Camila Andrea Guerrero-Bermúdez, Andrés Felipe Cardona-Cardona, Edwin Jesús Ariza-Parra, Juan I. Aróstegui, Anna Mensa‐Vilaró, Jordi Yagüe, Gloria Vásquez, Carlos Horacio Muñoz‐Vahos,
Tópico(s): IgG4-Related and Inflammatory Diseases
2022 - Springer Science+Business Media | Clinical Rheumatology
Juan Villar-Vesga, Camilo Grajales, Catalina Burbano, Adriana Lucía Vanegas-García, Carlos Horacio Muñoz‐Vahos, Gloria Vásquez, Mauricio Rojas, Diana Castaño,
Patients with rheumatoid arthritis (RA) have increased amount of platelet-derived microparticles (PMPs) positive for citrullinated peptides (CPs) that form immune complexes (PMPs-ICs). Monocytes are important inflammatory mediators that play a role in the clearance of PMPs-ICs. We aimed to generate PMPs-ICs in vitro and determine its effect on monocytes from patients with RA and healthy individuals (HI). PMPs from patients showed platelet markers, mitochondria content, and phosphatidylserine exposure ...
Tópico(s): Inflammatory Biomarkers in Disease Prognosis
2018 - Elsevier BV | Cellular Immunology
Catalina Burbano, José A. Gómez‐Puerta, Carlos Horacio Muñoz‐Vahos, Adriana Lucía Vanegas-García, Mauricio Rojas, Gloria Vásquez, Diana Castaño,
Abstract Non‐classical monocytes infiltrate the kidney parenchyma and participate in tissue damage in patients with lupus nephritis (LN). Circulating microparticles (MPs) seem to play critical roles in the activation of monocytes in systemic lupus erythematosus (SLE) patients. This study aims to characterize the phenotypes of MPs and monocyte subsets in LN patients and to determine their potential to discriminate between SLE patients with and without LN. Blood and urine samples from SLE patients were ...
Tópico(s): Renal Diseases and Glomerulopathies
2018 - Wiley | European Journal of Immunology
Carlos Horacio Muñoz‐Vahos, Sebastián Herrera, Álvaro Arbeláez-Cortés, Daniel Jaramillo-Arroyave, Luis Alonso González, G. Vásquez-Duque, Mauricio Restrepo‐Escobar, Luis Alfonso Correa Londoño, Luis Fernando Arias-Restrepo, Adriana Lucía Vanegas-García,
The aims of this study were to describe clinical and laboratory manifestations of patients with levamisole-adulterated cocaine-induced vasculitis/vasculopathy and to propose a skin classification according to the distribution and severity of lesions.We report the characteristics of 30 patients admitted with levamisole-adulterated cocaine-induced vasculitis/vasculopathy in 4 high-complexity institutions in Colombia, from December 2010 to May 2017. We compare our findings with the main published series. ...
Tópico(s): Venomous Animal Envenomation and Studies
2018 - Lippincott Williams & Wilkins | JCR Journal of Clinical Rheumatology
Catalina Burbano, Mauricio Rojas, Carlos Horacio Muñoz‐Vahos, Adriana Lucía Vanegas-García, Luis A. Correa, Gloria Vásquez, Diana Castaño,
Abstract Patients with rheumatoid arthritis (RA) and autoantibodies, such as rheumatoid factor and those against cyclic citrullinated peptides, are designated as seropositive and have a more severe disease with worse prognosis than seronegative RA patients. Understanding the factors that participate in systemic inflammation, in addition to articular commitment, would allow better treatment approaches for prevention of RA comorbidities and disease reactivation. We evaluated whether monocyte subsets ...
Tópico(s): Autoimmune and Inflammatory Disorders Research
2018 - Nature Portfolio | Scientific Reports
Laura Atehortúa, Mauricio Rojas, Gloria Vásquez, Carlos Horacio Muñoz‐Vahos, Adriana Lucía Vanegas-García, Rafael Posada‐Duque, Diana Castaño,
Endothelial activation and damage is commonly observed in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) and is related to development of atherosclerosis and cardiovascular diseases. Different components of the immune system seem to participate in the endothelial injury, such as generation of autoantibodies and formation of immune complexes (ICs). Microparticles (MPs) and their immune complexes (MPs-ICs) are increased in the circulation of patients with SLE and RA; therefore, ...
