Cédric S. Tremblay, Thu Hoàng, Trang Hoang,
Tópico(s): Acute Myeloid Leukemia Research
2010 - Academic Press | Progress in molecular biology and translational science
Thanh Son Pham, Thao Duy Nguyen, Bùi Sơn Tùng, Bui Xuan Khuyen, Thu Trang Hoang, Quang Minh Ngo, Le Thi Hong Hiep, Vũ Đình Lãm,
Abstract In this article, we investigated the efficiency of a magnetic resonant wireless power transfer (MR-WPT) in conducting medium and found out an optimal frequency for designing the system. In conducting environment, the eddy current loss is generated by the high-frequency alternating currents in the coils. It is manifested by increased radiation resistance of resonator coil leads to decrease the quality factor ( Q -factor), which reduces the wireless power transfer (WPT) efficiency in conducting ...
Tópico(s): Wireless Body Area Networks
2021 - Nature Portfolio | Scientific Reports
Xiao Yin, Brett Hill, Trang Hoang, Fei Wen,
The intentional use of viruses for cancer therapy dates back over a century. As viruses are inherently immunogenic and naturally optimized delivery vehicles, repurposing viruses for drug delivery, tumor antigen presentation, or selective replication in cancer cells represents a simple and elegant approach to cancer treatment. While early virotherapy was fraught with harsh side effects and low response rates, virus-based therapies have recently seen a resurgence due to newfound abilities to engineer ...
Tópico(s): Viral gastroenteritis research and epidemiology
2021 - Elsevier BV | Seminars in Cancer Biology
Minh-Trung Dao, Nguyễn Võ Châu Ngân, Thanh-Nha Tran, Xuan-Du Nguyen, Duc-Thuong Vo, Van‐Kieu Nguyen, Le-Thuy-Thuy-Trang Hoang,
Plant-derived coagulants have exhibited a good potential in wastewater treatment due to their “green” characteristics, high coagulating-flocculating activity, cost-effectiveness, and biodegradability. Nevertheless, research studies have focused mainly on bench-scale experiments; pilot-scale and full-scale simulations are still limited. Herein, we firstly report a pilot-scale study of real domestic textile wastewater treatment using Cassia fistula coagulant. The material characterizations using Fourier- ...
Tópico(s): Constructed Wetlands for Wastewater Treatment
2021 - Hindawi Publishing Corporation | Journal of Chemistry
Natalia Baran, Alessia Lodi, Yogesh Dhungana, Shelley M. Herbrich, Meghan Collins, Shannon Sweeney, Renu Pandey, Anna Skwarska, Shraddha Patel, Mathieu Tremblay, Vinitha M. Kuruvilla, Antonio Cavazos, Mecit Kaplan, Marc O. Warmoes, Diogo F. T. Veiga, Ken Furudate, Shanti Rojas-Sutterin, André Haman, Yves Gareau, Anne Marinier, Helen Ma, Karine G. Harutyunyan, May Daher, Luciana Melo Garcia, Gheath Alatrash, Sujan Piya, Vivian Ruvolo, Wentao Yang, Sriram S. Shanmugavelandy, Ningping Feng, Jason Gay, Di Du, Jun J. Yang, Fieke W. Hoff, Marcin M. Kamiński, Katarzyna Tomczak, R. Eric Davis, Daniel Herranz, Adolfo A. Ferrando, Elias Jabbour, Maria Emilia Di Francesco, David T. Teachey, Terzah M. Horton, Steven M. Kornblau, Katayoun Rezvani, Guy Sauvageau, Mihai Gagea, Michael Andreeff, Koichi Takahashi, Joseph R. Marszalek, Philip L. Lorenzi, Jiyang Yu, Stefano Tiziani, Trang Hoang, Marina Konopleva,
Abstract T-cell acute lymphoblastic leukemia (T-ALL) is commonly driven by activating mutations in NOTCH1 that facilitate glutamine oxidation. Here we identify oxidative phosphorylation (OxPhos) as a critical pathway for leukemia cell survival and demonstrate a direct relationship between NOTCH1 , elevated OxPhos gene expression, and acquired chemoresistance in pre-leukemic and leukemic models. Disrupting OxPhos with IACS-010759, an inhibitor of mitochondrial complex I, causes potent growth inhibition ...
