... From J. C. Hartzell. To Mr. W. H. Hoeke. Pa. Av. And 8th St., Washington, D. C.
0000 - Gale Group | NCCO EuropeAfrica
Maaike Schilperoort, Andrea D. van Dam, Geerte Hoeke, Irina G. Shabalina, Anthony Okolo, Aylin C. Hanyaloglu, Lea Dib, Isabel M. Mol, Natarin Caengprasath, Yi‐Wah Chan, Sami Damak, Anne Reifel Miller, Tamer Coşkun, Bharat Shimpukade, Trond Ulven, Sander Kooijman, Patrick C.N. Rensen, Mark Christian,
... Search for more papers by this author Geerte Hoeke Geerte Hoeke Division of Endocrinology, Department of Medicine, Leiden University ... Search for more papers by this author Geerte Hoeke Geerte Hoeke Division of Endocrinology, Department of Medicine, Leiden University ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2018 - Springer Nature | EMBO Molecular Medicine
Tj. B. van Wimersma Greidanus, M.C.G. van Praag, Rachel Kalmann, Gabriël J.E. Rinkel, Gerda Croiset, E.C. Hoeke, M.A.H. van Egmond, M. Fekete,
... NetherlandsSearch for more papers by this authorE.C. Hoeke, E.C. Hoeke Rudolf Magnus Institute for Pharmacology, University of Utrecht, ... NetherlandsSearch for more papers by this authorE.C. Hoeke, E.C. Hoeke Rudolf Magnus Institute for Pharmacology, University of Utrecht, ...
Tópico(s): Receptor Mechanisms and Signaling
1982 - Wiley | Annals of the New York Academy of Sciences
... dinitro-phenyl isocyanates as reagents for alcohols† F. Hoeke, F. Hoeke Leiden, Organic Chemical Laboratory of the UniversitySearch for more papers by this author F. Hoeke, F. Hoeke Leiden, Organic Chemical Laboratory of the UniversitySearch for ...
Tópico(s): Synthesis and Biological Evaluation
1935 - Royal Netherlands Chemical Society | Recueil des Travaux Chimiques des Pays-Bas
Anita I. R. Spanjer, Hoeke A. Baarsma, Lisette M. Oostenbrink, Sepp R. Jansen, Christine C. Kuipers, Michael Lindner, Dirkje S. Postma, Herman Meurs, Irene H. Heijink, Reinoud Gosens, Mélanie Königshoff,
... for more papers by this authorHoeke A. Baarsma, Hoeke A. Baarsma Comprehensive Pneumology Center, Helmholtz Center Munich, ... for more papers by this authorHoeke A. Baarsma, Hoeke A. Baarsma Comprehensive Pneumology Center, Helmholtz Center Munich, ...
Tópico(s): Neonatal Respiratory Health Research
2016 - Wiley | The FASEB Journal
Paul J. Lioy, Stephen M. Rappaport,
... Otto W, Kohajda T, Roeder S, Müller A, Hoeke H, Matysik S, Schlink U, Borte M, Herbarth ... date: 1-Aug-2015. Remane D, Grunwald S, Hoeke H, Mueller A, Roeder S, von Bergen M ... 40-44), Online publication date: 1-Aug-2015. Hoeke H, Roeder S, Bertsche T, Lehmann
Tópico(s): Climate Change and Health Impacts
2011 - National Institute of Environmental Health Sciences | Environmental Health Perspectives
Wim De Clercq, Roland Dreesen, Jan Dumolyn, Ward Leloup, Jan Trachet,
... eastern British coasts. The clustering of stones at Hoeke has drawn particular attention to the Hanseatic connection ... Bruges and to the small harbour town of Hoeke, which hosted the staple of stockfish and various ...
2017 - Cambridge University Press | European Journal of Archaeology
Paulina Biernacka, Wim De Clercq, Stijn Dewaele, Frank Vanhaecke, Johan De Grave,
Archaeological research at Hoeke, a Late Medieval outer harbour of Bruges (Belgium), has revealed large quantities of iron slags, fuel and other remains ...
