Kosuke Yoshimi, Hiroyuki Goto, Masaki Otsuka, Shusuke Yoshikawa, Toshikazu Omodaka, Yoshio Kiyohara,
... co.jpSearch for more papers by this authorHiroyuki Goto, Hiroyuki Goto Department of Dermatology, Tottori University Hospital, Tottori, ... co.jpSearch for more papers by this authorHiroyuki Goto, Hiroyuki Goto Department of Dermatology, Tottori University Hospital, Tottori, JapanSearch ...
Tópico(s): Colorectal and Anal Carcinomas
2017 - Wiley | The Journal of Dermatology
Ryoko Kimura, Kazunari Sugita, Ayako Ito, Hiroyuki Goto, Osamu Yamamoto,
... Yonago, JapanSearch for more papers by this authorHiroyuki Goto, Hiroyuki Goto Division of Dermatology, Department of Medicine of ... Yonago, JapanSearch for more papers by this authorHiroyuki Goto, Hiroyuki Goto Division of Dermatology, Department of Medicine of Sensory ...
Tópico(s): Mast cells and histamine
2017 - Wiley | Journal of Cutaneous Pathology
Makoto Kondo, Hiroyuki Goto, Shinya Yamamoto,
... ne.jpSearch for more papers by this authorHiroyuki Goto, Hiroyuki Goto Department of Dermatology, Yokkaichi Municipal Hospital, Yokkaichi, ... ne.jpSearch for more papers by this authorHiroyuki Goto, Hiroyuki Goto Department of Dermatology, Yokkaichi Municipal Hospital, Yokkaichi, JapanSearch ...
Tópico(s): T-cell and B-cell Immunology
2016 - Wiley | The Journal of Dermatology
Yoshiya HATA, Hiroyuki Goto, Masayuki Yoshimi,
... by this author on: GSW Google Scholar Hiroyuki Goto; Hiroyuki Goto bDisaster Prevention Research Institute, Kyoto University, Gokasho, Uji, ... Japan, hata@civil.eng.osaka-u.ac.jp Hiroyuki Goto bDisaster Prevention Research Institute, Kyoto University, Gokasho, Uji, ... Tools Get Permissions Search Site Citation Yoshiya Hata, Hiroyuki Goto, Masayuki Yoshimi; Preliminary Analysis of Strong Ground Motions ...
Tópico(s): earthquake and tectonic studies
2016 - Seismological Society of America | Seismological Research Letters
Hiroyuki Goto, Hitoshi Morikawa, Masaru Inatani, Yu Ogura, Satoshi TOKUE, Xiaoling Zhang, M. Iwasaki, Mitsunori Araki, Sumio SAWADA, A. Zerva,
... Seismic Array Observations in Furukawa District, Japan Hiroyuki Goto; Hiroyuki Goto aDisaster Prevention Research Institute, Kyoto University, Gokasho, Uji, ... on: GSW Google Scholar Author and Article Information Hiroyuki Goto aDisaster Prevention Research Institute, Kyoto University, Gokasho, Uji, ... Tools Icon Tools Get Permissions Search Site Citation Hiroyuki Goto, Hitoshi Morikawa, Masayuki Inatani, Yumiko Ogura, Satoshi Tokue, ...
Tópico(s): Seismology and Earthquake Studies
2012 - Seismological Society of America | Seismological Research Letters
Hiromasa Goto, Hiroyuki Yoneyama, Fumihiro Togashi, Reina Ohta, Akitsu Tsujimoto, Eiji Kita, Ken‐ichi Ohshima, Daniel J. Rosenberg,
... Electrochemical Methods and Demonstration of a Polymer BatteryHiromasa Goto , Hiroyuki Yoneyama , Fumihiro Togashi , Reina Ohta , Akitsu Tsujimoto , Eiji ...
Tópico(s): Conducting polymers and applications
2008 - American Chemical Society | Journal of Chemical Education
Keiichi Yamanaka, Hiroyuki Murota, Hiroyuki Goto, Shinya Yamamoto, Ichiro Katayama, Yoshiki Taniguchi, Hitoshi Mizutani,
... Suita, JapanSearch for more papers by this authorHiroyuki Goto, Hiroyuki Goto Department of Dermatology, Yokkaichi Municipal Hospital, Yokkaichi, ... Suita, JapanSearch for more papers by this authorHiroyuki Goto, Hiroyuki Goto Department of Dermatology, Yokkaichi Municipal Hospital, Yokkaichi, JapanSearch ...