Tópico(s): RNA modifications and cancer
2022 - Nature Portfolio | Nature Communications
Xinhui Zhao, Boris Bartholdy, Yukiya Yamamoto, Erica Evans, Meritxell Alberich-Jordà, Philipp B. Staber, Touati Benoukraf, Pu Zhang, Junyan Zhang, Bon Q. Trinh, John D. Crispino, Trang Hoang, Mahmoud A. Bassal, Daniel G. Tenen,
Abstract The Ets transcription factor PU.1 is essential for inducing the differentiation of monocytes, macrophages, and B cells in fetal liver and adult bone marrow. PU.1 controls hematopoietic differentiation through physical interactions with other transcription factors, such as C/EBPα and the AP-1 family member c-Jun. We found that PU.1 recruits c-Jun to promoters without the AP-1 binding sites. To address the functional importance of this interaction, we generated PU.1 point mutants that do ...
Tópico(s): Immune cells in cancer
2022 - Nature Portfolio | Communications Biology
... doi.org/10.5465/amle.2017.0277Huong T Hoang, Trang T Nguyen, Jerry F Reynolds Buddhism-based charity, ...
Tópico(s): Vietnamese History and Culture Studies
1956 - University of Chicago Press | Social Service Review
... Crossref reports the following articles citing this article:Trang Hoang Fiscal competition and state pension reforms, Public Budgeting & ...
Tópico(s): Gender, Labor, and Family Dynamics
1980 - University of Chicago Press | The Journal of Politics
Suzanne M. Watt, David J. Gilmore, Donald Metcalf, Stephen Cobbold, Trang Hoang, Herman Waldmann,
Abstract A rat monoclonal antibody, YBM/42, directed against mouse leukocyte common antigen, was used for the analysis and separation of hemopoietic progenitor cells from mouse bone marrow and fetal liver. Cells were fractionated on a FACS‐II cell sorter and the resulting subpopulations examined for their morphology and ability to form colonies in agar (for day 7 colonies) and methylcellulose (for day 2 erythroid clones). The antibody bound to all leukocytes, including blast cells and day 7 hemopoietic ...
Tópico(s): Erythrocyte Function and Pathophysiology
1983 - Wiley | Journal of Cellular Physiology
Nicole Onetto-Pothier, Nicole Aumont, André Haman, Charles-Etienne Bigras, GG Wong, SC Clark, A. De Léan, Trang Hoang,
Abstract Iodinated granulocyte-macrophage colony-stimulating factor (GM-CSF) was used to document the specific binding of GM-CSF to all acute myeloblastic leukemia (AML) samples examined in the present study. There was some heterogeneity in the number of GM-CSF binding sites per cell. To determine whether the low level of binding to some patient samples may be attributed to receptor occupancy by an endogenous source of GM-CSF, we devised an acid wash procedure that could remove surface- bound GM-CSF ...
Tópico(s): Immune Cell Function and Interaction
1990 - Elsevier BV | Blood
Daniel Feenberg, Jonathan Skinner,
... Crossref reports the following articles citing this article:Trang Hoang, James R. Harrington Tax incentive and household saving ...
Tópico(s): Gender, Labor, and Family Dynamics
1989 - University of Chicago Press | Tax Policy and the Economy
Patrick Tremblay, F. Pothier, Trang Hoang, Gilles Tremblay, Seymour Brownstein, Allan Liszauer, Paul Jolicoeur,
Transgenic mice carrying the v-Ha-ras oncogene under the control of the mouse mammary tumor virus long terminal repeat were produced. These mice exhibit several phenotypes: mammary tumors, bilateral hyperplasia of the harderian lacrimal gland, primary bronchio-alveolar lung adenocarcinoma, and splenomegaly. High levels of the transgene RNA were detected in mammary, harderian, and lung tumors. Accumulation of cells of the myeloid lineages was found in enlarged spleens. This phenotype may represent ...