Tópico(s): Archaeology and ancient environmental studies
2023 - Taylor & Francis | STAR Science & Technology of Archaeological Research
Ron Hoeke, Paul L. Jokiel, Robert W. Buddemeier, Russell E. Brainard,
Background Recent reviews suggest that the warming and acidification of ocean surface waters predicated by most accepted climate projections will lead to mass mortality and declining calcification rates of reef-building corals. This study investigates the use of modeling techniques to quantitatively examine rates of coral cover change due to these effects. Methodology/Principal Findings Broad-scale probabilities of change in shallow-water scleractinian coral cover in the Hawaiian Archipelago for ...
Tópico(s): Marine and fisheries research
2011 - Public Library of Science | PLoS ONE
Rita Costa, Darcy E. Wagner, Ali Doryab, Martina M. De Santis, Kenji Schorpp, Ina Rothenaigner, Mareike Lehmann, Hoeke A. Baarsma, Xueping Liu, Otmar Schmid, Mónica Campillos, Ali Önder Yildirim, Kamyar Hadian, Mélanie Königshoff,
Emphysema is an incurable disease characterized by loss of lung tissue leading to impaired gas exchange. Wnt/β-catenin signalling is reduced in emphysema, and exogenous activation of the pathway in experimental models in vivo and in human ex vivo lung tissue improves lung function and structure. We sought to identify a pharmaceutical able to activate Wnt/β-catenin signalling and assess its potential to activate lung epithelial cells and repair.We screened 1216 human-approved compounds for Wnt/β- ...
Tópico(s): Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
2021 - Wiley | British Journal of Pharmacology
Ron Hoeke, Hervé Damlamian, Jérôme Aucan, Moritz Wandres,
Tropical cyclone (TC) Pam formed in the central south Pacific in early March 2015. It reached a category 5 severity and made landfall or otherwise directly impacted several islands in Vanuatu, causing widespread damage and loss of life. It then moved along a southerly track between Fiji and New Caledonia, generating wind-waves of up to approximately 15 m, before exiting the region around March 15th. The resulting swell propagated throughout the central Pacific, causing flooding and damage to communities ...
Tópico(s): Coastal and Marine Dynamics
2021 - Frontiers Media | Frontiers in Marine Science
Dea van Lierop, Jge Soemers, Lisette Hoeke, G. Liu, Z. Chen, Dick Ettema, Johannes G. de Kruijf,
In many regions, governments are motivating increased bicycle ridership by designing new and improving existing bicycle infrastructure. Cycle highways are an effective and cost-efficient type of bicycle-specific infrastructure that are designed to provide a functional connection between places where people work, go to school and live. One important element of developing high quality cycle highways is the development of an effective wayfinding system which allows current, potential, and new users ...
Tópico(s): Evacuation and Crowd Dynamics
2020 - Elsevier BV | Journal of Transport Geography
Gundula Winter, Curt D. Storlazzi, Sean Vitousek, Ap van Dongeren, Robert McCall, Ron Hoeke, William Skirving, John J. Marra, Johan Reyns, Jérôme Aucan, Matthew J. Widlansky, J. M. Becker, Chris T. Perry, Gerd Masselink, Ryan Lowe, Murray R. Ford, Andrew Pomeroy, Fernando J. Méndez, Ana Rueda, Moritz Wandres,
Tropical coral reef-lined coasts are exposed to storm wave-driven flooding. In the future, flood events during storms are expected to occur more frequently and to be more severe due to sea-level rise, changes in wind and weather patterns, and the deterioration of coral reefs. Hence, disaster managers and coastal planners are in urgent need of decision-support tools. In the short-term, these tools can be applied in Early Warning Systems (EWS) that can help to prepare for and respond to impending storm- ...
Tópico(s): Ocean Waves and Remote Sensing
2020 - Frontiers Media | Frontiers in Marine Science
Garrett C. Millar, Ondrej Mitas, Wilco Boode, Lisette Hoeke, Joost de Kruijf, Anna Petrášová, Helena Mitášová,
Recent advancements in mobile sensing and wearable technologies create new opportunities to improve our understanding of how people experience their environment. This understanding can inform urban design decisions. Currently, an important urban design issue is the adaptation of infrastructure to increasing cycle and e-bike use. Using data collected from 12 cyclists on a cycle highway between two municipalities in The Netherlands, we coupled location and wearable emotion data at a high spatiotemporal ...
