Yasuhiro Fukushima, Yoshito Tsushima, Hiroyuki Takei, Ayako Taketomi-Takahashi, Hidenori Otake, Kengo Endo,
... author on: Oxford Academic PubMed Google Scholar Hiroyuki Takei, Hiroyuki Takei 1Department of Radiology, Gunma University Hospital, 3-39- ...
Tópico(s): Medical Imaging Techniques and Applications
2011 - Oxford University Press | Radiation Protection Dosimetry
Atsushi Takei, Lihua Jin, Hiroyuki Fujita, Atsushi Takei, Hiroyuki Fujita, Lihua Jin,
Wrinkles on thin film/elastomer bilayer systems provide functional surfaces. The aspect ratio of these wrinkles is critical to their functionality. Much effort has been dedicated to creating high-aspect-ratio structures on the surface of bilayer systems. A highly prestretched elastomer attached to a thin film has recently been shown to form a high-aspect-ratio structure, called a ridge structure, due to a large strain induced in the elastomer. However, the prestretch requirements of the elastomer ...
Tópico(s): Surface Modification and Superhydrophobicity
2016 - American Chemical Society | ACS Applied Materials & Interfaces
Tadasato Nagano, Hisaaki Namba, Yuichi Abe, Hiroyuki Aoki, Nobuyuki Takei, Hiroyuki Nawa,
Abstract The ErbB1 ligand family includes epidermal growth factor (EGF), transforming growth factor‐α (TGFα), heparin‐binding EGF‐like growth factor, amphiregulin and betacellulin. Previously, we demonstrated that TGFα decreases α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA)‐type glutamate receptors in cultured neocortical γ‐aminobutyric acid (GABA) neurons. In the present study, we examined in vivo effects of EGF and TGFα in the mouse neocortex using electrophysiological and biochemical ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2007 - Wiley | European Journal of Neuroscience
Kazuhiro Kitajima, Yasuo Miyoshi, Tetsuro Sekine, Hiroyuki Takei, Kimiteru Ito, Akihiko Suto, Hayato Kaida, Kazunari Ishii, Hiromitsu Daisaki, Koichiro Yamakado,
... Kitajima 1 , Yasuo Miyoshi 2 , Tetsuro Sekine 3 , Hiroyuki Takei 4 , Kimiteru Ito 5 , Akihiko Suto 6 , Hayato ...
Tópico(s): MRI in cancer diagnosis
2021 - Impact Journals LLC | Oncotarget
Tomoyuki Imagawa, Shumpei Yokota, Masaaki Mori, Takako Miyamae, Syuji Takei, Hiroyuki Imanaka, Yasuhito Nerome, Naomi Iwata, Takuji Murata, Mari Miyoshi, Norihiro Nishimoto, Tadamitsu Kishimoto,
... on: Oxford Academic Google Scholar Syuji Takei, Syuji Takei Department of Pediatrics, Kagoshima University, Kagoshima, Japan Search for other works by this author on: Oxford Academic Google Scholar Hiroyuki Imanaka, Hiroyuki Imanaka Department of Pediatrics, Kagoshima University, ...
Tópico(s): Adolescent and Pediatric Healthcare
2011 - Oxford University Press | Modern Rheumatology
Humihiko Takei, Hiroyuki Takeya, Yasuhiro Iye, T. Tamegai, Fumiko Sakai,
Single crystals of high-temperature superconductor YBa 2 Cu 3 O x have successfully been prepared using a CuO flux method. Two types of crystals of a mm-size are obtained: irregular blocks with the (001) habit and thin plates with the well-developed (001) plane. EPMA shows that the ratio Y/Ba/Cu is 1.0/1.9/2.9 and no apparent difference in metal composition is observed between the two. Electrical resistivity measurements show that the block crystals are metallic and exhibit a sharp superconducting ...