Tópico(s): Cancer Research and Treatments
1989 - Taylor & Francis | Molecular and Cellular Biology
Julie Lacombe, Sabine Herblot, Shanti Rojas‐Sutterlin, André Haman, Stéphane Barakat, Norman N. Iscove, Guy Sauvageau, Trang Hoang,
Abstract The majority of long-term reconstituting hematopoietic stem cells (LT-HSCs) in the adult is in G0, whereas a large proportion of progenitors are more cycling. We show here that the SCL/TAL1 transcription factor is highly expressed in LT-HSCs compared with short-term reconstituting HSCs and progenitors and that SCL negatively regulates the G0-G1 transit of LT-HSCs. Furthermore, when SCL protein levels are decreased by gene targeting or by RNA interference, the reconstitution potential of ...
Tópico(s): Immune Cell Function and Interaction
2009 - Elsevier BV | Blood
Karine Huber, Luu Le Loan, Trang Hoang, Sophie Ravel, F Rodhain, Anna‐Bella Failloux,
Abstract Dengue haemorrhagic fever emerged in the 1950s and has become a major public health concern in most Asian countries. In Vietnam, little is known about the intraspecific variation of the vector and its consequences on vectorial capacity. Here we report the use of microsatellite markers to differentiate Aedes aegypti populations in Ho Chi Minh City, a typical, overcrowded Asian city. Six microsatellite loci, with 5–14 alleles per locus, were scored in 20 mosquito samples collected in 1998 ...
Tópico(s): Plant and animal studies
2002 - Wiley | Molecular Ecology
Sabine Herblot, Peter D. Aplan, Trang Hoang,
The E2A locus is a frequent target of chromosomal translocations in B-cell acute lymphoblastic leukemia (B-ALL). E2A encodes two products, E12 and E47, that are part of the basic helix-loop-helix (bHLH) family of transcription factors and are central in B lineage differentiation. E2A haplo-insufficiency hinders progression through three major checkpoints in B-cell development: commitment into the B lineage, at the pro-B to pre-B transition, and in the induction of immunoglobulin M (IgM) expression ...
Tópico(s): Acute Myeloid Leukemia Research
2002 - Taylor & Francis | Molecular and Cellular Biology
Mathieu Tremblay, Sabine Herblot, Éric Lécuyer, Trang Hoang,
The expression of the pT alpha gene is required for effective selection, proliferation, and survival of beta T-cell receptor (beta TCR)-expressing immature thymocytes. Here, we have identified two phylogenetically conserved E-boxes within the pT alpha enhancer sequence that are required for optimal enhancer activity and for its stage-specific activity in immature T cells. We have shown that the transcription factors E2A and HEB associate with high affinity to these E-boxes. Moreover, we have identified ...
Tópico(s): Melanoma and MAPK Pathways
2003 - Elsevier BV | Journal of Biological Chemistry
Cornelis F. Calkhoven, Christine Müller, Richard Martin, Goradz Krosl, Trang Hoang, Achim Leutz,
We investigated the translational regulation of SCL protein expression and its role in hematopoietic lineage choice. We show that the expression of different SCL protein isoforms is regulated by signal transduction pathways that modulate translation initiation factor (eIF) function. A conserved small upstream open reading frame (uORF) in SCL transcripts acts as a cis -regulatory element for isoform expression. At the onset of erythroid differentiation, truncated SCL protein isoforms arise by alternative ...
Tópico(s): Immune Cell Function and Interaction
2003 - Cold Spring Harbor Laboratory Press | Genes & Development
Loretta L. Doan, Mary Kate Kitay, Qing Yu, Alfred Singer, Sabine Herblot, Trang Hoang, S E Bear, Herbert C. Morse, Philip N. Tsichlis, H. Leighton Grimes,
Abstract T cell differentiation in the thymus is dependent upon signaling through the TCR and is characterized by the resulting changes in expression patterns of CD4 and CD8 surface coreceptor molecules. Although recent studies have characterized the effects of proximal TCR signaling on T cell differentiation, the downstream integration of these signals remains largely unknown. The growth factor independence-1 (GFI1) and GFI1B transcriptional repressors may regulate cytokine signaling pathways to ...