Tópico(s): Atherosclerosis and Cardiovascular Diseases
2019 - BioMed Central | Arthritis Research & Therapy
Catalina Burbano, Juan Villar-Vesga, Gloria Vásquez, Carlos Horacio Muñoz‐Vahos, Mauricio Rojas, Diana Castaño,
Patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) demonstrate increased circulating microparticles (MP). These vesicles, primarily those that form immune complexes (MP-IC), may activate monocytes. We evaluated the effect of MP and MP-IC in the differentiation of monocytes to macrophages (monocyte-derived macrophages; MDM) and for consequences in autologous lymphocyte activation. Monocytes from healthy controls (HC) and patients with RA and SLE that differentiated into MDM ...
Tópico(s): Immune cells in cancer
2019 - Frontiers Media | Frontiers in Immunology
Luis Alonso González, Jaime Alberto Coral-Enríquez, Mauricio Restrepo‐Escobar, Carlos Horacio Muñoz‐Vahos, Daniel Jaramillo-Arroyave, Adriana Lucía Vanegas-García, Ruth Eraso, Gloria Vásquez, Fabián Jaimes,
Tópico(s): Rheumatoid Arthritis Research and Therapies
2020 - Springer Science+Business Media | Clinical Rheumatology
Tomás Urrego-Callejas, Simón Sandoval Álvarez, Luis Fernando Arias, Blanca Ortiz Reyes, Adriana Lucía Vanegas-García, Luis Alonso González, Carlos Horacio Muñoz‐Vahos, Gloria Vásquez, Luís F. Quintana, José A. Gómez‐Puerta,
Tópico(s): T-cell and B-cell Immunology
2020 - Springer Science+Business Media | Clinical Rheumatology
Héctor Rincón-Arévalo, Mauricio Rojas, Adriana Lucía Vanegas-García, Carlos Horacio Muñoz‐Vahos, Janine Orejuela-Erazo, Gloria Vásquez, Diana Castaño,
Patients with rheumatoid arthritis (RA) may be classified as seropositive or seronegative according to the presence of autoantibodies. An abnormal B cell phenotype and function could be one of the main components of the immunopathology of seropositive patients; however, there is little information regarding B cell defects in these patients. This study shows a broad characterization of the B cell phenotype and function in patients with seropositive RA. We focused mainly on the evaluation of subsets, ...
Tópico(s): T-cell and B-cell Immunology
2021 - Oxford University Press | Clinical & Experimental Immunology
José Luis Arias Gonzáles, Horacio Muñoz Durán,
El presente estudio tuvo como objetivo elaborar y validar una escala para medir la capacidad de liderazgo en un entorno de trabajo remoto. La población estuvo conformada por 556 colaboradores de diez empresas de los sectores educación, textil, telecomunicaciones, consultoría y comercio de las regiones de Lima, Arequipa, Cusco, Puno y Tacna en Perú. El instrumento inicialmente estuvo conformado por 29 reactivos, que pasaron por tres etapas: el juicio de expertos, el alfa de Cronbach y el índice KMO ( ...
Tópico(s): Business, Innovation, and Economy
2021 - Pontifical Catholic University of Peru | Contabilidad y Negocios
David Moisés Severiche Maury, Mauricio Restrepo Escobar, Luis Alonso González Naranjo, A. García, Carlos Horacio Muñoz Vahos, Gloria María Vásquez Duque,
El lupus eritematoso sistémico es una enfermedad autoinmune, multisistémica de etiología desconocida, que afecta principalmente a mujeres en edad reproductiva. Dentro de las manifestaciones más frecuentes se encuentran los compromisos renal e inmunológico; el primero es el responsable de gran parte de la morbimortalidad de los pacientes y el segundo está fuertemente asociado a múltiples manifestaciones clínicas. Analizar la prevalencia y características de las principales manifestaciones clínicas ...
Tópico(s): T-cell and B-cell Immunology
2014 - Elsevier BV | Revista Colombiana de Reumatología
Jesús Horacio, Efrén Muñoz-Narciso, Alan S. Trenhaile, Augusto Pérez Albertí,
Historical air photographs, LiDAR, and an unmanned aerial vehicle (UAV) were used to record the movement, from 1956 to 2018, of a clay and clast earthflow in a coastal valley in northwestern Spain. Two procedures were employed. The first tracked changes, in a GIS environment, in the location of eight, easily identified objects on the surface of the deposit (large boulders, topographic lobes, and the foundations of an old hut). The second used DEMs of Difference (DoDs) based on Digital Elevation Models ...