Tópico(s): Psoriasis: Treatment and Pathogenesis
2015 - Wiley | The Journal of Dermatology
Kosuke Yoshimi, Junji Wasa, Masaki Otsuka, Shusuke Yoshikawa, Hiroyuki Goto, Toshikazu Omodaka, Hirohisa Katagiri, Hideki Murata, Seiichi Hosaka, Yoshio Kiyohara,
... Shizuoka, JapanSearch for more papers by this authorHiroyuki Goto, Hiroyuki Goto Division of Dermatology, Shizuoka Cancer Center, Shizuoka, ... Shizuoka, JapanSearch for more papers by this authorHiroyuki Goto, Hiroyuki Goto Division of Dermatology, Shizuoka Cancer Center, Shizuoka, JapanSearch ...
Tópico(s): Sarcoma Diagnosis and Treatment
2017 - Wiley | The Journal of Dermatology
Hiroshi Yokouchi, Hiroshi Nishihara, Toshiyuki Harada, Takashi Ishida, Shigeo Yamazaki, Hajime Kikuchi, Satoshi Oizumi, Hidetaka Uramoto, Fumihiro Tanaka, Masao Harada, Kenji Akie, Fumiko Sugaya, Yuka Fujita, Kei Takamura, Tetsuya Kojima, Mitsunori Higuchi, Osamu Honjo, Yoshinori Minami, Naomi Watanabe, Aya Goto, Hiroyuki Suzuki, Hirotoshi Dosaka‐Akita, Hiroshi Isobe, Masaharu Nishimura, Mitsuru Munakata,
... 17 , Yoshinori Minami 18 , Naomi Watanabe 19 , Aya Goto 20 , Hiroyuki Suzuki 16 , Hirotoshi Dosaka-Akita 21 , Hiroshi Isobe ...
Tópico(s): Lung Cancer Treatments and Mutations
2016 - Impact Journals LLC | Oncotarget
Hiroki Morisako, Takeo Goto, Hiroyuki Goto, Christian A. Bohoun, Samantha Tamrakar, Kenji Ohata,
OBJECTIVE Craniopharyngiomas remain a particularly formidable challenge in the neurosurgical field. Because these lesions involve the hypothalamus and ophthalmological systems, their resection is associated with either higher rates of mortality and recurrence or a lower rate of radical resection. The authors report the outcomes of aggressive surgeries based on an anatomical subclassification of craniopharyngiomas. METHODS Clinical and ophthalmological examinations, imaging studies, endocrinological ...
Tópico(s): Glioma Diagnosis and Treatment
2016 - American Association of Neurological Surgeons | Neurosurgical FOCUS
Keiichi Yamanaka, Makoto Kondo, Hiroyuki Goto, Shinya Yamamoto, Yoshiki Taniguchi, Hitoshi Mizutani,
... Tsu, JapanSearch for more papers by this authorHiroyuki Goto, Hiroyuki Goto Department of Dermatology, Yokkaichi Municipal hospital, Yokkaichi, ... Tsu, JapanSearch for more papers by this authorHiroyuki Goto, Hiroyuki Goto Department of Dermatology, Yokkaichi Municipal hospital, Yokkaichi, JapanSearch ...
Tópico(s): Eosinophilic Disorders and Syndromes
2015 - Wiley | The Journal of Dermatology
Haruna Goto, Hiroyuki Hara, Takane Takayanagi, Tadashi Terui,
... of primary hepatocellular carcinoma Haruna Goto MD, Haruna Goto MD Departments of DermatologySearch for more papers by this authorHiroyuki Hara MD, Hiroyuki Hara MD Functional Morphology, Nihon University School of ... papers by this author Haruna Goto MD, Haruna Goto MD Departments of DermatologySearch for more papers by this authorHiroyuki Hara MD, Hiroyuki Hara MD Functional Morphology, Nihon University School of ...
Tópico(s): Genetic and rare skin diseases.
2011 - Wiley | International Journal of Dermatology
Shinya Goto, Hiroyuki Sakai, M. Goto, Miyuki Ono, Yasuo Ikeda, Shunnosuke Handa, Zaverio M. Ruggeri,
Background —Experiments under controlled flow conditions indicate that the binding of von Willebrand factor (vWF) to platelet glycoprotein (GP) Ibα and integrin α IIb β 3 (GP IIb/IIIa complex) is crucial for aggregation at elevated shear rates. We have tested how the plasma of patients with acute myocardial infarction affects this process. Methods and Results —Citrated plasma was obtained from 18 patients with acute myocardial infarction within 6 hours from the onset of symptoms and from 26 control subjects ...
