Josep M. Campistol, Johan W. de Fijter, Björn Nashan, Hallvard Holdaas, Š Vı́tko, Christophe Legendre,
... allograft nephropathy (CAN)/interstitial fibrosis and tubular atrophy (IFTA) and death with a functioning graft. CAN/IFTA CAN/IFTA is a pathophysiologic entity that accounts for one ... 4). Changes in renal pathology associated with CAN/IFTA include IFTA, arteriolar hyalinosis, arteriosclerosis, and glomerulosclerosis, which are accompanied ... that can contribute to the development of CAN/IFTA, including an acute rejection episode within 1 year ... and is implicated in the development of CAN/IFTA (11) because of inflammation and stimulation of the ...
Tópico(s): Organ Transplantation Techniques and Outcomes
2011 - Wolters Kluwer | Transplantation
Johanna W.A.M. Celie, K. Katta, Saritha Adepu, Wynand B.W.H. Melenhorst, Rogier M. Reijmers, Edith Slot, Robert H.J. Beelen, Marcel Spaargaren, Rutger J. Ploeg, Gerjan Navis, Jaap J. Homan van der Heide, Marcory C. R. F. van Dijk, Harry van Goor, Jacob van den Born,
... acute allograft rejection biopsies (Tx-AR), and Tx-IFTA (interstitial inflammation/tubular atrophy biopsies; Figure 1b). This ... biopsies examined. Within the Tx-AR and Tx-IFTA group, the percentage of syndecan-1–positive TECs ... 1–positive TECs in the more severe Tx-IFTA grades, which was, however, not statistically different. To ... Tx-protocol, Tx-MHA, Tx-AR, and Tx-IFTA groups together), indicating that a longer time between ... However, in subgroups of Tx-MHA and Tx-IFTA, which were matched according to similar time Tx ...
Tópico(s): Hemostasis and retained surgical items
2012 - Elsevier BV | Kidney International
Dler Besarani, Lucia Cerundolo, John D. Smith, J. Procter, Martin Barnardo, Ian S. Roberts, Peter J. Friend, Marlene L. Rose, Susan V. Fuggle,
... is associated with interstitial fibrosis and tubular atrophy (IFTA).In this retrospective study, sera from 70 recipients of renal allografts (40 controls, 30 IFTA) were studied. The biopsy diagnosis of interstitial fibrosis and tubular atrophy (IFTA) was based on random, cause-indicating biopsies. Sera ... up to 5 years posttransplant or diagnosis of IFTA and assayed by ELISA for IgM and IgG ... year after transplantation compared with pretransplant for both IFTA and controls groups (P<0.001). There was ... the mean level of IgM AVA achieved by IFTA and control groups. The mean pretransplant levels of ...
Tópico(s): Systemic Sclerosis and Related Diseases
2014 - Wolters Kluwer | Transplantation
Xuejing Zhu, Xiaofen Xiong, Shuguang Yuan, Li Xiao, Xiao Fu, Yang Yuan, Chengyuan Tang, Liyu He, Fuyou Liu, Lin Sun,
The association between interstitial fibrosis and tubular atrophy (IFTA) and the clinical outcomes in diabetic nephropathy (DN) ... evaluate the clinical predictors and renal prognosis of IFTA score in patients with DN. 52 cases with ... biopsy were divided into three groups according to IFTA score. The χ2 test or Fisher’s exact ... which clinical factors might be the predictors of IFTA score. Compared to IFTA score 1 group, the patients in score 3 ... A close relationship between the clinical findings and IFTA was observed, such as IFTA with eGFR(r = − ...
Tópico(s): Skin Diseases and Diabetes
2015 - Elsevier BV | Journal of Diabetes and its Complications
Brian D. Modena, Rachel J. Milam, F. Harrison, Jennifer A. Cheeseman, Michaël Abécassis, John J. Friedewald, Allan D. Kirk, Daniel R. Salomon,
... the development of interstitial fibrosis and tubular atrophy (IFTA) suggests the role of immune-mediated tissue injury. We hypothesized that developing IFTA correlates with altered urinary tract microbiomes (UMBs). UMBs ... gene sequencing in 25 patients developing biopsy-proven IFTA compared to 23 transplant patients with normal biopsies ... dominant genera in HC males, was lower in IFTA and TX males at 1 month compared to ... 6–8 months, Streptococcus was further decreased in IFTA males, but normalized in TX. IFTA males and ...
