Michael Babich, Kathleen L. King, Robert A. Nissenson,
... 3H]inositol trisphosphate (IP3) and [3H]inositol bisphosphate (IP2) formation. The increases in [3H]IP2 and [3H]IP3 produced by GTP were 8. ... 6- and 11.9-fold increase in [3H]IP2 and [3H]IP3, respectively. The stimulatory effects of ... decreased membrane [3H]phosphoinositides concomitantly with increased [3H]IP2 and [3H]IP3. The GDP analog guanosine 5′- ... 2-thiodiphosphate, GDPβ) alone did not alter [3H]IP2 or [3H]IP3 production but at 10−4 ... 8- and 2.0-fold stimulation of [3H]IP2 and [3H]IP3, respectively. In the presence of ...
Tópico(s): Muscle Physiology and Disorders
1989 - Oxford University Press | Journal of Bone and Mineral Research
Abdelkarim Sabri, Sasha G. Alcott, Hasnae Elouardighi, Elena S. Pak, Claudia K. Derian, Patricia Andrade‐Gordon, Kathleen W. Kinnally, Susan F. Steinberg,
... SFLLRN (300 μm) results in transient elevations of IP2/IP3, followed by a more sustained accumulation of ... contrast, cathepsin G promotes the progressive accumulation of IP2 and IP3 (to levels as high or higher ... with only a relatively minor associated increase in IP2/IP3 levels. This is quite distinct from the ... cathepsin G, which promotes the preferential accumulation of IP2/IP3. The actions of cathepsin G and thrombin ... Res. 2000; 86: 1047-1053Google Scholar). In contrast, IP2/IP3 accumulation in response to cathepsin G is ...
Tópico(s): Cell Adhesion Molecules Research
2003 - Elsevier BV | Journal of Biological Chemistry
Shinya Kasajima, Chidori Katagiri, Toshikazu Morishita, Tatsuro Suzuki, Yuji Mukasa,
... with and without flies. Self-compatible 'IH3', hybrid 'IP2/IH3', and standard self-incompatible 'Kitawasesoba' were used ... purity. Approximately 10% segregation of pin plants from 'IP2/IH3' was observed. The harvest index of 'Kitawasesoba' ... experiments. The harvest index values of 'IH3' and 'IP2/IH3' were hardly affected by the presence or ... two genotypes. Large differences in these traits between 'IP2/IH3' and 'Kitawasesoba' were not observed in either ... that pollinated with flies. The seed yield of 'IP2/IH3' tended to be higher than that of ' ...
Tópico(s): Plant Parasitism and Resistance
2017 - Taylor & Francis | Plant Production Science
Michel Vignes, Emmanuelle Blanc, Janique Guiramand, Elsa Marina Álvarez González, Isabelle Sassetti, Max Récasens,
... formations of inositol monophosphate (IP1) and inositol bisphosphate (IP2). We found that glutamate (1 mM), which induces ... 05), produces an identical accumulation of IP1 and IP2. K+ (30 mM), which provokes an alkalinization of ... These combinations produce a strong decrease of the IP2 level concomitant with an increase of the IP1 formation, compared to the levels of IP1 and IP2 evoked by glutamate alone. The total amount of IPs (IP1 + IP2) produced by these combinations is not different from ... combinations produce an increased IP1 accumulation, while the IP2 formation is slightly decreased. When the internal medium ...
Tópico(s): Cellular transport and secretion
1996 - Elsevier BV | Neuropharmacology
Christopher E. Sims, Nancy L. Allbritton,
... I-1,4-P2, inositol 1,4-bisphosphate; IP2, all isomers of inositol bisphosphate; IP3, inositol 1, ... concentration of IP4; IP≤2, inositol, IP1, and IP2; [IP≤2], the sum of the concentration of inositol, IP1 and IP2; 5-phosphatase, inositol polyphosphate 5-phosphatase; 3-kinase, ... points of 5 min or less. Inositol bisphosphate (IP2) was then formed almost exclusively by dephosphorylation of ... IP1) were formed by subsequent dephosphorylation of that IP2. The products of the 5-phosphatase pathway were inositol, IP1, and IP2, and the sum of the concentrations of these ...