Tópico(s): Acute Myocardial Infarction Research
1999 - Lippincott Williams & Wilkins | Circulation
Rikio Settai, Shingo Araki, Parhat Ahmet, Melike Abliz, Kiyohiro Sugiyama, Yoshichika Ōnuki, Terutaka Gotô, Hiroyuki Mitamura, Tsuneaki Goto, Shigeru Takayanagi,
We have studied the origin of the cooperative Jahn-Teller effect and the metamagnetic transition in the orthorhombic compound PrCu 2 . We have determined the anisotropic ferroquadrupole phase diagram by measuring the specific heat and thermal expansion under magnetic fields. With increasing the field, the Jahn-Teller transition temperature increases slightly for the field along a - and c -axes, while it decreases intensively along the b -axis. The phase diagram can be explained quantitatively by including ...
Tópico(s): Magnetic Properties of Alloys
1998 - Physical Society of Japan | Journal of the Physical Society of Japan
Masafumi Goto, Hiroyuki Abé, Takahiro Ito‐Sasaki, Masafumi Goto, Akiko Inagaki, N. Ogawa, Keisei Fujimori, Yukinori Kurokawa, Tomokazu Matsue, S. Satomi,
The current methods for evaluating islet potency are not useful in clinical transplantation. Therefore, we need reliable, rapid methods enabling accurate prediction of islet quality. We evaluated respiratory activity using scanning electrochemical microscopy (SECM), glucose-stimulated respiratory activity, glucose-stimulated insulin release, ADP/ATP assays, insulin/DNA levels, and Trypan blue exclusion tests as predictive methods for the ability of isolated rat islets to cure syngeneic diabetic rats. ...
Tópico(s): Nanopore and Nanochannel Transport Studies
2009 - Elsevier BV | Transplantation Proceedings
Caihua Wang, Yuanzhong Li, Yukihiro Tsuboshita, Takuya Sakurai, Tsubasa Goto, Hiroyuki Yamaguchi, Yuichi Yamashita, Atsushi Sekiguchi, Hisateru Tachimori, Caihua Wang, Yuanzhong Li, Tsubasa Goto,
Abstract Alzheimer’s disease is a neurodegenerative disease that imposes a substantial financial burden on society. A number of machine learning studies have been conducted to predict the speed of its progression, which varies widely among different individuals, for recruiting fast progressors in future clinical trials. However, because the data in this field are very limited, two problems have yet to be solved: the first is that models built on limited data tend to induce overfitting and have low ...
Tópico(s): AI in cancer detection
2022 - Nature Portfolio | npj Digital Medicine
Ren Nanamiya, Hiroyuki Suzuki, Junko Takei, Guanjie Li, Nohara Goto, Hiroyuki Harada, Masaki Saito, Tomohiro Tanaka, Teizo Asano, Mika K. Kaneko, Yukinari Kato,
Golden (Syrian) hamster (Mesocricetus auratus) is a small animal model of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Pathological analyses of the tissues are required to understand the pathogenesis of SARS-CoV-2 and the evaluation of therapeutic modalities, including neutralizing monoclonal antibodies (mAbs). However, mAbs that recognize the golden hamster-derived antigens and distinguish specific cell types, such as the pneumocytes, are limited. Podoplanin (PDPN) is an ...
Tópico(s): Lymphatic Disorders and Treatments
2022 - Mary Ann Liebert, Inc. | Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
Masato Yoshida, Akira Mori, Atsuhiro Inaba, Masahiro Oka, Haruhiko Makino, Masashi Yamaguchi, Hisashi Fujita, Tomohiro Kawamoto, Mika Goto, Hiroyuki Kimura, Atsuo Baba, Tsuneo Yasuma,
A series of novel tetrahydropyrazolopyrimidine derivatives containing an adamantyl group were synthesized and evaluated as potential calcium-sensing receptor (CaSR) antagonists. After chemical modification of 9a, which was identified as a hit compound in a random screening of CaSR antagonist assay, 7,7-dimethyl derivative 16c was found to be the most active compound of this new series (IC(50)=10nM). We report the synthesis of this series and their biological activities and structure-activity relationship.
