Jaime Alioscha Cuervo-Parra, Víctor Hugo Pérez-España, Ernesto A. Zavala‐González, Martín Peralta-Gil, José Esteban Aparicio-Burgos, Teresa Romero‐Cortés,
Globally, corn is the most economically important crop, surpassing crops such as wheat, rice and barley. However, the presence of pathogenic fungi associated with corn, have favoured the appearance of diseases that cause economic loss. Therefore, the aim of the present study is to assess the efficacy of treatments in vitro and in vivo with Trichoderma asperellum in controlling the disease severity and the yield reduction in corn plants caused by Fusarium verticillioides and Ustilago maydis. In vitro ...
Tópico(s): Mycotoxins in Agriculture and Food
2022 - Taylor & Francis | Biocontrol Science and Technology
Joseph Pidala, J Kim, Claudio Anasetti, M A Kharfan-Dabaja, Teresa Field, Janelle Perkins, Ernesto Ayala, Lia Perez, Hugo F. Fernández,
Myeloablative doses of BU and fludarabine followed by allogeneic hematopoietic cell transplantation offer effective therapy for AML. We anticipated that pharmacokinetic targeting of i.v. BU to 5300 μ/L min/day × 4 (targeted i.v. BU and fludarabine (t-i.v. BU/Flu)) would limit nonrelapse mortality (NRM) in adults up to 70 years of age. We assessed the safety and efficacy of t-i.v. BU/Flu in a series of 100 adults (median age 48, range 22–69 years) with AML in the first CR (CR1) with high risk of treatment ...
Tópico(s): Acute Lymphoblastic Leukemia research
2010 - Springer Nature | Bone Marrow Transplantation
Janelle Perkins, Teresa Field, J Kim, M A Kharfan-Dabaja, Ernesto Ayala, Lia Perez, Hugo F. Fernández, Karen Fancher, Cheryl Tate, Leslie M. Shaw, Michael C. Milone, JoAnn Gardiner, S.M. Miller, Claudio Anasetti,
Tópico(s): Hematopoietic Stem Cell Transplantation
2010 - Springer Nature | Bone Marrow Transplantation
J. Alejandro Morales, Román Saldaña, Manuel H. Santana-Castolo, Carlos E. Torres-Cerna, Ernesto Borrayo, Adriana P. Mendizábal, Hugo Vélez‐Pérez, Gerardo Mendizabal‐Ruiz,
Genomic signal processing (GSP) is based on the use of digital signal processing methods for the analysis of genomic data. Convolutional neural networks (CNN) are the state-of-the-art machine learning classifiers that have been widely applied to solve complex problems successfully. In this paper, we present a deep learning architecture and a method for the classification of three different functional genome types: coding regions (CDS), long noncoding regions (LNC), and pseudogenes (PSD) in genomic data, ...
Tópico(s): Machine Learning in Bioinformatics
2020 - Hindawi Publishing Corporation | Mathematical Problems in Engineering
Ernesto Borrayo, Gerardo Mendizabal‐Ruiz, Hugo Vélez‐Pérez, Rebeca Romo‐Vázquez, Adriana P. Mendizábal, J. Alejandro Morales,
Genomic signal processing (GSP) refers to the use of digital signal processing (DSP) tools for analyzing genomic data such as DNA sequences. A possible application of GSP that has not been fully explored is the computation of the distance between a pair of sequences. In this work we present GAFD, a novel GSP alignment-free distance computation method. We introduce a DNA sequence-to-signal mapping function based on the employment of doublet values, which increases the number of possible amplitude values ...
Tópico(s): Genomics and Phylogenetic Studies
2014 - Public Library of Science | PLoS ONE
R. Amador, Alicia Polanco, Hugo Hernández, Ernesto Pérez, Agnes Nagy,
A compensation circuit has been developed to reduce the VBE wafer spread of a bipolar transistor by taking advantage of the correlation between pinched base resistor RP and IS of the Ebers-Moll model. This compensation circuit was used in the design of a Celsius temperature sensor with intrinsic reference, improving its accuracy at least five times within the 0 °C to 100 °C interval. Accuracy has been calculated considering wafer level statistical modeling of bipolar IC parameters, circuit sensitivity, ...