Tópico(s): Genetics, Aging, and Longevity in Model Organisms
1998 - Elsevier BV | Journal of Biological Chemistry
Jessica C. Price, Elham Azizi, L.A. Naiche, Jenny G. Parvani, Priyanka Shukla, Seoyeon Kim, Jill K. Slack‐Davis, Dana Pe’er, Jan Kitajewski,
... the murine ovarian surface epithelial cell line, ID8 IP2. Notch3 was activated in ID8 IP2 cells via expression of the Notch3 intracellular domain (Notch3IC). Notch3IC ID8 IP2 cells injected intraperitoneally caused accelerated ascites and reduced survival compared to control ID8 IP2, particularly in early stages of disease. We interrogated downstream targets of Notch3IC in ID8 IP2 cells by RNA sequencing and found significant induction ... encode adhesion and extracellular matrix proteins. Notch3IC ID8 IP2 showed increased expression of ITGA1 mRNA and cell- ...
Tópico(s): Wnt/β-catenin signaling in development and cancer
2020 - Public Library of Science | PLoS ONE
Romain Darrigrand, Alison Pierson, Marine Rouillon, Dolor Renko, Mathilde Boulpicante, David Bouyssié, Emmanuelle Mouton‐Barbosa, Julien Marcoux, Camille Garcia, Michael Ghosh, Mouâd Alami, Sébastien Apcher,
... and its water-soluble and non-toxic derivative IP2 act at the production stage of the pioneer translation products (PTPs). We showed that IP2 increases PTP-derived antigen presentation in cancer cells in vitro and impairs tumor growth in vivo. IP2 action is long-lasting and dependent on the ... of MCA205 fibrosarcoma is modified upon treatment with IP2. In particular, IP2 enhances the presentation of an exon-derived epitope from the tumor suppressor nischarin. The combination of IP2 with a peptide vaccine targeting the nischarin-derived ...
Tópico(s): vaccines and immunoinformatics approaches
2021 - Nature Portfolio | Communications Biology
Inositol 1,4-bisphosphate (IP2) which rapidly accumulates during cell activation, strongly stimulates an increase in cytoskeletal actin in saponin-permeated platelets, and the effect ... increases by 41%, and then slowly increases further. IP2 induces the increase in cytoskeletal actin in a ... half-maximal effect requires approximately 2 microM of IP2. Inositol 1,4,5- triphosphate, the messenger for ... in cytoskeletal actin, but is less effective than IP2. Inositol 1-monophosphate and inositol 2-monophosphate have ...
Tópico(s): Enzyme Production and Characterization
1994 - Wiley | Cell Biology International
C.D. Cates, Thomas W. Myers, Louise A. Berben,
Reaction of M+[(IP2-)2Ga]− (IP = iminopyridine, M = Bu4N, 1a; (DME)3Na, 1b) with pyridine N-oxide affords two-electron-oxidized (IP–)2Ga( ... two-electron chemistry, outer sphere oxidation of M+[(IP2-)2Ga]− using either 1 or 2 equiv of ... electron processes and only the (IP–)2GaX and [(IP2-)2Ga]− oxidation states are thermodynamically accessible to us. ... thermodynamic accessibility of the mixed-valent states of (IP2-)(IP–)E, where E = Al or Ga, can ... These measurements indicated that the mixed-valent state [(IP2-)(IP–)Ga]+ is not significantly stabilized with respect ...
Tópico(s): Synthesis and characterization of novel inorganic/organometallic compounds
2012 - American Chemical Society | Inorganic Chemistry
Jeremy P. Young, Priyanta Herath, Simon B. Eickhoff, Joon Ho Choi, Christian Grefkes, Karl Zilles, Per E. Roland,
... cytoarchitectural probability maps of area 2, IP1, and IP2 along the intraparietal sulcus and the parietal opercular ... evidence of separate representations in OP1, OP4, and IP2. The overlap of hand and foot representations increased ... order: area 3a, 3b, 1, 2, IP1, OP4, IP2, and OP1. There were significant foot representations but ... the signal bilaterally in area 2, IP1, and IP2. These results indicate that somatosensory areas in humans ... following order: 3a, 3b, 1, 2, IP1, OP4, IP2, and OP1. Higher order areas such as IP1, ...
Tópico(s): Hemispheric Asymmetry in Neuroscience
2004 - Society for Neuroscience | Journal of Neuroscience
Masaaki Suzuki, Ryōji Noyori, Bengt Långström, Yasuyoshi Watanabe,
... that selectively bind to a novel PGI2 receptor, IP2, expressed in the central nervous system (CNS). This ... 15R configuration exhibits high binding affinity for the IP2 receptor in the thalamus (IC50 = 32 nM) and ... influence the binding characteristics. The features of the IP2 receptor were elucidated by quantitative mapping, specificity studies, ... The PET experiments accomplished the imaging of the IP2 receptor in the brain of living rhesus monkeys ... ten-fold higher affinity and selectivity for the IP2 receptor than original 15R-TIC. Neither 15R-TIC ...