Tópico(s): Color perception and design
2020 - Elsevier BV | Computers Environment and Urban Systems
Enchen Zhou, Geerte Hoeke, Li Zhuang, Arthur C. Eibergen, Amber W. Schonk, Martijn Koehorst, Renze Boverhof, Rick Havinga, Folkert Kuipers, Tamer Coşkun, Mariëtte R. Boon, Albert K. Groen, Patrick C.N. Rensen, Jimmy F.P. Berbée, Yanan Wang,
Brown fat activation accelerates the uptake of cholesterol-enriched remnants by the liver and thereby lowers plasma cholesterol, consequently protecting against atherosclerosis development. Hepatic cholesterol is then converted into bile acids (BAs) that are secreted into the intestine and largely maintained within the enterohepatic circulation. We now aimed to evaluate the effects of prolonged brown fat activation combined with inhibition of intestinal BA reabsorption on plasma cholesterol metabolism ...
Tópico(s): Peroxisome Proliferator-Activated Receptors
2019 - Oxford University Press | Cardiovascular Research
A. Schiller, Gary B. Brassington, Peter R. Oke, Madeleine Cahill, Prasanth Divakaran, M. Entel, J. Freeman, David A. Griffin, Mike Herzfeld, Ron Hoeke, Huang Xinmei, Emlyn Jones, Edward King, Barbra Parker, Tracey Pitman, Uwe Rosebrock, Jessica Sweeney, Andy Taylor, Marcus Thatcher, Robert Woodham, Aihong Zhong,
The operational Australian Bluelink ocean forecast system is used to transform physical oceanographic observations into coherent analyses and predictions. These analyses and predictions form the basis for information services about the marine environment and its ecosystem, and can provide boundary data for weather predictions. Bluelink information services are available to marine industries (e.g. commercial fishing, aquaculture, shipping, oil and gas, renewable energy), government agencies (e.g. search ...
Tópico(s): Marine and coastal ecosystems
2019 - Taylor & Francis | Journal of Operational Oceanography
Julian O’Grady, Kathleen L. McInnes, Mark Hemer, Ron Hoeke, Alec Stephenson, Frank Colberg,
Abstract Empirical equations for wave breaking and wave setup are compared with archived shoreline wave setup measurements to investigate the contribution of wind waves to extreme Mean Total Water Levels (MTWL, the mean height of the shoreline), for natural beaches exposed to open ocean wind waves. A broad range of formulations is compared through linear regression and quantile regression analysis of the highest measured values. Shoreline wave setup equations are selected based on the availability ...
Tópico(s): Tropical and Extratropical Cyclones Research
2019 - Wiley | Journal of Geophysical Research Oceans
Veronika Hoeke, Laura Tociu, David A. Case, Lance C. Seefeldt, Simone Raugei, Brian M. Hoffman,
We have shown that the key state in N2 reduction to two NH3 molecules by the enzyme nitrogenase is E4(4H), the "Janus" intermediate, which has accumulated four [e–/H+] and is poised to undergo reductive elimination of H2 coupled to N2 binding and activation. Initial 1H and 95Mo ENDOR studies of freeze-trapped E4(4H) revealed that the catalytic multimetallic cluster (FeMo-co) binds two Fe-bridging hydrides, [Fe–H–Fe]. However, the analysis failed to provide a satisfactory picture of the relative spatial ...
Tópico(s): ATP Synthase and ATPases Research
2019 - American Chemical Society | Journal of the American Chemical Society
Frank Colberg, Kathleen L. McInnes, Julian O’Grady, Ron Hoeke,
Abstract. Projections of sea level rise (SLR) will lead to increasing coastal impacts during extreme sea level events globally; however, there is significant uncertainty around short-term coastal sea level variability and the attendant frequency and severity of extreme sea level events. In this study, we investigate drivers of coastal sea level variability (including extremes) around Australia by means of historical conditions as well as future changes under a high greenhouse gas emissions scenario ( ...