Tópico(s): Advanced Sensor Technologies Research
1998 - Elsevier BV | Sensors and Actuators A Physical
Joseph Pidala, Marcie Tomblyn, Taiga Nishihori, Ernesto Ayala, Teresa Field, Hugo F. Fernández, Lia Perez, Fred Locke, Melissa Alsina, José L. Ochoa, Janelle Perkins, Cheryl Tate, Jamie Shapiro, Michelle Conwell, Ryan Bookout, Claudio Anasetti,
Severe acute graft-versus-host disease (aGVHD) remains a major source of morbidity and mortality following mismatched unrelated donor hematopoietic cell transplantation (HCT). Through a retrospective analysis, we investigated the efficacy of GVHD prophylaxis with rabbit anti-thymocyte globulin (ATG) 7.5 mg/kg (1 mg/kg given on day -3, then 3.25 mg/kg/day on days -2 and -1 before stem cell infusion) followed by standard tacrolimus plus methotrexate in a consecutive series of 45 HLA partially matched unrelated ...
Tópico(s): T-cell and B-cell Immunology
2011 - Elsevier BV | Biology of Blood and Marrow Transplantation
Janelle Perkins, Jongphil Kim, Claudio Anasetti, Hugo F. Fernández, Lia Perez, Ernesto Ayala, Mohamed A. Kharfan‐Dabaja, Marcie Tomblyn, Daniel M. Sullivan, Joseph A. Pidala, Teresa Field,
Systemic exposure to high-dose busulfan has been correlated with efficacy and toxicity after hematopoietic cell transplantation for malignancy. We used the area under the concentration-time curve (AUC) to prospectively determine the maximally tolerated systemic exposure to i.v. busulfan when given once daily after fludarabine administered at 40 mg/m2 for 4 days. Three target AUC levels were planned: 6,000, 7,500, and 9,000 μM-min. Included were patients 16 to 65 years old, with a hematologic malignancy, ...
Tópico(s): Multiple Myeloma Research and Treatments
2011 - Elsevier BV | Biology of Blood and Marrow Transplantation
Joseph Pidala, Jongphil Kim, Teresa Field, Ali McBride, Mohamed A. Kharfan‐Dabaja, Janelle Perkins, Hugo F. Fernández, Lia Perez, Ernesto Ayala, Claudio Anasetti,
Infliximab has demonstrated activity in the treatment of steroid-refractory acute graft-versus-host disease (aGVHD). We aimed to confirm the effectiveness of infliximab as a salvage therapy for steroid-refractory aGVHD. In a series of 52 patients, 71% of whom had grade III-IV aGVHD, only 15% achieved complete remission (CR) with the use of infliximab alone as salvage therapy. CR of aGVHD differed according to overall aGVHD grade at salvage (grade II, 5/15; grade III, 2/17; grade IV, 1/20; P=.03). Median ...
Tópico(s): Virus-based gene therapy research
2009 - Elsevier BV | Biology of Blood and Marrow Transplantation
Joseph Pidala, J Kim, Janelle Perkins, Teresa Field, Hugo F. Fernández, Lia Perez, Ernesto Ayala, M A Kharfan-Dabaja, Claudio Anasetti,
Tópico(s): Immune Cell Function and Interaction
2009 - Springer Nature | Bone Marrow Transplantation
Jorge E. Rivera‐Salinas, Karla M. Gregorio‐Jáuregui, Antonio Romero‐Serrano, Alejandro Cruz‐Ramírez, Ernesto Hernández‐Hernández, Argelia Fabiola Miranda Pérez, Víctor Hugo Gutiérrez Pérez,
Although the porosity in Al-SiC metal matrix composites (MMC) can be diminished; its existence is unavoidable. The purpose of this work is to study the effect of porosity on Young’s modulus of SiC reinforced aluminum matrix composites. Finite element analysis is performed based on the unit cell and the representative volume element approaches. The reliability of the models is validated by comparing the numerical predictions against several experimental data ranging in low- and high-volume fractions ...
Tópico(s): Aluminum Alloy Microstructure Properties
2020 - Multidisciplinary Digital Publishing Institute | Metals
Janelle Perkins, Teresa Field, Jongphil Kim, Mohamed A. Kharfan‐Dabaja, Hugo F. Fernández, Ernesto Ayala, Lia Perez, XU Mian, Melissa Alsina, Leonel Ochoa, Daniel M. Sullivan, William E. Janssen, Claudio Anasetti,
Tacrolimus (Tac) plus methotrexate (MTX) is a standard regimen for graft-versus-host disease (GVHD) prophylaxis. Mycophenolate mofetil (MMF) is sometimes used instead of MTX to minimize toxicity, despite the lack of controlled studies demonstrating efficacy. We conducted a single-center, randomized phase II trial comparing Tac + MMF to Tac + MTX. Intent-to-treat analyses included 42 patients randomized to Tac + MMF and 47 to Tac + MTX. Patient characteristics were not different between the study arms. Patients ...