Tópico(s): Superconductivity in MgB2 and Alloys
1987 - Institute of Physics | Japanese Journal of Applied Physics
Syuji Kawada, Iwao Takei, Hiroyuki Abé,
Single crystals of KOH-doped ice were grown by a modified Bridgemann method and the dielectric relaxation spectrum was measured in the wide temperature range, from near the melting point to about 65 K in order to elucidate the origin of acceleration of the dielectric relaxation by KOH-doping. It was found that the new relaxational process, in which the dielectric relaxation is greatly accelerated appears near the eutectic point (108 K) and it follows the Arrhenius relation below about 90 K. The phase ...
Tópico(s): Glass properties and applications
1989 - Physical Society of Japan | Journal of the Physical Society of Japan
Taizo Hijioka, Nobuhiro Sato, Takakatsu Matsumura, Harumasa Yoshihara, Yoshiyuki Takei, Hiroyuki Fukui, Masahide Oshita, Sunao Kawano, Takenobu Kamada,
The hypothesis was tested whether ingestion of ethanol might disturb the hepatic microcirculation with resulting hepatic hypoxia. Infusion of ethanol increased the portal pressure concentration-dependently in rat livers perfused with Krebs-Henseleit buffer at a constant flow rate (Emax = 11.5 cm H2O, EC50 = 90 mM). This increase in portal pressure was due to hepatic vasoconstriction, since it diminished in the presence of sodium nitroprusside, a direct acting vasodilator. The regional hepatic tissue ...
Tópico(s): Eicosanoids and Hypertension Pharmacology
1991 - Elsevier BV | Biochemical Pharmacology
Mako Narisawa‐Saito, Yuriko Iwakura, Meiko Kawamura, Kazuaki Araki, Shunji Kozaki, Nobuyuki Takei, Hiroyuki Nawa,
In hippocampal neurons, the exocytotic process of α-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA)-type glutamate receptors is known to depend on activation ofN-methyl-d-aspartate channels and its resultant Ca2+ influx from extracellular spaces. Here we found that brain-derived neurotrophic factor (BDNF) induced a rapid surface translocation of AMPA receptors in an activity-independent manner in developing neocortical neurons. The receptor translocation became evident within hours as monitored ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2002 - Elsevier BV | Journal of Biological Chemistry
T. Nagano, Yojiro Yanagawa, Kenta Obata, Mako Narisawa‐Saito, Hisaaki Namba, Yo Otsu, Nobuyuki Takei, Hiroyuki Nawa,
The regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors is implicated in synaptic plasticity. Although we have found that brain-derived neurotrophic factor (BDNF) triggers surface translocation of AMPA receptor proteins, the physiological significance of the BDNF effect remained to be determined. The present immunohistochemical studies revealed that cortical GABAergic neurons exhibited the most striking response to BDNF. Accordingly, we monitored AMPA- ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2003 - Elsevier BV | Molecular and Cellular Neuroscience
Hussam Jourdi, Yuriko Iwakura, Mako Narisawa‐Saito, Kyoko Ibaraki, Huabao Xiong, Masahiko Watanabe, Yasunori Hayashi, Nobuyuki Takei, Hiroyuki Nawa,
Postsynaptic molecules with PDZ domains (PDZ proteins) interact with various glutamate receptors and regulate their subcellular trafficking and stability. In rat neocortical development, the protein expression of AMPA-type glutamate receptor GluR1 lagged behind its mRNA expression and rather paralleled an increase in PDZ protein levels. One of the neurotrophins, brain-derived neurotrophic factor (BDNF), appeared to contribute to this process, regulating the PDZ protein expression. In neocortical cultures, ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2003 - Elsevier BV | Developmental Biology
Hiroaki Shibahara, Satoru Takamizawa, Yuki Hirano, Ayustawati, Yuji Takei, Hiroyuki Fujiwara, Saori Tamada, Ikuo Sato,
Since transvaginal hydrolaparoscopy (THL) was introduced as the first-line procedure in the early stages of the exploration of the adnexal structures in infertile women, it has been shown that THL is a less traumatic and a more suitable outpatient procedure than diagnostic laparoscopy. This study was performed to investigate the relationships between Chlamydia trachomatis antibody titers and tubal pathology assessed using THL in infertile women.The C. trachomatis antibody titers (IgG and IgA) were ...