Tópico(s): Clostridium difficile and Clostridium perfringens research
2016 - Elsevier BV | American Journal of Transplantation
Clara García-Carro, Christina Dörje, Anders Åsberg, Karsten Midtvedt, Helge Scott, Finn P. Reinholt, Hallvard Holdaas, Daniel Serón, Anna Varberg Reisæter,
In Brief Background Interstitial fibrosis and tubular atrophy (IFTA) associated with interstitial inflammation in nonscarred areas (IFTA+i) is associated with poorer graft outcome than inflammation without IFTA or IFTA without inflammation. Methods We evaluated if histological categories ... inflammation (i+t≥2 and ci+ct≤1), IFTA (i+t≤1 and ci+ct≥2) or IFTA+i (i+t≥2 and ci+ct≥2). ... weeks was: normal (n = 206), inflammation (n = 29), IFTA (n = 255), and IFTA+i (n = 108). Moderate/severe interstitial fibrosis (ci≥ ... 3.4% with inflammation, in 13.8% with IFTA, and in 24.5% with IFTA+i (P = ...
Tópico(s): Liver Disease and Transplantation
2016 - Wolters Kluwer | Transplantation
Reynold I. Lopez‐Soler, Jeffrey A. Borgia, Siva Kanangat, Cristina Fhied, D Conti, D. Constantino, Ashar Ata, Ryan Chan, Z. Wang,
... have been correlated with interstitial fibrosis/tubular atrophy (IFTA). In this study, we examine the association between ... anti-vimentin antibodies and the subsequent development of IFTA.Sera obtained before renal transplantation from 97 transplant ... vimentin antibodies. Results were correlated with findings of IFTA on biopsy as well as graft function and ... of 97 patients were diagnosed by biopsy with IFTA 2.9 (±2.1) years after renal transplantation. Patients with IFTA on biopsy had higher mean concentration of anti- ...
Tópico(s): RNA regulation and disease
2016 - Elsevier BV | Transplantation Proceedings
Brian D. Modena, Sunil M. Kurian, Lillian W. Gaber, Jill Waalen, Andrew I. Su, Terri Gelbart, Tony S. Mondala, Steve R. Head, Suzanne L. Papp, Raymond L. Heilman, John J. Friedewald, Stuart M. Flechner, Christopher L. Marsh, Randall S. Sung, Hamid Shidban, Laurence Chan, Michaël Abécassis, Daniel R. Salomon,
Interstitial fibrosis and tubular atrophy (IFTA) is found in approximately 25% of 1-year biopsies posttransplant. It is known that IFTA correlates with decreased graft survival when histological evidence ... inflammation is present. Identifying the mechanistic etiology of IFTA is important to understanding why long-term graft ... with matching clinical and outcome data. Eighty-one IFTA biopsies were divided into subphenotypes by degree of histological inflammation: IFTA with AR, IFTA with inflammation, and IFTA without ...
Tópico(s): Renal Transplantation Outcomes and Treatments
2016 - Elsevier BV | American Journal of Transplantation
Supanat Worawichawong, Suchin Worawichawong, Piyanuch Radinahamed, Dittapol Muntham, Nuankanya Sathirapongsasuti, Arkom Nongnuch, Montira Assanatham, Chagriya Kitiyakara,
The degree of tubular atrophy and interstitial fibrosis (IFTA) is an important prognostic factor in glomerulonephritis. Imbalance ... such as epidermal growth factor (EGF) likely determine IFTA severity. In separate studies, elevated MCP-1 and ... EGF have been shown to be associated with IFTA severity. In this study, we aim to evaluate ... to each biomarker individually for moderate to severe IFTA in primary glomerulonephritis (GN).Urine samples were collected ... 1 ratio from primary GN, all correlated with IFTA (n=58). By univariate analysis, glomerular filtration rate, ...