Tópico(s): Renal Transplantation Outcomes and Treatments
2010 - Elsevier BV | Biology of Blood and Marrow Transplantation
Joseph Pidala, Marcie Tomblyn, T. Nishihori, Teresa Field, Ernesto Ayala, Janelle Perkins, Hugo F. Fernández, Frederick L. Locke, L. Perez, J. L. Ochoa, Melissa Alsina, Claudio Anasetti,
Advances in acute graft-versus-host disease therapy are needed.We examined the efficacy of sirolimus as primary therapy for acute graft-versus-host disease in 32 patients.Acute graft-versus-host disease involved the skin in 53% of cases, gastrointestinal tract in 66%, liver in 16%. The syndrome was overall grade 1 in 12% cases, grade 2 in 75%, and grade 3 in 13%. Sirolimus was targeted to achieve serum trough levels of 5-14 ng/mL. Sixteen (50%) patients achieved sustained, complete resolution of ...
Tópico(s): Renal Transplantation Outcomes and Treatments
2011 - Ferrata Storti Foundation | Haematologica
Teresa Field, Janelle Perkins, Yifan Huang, Mohamed A. Kharfan‐Dabaja, Melissa Alsina, Ernesto Ayala, Hugo F. Fernández, William E. Janssen, Jeffrey E. Lancet, Lia Perez, Daniel M. Sullivan, Alan F. List, Claudio Anasetti,
Relapse remains a leading cause for treatment failure after hematopoietic cell transplantation (HCT) in patients with intermediate- or high-risk myelodysplastic syndrome (MDS). To discern the impact of 5-azacitine treatment pretransplant on the risk for relapse after HCT, we analyzed the post transplant outcomes of all 54 consecutive patients with MDS or chronic myelomonocytic leukemia who received HCT from HLA-compatible donors according to pretransplant 5-azacitidine exposure. Thirty patients received ...
Tópico(s): Multiple Myeloma Research and Treatments
2009 - Springer Nature | Bone Marrow Transplantation
Juan Carlos Reséndiz Aparicio, Ernesto Rodríguez Camino, Jorge Contreras Bernal, Hugo Ceja Moreno, Eduardo Barragán Pérez, Saúl Garza Morales, Jorge Malagón Valdez, Francisco Ortega González,
In some studies in children, topiramate showed efficacy.To evaluate efficacy, tolerability and safety of topiramate in monotherapy in newly diagnosed epilepsy vs carbamazepine in children.In a multicentre, open-label, comparative and randomized study patients with partial epilepsy, were randomized to received topiramate or carbamazepine treatment. Patients with degenerative disease were excluded. Data were analysed by SPSS statistical program v. 11.0, and non parametric test. Comparisons between ...
Tópico(s): Attention Deficit Hyperactivity Disorder
2004 - Viguera Publishers | Revista de Neurología
Farhad Khimani, J Kim, L Chen, Erin Dean, Victoria T. Rizk, Brian C. Betts, Taiga Nishihori, Frederick L. Locke, Asmita Mishra, Lia Perez, Ernesto Ayala, M A Kharfan-Dabaja, Michael L. Nieder, Hugo F. Fernández, Claudio Anasetti, Joseph Pidala,
Sirolimus (SIR)/tacrolimus (TAC) is an alternative to methotrexate (MTX)/TAC. However, rational selection among these GvHD prophylaxis approaches to optimize survival of individual patients is not possible based on current evidence. We compared SIR/TAC (n=293) to MTX/TAC (n=414). The primary objective was to identify unique predictors of overall survival (OS). Secondary objective was to compare acute and chronic GvHD, relapse, non-relapse mortality, thrombotic microangiopathy (TMA), hepatic veno-occlusive ...