Tópico(s): Ovarian cancer diagnosis and treatment
2003 - Wiley | American Journal of Reproductive Immunology
Makoto Mizuno, Hiroki Kawamura, Nobuyuki Takei, Hiroyuki Nawa,
Tópico(s): Bioactive Compounds and Antitumor Agents
2008 - Springer Science+Business Media | Journal of Neural Transmission
Yuriko Iwakura, Ran Wang, Yuichi Abe, Ying‐shan Piao, Yuji Shishido, Shigeki Higashiyama, Nobuyuki Takei, Hiroyuki Nawa,
Epidermal growth factor (EGF) and structurally related peptides promote neuronal survival and the development of midbrain dopaminergic neurons; however, the regulation of their production has not been fully elucidated. In this study, we found that the treatment of striatal cells with dopamine agonists enhances EGF release both in vivo and in vitro. We prepared neuron-enriched and non-neuronal cell-enriched cultures from the striatum of rat embryos and challenged those with various neurotransmitters ...
Tópico(s): Signaling Pathways in Disease
2011 - Wiley | Journal of Neurochemistry
Yuriko Iwakura, Yingjun Zheng, Maria Sibilia, Yuichi Abe, Ying‐shan Piao, Daisaku Yokomaku, Ran Wang, Yuta Ishizuka, Nobuyuki Takei, Hiroyuki Nawa,
J. Neurochem. (2011) 10.1111/j.1471‐4159.2011.07287.x Abstract Although epidermal growth factor (EGF) receptor (ErbB1) is implicated in Parkinson’s disease and schizophrenia, the neurotrophic action of ErbB1 ligands on nigral dopaminergic neurons remains controversial. Here, we ascertained colocalization of ErbB1 and tyrosine hydroxylase (TH) immunoreactivity and then characterized the neurotrophic effects of ErbB1 ligands on this cell population. In mesencephalic culture, EGF and glial‐derived neurotrophic ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2011 - Wiley | Journal of Neurochemistry
Shigeru Saito, Kazufumi Tsujimoto, Kenji Kikuchi, Yuji Kurata, Toshinobu Sasa, Makoto Umeno, Kenji Nishihara, Motoharu Mizumoto, Nobuo Ouchi, H. Takei, Hiroyuki Oigawa,
Tópico(s): Nuclear Physics and Applications
2006 - Elsevier BV | Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment
Hisaaki Namba, Tadasato Nagano, Yuriko Iwakura, Huabao Xiong, Hussam Jourdi, Nobuyuki Takei, Hiroyuki Nawa,
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2006 - Elsevier BV | Molecular and Cellular Neuroscience
Naoko Taniguchi, Yo Shinoda, Nobuyuki Takei, Hiroyuki Nawa, Akihiko Ogura, Keiko Tominaga‐Yoshino,
Tópico(s): Retinal Development and Disorders
2006 - Elsevier BV | Neuroscience Letters
Tomoko Sugiura, Nobuaki Maeno, Yasushi Kawaguchi, Syuji Takei, Hiroyuki Imanaka, Yoshifumi Kawano, Hisae Terajima-Ichida, Masako Hara, Naoyuki Kamatani,
Recently, we reported that genetic polymorphisms within the human IL18 gene were associated with disease susceptibility to adult-onset Still's disease (AOSD), which is characterized by extraordinarily high serum levels of IL-18. Because high serum IL-18 induction has also been observed in the systemic type of juvenile idiopathic arthritis (JIA), we investigated whether similar genetic skewing is present in this disease. Three haplotypes, S01, S02, and S03, composed of 13 genetic polymorphisms covering ...