Tópico(s): Vasculitis and related conditions
2016 - Karger Publishers | Kidney & Blood Pressure Research
Brian J. Nankivell, Meena Shingde, Karen Keung, Caroline Fung, Richard Borrows, Philip J. O’Connell, Jeremy R. Chapman,
... areas of interstitial fibrosis and tubular atrophy (i-IFTA) is associated with adverse outcomes in kidney transplantation. We evaluated i-IFTA in 429 indication- and 2052 protocol-driven biopsy ... immunosuppression, and outcome. Sequential histology demonstrated that i-IFTA was preceded by cellular interstitial inflammation and followed ... IF/TA. The prevalence and intensity of i-IFTA increased with developing chronic fibrosis and correlated with ... reduced histologic inflammation in unscarred and scarred i-IFTA compartments, ameliorated progression of IF, and increased conversion ...
Tópico(s): Transplantation: Methods and Outcomes
2017 - Elsevier BV | American Journal of Transplantation
Konrad S. Famulski, Philip F. Halloran,
... of inflammation in areas of atrophy scarring (i-IFTA) in renal transplant biopsies by Nankivell et al1Nankivell ... inflammatory fibrosis in kidney transplantation: the Banff i-IFTA lesion [published online ahead of print 2017]. Am ... contradicting the previous Banff consensus opinion that i-IFTA lesions are a reflection of injury and a ... analyses do not support the conclusion that i-IFTA indicates chronic active TCMR. Inflammation is a well- ... fibrosis that will initially be inflamed (ie, i-IFTA). Active TCMR is best diagnosed by molecular classifiers, ...
Tópico(s): Renal and Vascular Pathologies
2018 - Elsevier BV | American Journal of Transplantation
... the lesion noted interstitial fibrosis and tubular atrophy (IFTA), with prominent accompanying glomerulosclerosis and variable but not ... addition to and often associated with areas of IFTA, involving the cortex and frequently the region of ... treated, this is followed by the development of IFTA with inflammation persistent within scarred areas of the ... referred to in the transplant community as i-IFTA.5Nankivell B, Shingde M, Keung K, et al. ... inflammatory fibrosis in kidney transplantation: the Banff i-IFTA lesion. Am J Transplant., in press. https://doi. ...
Tópico(s): Kidney Stones and Urolithiasis Treatments
2018 - Elsevier BV | Kidney International
Philip F. Halloran, Arthur J. Matas, Bertram L. Kasiske, Katelynn S. Madill-Thomsen, Martina Macková, Konrad S. Famulski,
... biopsies, inflammation in areas of atrophy-fibrosis (i-IFTA) is associated with increased risk of failure, presumably ... study explored the frequency of rejection in i-IFTA, by using histology Banff 2015 and a microarray- ... system (MMDx). In unselected indication biopsies (108 i-IFTA, 73 uninflamed IFTA [i0-IFTA], and 53 no IFTA), i-IFTA biopsies occurred later, showed more scarring, and had ... cell-mediated rejection (TCMR) was infrequent in i-IFTA based on histology (8%) and MMDx (16%). Twelve i-IFTA biopsies (11%) had molecular TCMR not diagnosed by ...
Tópico(s): Organ Transplantation Techniques and Outcomes
2018 - Elsevier BV | American Journal of Transplantation
Arthur J. Matas, Erika S. Helgeson, Robert S. Gaston, Fernando G. Cosio, Roslyn B. Mannon, Bertram L. Kasiske, Lawrence G. Hunsicker, Sita Gourishankar, David N. Rush, J. Michael Cecka, John E. Connett, Joseph P. Grande,
Inflammation in areas of fibrosis (i-IFTA) in posttransplant biopsy specimens has been associated with decreased death-censored graft survival (DC-GS). Additionally, an i-IFTA score ≥ 2 is part of the diagnostic criteria ... CA TCMR). We examined the impact of i-IFTA and t-IFTA (tubulitis in areas of atrophy) in the first ... SD) 1.7 ± 1.4 years posttransplant. I-IFTA, present in 196 biopsy specimens, was strongly correlated with t-IFTA, and Banff i. Of the 196, 37 (18. ... concurrent i score = 0. Unlike previous studies, i-IFTA = 1 (vs 0) was associated with worse 3- ...