Tópico(s): Estrogen and related hormone effects
2000 - Oxford University Press | Bulletin of the Chemical Society of Japan
Maria Derkacheva, Yvonne Steinbach, Thomas Wildhaber, Iva Mozgová, Walid Mahrez, Paolo Nanni, Sylvain Bischof, Wilhelm Gruissem, Lars Hennig,
... of unique peptides/ probability of identification 95% IP1-IP2-IP3-IP4 Sequence coverage (%) IP1-IP2-IP3-IP4 Protein identification probability (%) IP1-IP2-IP3-IP4 EMF2 12-13-12-12 15- ... of unique peptides/probability of identification 95% IP1-IP2-IP3-IP4 Sequence coverage (%) IP1-IP2-IP3-IP4 Protein identification probability (%) IP1-IP2-IP3-IP4 MSI1 19-34-20-27 52- ...
Tópico(s): Plant Genetic and Mutation Studies
2013 - Springer Nature | The EMBO Journal
Victoria Mazoteras‐Pardo, Ricardo Vallejo, Marta Elena Losa‐Iglesias, Daniel López‐López, Patricia Palomo‐López, David Rodríguez‐Sanz, César Calvo‐Lobo,
... Society of Hypertension International Protocol revision 2010 (ESH-IP2) was developed to assess the validity of automatic ... the iHealth Track blood pressure monitor meets ESH-IP2 requirements for self-measurement of blood pressure and ... population.This study was a descriptive investigation. ESH-IP2 requires a total number of 33 participants. For ... sample of 33 participants.iHealth Track fulfilled ESH-IP2 requirements and passed the validation process successfully. We ... rate. With regard to part 2 of ESH-IP2, we observed a minimum of 2 of 3 ...
Tópico(s): Cardiovascular Health and Disease Prevention
2019 - JMIR Publications | JMIR mhealth and uhealth
Nitin Tupperwar, Shimi Meleppattu, Rohit Shrivastava, Nofar Baron, Ayelet Gilad, Gerhard Wagner, Mélissa Léger-Abraham, Michal Shapira,
... We describe a novel LeishIF4E-interacting protein, Leish4E-IP2, which contains a conserved Y(X)4LΦ IF4E- ... Despite its capacity to bind several LeishIF4Es, Leish4E-IP2 was not detected in m7GTP-eluted cap-binding ... we show that a recombinant form of Leish4E-IP2 inhibits the cap-binding activity of LeishIF4E-1 ... transgenic parasites expressing a tagged version of Leish4E-IP2 also display reduced cap-binding activities of tested ... than a single LeishIF4E, we suggest that Leish4E-IP2 could serve as a broad-range repressor of ...
Tópico(s): Biochemical and Molecular Research
2020 - Oxford University Press | Nucleic Acids Research
Xiumin Yu, Yinan Li, Dongjie Liu, Zezhou Guo, Jiahua Zhang, Qi Zhu,
... injection. Compared with the second hydrogen injection proportion (IP2) = 0, the split hydrogen direct injection can promote ... period, and reduce the cyclic variation. When the IP2 is 25%, 50% and 75%, the engine torque ... 2.3% and 0.6% respectively. Compared with IP2 = 100%, HC emissions are reduced by 7.8%, ... 13.8% and 7.9% respectively, when the IP2 is 25%, 50% and 75%. As second hydrogen ... emissions with IT2 are not consistent at different IP2. Considering the engine's dynamics and emission characteristics, ...
Tópico(s): Catalytic Processes in Materials Science
2022 - Elsevier BV | International Journal of Hydrogen Energy
... two partially correlated noise current generators ip1 and ip2, ip1, connected across the emitter junction and ip2 connected across the collector junction. (ipi2)av, (ip22)av and (ip1*ip2)av are calculated. At low frequencies emitter and ... current show full shot effect and ip1 and ip2 are almost completely correlated; at higher frequencies the ... in parallel to the collector junction. (e82)av, (ip2)av and (e8*ip)av are calculated. At ...
Tópico(s): Electrostatic Discharge in Electronics
1955 - Institute of Electrical and Electronics Engineers | Proceedings of the IRE
George A. Kfoury, Stanley E. Kerr,
... was revealed by the isolation of inositol diphosphate (IP2) from an acid hydrolysate, and its glyceryl derivative ... separated by refractionation with a formate system yielding IP2 and glycerol diphosphate. 3. 3. The mixed glyceryl derivatives of IP2 and glycerol diphosphate were secured by chromatographic fractionation ... the alkaline hydrolysate. Based on the recovery of IP2 and its glyceryl derivative, the content of DPI ... 1, V/V). 5. 5. Most of the IP2 found in pacreatic lipid occured in material insoluble ...