Tópico(s): Flood Risk Assessment and Management
2019 - Elsevier BV | CATENA
Diana Rodríguez-Vera, Juan Rodrigo Salazar, Marvin A. Soriano‐Ursúa, Jessica Guzmán-Pérez, Arely Vergara‐Castañeda, Horacio Muñoz Durán, Gabriela L. Ramírez-Velez, Alonso Vivar-Sierra, Carlos Rogelio Naranjo-Navarro, Patricia Meza-Meneses, Marco A. Loza-Mejía, Rodolfo Pinto‐Almazán,
Background and Objectives: The development of severe COVID-19 is related to the preexistence of comorbidities and an inadequate nutritional status. The latter is a critical factor for the development of infection and the progression of the disease. Notably, optimal nutrition impacts immune system function, as malnutrition is related to high cytokine levels in the late phase of the disease, correlating with a poor prognosis. In this sense, omega-3 fatty acids (O3FAs) have anti-inflammatory properties ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2024 - Multidisciplinary Digital Publishing Institute | Diseases
Ricardo Ramírez-Barrantes, Claudio Córdova, Horacio Poblete, Pablo Muñoz, Ivanny Marchant, Florence Wianny, Pablo Olivero,
The development of new strategies to renew and repair neuronal networks using neural plasticity induced by stem cell graft could enable new therapies to cure diseases that were considered lethal until now. In adequate microenvironment a neuronal progenitor must receive molecular signal of a specific cellular context to determine fate, differentiation, and location. TRPV1, a nonselective calcium channel, is expressed in neurogenic regions of the brain like the subgranular zone of the hippocampal ...
Tópico(s): Plant and Biological Electrophysiology Studies
2016 - Hindawi Publishing Corporation | Neural Plasticity
Produção Nacional
Revisado por pares
Araceli Lorena Montes-Dominguez, Jesus Arian Avena-Soto, Jorge Luis Lizarraga-Rodriguez, Rodrigo de Jesus Perez-Gala, Stephanie Jimenez-Gutierrez, Jesus Alberto Sotelo-Falomir, Fernando Marino Pinzon-Miranda, Francisco Martínez‐Pérez, Horacio A. Muñoz-Rubí, Darío Chávez-Herrera, Laura Rebeca Jiménez-Gutiérrez,
Shrimp fisheries are among the most important fisheries worldwide, and shrimp culture has increased considerably in recent years. Most current studies on reproduction-related genes have been conducted on cultured shrimp. However, gene expression is intimately linked to physiological and environmental conditions, and therefore an organism’s growth environment has a great influence on reproduction. Thus, gene expression profiling, should be applied in fisheries studies. Here, we identified the expression ...
Tópico(s): Marine Bivalve and Aquaculture Studies
2021 - PeerJ, Inc. | PeerJ
Cora Stoker, Pablo M. Beldoménico, Verónica L. Bosquiazzo, Marcelo A. Zayas, Florencia Rey, Horacio A. Rodríguez, Mónica Muñoz‐de‐Toro, Enrique H. Luque,
Human and wildlife are exposed at critical periods of development to endocrine disruptor chemicals (EDC) that may be responsible for reproductive disorders. To test the hypothesis that in ovum exposure to EDC at a critical period for gonadal organogenesis alters post-hatching folliculogenesis and steroidogenesis in Caiman latirostris, we studied the impact of in ovum exposure to 17 beta-estradiol (E2), bisphenol A (BPA), endosulfan (END) and atrazine (ATZ) on gonadal differentiation, follicular dynamics ...
Tópico(s): Sperm and Testicular Function
2008 - Elsevier BV | General and Comparative Endocrinology
José Arturo de Juan, Horacio López‐Córcoles, R. Muñoz, M. R. Picornell,
This study was conducted to evaluate yield and yield components of saffron (Crocus sativus L.) in response to (i) production system (PS) (irrigated vs. non-irrigated); (ii) corm size (CS) (medium −2.25 to 3 cm diameter vs. small corms <2.25 cm diameter); (iii) planting depth (PD) (10 cm vs. 20 cm); and iv) planting density (PDEN) (51 corms m−2 vs. 69 corms m−2). This fully replicated multifactorial design was started in August 2000, and carried through November 2003, when the fourth saffron harvest took place. ...