Tópico(s): Transplantation: Methods and Outcomes
2020 - Elsevier BV | American Journal of Transplantation
Erika S. Helgeson, Roslyn B. Mannon, Joseph P. Grande, Robert S. Gaston, Michael Cecka, Bertram L. Kasiske, David N. Rush, Sita Gourishankar, Fernando G. Cosio, Lawrence G. Hunsicker, John E. Connett, Arthur J. Matas,
Inflammation in areas of fibrosis (i-IFTA) in posttransplant biopsies is part of the diagnostic criteria for chronic active TCMR (CA TCMR -- i-IFTA ≥ 2, ti ≥ 2, t ≥ 2). We evaluated i-IFTA and CA TCMR in the DeKAF indication biopsy ... to biopsy = 7.8 years). Grouped by i-IFTA scores, the 3-year postbiopsy DC-GS is ... AR) was more common in those with i-IFTA on biopsy, the majority of those with i-IFTA had not had previous AR. There was no ... previous AR (AMR, TCMR) and presence of i-IFTA. In both cohorts, i-IFTA was associated with ...
Tópico(s): Organ Transplantation Techniques and Outcomes
2020 - Elsevier BV | American Journal of Transplantation
Shudan Wang, Anna Broder, Daming Shao, Vartika Kesarwani, Brianna Boderman, Jennifer Aguilan, Simone Sidoli, Masako Suzuki, John M. Greally, Yvonne M. Saenger, Brad H. Rovin, J. Michelle Kahlenberg,
... are associated with interstitial fibrosis and tubular atrophy (IFTA) in LN and correlate with the key mediators ... CD59 ratio between LN patients with moderate/severe IFTA and none/mild IFTA. IFTA was defined as none/mild (<25% of interstitium ... proteins enriched in LN patients with moderate/severe IFTA were correlated with serum creatinine, TGFβR1, TGFβR2, PDGFβ, ... 46 (21.7%) LN patients had moderate/severe IFTA on kidney biopsy. LN patients with moderate/severe IFTA had an increased urinary C9-to-CD59 ratio [ ...
Tópico(s): Complement system in diseases
2023 - Elsevier BV | Seminars in Arthritis and Rheumatism
Yi Zheng, Clarissa A. Cassol, Saemi Jung, Divya Veerapaneni, Vipul C. Chitalia, Kevin Ren, Shubha S. Bellur, Peter Boor, Laura Barisoni, Sushrut S. Waikar, Margrit Betke, Vijaya B. Kolachalama,
Interstitial fibrosis and tubular atrophy (IFTA) on a renal biopsy are strong indicators of disease chronicity and prognosis. Techniques that are typically used for IFTA grading remain manual, leading to variability among pathologists. Accurate IFTA estimation using computational techniques can reduce this variability ... overall context at the WSI level to predict IFTA grade. WSIs (n = 67) were obtained from The ... and provided fibrosis scores that were converted to IFTA grades: ≤10% (none or minimal), 11% to 25% ( ...