Tópico(s): Adolescent and Pediatric Healthcare
2017 - Springer Nature | Bone Marrow Transplantation
Eduardo Rodríguez-Noriega, Esteban González-Díaz, Rayo Morfín‐Otero, Gerardo F. Gomez-Abundis, Jaime Briseño-Ramírez, Héctor Raúl Pérez-Gómez, Hugo López‐Gatell, Celia Alpuche‐Aranda, Ernesto Ramírez, Irma López, Miguel Iguala, Ietza Bojórquez, Ethel Palacios Zavala, Mauricio Hernández, Tammy L. Stuart, Margarita E. Villarino, Marc‐Alain Widdowson, Steve Waterman, Timothy M. Uyeki, Eduardo Azziz‐Baumgartner,
Background Pandemic influenza A (H1N1) virus emerged during 2009. To help clinicians triage adults with acute respiratory illness, a scoring system for influenza-like illness (ILI) was implemented at Hospital Civil de Guadalajara, Mexico. Methods A medical history, laboratory and radiology results were collected on emergency room (ER) patients with acute respiratory illness to calculate an ILI-score. Patients were evaluated for admission by their ILI-score and clinicians' assessment of risk for developing ...
Tópico(s): Pneumonia and Respiratory Infections
2010 - Public Library of Science | PLoS ONE
R. Amador, Alicia Polanco, Hugo Hernández, Ernesto Pérez, Agnes Nagy,
A circuit which reduces the VBE wafer spread of a standard bipolar transistor in linear ICs is described. This compensation circuit takes advantage of the close correlation between Is and βr. The spread of VBE is the major source of output error in IC temperature sensors with intrinsic reference, which thereby require resistive trimming.
Tópico(s): Analog and Mixed-Signal Circuit Design
1992 - Institution of Engineering and Technology | Electronics Letters
Verónica Gisela López-Martínez, Jorge Guerrero‐Álvarez, José Gustavo Ronderos-Lara, Mario Alfonso Murillo-Tovar, Jorge Ernesto Solá-Pérez, Ismael León‐Rivera, Hugo Saldarriaga-Noreña,
The aim of this work was to determine Fulvic Acids (FAs) in sediments to better know their composition at the molecular level and to propose substructures and structures of organic precursors. The sediment samples were obtained from a priority area for the conservation of ecosystems and biodiversity in Mexico. FAs were extracted and purified using modifications to the International Humic Substances Society method. The characterization was carried out by 1D and 2D nuclear magnetic resonance (NMR) and ...
Tópico(s): Marine and coastal ecosystems
2021 - Multidisciplinary Digital Publishing Institute | Molecules
Ghada M Kunter, Janelle Perkins, Joseph Pidala, Taiga Nishihori, Mohamed A. Kharfan‐Dabaja, Teresa Field, Hugo F. Fernández, Lia Perez, Frederick L. Locke, Ernesto Ayala, Marcie Tomblyn, Jose L. Ochoa‐Bayona, Brian C. Betts, Michael L. Nieder, Claudio Anasetti,
Allogeneic hematopoietic cell transplantation offers improved survival in patients with ALL, but with regimens containing TBI, the nonrelapse mortality is 20-40%. Efforts to lessen transplant toxicities by reducing conditioning regimen intensity have led to increased relapse risk. Therefore, there is a need for less toxic regimens that maintain an anti-leukemia effect. We report here a retrospective review of 65 patients with ALL in first remission receiving grafts from allogeneic donors after fludarabine ...
Tópico(s): Hematopoietic Stem Cell Transplantation
2013 - Springer Nature | Bone Marrow Transplantation
Joseph Pidala, Jongphil Kim, Brian C. Betts, Melissa Alsina, Ernesto Ayala, Hugo F. Fernández, Teresa Field, Mohamed A. Kharfan‐Dabaja, Frederick L. Locke, Asmita Mishra, Taiga Nishihori, Leonel Ochoa-Bayona, Lia Perez, Marcie L. Riches, Claudio Anasetti,
Standard primary therapy for chronic graft-versus-host disease (GVHD) is incompletely effective. Based on biologic insights implicating pathogenic B cells, we conducted a phase I trial examining the combination of standard (1 mg/kg/day prednisone) glucocorticoid therapy with ofatumumab, a humanized anti-CD20 monoclonal antibody, for primary chronic GVHD therapy. Patients ages ≥ 18 with National Institutes of Health Consensus moderate-to-severe chronic GVHD newly requiring 1 mg/kg/day prednisone were ...
