Qi Xie, Min-Yi Wu, Ding-Xuan Zhang, Yi Yang, Bao-Shuai Wang, Jing Zhang, Jin Xu, Weide Zhong, Jia‐Ni Hu,
To investigate the anticancer effect of a recombinant adenovirus-mediated p53 (rAd-p53) combined with 5-fluorouracil (5-FU) in human colon cancer resistant to 5-FU in vivo and the mechanism of rAd-p53 in reversal of 5-FU resistance.Nude mice bearing human colon cancer SW480/5-FU (5-FU resistant) were randomly assigned to four groups (n = 25 each): control group, 5-FU group, rAd-p53 group, and rAd-p53 + 5-FU group. At 24 h, 48 h, 72 h, 120 h and 168 h after treatment, 5 mice were randomly selected from each ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2016 - Baishideng Publishing Group | World Journal of Gastroenterology
Fanchi Li, Min Ni, Hua Zhang, Binbin Wang, Kaizun Xu, Jianghai Tian, Jingsheng Hu, Weide Shen, Bing Li,
Silkworm (Bombyx mori) is an important economic insect and a model species for Lepidopteran. Each year, O,O-diethyl O-(alpha-cyanobenzylideneamino) phosphorothioate (phoxim) pesticide poisoning in China results in huge economic losses in sericulture. Silkworm fat body is the main organ for nutrient storage, energy supply, intermediary metabolism, and detoxification. Microarray analysis of silkworm Cytochrome P450 detoxification enzyme genes revealed that all tested P450 4 (CYP4) family genes are expressed ...
Tópico(s): Insect-Plant Interactions and Control
2014 - Elsevier BV | Pesticide Biochemistry and Physiology
Qing Sun, Fan Wang, Wei Li, Weide Li, Yang-Chun Hu, Li Song, Jianhong Zhu, Meng‐Liang Zhou, Chun‐Hua Hang,
Subarachnoid hemorrhage usually results in poor clinical outcome and devastating neurological deficits. The early brain injury and delayed vasospasm after subarachnoid hemorrhage (SAH) are involved in the poor prognosis to the patients, while the mechanisms have not been well elucidated. Previous studies found an up-regulation of Toll-like receptor 4 (TLR4), inflammatory factors and high-mobility group box 1 (HMGB1) in the cortex after SAH. Increased inflammatory response contributes to the early brain ...
Tópico(s): Intracranial Aneurysms: Treatment and Complications
2013 - Elsevier BV | Medical Hypotheses
Junju Su, Bing Li, Cheng Shen, Zhou Zhu, Xuezi Sang, Suxin Gui, Yi Xie, Qingqing Sun, Zhe Cheng, Jie Cheng, Rengping Hu, Weide Shen, Qingyou Xia, Ping Zhao, Fashui Hong,
Phoxim (O,O-diethyl O-(alpha-cyanobenzylideneamino) phosphorothioate) is a powerful organophosphorus pesticide with high potential for Bombyx mori larvae of silkworm exposure. However, it is possible that during the phoxim metabolism, there is generation of reactive oxygen species (ROS) and phoxim may produce oxidative stress and neurotoxicity in an intoxicated silkworm. Titanium dioxide nanoparticles (TiO2 NPs) pretreatment has been demonstrated to increase antioxidant capacity and acetylcholinesterase ( ...
Tópico(s): Insect Pest Control Strategies
2013 - Wiley | Environmental Toxicology
Bin Kang, Daming He, Lisa Perrett, Hongyuan Wang, Wenxian Hu, Weide Deng, Yunfei Wu,
Tópico(s): Fish biology, ecology, and behavior
2009 - Springer Science+Business Media | Reviews in Fish Biology and Fisheries
Deng-Hu Wang, Yunsheng Hu, Junjie Du, Yunyu Hu, Weide Zhong, Weijun Qin,
Tópico(s): Adipose Tissue and Metabolism
2008 - Springer Science+Business Media | Endocrine
Raoul C. Reulen, Stefan de Vogel, Weide Zhong, Zhaohui Zhong, Liping Xie, Zhiquan Hu, Yilan Deng, Kai Yang, Yuxiang Liang, Xing Zeng, Yong Chuan Wong, Po‐Chor Tam, Marjolein Hemelt, Maurice P. Zeegers,
Recent meta-analyses have suggested a modest protective effect of high levels of physical activity on developing both prostate and bladder cancer, but significant heterogeneity between studies included in these meta-analyses existed. To our knowledge, few Chinese studies investigated the association between physical activity and prostate cancer and none between physical activity and bladder cancer. Given the inconsistencies between previous studies and because studies on the relation between physical ...