Tópico(s): Radiomics and Machine Learning in Medical Imaging
2021 - Elsevier BV | American Journal Of Pathology
Miho Shimizu, Kengo Furuichi, Shinji Kitajima, Tadashi Toyama, Megumi Oshima, Hisayuki Ogura, Kōichi Sato, Shiori Nakagawa, Yuta Yamamura, Taro Miyagawa, Akinori Hara, Yasunori Iwata, Norihiko Sakai, Kiyoki Kitagawa, Mitsuhiro Yoshimura, Hitoshi Yokoyama, Takashi Wada,
... levels and renal interstitial fibrosis and tubular atrophy (IFTA) on long-term outcomes in type 2 diabetes ... of 233 patients were enrolled. The severity of IFTA was scored according to the classification by the ... were stratified according to baseline Hb tertiles by IFTA status. The outcomes were the first occurrence of ... cause mortality.At baseline, 151 patients had severe IFTA. There were no patients who have been received ... the time of renal biopsy. The severity of IFTA was the independent pathological factor of lower Hb ...
Tópico(s): Erythropoietin and Anemia Treatment
2021 - BioMed Central | BMC Nephrology
Pranav S. Garimella, Ronit Katz, Sushrut S. Waikar, Anand Srivastava, Insa M. Schmidt, Andrew N. Hoofnagle, Ragnar Pálsson, Helmut G. Rennke, Isaac E. Stillman, Ke Wang, Bryan Kestenbaum, Joachim H. Ix,
... histopathologic quantification of interstitial fibrosis and tubular atrophy (IFTA) is associated with lower tubular secretory clearance in ... biopsies for clinical indications. Exposures Semiquantitative score of IFTA reported by 2 trained pathologists. Outcomes We measured ... to-plasma ratios (UPRs) of these solutes with IFTA score after controlling for estimated glomerular filtration rate ( ... 819 mg/g. Compared with individuals with ≤25% IFTA, those with >50% IFTA had 12%-37% lower UPRs for all 9 ... and spot measures of secretory solutes. Conclusions Greater IFTA severity is associated with lower clearance of endogenous ...
Tópico(s): Renal Diseases and Glomerulopathies
2021 - Elsevier BV | American Journal of Kidney Diseases
Ambarish M. Athavale, Peter D. Hart, M. Itteera, David Cimbaluk, Tushar Patel, Anas Alabkaa, José A.L. Arruda, Ashok Singh, Avi Z. Rosenberg, Hemant Kulkarni,
Importance Interstitial fibrosis and tubular atrophy (IFTA) is a strong indicator of decline in kidney function and is measured using histopathological assessment of kidney biopsy core. At present, a noninvasive test to assess IFTA is not available. Objective To develop and validate a deep learning (DL) algorithm to quantify IFTA from kidney ultrasonography images. Design, Setting, and Participants ... algorithm was trained, validated, and tested to classify IFTA from kidney ultrasonography images. Of 6135 Crimmins-filtered ...
Tópico(s): Ultrasound and Hyperthermia Applications
2021 - American Medical Association | JAMA Network Open
Xin-Yue Ge, Zhong-Kai Lan, Qiaoqing Lan, Huashan Lin, Guodong Wang, Jing Chen,
... three grades: mild interstitial fibrosis and tubular atrophy (IFTA), fibrotic area < 25%; moderate IFTA, fibrotic area 26-50%; and severe IFTA, fibrotic area > 50%. After extracting radiomics from B- ... two classification schemes: mild versus moderate-to-severe IFTA, and mild-to-moderate versus severe IFTA. A nomogram was constructed based on multiple logistic ... 150 patients undergoing kidney biopsy were enrolled (mild IFTA: n = 74; moderate IFTA: n = 33; severe IFTA: n = 43) and randomized into training (n = 105) ... To differentiate between mild and moderate-to-severe IFTA, a nomogram incorporating STE radiomics, albumin, and estimated ...
Tópico(s): Renal cell carcinoma treatment
2022 - Springer Science+Business Media | European Radiology
Aravind Cherukuri, Khodor I. Abou‐Daya, Raad Chowdhury, Rajil Mehta, Sundaram Hariharan, Parmjeet Randhawa, David M. Rothstein,
... 12 mos), premature interstitial fibrosis and tubular atrophy (IFTA) and decreased seven-year graft survival. However, decreased ... BL patients who progressed to late AR or IFTA, and was not influenced by treatment. Although tSNE ... 12 mos), premature interstitial fibrosis and tubular atrophy (IFTA) and decreased seven-year graft survival. However, decreased ... BL patients who progressed to late AR or IFTA, and was not influenced by treatment. Although tSNE ... months post-transplant, interstitial fibrosis and tubular atrophy (IFTA) at 1 year, patient survival, and death-censored ...