Tópico(s): Kawasaki Disease and Coronary Complications
2006 - BioMed Central | Arthritis Research & Therapy
Hidekazu Sotoyama, Hisaaki Namba, Nobuyuki Takei, Hiroyuki Nawa,
Tópico(s): Growth Hormone and Insulin-like Growth Factors
2006 - Springer Science+Business Media | Psychopharmacology
Tomoyuki Imagawa, Shumpei Yokota, Masaaki Mori, Takako Miyamae, Syuji Takei, Hiroyuki Imanaka, Yasuhito Nerome, Naomi Iwata, Takuji Murata, Mari Miyoshi, Norihiro Nishimoto, Tadamitsu Kishimoto,
We evaluated the safety and efficacy of tocilizumab in polyarticular-course juvenile idiopathic arthritis (pJIA) with polyarticular or oligoarticular onset. Patients received 8 mg/kg tocilizumab every 4 weeks in the open-label studies: initial study (to week 12) and then an extension study (at least 48 weeks). Nineteen patients intractable to conventional methotrexate therapy were enrolled. Seventeen patients had polyarticular-onset pJIA; two had oligoarticular-onset pJIA. Mean age was 11.6 years; ...
Tópico(s): Acute Lymphoblastic Leukemia research
2012 - Oxford University Press | Modern Rheumatology
Naomasa Kakiya, Takashi Saito, Per Nilsson, Yukio Matsuba, Satoshi Tsubuki, Nobuyuki Takei, Hiroyuki Nawa, Takaomi C. Saido,
Neprilysin is one of the major amyloid-β peptide (Aβ)-degrading enzymes, the expression of which declines in the brain during aging. The decrease in neprilysin leads to a metabolic Aβ imbalance, which can induce the amyloidosis underlying Alzheimer disease. Pharmacological activation of neprilysin during aging therefore represents a potential strategy to prevent the development of Alzheimer disease. However, the regulatory mechanisms mediating neprilysin activity in the brain remain unclear. To address ...
Tópico(s): Nerve injury and regeneration
2012 - Elsevier BV | Journal of Biological Chemistry
Ying‐shan Piao, Yuriko Iwakura, Nobuyuki Takei, Hiroyuki Nawa,
Using two-site enzyme immunoassays, we measured protein levels of epidermal growth factor (EGF), transforming growth factor alpha (TGF alpha), and heparin-binding epidermal growth factor (HB-EGF) in adult rat brain, and compared them with the phosphorylation levels of their receptor (ErbB 1). There were significant variations in the brain distributions of each ErbB 1 ligand. Among these ErbB 1 ligands, HB-EGF protein levels were higher than those of TGF alpha and those of EGF were the lowest. TGF alpha ...
Tópico(s): Glycosylation and Glycoproteins Research
2005 - Elsevier BV | Neuroscience Letters
Daisaku Yokomaku, Hussam Jourdi, Akiyoshi Kakita, T. Nagano, Hitoshi Takahashi, Nobuyuki Takei, Hiroyuki Nawa,
Scaffolding proteins containing postsynaptic density-95/discs large/zone occludens-1 (PDZ) domains interact with synaptic receptors and cytoskeletal components and are therefore implicated in synaptic development and plasticity. Little is known, however, about what regulates the expression of PDZ proteins and how the levels of these proteins influence synaptic development. Here, we show that ligands for epidermal growth factor receptors (ErbB1) decrease a particular set of PDZ proteins and negatively ...
Tópico(s): Neuroscience and Neuropharmacology Research
2005 - Elsevier BV | Neuroscience
Yuji Kashiwakura, Masami Watanabe, Norihiro Kusumi, Katsuhiko Sumiyoshi, Yasutomo Nasu, Hiroshi Yamada, Tatsuya Sawamura, Hiromi Kumon, Kohji Takei, Hiroyuki Daida,
On exposure to oxidized low-density lipoprotein (oxLDL), vascular cells generally undergo apoptosis, which is one of the major pathogenic factors of atherosclerosis. In this study, we examined the role of dynamin (a crucial GTPase protein in endocytosis) in oxLDL-induced apoptosis of vascular smooth muscle cells (VSMC).After oxLDL stimulation, dynamin-2 colocalized with LOX-1 around the cell surface, as well as oxLDL in the cytoplasm, suggesting that dynamin-2 was involved in scavenger receptor-mediated ...