Tópico(s): Saffron Plant Research Studies
2009 - Elsevier BV | Industrial Crops and Products
Horacio Reyes, Blanca M. Munõz, Norberto Farfán, Rosa Santillán, Susana Rojas‐Lima, Pascal G. Lacroix, Keitaro Nakatani,
A series of eighteen new 'push–pull' molecules obtained by self-assembly of salicylideniminophenols and various phenylboronic acids is reported. Electric field-induced second-harmonic measurements of the nonlinear optical response reveal that the nature of the phenylboron moieties has a modest influence on the molecular hyperpolarizabilities (β). The crystal data available suggest the possibility of easy rotation of the phenyl substituents, with an energy barrier around 10 kcal mol−1, while a computational ...
Tópico(s): Crystal structures of chemical compounds
2002 - Royal Society of Chemistry | Journal of Materials Chemistry
Oscar E. Rivera, Jorgelina Varayoud, Horacio A. Rodríguez, Mónica Muñoz‐de‐Toro, Enrique H. Luque,
We hypothesized that neonatal xenoestrogen exposure affects the ovarian follicular dynamics in lambs. Female lambs were exposed from postnatal day (PND) 1–14 to low doses of diethylstilbestrol (DES) or bisphenol A (BPA). At PND 30, the follicular dynamics and ovarian biomarkers (ERα, ERβ, AR, Ki67, p27) were evaluated. Lambs exposed to DES or BPA showed a decline in the stock of primordial follicles with stimulation of follicular development. BPA reduced ovarian weight and increased the number of multioocyte ...
Tópico(s): Toxic Organic Pollutants Impact
2011 - Elsevier BV | Reproductive Toxicology
Verónica L. Bosquiazzo, Milena Durando, Jorgelina Varayoud, Jorge G. Ramos, Horacio A. Rodríguez, Mónica Muñoz‐de‐Toro, Enrique H. Luque,
The uterine cervix at term undergoes histomorphological changes that resemble an inflammatory process. The aim of this study was to better characterize these changes, describing the temporal and spatial pattern of macrophages and mast cells (MC) distribution in the uterine cervix and assessing whether both cells exert a coordinated action on angiogenesis. Macrophages and MC were identified by immunohistochemistry in cervical tissue from cycling, pregnant and postpartum rats. In order to inhibit MC ...
Tópico(s): Pregnancy-related medical research
2005 - Elsevier BV | Journal of Reproductive Immunology
Enrique H. Luque, Jorge G. Ramos, Horacio A. Rodríguez, Mónica Muñoz‐de‐Toro,
Previous studies have demonstrated that during parturition the physiological ripening that permits dilation of the cervical canal is due to a widespread collagenolysis that follows a heavy polymorphonuclear leukocyte invasion of the uterine cervix. The aim of this study was to investigate whether there is any association between the ovarian steroid hormones involved in rat parturition and this phenomenon. Pregnant or pseudopregnant rats were ovariectomized (OVX) at Day 9 and then given a hormonal ...
Tópico(s): Pregnancy-related medical research
1996 - Oxford University Press | Biology of Reproduction
Norma Moreno-Méndoza, Joaquín Herrera-Muñoz, Horacio Merchant‐Larios,
Mesonephric stromal cells have previously been shown to migrate into the genital ridge and to be necessary for seminiferous cord formation in organ culture. Here, we asked Whether there is a specific requirement for mesonephric stromal cells or whether another source of mesonephric stromal cells can be substituted. Hindlimb buds were immersed in a vital stain and then grafted to male gonad primordia and cultured for 96 hr. Immunocytochemical staining of laminin was used to identify seminiferous ...
