsuda, Fumi Sato, Shinji Hasegawa, Kenichi Ishigami, Minoru Ichikawa, Takashi Takagi, Moriaki Inoko, Masaaki Hoshiga, Shuichi Fujita, Takeda Yoshihiro, Takahiko Kawarabayashi, Hideyuki Takaoka, Kenji Nakajima, Tadashi Yuguchi, Tatsuya Kawasaki, Yukinori Shinoda, Yukihito Sato, Masaharu Ishihara, Yuki Matsumoto, Hiroya Kawai, Tomofumi Takaya, Kouki Matsuo, Toshiaki Mano, Ken–ichi Hirata, Eriko Hisamatsu, Nobutaka Inoue, Koichi Tamita, N Mukohara, Hisashi Shimoyama, Toru Miyajima, Toshihiro Tamura, Yodo Tamaki, Megumi Suzuki, Ryoji Yokota, Manabu Horii, Kazuo Yamanaka, Hiroyuki Kawata, Yukihiro Hashimoto, Yasuki Nakada, Hitoshi Nakagawa, Tomoya Ueda, Taku Nishida, Ayako Seno, Makoto Watanabe, Takashi Akasaka, Takashi Tanimoto, Mamoru Toyofuku, Kazuhiro Yamamoto, Yoshiharu Kinugasa, Masayuki Hirai, Hiroshi Nasu, Kinya Shirota, Tsuyoshi ODA, Takefumi Oka, Kazushige Kadota, Masanobu Ohya, Hiroshi Ito, Kazufumi Nakamura, Soichiro Ogura, Soichiro Fuke, Shiro Uemura, Hiromi Matsubara, Atsuyuki Watanabe, Nobuyuki Morishima, Kihara Yasuki, Takayuki Hidaka, Hironori Ueda, Yujiro Ono, Yuji Muraoka, Miyo Hatanari, Yoshinori Miyamoto, Keigo Dote, Masaya Kato, Masafumi Yano, Mamoru Mochizuki, Yasuhiro Ikeda, Hiroyuki Fujinaga, Shinobu Hosokawa, Masataka Sata, Koji Yamaguchi, Naoko Aki,
Fulminant myocarditis presentation (FMP) is a rare and severe presentation of myocarditis. The natural history of FMP and its clinical features associated with poor outcomes are incompletely understood because there is a lack of generalizable evidence.This multicenter retrospective cohort study included patients hospitalized with histologically proven myocarditis who underwent catecholamine or mechanical support from 235 cardiovascular training hospitals across Japan between April 2012 and March ...
Lippincott Williams & Wilkins
Atsushi Oku, Kikukazu Sakatsuji, Misaki Yoshioka, Misako Doi, H Miyamoto, Toshifumi Taniuchi, Tsuneo Nakayama, Shingo Nishioka, I Yataka, Hiroya Nakata, Akira Ohshima,
Tópico(s): Esophageal Cancer Research and Treatment
1990 - Universa Press | Acta gastro-enterologica belgica
Tanaka Eri, Mikiko Mano, Miki Matsumoto, Hiroya Hasegawa, Chikako Segawa, Rei Shinagawa, SHIHO TOMITA, Aoi Minoda, Yuka Oku, Hisao Shigematsu, Hideaki Sakashita, Naoto Suda,
"Postoperative evaluation of secondary bone graft using platelet-rich plasma (PRP) in unilateral cleft lip and palate patients." Orthodontic Waves, 75(1), p. 25
Tópico(s): Oral and Maxillofacial Pathology
2016 - Elsevier BV | Orthodontic Waves
Meyer Zum Gottesberge, J.K. Mai, Tien-Chen Liu, Catharina Jacobsson, Gösta Granström, Takayoshi Itaya, Etsuo Yamamoto, Hiroya Kitano, Yoshiro Yazawa, Kazutomo Kitajima, Takanobu Kunihiro, Jin Kanzaki, Shigemitsu Yoshihara, Yasuo Satoh, H. J. Rosingh, H.P. Wit, Arend M. Sulter, F.W.J. Albers, Tsuneyuki Oku, Makoto Hasegewa, B.N. Kumar, R. M. Walsh, Noel Walter, John T. Little, C. Arens, T. Dreyer, B. Eistert, H. Glanz, Ryuzo Shiobara, Setsuyo Abe, Emanuele Scarano, Gaetano Paludetti, Federica Frusoni, Roberto Deli, Maurizio Maurizi, P. T. Yen, Philippe Herman, T. van den Abbeele, Ching‐Ting Tan, P. Bordure, R. Marianowski, Gérard Friedlander, Patrice Tran Ba Huy, Isabelle Fini-Storchi, P. Frosini,
1997 - Karger Publishers | ORL