Tópico(s): Bladder and Urothelial Cancer Treatments
2017 - Public Library of Science | PLoS ONE
Binbin Wang, Fanchi Li, Min Ni, Hua Zhang, Kaizun Xu, Jianghai Tian, Jingsheng Hu, Weide Shen, Bing Li,
Abstract CeCl 3 can reduce the damage caused by OP pesticides, in this study we used the brain of silkworms to investigate the mechanism of CeCl 3 effects on pesticide resistance. The results showed that phoxim treatments led to brain damages, swelling and death of neurons, chromatin condensation and mitochondrial damage. Normal nerve conduction was severely affected by phoxim treatments, as revealed by: increases in the contents of neurotransmitters Glu, NO and ACh by 63.65%, 61.14% and 98.54%, ...
Tópico(s): Environmental Toxicology and Ecotoxicology
2015 - Nature Portfolio | Scientific Reports
Yangyang Li, Min Ni, Fanchi Li, Hua Zhang, Kaizun Xu, Xiaoming Zhao, Jianghai Tian, Jingsheng Hu, Binbin Wang, Weide Shen, Bing Li,
Tópico(s): Insect Resistance and Genetics
2015 - Springer Science+Business Media | Biological Trace Element Research
Min Ni, Fanchi Li, Binbin Wang, Kaizun Xu, Hua Zhang, Jingsheng Hu, Jianghai Tian, Weide Shen, Bing Li,
Tópico(s): Insect and Arachnid Ecology and Behavior
2014 - Springer Science+Business Media | Biological Trace Element Research
Bing Li, Xiaohong Yu, Suxin Gui, Yi Xie, Xiaoyang Zhao, Jie Hong, Qingqing Sun, Xuezi Sang, Lei Sheng, Zhe Cheng, Jie Cheng, Rengping Hu, Ling Wang, Weide Shen, Fashui Hong,
Phoxim is a useful organophosphate (OP) pesticide used in agriculture in China, however, exposure to this pesticide can result in a significant reduction in cocooning in Bombyx mori (B. mori). Titanium dioxide nanoparticles (TiO2 NPs) have been shown to decrease phoxim-induced toxicity in B. mori; however, very little is known about the molecular mechanisms of silk gland damage due to OP exposure and repair of gland damage by TiO2 NP pretreatment. In the present study, exposure to phoxim resulted in ...
Tópico(s): Viral Infectious Diseases and Gene Expression in Insects
2013 - Elsevier BV | Chemosphere
Xiangjun Meng, Qiwu Mi, Tao Hu, Weide Zhong,
To evaluate the clinical value of computed tomography angiography (CTA) in reducing the risk of hemorrhage associated with mini-percutaneous nephrolithotomy (PCNL).A total of 158 patients with renal or ureter stones who had undergone mini-percutaneous nephrolithotomy were retrospectively enrolled into this study from May of 2011 to April of 2014. Group 1 (65 patients) underwent computed tomography angiography, and Group 2 (93 patients) underwent non-contrast CT. The clinical characteristics of the patients ...
Tópico(s): Dialysis and Renal Disease Management
2015 - Sociedade Brasileira de Urologia | International braz j urol
Sijin Liu, Cai Zi-wei, Yajun Liu, Meiyu Dong, Liqiu Sun, Guo-Fa Hu, Ying-Yun Wei, Weide Lao,
To examine the role of nucleostemin in the growth regulation of gastric cancer, liver cancer and other cancers.RT-PCR was used to clone the fragment of nucleostemin cDNA from HEK 293 cells. Eighteen kinds of malignant tumor tissues including gastric adenocarcinoma and liver cancer tissues, 3 kinds of benign tumor tissues, 3 kinds of benign hyperplastic tissues and normal tissues were employed to examine nucleostemin gene expression by RT-PCR, Slot blot, Northern blot and in situ hybridization.We ...
Tópico(s): RNA Interference and Gene Delivery
2004 - Baishideng Publishing Group | World Journal of Gastroenterology
Menghao Liu, Jun Zhang, Chenxu Zhu, Xiaoxue Zhang, Weide Xiao, Yongchang Yan, Lulu Liu, Hu Zeng, Yi Qin Gao, Chengqi Yi,
Abstract DNA glycosylases must distinguish the sparse damaged sites from the vast expanse of normal DNA bases. However, our understanding of the nature of nucleobase interrogation is still limited. Here, we show that hNEIL1 (human endonuclease VIII-like 1) captures base lesions via two competing states of interaction: an activated state that commits catalysis and base excision repair, and a quarantine state that temporarily separates and protects the flipped base via auto-inhibition. The relative ...