Tópico(s): Drug Transport and Resistance Mechanisms
1964 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Specialized Section on Lipids and Related Subjects
Thomas V. Waehneldt, G. Jeserich,
... intermediate proteins IP1 (23,000 mol.wt.) and IP2 (26,200 mol.wt.), and two basic proteins ... myelin P0 glycoprotein are bound by IP1 and IP2, but not by 36K. None of the trout ... or palmitate leads to radiolabeling of IP1 and IP2. Under autolytic in situ conditions the appearance of ... noted, with parallel reduction of both IP1 and IP2, indicating sequence homologies between IP1 and IP2. The 36K protein is not affected by autolysis.
Tópico(s): Calpain Protease Function and Regulation
1984 - Elsevier BV | Brain Research
Michael J. Dimino, Judith Snitzer, Kathleen Brown,
... LH increased accumulation of inositol phosphate (IP), -bisphosphate (IP2), and trisphosphate (IP3) by severalfold. Furthermore, 0.01 ... was necessary to measure IP accumulation, but not IP2 and IP3 accumulations. However, IP2 and IP3 accumulations were higher in LH-treated ... pretreatment with LiCl. Maximal increases in IP3 and IP2 accumulations occurred approximately 15 min and 30 min, ... treatment, did not hydrolyze [3H]IP3 to [3H]IP2 or [3H]IP. Thus, it is hypothesized that ...
Tópico(s): Reproductive Biology and Fertility
1987 - Oxford University Press | Biology of Reproduction
Kevin Maier, Charles O. Rutledge,
... inositol 1-phosphate (IP); inositol 1,4-bisphosphate (IP2); mixture of inositol 1,4,5-trisphosphate and ... mixture (CHCl3-MeOH). The amounts of IP and IP2 formed by a maximal concentration of veratrine were ... min) for both norepinephrine and veratrine. Stimulation of IP2 and IP3 formation by veratrine reached a maximum ... only partially antagonizing the norepinephrine response. Norepinephrine-induced IP2 formation was less sensitive to manganese than was ... mechanisms. The data also suggest that IP and IP2 may be produced directly from phosphatidylinositol and phosphatidylinositol ...
Tópico(s): Hemoglobinopathies and Related Disorders
1987 - American Society for Pharmacology and Experimental Therapeutics | Journal of Pharmacology and Experimental Therapeutics
Guy P. Heathers, Peter B. Corr, Leona J. Rubin,
... levels of inositol (1,4)-bisphosphate (1,4-IP2), inositol (1,3)-bisphosphate (1,3-IP2), inositol (3,4)-bisphosphate (3,4-IP2), inositol (1,3,4)-trisphosphate (1,3,4- ... by 60 seconds of norepinephrine stimulation. 1,4-IP2, 1,3-IP2 and 1,3,4-IP3 were increased markedly ...
Tópico(s): Trace Elements in Health
1988 - Elsevier BV | Biochemical and Biophysical Research Communications
Cherie Gambley, A. K. Miles, Mark Ramsden, VJ Doogan, J. E. Thomas, K. S. Parmenter, Peter Whittle,
... disease was subsequently detected on two other farms (IP2 and IP3) within the same area and studies ... disease first occurred on IP1 and spread to IP2 and IP3. The oldest, naturally infected plant tissue ... for several months before detection and established on IP2 and IP3 during the second quarter (i.e. ... than 4% of trees within a block, on IP2 and IP3. The mechanisms proposed for disease spread ... combination with abundant water. Spread between blocks on IP2 was attributed to movement of contaminated farm equipment ...
Tópico(s): Plant-Microbe Interactions and Immunity
2009 - Springer Science+Business Media | Australasian Plant Pathology
Incontinentia Pigmenti 2 (IP2) is an X-linked dominant disorder with male lethality. Affected females display a characteristic skin eruption that evolves through ... in fibroblasts has been observed in females with IP2; however, sample sizes have been small and methods ... X-inactivation in a large group of multigenerational IP2 families, in smaller families, and in isolated cases. Ninety-eight percent of affected females in multigenerational IP2 pedigrees show completely skewed patterns of X-inactivation, ...