Tópico(s): Cytomegalovirus and herpesvirus research
2022 - Elsevier BV | Kidney International
Oliver E. Blacque, Chunmei Li, Peter N. Inglis, Muneer A. Esmail, Guangshuo Ou, Allan K. Mah, David L. Baillie, Jonathan M. Scholey, Michel R. Leroux,
... Caenorhabditis elegans IFT gene, IFT-associated gene 1 (ifta-1), which encodes a WD repeat-containing protein ... unknown function. Both the C. elegans and human IFTA-1 proteins localize to the base of cilia, and in C. elegans, IFTA-1 can be observed to undergo IFT. IFTA-1 is required for the function and assembly of cilia, because a C. elegans ifta-1 mutant displays chemosensory abnormalities and shortened cilia ... of retrograde transport defects. Analyses of C. elegans IFTA-1 localization/motility along bbs mutant cilia, where ...
Tópico(s): Biomedical Research and Pathophysiology
2006 - American Society for Cell Biology | Molecular Biology of the Cell
Musab S. Hommos, Caihong Zeng, Zhihong Liu, Jonathan P. Troost, Avi Z. Rosenberg, Matthew Palmer, Walter K. Kremers, Lynn D. Cornell, Fernando C. Fervenza, Laura Barisoni, Andrew D. Rule,
... arteriosclerosis, arteriolosclerosis, and interstitial fibrosis and tubular atrophy (IFTA).1Tracy R.E. Ishii T. What is 'nephrosclerosis'? ... age compared with no GSG. Other biopsy findings (IFTA, arteriolar hyalinosis, and arteriosclerosis) were higher in those ... age) compared with no GSG. The amount of IFTA was markedly more severe with GSG abnormal for ... 0001 Percentage GSG09<0.000138<0.0001 Cortical IFTA 0–3dCortical IFTA was semiquantified as 0 ( 50%).0.001<0. ... end-stage renal disease; GSG, globally sclerotic glomeruli; IFTA, interstitial fibrosis and tubular atrophy. Values are N (%), ...
Tópico(s): Ion Transport and Channel Regulation
2017 - Elsevier BV | Kidney International
Zahraa Mohammed‐Ali, Tomáš Tokár, Ihor Batruch, Shelby Reid, Alexandre Tavares‐Brum, Paul S. F. Yip, Héloïse Cardinal, Marie‐Josée Hébert, Yanhong Li, S. Joseph Kim, Igor Jurišica, Rohan John, Ana Konvalinka,
Interstitial fibrosis/tubular atrophy (IFTA) is an important cause of kidney allograft loss; however, noninvasive markers to identify IFTA or guide antifibrotic therapy are lacking. Using angiotensin II (AngII) as the prototypical inducer of IFTA, we previously identified 83 AngII-regulated proteins in ... hypothesized that their urine excretion will correlate with IFTA in kidney transplant patients.Urine excretion of 6 ... be increased in 15 kidney transplant recipients with IFTA compared with 20 matched controls with no IFTA ( ...
Tópico(s): Systemic Sclerosis and Related Diseases
2019 - Wolters Kluwer | Transplantation
Michał Gniewkiewicz, Izabela Paszkowska, Jolanta Gozdowska, Katarzyna Czerwińska, Anna Sadowska-Jakubowicz, Dominika Dęborska−Materkowska, Agnieszka Perkowska‐Ptasińska, Maciej Kosieradzki, Magdalena Durlik,
... progressive CAD are interstitial fibrosis and tubular atrophy (IFTA). MicroRNAs are small, regulatory RNAs involved in many ... and determine their application in the evaluation of IFTA and kidney allograft function. The expression levels of ... of 31 kidney transplant recipients with biopsy-assessed IFTA (IFTA 0 + I: n = 17; IFTA II + III: n = 14) by real-time quantitative ... gene. MiR-21 was significantly up-regulated in IFTA II + III group compared to IFTA 0 + I group (p = 0.003). MiR-21 ... 21 is associated with renal allograft dysfunction and IFTA. Therefore, it could be considered as a potential ...