Tópico(s): Bacterial Genetics and Biotechnology
2021 - Nature Portfolio | Nature Communications
Bing Li, Yi Xie, Zhe Cheng, Jie Cheng, Rengping Hu, Yaling Cui, Xiaolan Gong, Weide Shen, Fashui Hong,
Tópico(s): Physiological and biochemical adaptations
2011 - Springer Science+Business Media | Biological Trace Element Research
Zihan Hao, Weide Li, Jinran Wu, Shaotong Zhang, Shujuan Hu,
As one of the critical indicators of the lake ecosystem, the lake surface water temperature is an important indicator for measuring lake ecological environment. However, there is a complex nonlinear relationship between lake surface water temperature and climate variables, making it difficult to accurately predict. Fortunately, satellite remote sensing provides a wealth of data to support further improvements in prediction accuracy. In this paper, we construct a new deep learning model for mining ...
Tópico(s): Flood Risk Assessment and Management
2023 - Multidisciplinary Digital Publishing Institute | Remote Sensing
Yukai Zheng, Weide Fu, Rencheng Zhu, Zhanbo Hu, Gang Chen, Xin‐Sheng Chai,
This paper reported a novel method for the determination of total phosphorus (TP) content in soil and sludge by a headspace gas chromatography (HS-GC) method. It was based on a reaction between the soluble phosphate in the digestion solution and calcium oxalate solid to form a calcium phosphate precipitate and release oxalate ions, which can react with permanganate to form carbon dioxide, which was then measured by HS-GC. The results showed the complete conversion of phosphate (meanwhile to free oxalate ...
Tópico(s): Wastewater Treatment and Nitrogen Removal
2019 - Royal Society of Chemistry | RSC Advances
Fanchi Li, Jingsheng Hu, Jianghai Tian, Kaizun Xu, Min Ni, Binbin Wang, Weide Shen, Bing Li,
Silkworm (Bombyx mori) is an important economic insect. Each year, poisoning caused by phoxim pesticide leads to huge economic losses in sericulture in China. Silkworm midgut is the major organ for food digestion and nutrient absorption. In this study, we found that the activity and expression of nutrition metabolism-related enzymes were dysregulated in midgut by phoxim exposure. DGE analysis revealed that 40 nutrition metabolism-related genes were differentially expressed. qRT-PCR results indicated ...
Tópico(s): Insect Resistance and Genetics
2015 - Elsevier BV | Chemosphere
Qing Sun, Wei Wu, Yang-Chun Hu, Hua Li, Dingding Zhang, Song Li, Wei Li, Weide Li, Biao Ma, Jianhong Zhu, Meng‐Liang Zhou, Chun‐Hua Hang,
Translocation of high-mobility group box 1 (HMGB1) from nucleus could trigger inflammation. Extracellular HMGB1 up-regulates inflammatory response in sepsis as a late mediator. However, little was known about its role in subarachnoid hemorrhage-inducible inflammation, especially in the early stage. This study aims to identify whether HMGB1 translocation occurred early after SAH and also to clarify the potential role of HMGB1 in brain injury following SAH. Sprague-Dawley (SD) rats were randomly divided ...
Tópico(s): S100 Proteins and Annexins
2014 - BioMed Central | Journal of Neuroinflammation
Qiongzhu Dong, Xiaofei Zhang, Yue Zhao, Hu‐Liang Jia, Haijun Zhou, Chun Dai, Haijing Sun, Yi Qin, Weide Zhang, Ning Ren, Qing‐Hai Ye, Lun‐Xiu Qin,
Osteopontin (OPN) plays a crucial role in hepatocellular carcinoma (HCC) metastasis. However, little is known about the impact of OPN polymorphisms on cancer progression. In this study, we first identified the single nucleotide polymorphisms (SNPs) in the OPN promoter region by direct sequencing in 30 HCCs, and then evaluated the prognostic values of the selected ones in two large cohorts of 826 HCC patients. The identified SNPs were functionally analyzed using in vitro and in vivo assays and their ...
Tópico(s): dental development and anomalies
2012 - Lippincott Williams & Wilkins | Hepatology
Li Wang, Lei Jiang, Dongyan Pan, Qinghua Wang, Zeyu Yin, Zijian Kang, Haoran Tian, Xuqiang Geng, Jinsong Shao, Wenjie Pan, Jian Yin, Fang Li, Yue Wang, Weide Zhang, Zhixiu Li, Jun Zheng, Wenxin Hu, Yunbao Pan, Dong Yu, Shicheng Guo, Wei Lu, Qiang Li, Yunyun Zhou, Huji Xu,
The impact of COVID-19 on public health has mandated an 'all hands on deck' scientific response. The current clinical study and basic research on COVID-19 are mainly based on existing publications or our knowledge of coronavirus. However, efficiently retrieval of accurate, relevant knowledge on COVID-19 can pose significant challenges for researchers. To improve quality in accessing important literature findings, we developed a novel natural language processing (NLP) method to automatically recognize ...