Tópico(s): Tropical and Extratropical Cyclones Research
2019 - Copernicus Publications | Natural hazards and earth system sciences
Diana Greenslade, Mark Hemer, Alexander V. Babanin, Ryan Lowe, Ian L. Turner, Hannah E. Power, Ian R. Young, Daniel Ierodiaconou, Greg Hibbert, Greg Williams, Saima Aijaz, João Albuquerque, Stewart C. R. Allen, Michael L. Banner, Paul Branson, Steve Buchan, Andrew Burton, John A. T. Bye, Nick Cartwright, Amin Chabchoub, Frank Colberg, Stephanie Contardo, François Dufois, Craig Earl‐Spurr, David Farr, Ian Goodwin, Jim R. Gunson, Jeff E. Hansen, David J. Hanslow, Mitchell D. Harley, Yasha Hetzel, Ron Hoeke, Nicole L. Jones, Michael A. Kinsela, Qingxiang Liu, Oleg Makarynskyy, Hayden Marcollo, Said Mazaheri, Jason McConochie, Grant Millar, Tim Moltmann, Neal Moodie, Joao Morim, Russel P. Morison, Jana Orszaghova, Charitha Pattiaratchi, Andrew Pomeroy, Roger Proctor, David Provis, Ruth Reef, Dirk P. Rijnsdorp, Martin Rutherford, Eric Schulz, Jake Shayer, Kristen D. Splinter, Craig Steinberg, Darrell Strauss, Greg Stuart, Graham Symonds, Karina Tarbath, Daniel C. Taylor, James Taylor, Darshani Thotagamuwage, Alessandro Toffoli, Alireza Valizadeh, Jonathan van Hazel, Guilherme Vieira da Silva, Moritz Wandres, Colin Whittaker, D. Keith Williams, Gundula Winter, Jiangtao Xu, Aihong Zhong, Stefan Zieger,
Abstract The Australian marine research, industry, and stakeholder community has recently undertaken an extensive collaborative process to identify the highest national priorities for wind-waves research. This was undertaken under the auspices of the Forum for Operational Oceanography Surface Waves Working Group. The main steps in the process were first, soliciting possible research questions from the community via an online survey; second, reviewing the questions at a face-to-face workshop; and ...
Tópico(s): Tropical and Extratropical Cyclones Research
2019 - American Meteorological Society | Bulletin of the American Meteorological Society
Sally L. Lavender, Ron Hoeke, Deborah J. Abbs,
Abstract. Tropical cyclones (TCs) result in widespread damage associated with strong winds, heavy rainfall and storm surge. TC Yasi was one of the most powerful TCs to impact the Queensland coast since records began. Prior to Yasi, the SSTs in the Coral Sea were higher than average by 1–2 ∘C, primarily due to the 2010/2011 La Niña event. In this study, a conceptually simple idealised sensitivity analysis is performed using a high-resolution regional model to gain insight into the influence of SST ...
Tópico(s): Climate variability and models
2018 - Copernicus Publications | Natural hazards and earth system sciences
Jérôme Aucan, Ron Hoeke, Curt D. Storlazzi, Justin E. Stopa, Moritz Wandres, Ryan Lowe,
Tópico(s): Climate variability and models
2018 - Nature Portfolio | Nature Climate Change
Wioletta Skrońska-Wąsek, Reinoud Gosens, Mélanie Königshoff, Hoeke A. Baarsma,
The WNT signalling cascades have emerged as critical regulators of a wide variety of biological aspects involved in lung development as well as in physiological and pathophysiological processes in the adult lung. WNTs (secreted glycoproteins) interact with various transmembrane receptors and co-receptors to activate signalling pathways that regulate transcriptional as well as non-transcriptional responses within cells. In physiological conditions, the majority of WNT receptors and co-receptors can ...
Tópico(s): Cancer-related gene regulation
2018 - Elsevier BV | Pharmacology & Therapeutics
Stephanie Contardo, Ron Hoeke, Mark Hemer, Graham Symonds, Kathleen L. McInnes, Julian O’Grady,
Wave energy is a potential emerging contributor to future global low-emission energy needs. If wave energy is to become a significant part of renewable energy portfolios, then wave energy converters (WECs) will need to be installed in large numbers in array configurations. The environmental effects of wave energy extraction to date has relied on physical (i.e., tank) and numerical modelling studies. In this study, a network of in situ wave measurement devices were deployed around an array of three ...