Tópico(s): Immune Cell Function and Interaction
2003 - American Association of Immunologists | The Journal of Immunology
Adolfo A. Ferrando, Sabine Herblot, Teresa Palomero, Thomas Hansen, Trang Hoang, Edward A. Fox, A. Thomas Look,
Aberrant expression of transcription factor oncogenes such as HOX11, HOX11L2, TAL1/SCL, LYL1, LMO1, and LMO2 can be detected in lymphoblasts from up to 80% of patients with acute T-cell lymphoblastic leukemia (T-ALL). Transcriptional activation of these oncogenes in leukemic cells typically results from chromosomal rearrangements that place them next to highly active cis-acting transcriptional regulatory elements. However, biallelic activation of TAL1 in some T-ALL cases has been previously proposed. ...
Tópico(s): Acute Myeloid Leukemia Research
2003 - Elsevier BV | Blood
Tsvee Lapidot, Christian Sirard, Josef Vormoor, Barbara Murdoch, Trang Hoang, Julio Roberto Cáceres‐Cortés, Mark D. Minden, Bruce M. Paterson, Michael A. Caligiuri, John E. Dick,
Tópico(s): Immune cells in cancer
1994 - Nature Portfolio | Nature
Ivan Topisirović, Nadeem Siddiqui, Slobodanka Orolicki, Lucy Skrabanek, Mathieu Tremblay, Trang Hoang, Katherine L. B. Borden,
Eukaryotic translation initiation factor 4E (eIF4E) is encoded by a potent oncogene which is highly elevated in many human cancers. Few studies have investigated how the level, and thus activity, of eIF4E is regulated in healthy (noncancerous) cells and how they become elevated in malignant cells. Here, our studies reveal a novel mechanism by which eIF4E levels are regulated at the level of mRNA stability. Two factors known to modulate transcript stability, HuR and the p42 isoform of AUF1, compete ...
Tópico(s): RNA and protein synthesis mechanisms
2008 - Taylor & Francis | Molecular and Cellular Biology
Mathieu Tremblay, Cédric S. Tremblay, Sabine Herblot, Peter D. Aplan, Josée Hébert, Claude Perreault, Trang Hoang,
Deciphering molecular events required for full transformation of normal cells into cancer cells remains a challenge. In T-cell acute lymphoblastic leukemia (T-ALL), the genes encoding the TAL1/SCL and LMO1/2 transcription factors are recurring targets of chromosomal translocations, whereas NOTCH1 is activated in >50% of samples. Here we show that the SCL and LMO1 oncogenes collaborate to expand primitive thymocyte progenitors and inhibit later stages of differentiation. Together with pre-T-cell antigen ...
Tópico(s): CAR-T cell therapy research
2010 - Cold Spring Harbor Laboratory Press | Genes & Development
Éric Lécuyer, Simon Larivière, Marie‐Claude Sincennes, André Haman, Rachid Lahlil, Margarita Todorova, Mathieu Tremblay, Brian C. Wilkes, Trang Hoang,
Gene expression programs are established by networks of interacting transcription factors. The basic helix-loop-helix factor SCL and the LIM-only protein LMO2 are components of transcription factor complexes that are essential for hematopoiesis. Here we show that LMO2 and SCL are predominant interaction partners in hematopoietic cells and that this interaction occurs through a conserved interface residing in the loop and helix 2 of SCL. This interaction nucleates the assembly of SCL complexes on ...
Tópico(s): Viral Infectious Diseases and Gene Expression in Insects
2007 - Elsevier BV | Journal of Biological Chemistry
Benoı̂t Grondin, Martin Lefrançois, Mathieu Tremblay, Marianne Saint-Denis, André Haman, Kazuo Waga, André Bédard, Daniel G. Tenen, Trang Hoang,
Transcription factors can function as DNA-binding-specific activators or as coactivators. c-Jun drives gene expression via binding to AP-1 sequences or as a cofactor for PU.1 in macrophages. c-Jun heterodimers bind AP-1 sequences with higher affinity than homodimers, but how c-Jun works as a coactivator is unknown. Here, we provide in vitro and in vivo evidence that c-Jun homodimers are recruited to the interleukin-1β (IL-1β) promoter in the absence of direct DNA binding via protein-protein interactions ...