Tópico(s): T-cell and B-cell Immunology
2015 - Elsevier BV | Biology of Blood and Marrow Transplantation
Stella Santarone, Joseph Pidala, Marta Di Nicola, Teresa Field, Melissa Alsina, Ernesto Ayala, William E. Janssen, Mohamed A. Kharfan‐Dabaja, Leonel Ochoa, Lia Perez, Janelle Perkins, Jyoti Raychaudhuri, Hugo F. Fernández, Claudio Anasetti,
We aimed to evaluate the safety and efficacy of fludarabine (FLU) and pharmacokinetic-targeted busulfan (BU) as conditioning regimen for hematopoietic cell transplantation (HCT) in adult patients with acute lymphoid leukemia (ALL). Forty-four patients with ALL (27 in first complete remission [CR1] and 17 in more advanced disease stage: 4 with primary induction failure [PIF], 12 in CR2, and 1 in CR3) received FLU and pharmacokinetic-targeted BU as preparative therapy for HCT. Grafts were T-replete, filgrastim- ...
Tópico(s): Childhood Cancer Survivors' Quality of Life
2011 - Elsevier BV | Biology of Blood and Marrow Transplantation
Hugo Jiménez-Pérez, Ernesto A. Lacomba,
We introduce a restricted four body problem in a 2 + 2 configuration extending the classical circular Sitnikov problem to the circular double Sitnikov problem. Since the secondary bodies are moving on the perpendicular line to the plane where the primaries evolve, almost every solution is a collision orbit. We extend the solutions beyond collisions with a symplectic regularization and study the set of energy surfaces that contain periodic orbits.
Tópico(s): Stellar, planetary, and galactic studies
2009 - Birkhäuser | Qualitative Theory of Dynamical Systems
Joseph Pidala, J. Kim, Michael J. Schell, S. J. Lee, Ryan Hillgruber, V. Nye, Ernesto Ayala, Melissa Alsina, Brian C. Betts, Ryan Bookout, Hugo F. Fernández, Teresa Field, Frederick L. Locke, Taiga Nishihori, J. L. Ochoa, Lia Perez, Janelle Perkins, J. Shapiro, Cheryl Tate, Marcie Tomblyn, Claudio Anasetti,
Factors relevant to finding a suitable unrelated donor and barriers to effective transplant utilization are incompletely understood. Among a consecutive series of unrelated searches (n=531), an 8/8 HLA-A, -B, -C and -DRB1-matched unrelated donor was available for 289 (54%) patients, 7/8 for 159 (30%) and no donor for 83 (16%). Patients of Caucasian race (P<0.0001) were more likely to find a donor. Younger age (P=0.01), Caucasian race (P=0.03), lower CIBMTR (Center for International Blood and Marrow Transplantation ...
Tópico(s): Renal Transplantation Outcomes and Treatments
2012 - Springer Nature | Bone Marrow Transplantation
Jorge Ernesto Solá-Pérez, Hugo Saldarriaga-Noreña, Mario Alfonso Murillo-Tovar,
Ultrasound-assisted pretreatment under mild operating conditions has been investigated for intensification of delignification to facilitate the obtaining of ethyl levulinate from biomass. The effect of pH (2 - 12), temperature (30°C - 70°C) and pretreatment time (0 - 120 minutes) has been studied for different biomass samples. The most favorable conditions were basic pH, temperature of 70°C and pretreatment time of 2 h, obtaining values of delignification near 80 percent. The ethyl levulinate is obtained ...
Tópico(s): Microbial Metabolic Engineering and Bioproduction
2017 - | Journal of Agricultural Chemistry and Environment
José Luís Anaya-López, Eduardo Raymundo Garrido-Ramírez, Elizabeth Chiquito‐Almanza, Óscar Hugo Tosquy Valle, Francisco Javier Ibarra-Pérez, Ernesto López‐Salinas,
El frijol negro opaco de acervo mesoamericano se consume y produce en México. Con el objetivo de identificar líneas recombinantes de frijol negro opaco resistentes al virus del mosaico (BCMV), al virus del mosaico y la necrosis (BCMNV) y al virus del mosaico amarillo dorado del frijol (BGYMV), durante 2015 y 2016 se evaluó una colección de 70 genotipos que incluyeron 20 variedades y 50 líneas recombinantes (LR). Las LR derivaron de tres diferentes cruzas: ‘Negro Papaloapan’/SEN-46, ‘Negro Citlali’/ ...