Tópico(s): Autophagy in Disease and Therapy
2004 - Lippincott Williams & Wilkins | Circulation
Nobuaki Maeno, Syuji Takei, Hiroyuki Imanaka, Kimie Yamamoto, Kazumi Kuriwaki, Yoshifumi Kawano, Hiroshi Oda,
Abstract The aberrant induction of proinflammatory cytokines is considered to be crucial in the pathogenesis of systemic juvenile idiopathic arthritis and adult‐onset Still's disease. Interleukin‐18 (IL‐18) in particular has been reported to be a candidate for the key cytokine in both diseases; however, the origin of IL‐18 is unclear. To clarify the origin, we investigated specimens from various organs obtained during autopsy of a child with systemic JIA and macrophage activation syndrome, using ...
Tópico(s): Immune Cell Function and Interaction
2004 - Wiley | Arthritis & Rheumatism
Takao Itoi, Yasushi Shinohara, Kazuya Takeda, Kazuo Takei, Hiroyuki Ohno, Kazuma Ohyashiki, Naoyuki Yahata, Yoshiro Ebihara, Toshihiko Saito,
Background: Telomerase activity is detectable in more than 85% of primary cancers. We determined telomerase activity in biopsy specimens obtained from biliary tract cancers to evaluate the clinical application of telomerase activity detection in combination with p53 immunostaining and routine histologic examination. Methods: Biospy specimens obtained during percutaneous transhepatic cholangioscopy from 13 patients with cholangiocarcinoma, 3 patients with gallbladder carcinoma, and 4 patients with ...
Tópico(s): Telomeres, Telomerase, and Senescence
2000 - Elsevier BV | Gastrointestinal Endoscopy
Nobutada Tabata, Masaaki Miyazawa, Ryuichi Fujisawa, Yumiko A. Takei, Hiroyuki Abé, Keiji Hashimoto,
ABSTRACT Several strains of mice, including MRL/MpJ mice homozygous for the Fas mutant lpr gene (MRL/ lpr mice), F 1 hybrids of New Zealand Black and New Zealand White mice, and BXSB/MpJ mice carrying a Y-linked autoimmune acceleration gene, spontaneously develop immune complex-mediated glomerulonephritis. The involvement of the envelope glycoprotein gp70 of an endogenous xenotropic virus in the formation of circulating immune complexes and their deposition in the glomerular lesions have been demonstrated, ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2000 - American Society for Microbiology | Journal of Virology
Nobuyuki Takei, Hiroyuki Nawa,
Target of rapamycin (TOR) was first identified in yeast as a target molecule of rapamycin, an anti-fugal and immunosuppressant macrolide compound. In mammals, its orthologue is called mTOR (mammalian TOR). mTOR is a serine/threonine kinase that converges different extracellular stimuli, such as nutrients and growth factors, and diverges into several biochemical reactions, including translation, autophagy, transcription, and lipid synthesis among others. These biochemical reactions govern cell growth ...
Tópico(s): Tuberous Sclerosis Complex Research
2014 - Frontiers Media | Frontiers in Molecular Neuroscience
Shiro Seki, Seiji Tsuzuki, Kikuko Hayamizu, Nobuyuki Serizawa, Shimpei Ono, Katsuhito Takei, Hiroyuki Doi, Yasuhiro Umebayashi,
We have measured physicochemical properties of five alkyltrimethylammonium cation-based room-temperature ionic liquids and compared them with those obtained from computational methods. We have found that static properties (density and refractive index) and transport properties (ionic conductivity, self-diffusion coefficient, and viscosity) of these ionic liquids show close relations with the length of the alkyl chain. In particular, static properties obtained by experimental methods exhibit a trend ...
Tópico(s): Material Dynamics and Properties
2014 - American Chemical Society | The Journal of Physical Chemistry B