Tópico(s): Renal Transplantation Outcomes and Treatments
2020 - Multidisciplinary Digital Publishing Institute | Diagnostics
Aleksandar Đenić, Marija Bogojevic, Aidan F. Mullan, Moldovan Sabov, Muhammad Sohaib Asghar, Sanjeev Sethi, Maxwell L. Smith, Fernando C. Fervenza, Richard J. Glassock, Musab S. Hommos, Andrew D. Rule,
... sclerosed glomeruli (GSG), interstitial fibrosis and tubular atrophy (IFTA), and arteriosclerosis (luminal stenosis) were available. We scanned ... appearing glomeruli, or segmentally sclerosed glomeruli); percentage of IFTA; IFTA foci density; percentage of artery luminal stenosis; arteriolar ... pathologists versus morphometry measures for percentages of GSG, IFTA, and luminal stenosis did not substantively differ in predicting outcomes. However, adding percentage of glomerulosclerosis, IFTA foci density, and arteriolar hyalinosis improved outcome prediction. ...
Tópico(s): Renal and Vascular Pathologies
2022 - American Society of Nephrology | Journal of the American Society of Nephrology
Jee Yeon Kim, Yu‐Mee Wee, Monica Young Choi, Hey Rim Jung, Ji Yoon Choi, Hyun Wook Kwon, Joo Hee Jung, Yong Mee Cho, Heounjeong Go, Minkyu Han, Young Hoon Kim, Duck Jong Han, Sung Shin,
... recipients had increased interstitial fibrosis and tubular atrophy (IFTA) scores at the 6-month protocol biopsy (IFTA group). The mean level of urinary TG2 in the IFTA group was higher compared to that of 5 other recipients without IFTA (no IFTA group). Conversely, the mean level of urinary syndecan-4 in the IFTA group was lower than levels in patients without IFTA. In the IFTA group, double immunofluorescent staining revealed that TG2 intensity ...
Tópico(s): Chronic Kidney Disease and Diabetes
2019 - | Annals of Surgical Treatment and Research
Julie Ho, David N. Rush, Ian W. Gibson, Martin Karpinski, Leroy Storsley, Jennifer Bestland, William P. Stefura, Kent T. HayGlass, Peter Nickerson,
... resulting in progressive interstitial fibrosis and tubular atrophy (IFTA) is a leading cause of graft loss. The ... early urinary predictors for the subsequent development of IFTA in a prospective cohort of patients (n=111) ... found that α1M and CXCL10 were associated with IFTA at 6 months but not at 24 months. ... and found that CCL2 was associated with both IFTA and graft dysfunction at 24 months. On univariate ... was a risk factor for developing 24-month IFTA, defined as ci+ct score more than 0 ( ... 028). Furthermore, CCL2 remained an independent predictor of IFTA on multivariate analysis (odds ratio 1.049, 95% ...
Tópico(s): Bipolar Disorder and Treatment
2010 - Wolters Kluwer | Transplantation
Alton B. Farris, Robert B. Colvin,
... pathways, with renal interstitial fibrosis and tubular atrophy (IFTA) as the final common pathway. Furthermore, there are multiple ways to assess IFTA. Recent findings Cells involved include tubular epithelial cells, ... these cellular and molecular pathways. Pathologic evaluation of IFTA is central in assessing the severity of chronic ... are a variety of methods used to assess IFTA. Most assessment of IFTA relies on pathologist assessment of special stains such ... clear consensus as to the best method. Summary IFTA results from on orchestration of cell types and ...
Tópico(s): Renal Diseases and Glomerulopathies
2012 - Lippincott Williams & Wilkins | Current Opinion in Nephrology & Hypertension