Tópico(s): Plant and soil sciences
2018 - National Institute of Forestry, Agriculture and Livestock Research ( INIFAP ) | Revista Mexicana de Ciencias Agrícolas
Mohamed A. Kharfan‐Dabaja, Claudio Anasetti, Hugo F. Fernández, Janelle Perkins, Jose L. Ochoa‐Bayona, Joseph Pidala, Lia Perez, Ernesto Ayala, Teresa Field, Melissa Alsina, Taiga Nishihori, Frederick L. Locke, Javier Pinilla‐Ibarz, Marcie Tomblyn,
One limitation of reduced-intensity preparative regimens is potential for graft failure. We have developed a regimen that targets CD4(+) lymphodepletion to ensure early and durable engraftment. The primary endpoint was achievement of ≥50% CD3(+) donor chimerism by day +28. Forty-two patients (median age, 53 years; range, 29 to 73 years) received pentostatin 4 mg/m(2) i.v. on days -28, -21, and -14 when the CD4(+) cell count was >100 cells/μL and on days -4 and -3 regardless of CD4(+) level. Rituximab 375 ...
Tópico(s): Acute Myeloid Leukemia Research
2013 - Elsevier BV | Biology of Blood and Marrow Transplantation
Daanish Hoda, Joseph Pidala, Norma Salgado-Vila, J Kim, Janelle Perkins, Ryan Bookout, Teresa Field, Lia Perez, Ernesto Ayala, Jose L. Ochoa‐Bayona, Jyotishankar Raychaudhuri, Melissa Alsina, J. N. Greene, William E. Janssen, Hugo F. Fernández, Claudio Anasetti, Mohamed A. Kharfan‐Dabaja,
Acute GVHD (aGVHD) is a major cause of morbidity and mortality in hematopoietic allograft recipients. The best therapy for patients failing to respond, or not tolerating, systemic glucocorticoids remains undefined. We evaluated the efficacy of sirolimus in 34 patients, median age of 49 (23-67) years, with steroid-refractory (n=31) or steroid-intolerant (n=3) aGVHD. aGVHD was diagnosed at a median of 34 (7-1042) days post allografting, and confirmed by biopsy in all cases. Initial aGVHD treatment consisted ...
Tópico(s): Immune Cell Function and Interaction
2009 - Springer Nature | Bone Marrow Transplantation
Joseph Pidala, Francisca Beato, Jongphil Kim, Brian C. Betts, Heather Jim, Elizabeth M. Sagatys, John E. Levine, James L.M. Ferrara, Umut Özbek, Ernesto Ayala, Marco L. Davila, Hugo F. Fernández, Teresa Field, Mohamed A. Kharfan‐Dabaja, Divis Khaira, Farhad Khimani, Frederick L. Locke, Asmita Mishra, Michael L. Nieder, Taiga Nishihori, Lia Perez, Marcie L. Riches, Claudio Anasetti,
T-helper 1 and T-helper 17 lymphocytes mediate acute graft-versus-host disease (GvHD). Interleukin 12 is critical for T-helper 1 differentiation and interleukin 23 for T-helper 17 maintenance. Interleukin 12 and 23 are heterodimeric cytokines that share the p40 subunit (IL-12/IL-23p40). In a randomized, blinded, placebo-controlled trial, we examined the biological impact and clinical outcomes following IL-12/IL-23p40 neutralization using ustekinumab. Thirty patients received peripheral blood mobilized ...
Tópico(s): T-cell and B-cell Immunology
2017 - Ferrata Storti Foundation | Haematologica
F. Szymanowski, Galo Ezequiel Balatti, Ernesto E. Ambroggio, A.A. Hugo, M. Florencia Martini, Gerardo D. Fidelio, Andrea Gómez‐Zavaglia, Mónica Pickholz, Pablo F. Pérez,
Eukaryotic antimicrobial peptides (AMPs) interact with plasma membrane of bacteria, fungi and eukaryotic parasites. Noteworthy, Lactobacillus delbrueckii subsp. lactis (CIDCA 133) and L. delbrueckii subsp. bulgaricus (CIDCA 331) show different susceptibility to human beta-defensins (β-sheet peptides). In the present work we extended the study to α-helical peptides from anuran amphibian (Aurein 1.2, Citropin 1.1 and Maculatin 1.1). We studied the effect on whole bacteria and liposomes formulated with ...
Tópico(s): Protein Hydrolysis and Bioactive Peptides
2019 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Biomembranes