Tópico(s): T-cell and B-cell Immunology
2007 - Taylor & Francis | Molecular and Cellular Biology
Trang Hoang, Patrice Rey, Vaudaine Marie-Helene, Danel Jean-Sebastien, Robert Philippe, Benech Philippe, Pierre Lemaı̂tre-Auger,
This paper concerns the design and the analysis of a surface acoustic wave (SAW) pressure sensor that is capable to work in high temperature (up to 800degC) environment. Novel structures of the device are also presented for self-temperature compensation. Special attention is made on the different possible multilayer structures that could be used, the behavior of the sensor, the electromechanical coupling factor, the wave velocity as well as the required RF matching circuit. These parameters are critical ...
Tópico(s): Advanced MEMS and NEMS Technologies
2007 - Institute of Electrical and Electronics Engineers | Proceedings of the IEEE International Frequency Control Symposium
Cynthia L. Carbonneau, Geneviève Despars, Shanti Rojas‐Sutterlin, Audrey Fortin, Oanh Lê, Trang Hoang, Christian Beauséjour,
Tópico(s): Cancer Cells and Metastasis
2011 - Elsevier BV | Blood
Ethan W. Dereszynski, Jesse Hostetler, Alan Fern, Tom Dietterich, Thao-Trang Hoang, Mark Udarbe,
We study the problem of learning probabilistic models of high-level strategic behavior in the real-time strategy (RTS) game StarCraft. The models are automatically learned from sets of game logs and aim to capture the common strategic states and decision points that arise in those games. Unlike most work on behavior/strategy learning and prediction in RTS games, our data-centric approach is not biased by or limited to any set of preconceived strategic concepts. Further, since our behavior model is ...
Tópico(s): Reinforcement Learning in Robotics
2011 - | Proceedings of the AAAI Conference on Artificial Intelligence and Interactive Digital Entertainment
Nicolas Goardon, Julie Anne Lambert, Patrick Rodriguez, Philippe Nissaire, Sabine Herblot, Pierre Thibault, Dominique Dumènil, John Strouboulis, Paul‐Henri Roméo, Trang Hoang,
Tópico(s): DNA Repair Mechanisms
2006 - Springer Nature | The EMBO Journal
Véronique Voisin, Corinne Barat, Trang Hoang, Éric Rassart,
ABSTRACT The Graffi murine leukemia virus (MuLV) was isolated in 1954 by Arnold Graffi, who characterized it as a myeloid leukemia-inducing retrovirus. He and his team, however, soon observed the intriguing phenomenon of hematological diversification, which corresponded to a decrease of myeloid leukemias and an increase of other types of leukemias. Recently, we derived two different molecular clones corresponding to ecotropic nondefective genomes that were named GV-1.2 and GV-1.4. The induced leukemias ...
Tópico(s): Virus-based gene therapy research
2006 - American Society for Microbiology | Journal of Virology
Trang Hoang, A. De Léan, André Haman, V. Beauchemin, Toshio Kitamura, S C Clark,
Myeloid cell lines and primary leukemic myeloblasts express two classes of granulocyte macrophage colony-stimulating factor (GM-CSF) binding sites of high (Kd 20-50 pM) and low affinity (Kd 5-10 nM). High affinity binding is caused by the association of two chains, p80 alpha and p130 beta, whereas p80 alpha alone confers low affinity binding only. Furthermore interleukin-3 (IL-3) competes for the binding of GM-CSF to its high affinity receptor (for review see Nicola, N. A., and Metcalf, D. (1991) Cell ...
Tópico(s): Immunotherapy and Immune Responses
1993 - Elsevier BV | Journal of Biological Chemistry