Tópico(s): Artificial Intelligence in Healthcare
2022 - Elsevier BV | Biomedical Journal
Yuan-jun Shao, Xian-qiong Hu, Guang-da Peng, Ruixian Wang, Rui-na Gao, Chao Lin, Weide Shen, Rui Li, Bing Li,
Tópico(s): Entomopathogenic Microorganisms in Pest Control
2012 - Springer Nature | Molecular Biology Reports
Zhiya Gu, Fanchi Li, Jingsheng Hu, Chao Ding, Chaoqian Wang, Jianghai Tian, Bin Xue, Kaizun Xu, Weide Shen, Bing Li,
Silkworm (Bombyx mori) is an economically important insect. It is relatively less resistant to certain chemicals and environment exposures such as pesticides and pathogens. After pesticide exposures, the silkworms are more susceptible to microbial infections. The mechanism underlying the susceptibility might be related to immune response and oxidative stress.A sublethal dose of phoxim combined with Bombyx mori nucleopolyhedrovirus (BmNPV) elevated the silkworm mortality at 96 h. We found a higher ...
Tópico(s): Insect and Pesticide Research
2016 - Wiley | Pest Management Science
Yang-Chun Hu, Qing Sun, Wei Li, Dingding Zhang, Biao Ma, Song Li, Weide Li, Meng‐Liang Zhou, Chun‐Hua Hang,
Tópico(s): S100 Proteins and Annexins
2013 - Springer Science+Business Media | Inflammation Research
Bing Li, Yi Xie, Zhe Cheng, Jie Cheng, Rengping Hu, Xuezi Sang, Suxin Gui, Qingqing Sun, Xiaolan Gong, Yaling Cui, Weide Shen, Fashui Hong,
Tópico(s): Insect Utilization and Effects
2012 - Springer Science+Business Media | Biological Trace Element Research
Bing Li, Yi Xie, Zhe Cheng, Jie Cheng, Rengping Hu, Suxin Gui, Xuezi Sang, Qingqing Sun, Xiaoyang Zhao, Lei Sheng, Weide Shen, Fashui Hong,
Tópico(s): Silk-based biomaterials and applications
2012 - Springer Science+Business Media | Biological Trace Element Research
Min Ni, Fanchi Li, Jianghai Tian, Jingsheng Hu, Hua Zhang, Kaizun Xu, Binbin Wang, Yangyang Li, Weide Shen, Bing Li,
Tópico(s): Insect Resistance and Genetics
2015 - Springer Science+Business Media | Biological Trace Element Research
Weide Fu, Rencheng Zhu, Huanyun Lin, Yukai Zheng, Zhanbo Hu,
Abstract The effects of different concentrations of organic matter on the biological activity and nitrogen removal performance of the anaerobic ammonium oxidation (anammox) system was studied. The results showed that under the conditions of low influent total organic carbon (TOC ≤ 100 mg/L), the activity rate of anammox bacteria was basically unaffected, the anammox bacteria and denitrifying bacteria formed a good synergistic effect, and the maximum total nitrogen (TN) removal efficiency reached 95.77%. ...
Tópico(s): Water Treatment and Disinfection
2021 - Pergamon Press | Water Science & Technology
Jianmei Tian, Jingsheng Hu, F. C. Li, Min Ni, Yangmeina Li, B. B. Wang, Kai Xu, Weide Shen, Bing Li,
Silkworm (Bombyx mori) is an important economic insect with a fat body that plays a crucial role in the storage and transfer of nutrients. It is also known that TiO2 nanoparticles (NPs) can improve feed efficiency and promote silk protein synthesis in the silkworm. In this study, we profiled gene expression in the silkworm fat body after TiO2 NP treatment, validated the major RNA-seq findings, and determined the contents of trehalose and triglyceride, the activity of lipase, and the amount of total ...
Tópico(s): Insect Utilization and Effects
2016 - The Company of Biologists | Biology Open
Jianguo Zhu, Yuxiang Liang, Weihong Chen, Shuxiong Xu, Yuanlin Wang, Jianxing Hu, Hui‐chan He, Weide Zhong, Zhaolin Sun,
Objective To evaluate the clinical efficiency of alpha1-adrenergic antagonists on stentless ureteroscopic lithotripsy treating uncomplicated lower ureteral stones. Materials and Methods From January 2007 to January 2013, 84 patients who have uncomplicated lower ureteral stones treated by ureteroscopic intracorporeal lithotripsy with the holmium laser were analyzed. The patients were divided into two groups, group A (44 patients received indwelled double-J stents) and group B (40 patients were treated ...
Tópico(s): Pediatric Urology and Nephrology Studies
2016 - Sociedade Brasileira de Urologia | International braz j urol