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2010 - Elsevier BV | Bioorganic & Medicinal Chemistry
Noriyuki Yuasa, Wei Zhang, Tomohiro Goto, Hiroyuki Sakaue, Ayano Matsumoto-Takasaki, Miyo Kimura, H. Ohshima, Yasunobu Tsuchida, Tomoyuki Koizumi, Keiko Sakai, Takumi Kojima, Kazuo Yamamoto, Munehiro Nakata, Yoko Fujita‐Yamaguchi,
Anti-mannotriose (Man3) antibodies were previously isolated from a Keio phage library displaying human single chain variable fragments (scFvs) using a neoglycolipid, Man3- dipalmitoylphosphatidylethanolamine. Of three genes constructed, the 5A3 clone was expressed in mouse myeloma NS0 cells as a conjugate with human IgG1 Fc (scFv-Fc) and characterized (Sakai, K., Shimizu, Y., Chiba, T., Matsumoto-Takasaki, A., Kusada, Y., Zhang, W., Nakata, M., Kojima, N., Toma, K., Takayanagi, A., Shimizu, N., and ...
Tópico(s): Galectins and Cancer Biology
2010 - Elsevier BV | Journal of Biological Chemistry
Hirotsugu Kamahara, Udin Hasanudin, Anugerah Widiyanto, Ryuichi TACHIBANA, Yoichi Atsuta, Naohiro Goto, Hiroyuki Daimon, Koichi Fujie,
Biodiesel derived from palm oil has been recognized as a high-productivity oil crop among the first generation of biofuels. This study evaluated and discussed the net energy balance for biodiesel in Indonesia by calculating the net energy ratio (NER) and net energy production (NEP) form the total energy input and output. The results of the calculation of energy input for the default scenario demonstrated that the primary energy inputs in the biodiesel production lifecycle were the methanol feedstock, ...
Tópico(s): Biofuel production and bioconversion
2010 - Elsevier BV | Biomass and Bioenergy
Hideaki Sekine, Haruhiko Taguchi, Hidehiro Watanabe, Shin Kawai, Yasunori Fujioka, Hajime Goto, Hiroyuki Kobayashi, Shigeru Kamiya,
Although mycoplasmal pneumonia has been generally considered to be a disease with good prognosis, a pathogenic host immune response has been associated with its occurrence. In the present study, the pathogenic significance of the immune response was examined using germ-free mice either infected intranasally with Mycoplasma pneumoniae or inoculated with M. pneumoniae antigens (soluble antigen and partially purified antigen). In gnotobiotic mice monoassociated with M. pneumoniae, 10(4) c.f.u. M. pneumoniae ...
Tópico(s): Respiratory viral infections research
2009 - Microbiology Society | Journal of Medical Microbiology
Hirofumi Komaki, Yutaka Nishigaki, Noriyuki Fuku, Hiroko Hosoya, Kei Murayama, Akira Ohtake, Yu‐ichi Goto, Hiroyuki Wakamoto, Yasutoshi Koga, Masashi Tanaka,
Recently we proposed the therapeutic potential of pyruvate therapy for mitochondrial diseases. Leigh syndrome is a progressive neurodegenerative disorder ascribed to either mitochondrial or nuclear DNA mutations. In an attempt to circumvent the mitochondrial dysfunction, we orally applied sodium pyruvate and analyzed its effect on an 11-year-old female with Leigh syndrome due to cytochrome c oxidase deficiency accompanied by cardiomyopathy. The patient was administered sodium pyruvate at a maintenance ...
Tópico(s): ATP Synthase and ATPases Research
2009 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - General Subjects
Toshimitsu Niwa, Takayuki Kobayashi, Sun Pi, Junichi Goto, Hiroyuki Oyama, Norihiro Kobayashi,
Cortisol levels in body fluids are useful for monitoring the function of the pituitary-adrenal axis. Here, we established an "enzyme-linked immunometric assay" (a noncompetitive-type ELISA) for cortisol based on idiotype-anti-idiotype reactions. Six different anti-idiotype monoclonal antibodies that recognized the variable regions of a newly established anti-cortisol antibody were generated using hybridoma technology; these were two beta-type and four alpha-type anti-idiotype antibodies, recognizing ...
Tópico(s): Receptor Mechanisms and Signaling
2009 - Elsevier BV | Analytica Chimica Acta
Kei Esaki, Shingo Yokota, Shizuka Egusa, Yuri Okutani, Yukiko Ogawa, Takuya Kitaoka, Masahiro Goto, Hiroyuki Wariishi,
Enzymatic glyco-modification of transparent cellulose films with lactose was achieved by nonaqueous biocatalysis, and rat hepatocyte attachment behavior to the lactose-modified cellulose films was investigated. Regenerated cellulose films were incubated with lactose using a surfactant-enveloped cellulase in lithium chloride/dimethylacetamide solvent at 37 °C for 24 h, and lactose molecules were successfully introduced to the cellulose films. The initial cell adhesion on the lactose-modified cellulose ...