Tópico(s): Urological Disorders and Treatments
1995 - Elsevier BV | Developmental Biology
Juan José Hernández Morante, Inmaculada Díaz Soler, Joaquín S. Galindo Muñoz, Horacio Pérez‐Sánchez, Ma del Carmen Barberá Ortega, Carlos Martínez, Juana Ma Morillas Ruiz,
Obesity is characterized by a resistance to appetite-regulating hormones, leading to a misalignment between the physiological signals and the perceived hunger/satiety signal. A disruption of the synthesis rhythm may explain this situation. The aim of this study was to evaluate the effect of dietary-induced weight loss on the daily rhythms of leptin and ghrelin and its influence on the daily variability of the appetite sensations of patients with obesity. Twenty subjects with obesity underwent a ...
Tópico(s): Dietary Effects on Health
2020 - Multidisciplinary Digital Publishing Institute | Nutrients
César U. Monjarás-Ávila, Ana C. Lorenzo‐Leal, Ana C. Luque-Badillo, Ninadh M. D’Costa, Claudia Chávez‐Muñoz, Horacio Bach,
Clear cell renal cell carcinoma (ccRCC) is a type of kidney cancer that arises from the cells lining the tubes of the kidney. The tumor immune microenvironment (TIME) of ccRCC is a complex interplay of various immune cells, cytokines, and signaling pathways. One of the critical features of the ccRCC TIME is the presence of infiltrating immune cells, including T cells, B cells, natural killer cells, dendritic cells, and myeloid-derived suppressor cells. Among these cells, CD8+ T cells are particularly ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2023 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
José L. Sánchez-Gloria, Constanza Estefanía Martínez-Olivares, Pedro Rojas‐Morales, Rogelio Hernández‐Pando, Roxana Carbó, Iván Rubio-Gayosso, Abraham S. Arellano‐Buendía, Karla M. Rada, Fausto Sánchez‐Muñoz, Horacio Osorio‐Alonso,
Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling. Recent evidence supports that inflammation plays a key role in triggering and maintaining pulmonary vascular remodeling. Recent studies have shown that garlic extract has protective effects in PAH, but the precise role of allicin, a compound derived from garlic, is unknown. Thus, we used allicin to evaluate its effects on inflammation and fibrosis in PAH. Male Wistar rats were divided into three groups: control ( ...
Tópico(s): Gout, Hyperuricemia, Uric Acid
2021 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Johanna Pedroza Díaz, Carlos Horacio Muñoz Vahos, Tania Paola Luján Chavarría, Gloria María Vásquez Duque, Blanca Lucía Ortiz Reyes,
El diagnóstico de lupus eritematoso sistémico neuropsiquiátrico (LES-NP) se basa en las características clínicas, utilizando la nomenclatura y descripción de caso del Colegio Americano de Reumatología 1999; sin embargo, la falta de especificidad de estos síndromes hacen difícil el diagnóstico. Identificar moléculas en perfiles proteicos del líquido cefalorraquídeo de pacientes con LES-NP, con expresión diferencial, que podrían utilizarse como biomarcadores para el diagnóstico. Se utilizaron 26 muestras ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2014 - Elsevier BV | Revista Colombiana de Reumatología
Francisco Javier Pérez Lara, Juan Manuel Carmona, Arturo Del Rey Moreno, H. Oliva Muñoz,
... D.; del Rey Moreno, Arturo M.D.; Oliva Munoz, Horacio M.D. Author Information
Tópico(s): Biliary and Gastrointestinal Fistulas
2014 - Lippincott Williams & Wilkins | Diseases of the Colon & Rectum
... stocks used in these studies, and to Juan Munoz, Ted Walter, and Horacio Pacagnini, former graduate assistants, for their part in ... stocks used in these studies, and to Juan Munoz, Ted Walter, and Horacio Pacagnini, former graduate assistants, for their part in ...
Tópico(s): Rice Cultivation and Yield Improvement
1965 - Wiley | Crop Science
Luis Savastano, Analía E. Castro, Marcos René Fitt, Martin F. Rath, Horacio E. Romeo, Estela M. Muñoz,
Superior cervical ganglionectomy (SCGx) is a valuable microsurgical model to study the role of the sympathetic nervous system in a vast array of physiological and pathological processes, including homeostatic regulation, circadian biology and the dynamics of neuronal dysfunction and recovery after injury. Despite having several experimental applications in the rat, a thorough description of a standardized procedure has never been published. Here, we provide a brief review of the principal features ...
Tópico(s): Heart Rate Variability and Autonomic Control
2010 - Elsevier BV | Journal of Neuroscience Methods