Tópico(s): Ocean Waves and Remote Sensing
2018 - Elsevier BV | Coastal Engineering
Aina Martín-Medina, Mareike Lehmann, Olivier Burgy, Sarah Hermann, Hoeke A. Baarsma, Darcy E. Wagner, Martina M. De Santis, Florian Ciolek, Thomas P. Hofer, Marion Frankenberger, Michaela Aichler, Michael Lindner, Wolfgang Gesierich, Andreas Güenther, Axel Walch, Christina Coughlan, Paul J. Wolters, Joyce Lee, Jürgen Behr, Mélanie Königshoff,
Rationale: Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease characterized by lung epithelial cell injury, increased (myo)fibroblast activation, and extracellular matrix deposition. Extracellular vesicles (EVs) regulate intercellular communication by carrying a variety of signaling mediators, including WNT (wingless/integrated) proteins. The relevance of EVs in pulmonary fibrosis and their potential contribution to disease pathogenesis, however, remain unexplored.Objectives: To characterize ...
Tópico(s): Pulmonary Hypertension Research and Treatments
2018 - American Thoracic Society | American Journal of Respiratory and Critical Care Medicine
Wenyan Wu, Kathleen L. McInnes, Julian O’Grady, Ron Hoeke, Michael Leonard, Seth Westra,
Abstract Dependence between extreme storm surge and rainfall can have significant implications for flood risk in coastal and estuarine regions. To supplement limited observational records, we use reanalysis surge data from a hydrodynamic model as the basis for dependence mapping, providing information at a resolution of approximately 30 km along the Australian coastline. We evaluated this approach by comparing the dependence estimates from modeled surge to that calculated using historical surge ...
Tópico(s): Ocean Waves and Remote Sensing
2018 - Wiley | Journal of Geophysical Research Oceans
Geerte Hoeke, Yanan Wang, Andrea D. van Dam, Isabel M. Mol, Eveline Gart, Henk G. Klop, Susan M. van den Berg, Elsbet H. Pieterman, P. Hans, Albert K. Groen, Patrick C.N. Rensen, Jimmy F.P. Berbée, Mariëtte R. Boon,
Background and aims Activation of brown adipose tissue (BAT) reduces both hyperlipidemia and atherosclerosis by increasing the uptake of triglyceride-derived fatty acids by BAT, accompanied by formation and clearance of lipoprotein remnants. We tested the hypothesis that the hepatic uptake of lipoprotein remnants generated by BAT activation would be accelerated by concomitant statin treatment, thereby further reducing hypercholesterolemia and atherosclerosis. Methods APOE*3-Leiden.CETP mice were ...
Tópico(s): Cardiovascular Disease and Adiposity
2017 - Elsevier BV | Atherosclerosis
Mareen Morawe, Henrike Hoeke, Dirk K. Wissenbach, Guillaume Lentendu, Tesfaye Wubet, Eileen Kröber, Steffen Kolb,
Methanol is an abundant atmospheric volatile organic compound that is released from both living and decaying plant material. In forest and other aerated soils, methanol can be consumed by methanol-utilizing microorganisms that constitute a known terrestrial sink. However, the environmental factors that drive the biodiversity of such methanol-utilizers have been hardly resolved. Soil-derived isolates of methanol-utilizers can also often assimilate multicarbon compounds as alternative substrates. ...
Tópico(s): Fermentation and Sensory Analysis
2017 - Frontiers Media | Frontiers in Microbiology
James B. Shope, Curt D. Storlazzi, Ron Hoeke,
Atoll islands are dynamic features that respond to seasonal alterations in wave conditions and sea level. It is unclear how shoreline wave run-up and erosion patterns along these low elevation islands will respond to projected sea-level rise (SLR) and changes in wave climate over the next century, hindering communities' preparation for the future. To elucidate how these processes may respond to climate change, extreme boreal winter and summer wave conditions under future sea-level rise (SLR) and wave ...
Tópico(s): Ocean Waves and Remote Sensing
2017 - Elsevier BV | Geomorphology
Hoeke A. Baarsma, Mélanie Königshoff,
Chronic lung diseases represent a major public health problem with only limited therapeutic options. An important unmet need is to identify compounds and drugs that target key molecular pathways involved in the pathogenesis of chronic lung diseases. Over the last decade, there has been extensive interest in investigating Wingless/integrase-1 (WNT) signalling pathways; and WNT signal alterations have been linked to pulmonary disease pathogenesis and progression. Here, we comprehensively review the ...
Tópico(s): Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
2017 - BMJ | Thorax