Tópico(s): Enzyme Production and Characterization
2009 - American Chemical Society | Biomacromolecules
Masahiro Tsuchida, Akira Ohara, Atsushi Manabe, M Kumagai, Hiroyuki Shimada, Akira Kikuchi, Tetsuya Mori, M. Saito, Masaharu Akiyama, Takashi Fukushima, K Koike, Masayuki Shiobara, Chitose Ogawa, T Kanazawa, Yasushi Noguchi, Sayako Oota, Y Okimoto, Hiromasa Yabe, Michiko Kajiwara, Daisuke Tomizawa, Katsuyoshi Ko, K Sugita, Takashi Kaneko, Miho Maeda, Takeshi Inukai, Hiroaki Goto, Hiroyuki Takahashi, Keiichi Isoyama, Y Hayashi, Ryota Hosoya, Ryoji Hanada,
Tópico(s): Acute Myeloid Leukemia Research
2009 - Springer Nature | Leukemia
Shizuka Egusa, Shingo Yokota, Kyoko K. Tanaka, Kei Esaki, Yuri Okutani, Yukiko Ogawa, Takuya Kitaoka, Masahiro Goto, Hiroyuki Wariishi,
Glyco-modification of a solid cellulose surface with lactosevia an enzymatic reaction was successfully achieved using a surfactant-enveloped enzyme (SEE) in a lithium chloride/dimethylacetamide solvent system. The unique biocatalyst, SEE, which is active in organic media, was prepared by protecting the surface of cellulase with the specific nonionic surfactant dioleyl-N-D-glucona-L-glutamate. Lactose, a second cellulase substrate, was introduced onto cellulose surfaces viaSEE-mediated enzymatic reaction. ...
Tópico(s): Biofuel production and bioconversion
2009 - Royal Society of Chemistry | Journal of Materials Chemistry
D. Kaji, K. Morimoto, Akira Yoneda, H. Hasebe, Akihiro Yoshida, Hiromitsu Haba, Shinichi Goto, Hiroyuki Kudo, Kosuke Morita,
A new gas-cooled rotating target system was developed for the heaviest element production. A target wheel with a diameter of 30.0 cm could be rotated up to 3000 rpm. A helium gas introduced into the target chamber mounted upstream of a gas-filled recoil separator, which enables an effective gas cooling of the target. The development has led to the successful production of heavy nuclides via cold fusion reactions of 208Pb(64Ni,n)271Ds, 209Bi(64Ni,n)272Rg, 208Pb(70Zn,n)277112, and 209Bi(70Zn,n)278113.
Tópico(s): Fusion materials and technologies
2008 - Elsevier BV | Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment
Shinya Fujii, Kiminori Ohta, Tokuhito Goto, Hiroyuki Kagechika, Yasuyuki Endo,
A novel series of androgen receptor (AR) ligands bearing an acidic heterocycle with hydrogen-bonding ability as the terminal polar group was developed. Since most non-steroidal AR ligands so far known are structurally limited to nitro- or cyanobenzanilide as the polar pharmacophore, development of alternative hydrogen-bonding components is required to obtain novel AR ligands. Various acidic heterocycles were introduced into a hydrophobic phenylcarborane (1-phenyl-1,12-dicarba-closo-dodecaborane) core ...
Tópico(s): Prostate Cancer Treatment and Research
2008 - Elsevier BV | Bioorganic & Medicinal Chemistry
Hiroshi Takahashi, Yutaka Tokue, Toru Kikuchi, Takao Kobayashi, Kazuhiro Gomi, I Goto, Hiroyuki Shiraïshi, Hideto Fukushi, K. Hirai, Toshihiro Nukiwa, Akira Watanabe,
A multicenter prospective cohort study to assess the occurrence and characteristics of acute Q fever associated with community acquired respiratory infections was performed. Among the 400 patients enrolled for the study, 10 (2.50%) patients (5 out of 120 cases of pneumonia, 3 out of 131 cases of acute bronchitis, and 2 out of 149 cases of upper respiratory infections) were diagnosed as having acute Q fever. Contact with dogs or cats before the onset of the disease was confirmed in most of the patients. ...
Tópico(s): Vector-Borne Animal Diseases
2004 - Elsevier BV | Diagnostic Microbiology and Infectious Disease
Hiroaki Goto, Hiroyuki Takahashi, Hisaki Fujii, Koichiro Ikuta, Shumpei Yokota,
Tópico(s): Peroxisome Proliferator-Activated Receptors
2003 - Springer Science+Business Media | International Journal of Hematology