Tópico(s): melanin and skin pigmentation
1996 - Oxford University Press | Human Molecular Genetics
Sree Rayavarapu, William Coley, Erdinç Çakır, Vanessa E. Jahnke, Shin’ichi Takeda, Yoshitsugu Aoki, Heather Grodish-Dressman, Jyoti K. Jaiswal, Eric P. Hoffman, Kristy J. Brown, Yetrib Hathout, Kanneboyina Nagaraju,
... Raw spectra were analyzed using Integrated Proteomics Pipeline (IP2) software (version 1.01), developed by Integrated Proteomics ... 35%. Protein identification and quantification were performed using IP2 software (version 1.01). Mass spectral data were uploaded into the IP2 software. Files from each lane were searched against ... 99492 Da) and heavy Lys (6.020 Da). IP2 uses the Sequest 2010 (06 10 13 1836) ... Census software (version 1.77), built into the IP2 platform, was used to determine the ratios of ...
Tópico(s): Biotin and Related Studies
2013 - Elsevier BV | Molecular & Cellular Proteomics
Kanako Saito, Yukiko Hishiki, Hakuo Takahashi,
... Society of Hypertension International Protocol, 2010 Revision (ESH IP2), as a separate study. Methods Three trained medical ... 2 mmHg, respectively, satisfying Part 1 of ESH IP2. Differences in SBP and DBP both satisfied Part 2 of ESH IP2. The number of absolute differences in the values ... of the ANSI/AAMI/ISO protocol and ESH IP2. Conclusion Omron HBP-1320 met all requirements of the ANSI/AAMI/ISO protocol and ESH IP2.
Tópico(s): Heart Rate Variability and Autonomic Control
2020 - Lippincott Williams & Wilkins | Blood Pressure Monitoring
Steve P. Watson, Randy T. McConnell, E G Lapetina,
... formation of radioactive inositol monophosphate (IP), inositol bisphosphate (IP2), and inositol trisphosphate (IP3) with less marked and ... the levels of radioactive inositol phospholipids. Formation of IP2 and IP3 could be detected 5 s after ... in human platelets also caused significant formation of IP2 and IP3 but not IP. These results suggest ... IP formed presumably arises from the hydrolysis of IP2. Prostacyclin inhibited thrombin-induced formation of all three ...
Tópico(s): Hemoglobinopathies and Related Disorders
1984 - Elsevier BV | Journal of Biological Chemistry
Akira Kikuchi, K. Ikeda, Osamu Kozawa, Yoshimi Takai,
... induce the formation of inositol bis-and trisphosphate (IP2 and IP3, respectively).When the intact cells were ... acetate, the fMLP-and GTP-induced formation of IP2 and IP3 was markedly reduced but the Ca2+- ... kinase C inhibited the fMLP-induced formation of IP2, but did not inhibit the GTP-or Ca2+- ... the GTPbinding protein leading to the formation of IP2.The reason for the failure of protein kinase ...
Tópico(s): Protein Tyrosine Phosphatases
1987 - Elsevier BV | Journal of Biological Chemistry
G. Jeserich, Thomas V. Waehneldt,
... against the trout CNS myelin proteins 36K and IP2 were prepared in rabbits and characterized by immunoblot ... or mammalian CNS and PNS. Antibodies against the IP2 glycoprotein specifically cross‐reacted with related intermediate proteins ( ... in peripheral nerves was seen only with anti‐IP2 antibodies.
Tópico(s): Neurogenesis and neuroplasticity mechanisms
1986 - Wiley | Journal of Neuroscience Research
Nicole Gallo‐Payet, Gilles Guillon, M N Balestre, Serge Jard,
... the formation of inositol monophosphate (IP), inositol diphosphate (IP2) and inositol triphosphate (IP3) in primary cultures of ... both cell types, the relative stimulations of IP, IP2, and IP3 formation were similar. Angiotensin II (ATII) ... dependent (up to 10-fold) increase in IP, IP2, and IP3, but had only a small effect ... cells. The dose dependencies for ATII-induced IP, IP2, and IP3 formation and aldosterone production were nearly ...
Tópico(s): Genetics, Aging, and Longevity in Model Organisms
1986 - Oxford University Press | Endocrinology
Susan M. Quirk, LEO E. REICHERT,
... phosphates [[3H]inositol mono-, di-, and triphosphates (IP, IP2, and IP3)] in FSH-treated cultures was 75- ... induced 4- to 5-fold increases in IP, IP2, and IP3 in experiments wherein FSH had no ... 24 h inhibited fluoride-induced generation of IP, IP2, and IP3 by 24-51%. Similar treatment with ... effect on basal or fluoride-induced generation of IP2 or IP3, but increased fluoride-induced generation of ...
Tópico(s): Reproductive Biology and Fertility
1988 - Oxford University Press | Endocrinology