Directory of Open Access Journals (DOAJ)
Bernard Katz, Andrew Robson, David Knight, Jon Ashworth, Greg Harper, Richard Whitehead, Robert Cole, James Moore, Adam Sherwin Media Reporter, Simon Barnes, Stella McCartney, Theodore Dalrymple, Paul Hoggart, Richard Hobson, Neal Harvey, Ben Webster Transport Correspondent and Charles Bremner, Philip Howard, J. P. Duguid, David Chater, Jeremy Kingston, Michael E. Coumbe, Carl Mortished, Patrick Barkham, Roger Maynard, Kevin Eason, Tony Arbour (Leader, Richmond upon Thames Council), Raymond Snoddy, Sam Lister, Stewart Tendler and Ian Cobain, Andrew Norfolk, Pat Gibson, David McVay, Jennai Cox Fitness Editor, Dominic Walsh, Steve Bird, Tom Bawden, Catherine Sykes, Ken Broad, Richard Ford and Richard Beeston, Andrew Oswald, Daniel Finkelstein, Angela Jameson Industrial Correspondent, Lindsay Sutton, Dan Sabbagh, Roger Maynard and Sam Lister, Jon Hills-Jones, Rose-Marie, Stephen Farrell, Oliver Wright, Hans Nichols, Philip Webster and Andrew Norfolk, Kevin Eason Motoring Editor, Roland Watson, Richard Lloyd Parry, Jonathan Stone, G. H. Spratt, Mark Court, James D. Bovington (Convener, Leeds in Europe), Caroline Merrell Banking Correspondent, Philippe Legrain (Chief Economist), Andy Graham, Russell Kempson, Vanora Bennett, Tony Halpin Education Editor, Suzy Jagger, Nigel Turner, Ross Clark, Michael W. Jeffels, Nick Thomas, Michael Theodoulou, Jill Sherman Whitehall Editor, Mark Henderson Science Correspondent, Michael Baws, Christopher Martin-Jenkins, Martin F. Seely, Jeremy Collis, David Powell Athletics Correspondent, G. G. Brownlee, Raymond Keene, Sean MacAulay, Irene Zoech, Robert Galster, Richard Owen, S. D. MacCallum, Roger Boyes, George Rodger, Ian Cobain and Stewart Tendler, Christopher Claxton, Oliver August, Nick Hasell, Joanne Hart, Stewart Tendler, Ashley Binns-Ward, Carolyn Asome, Simon Edwards, Tom Dart, Adam Fresco, Patrick Barkham and Simon de Bruxelles, Mary Ann Sieghart, James Doran, Philip Webster Political Editor, Christopher Walker, Iain MacLeod, Brian MacArthur, Mel Webb, Ray Richardson, Richard Askew, James Moore Stock Markets, Graham Searjeant Financial Editor, Jennai Cox, Richard Heller, Chris McGrath, Caitlin Moran, Modern Mutomba, Mark Court Health Industries Correspondent, Lea Paterson Economics Editor, Joy Davis, Grimsby, Derek Martin (President), Margaret M. Lloyd, Richard Miles, David Sinclair, Robert Heller, Gary Duncan Economics Correspondent, Mark Henderson, Martin Waller, Lisa Verrico, Carl Mortished International Business Editor, Lindsay Allen, Nigel Hawkes Health Editor, Laura Peek, Benedict Nightingale, Oliver Kamm, Oliver Kay and David McVay, Michael French, Stephen Dalton, Bill Edgar, Richard Morrison, James Christopher, Valerie Grove, Adam Sherwin, Abigail Rayner, Sally Patten, Jenny Davey, Market Drayton, Christopher Irvine,
... Cuture in Which both the Ruling Junta and Itrs Opposition Think Nothing of Unsing Children to Fight ...
2003 - Gale Group | TDA
Daisuke Kawauchi, Makoto Ohno, Mai Honda‐Kitahara, Yasuji Miyakita, Masamichi Takahashi, Shunsuke Yanagisawa, Yukie Tamura, Miyu Kikuchi, Koichi Ichimura, Yoshitaka Narita,
... recurs in the infratentorial region. Such Infratentorial recurrence (ITR) has some clinically unique characteristics, such as presenting ... receive additional radiotherapy. However, the clinical significances of ITR are not well studied.We reviewed newly diagnosed ... our institution between October 2008 and December 2018. ITR was defined as any type of recurrence in ... GBM, six (4.5%) were classified as having ITR. There was no significant difference in median duration from the first surgery to ITR development between patients with and without ITR (12. ...
Tópico(s): Advanced Neuroimaging Techniques and Applications
2023 - BioMed Central | BMC Neurology
National Bureau of Economic Research (NBER)
Junping Zhang, Ping Guo, Xiangping Yu, Dylan Frabutt, Anh K. Lam, Patrick L. Mulcrone, Matthew Chrzanowski, Jenni Firrman, Derek Pouchnik, Nianli Sang, Yong Diao, Roland W. Herzog, Weidong Xiao,
... between two flanking copies of inverted terminal repeats (ITR). An ITR functions as the replication origin for AAV vectors ... cis-plasmid carrying the gene of interest and ITR, an AAV trans-plasmid encoding AAV structural genes ... including the transgene expression cassette and flanking AAV ITRs. (2) Snapback genomes (SBGs) had the left or ... Incomplete rAAV genomes (ICGs) had an intact 3' ITR and partial AAV genome. These were presumably formed ... 2.3k, the vector DNA sizes from two ITRs to the breakpoints were 1.8 kb and ...
Tópico(s): Viral Infectious Diseases and Gene Expression in Insects
2022 - Cell Press | Molecular Therapy — Nucleic Acids
National Bureau of Economic Research (NBER)
Xiufang Pan, Yongping Yue, Maria Boftsi, Lakmini P. Wasala, Ngoc Tam Tran, Keqing Zhang, David J. Pintel, Phillip W.L. Tai, Dongsheng Duan,
Inverted terminal repeats (ITRs) are the only wild-type components retained in the genome of adeno-associated virus (AAV) vectors. To determine whether ITR modification is a viable approach for AAV vector ... we rationally deleted all CpG motifs in the ITR and examined whether CpG elimination compromises AAV-vector production and transduction. Modified ITRs were stable in the plasmid and maintained the ... nature in purified vectors. Replacing the wild-type ITR with the CpG-free ITR did not affect vector genome encapsidation. However, the ...
Tópico(s): RNA Interference and Gene Delivery
2021 - Springer Nature | Gene Therapy
National Bureau of Economic Research (NBER)
Alexis J. Maravilla, Marcela Rosato, Josep A. Rosselló,
... telomeric repeats in interstitial regions of plant chromosomes (ITRs) through molecular cytogenetic techniques was achieved several decades ... of currently available data, it is shown that ITRs are widespread in major evolutionary lineages sampled. However, ... 8% of the studied species. The number of ITR sites greatly varies among congeneric species and higher ... units, and range from one to 72 signals. ITR signals mostly occurs as homozygous loci in most species, however, odd numbers of ITR sites reflecting a hemizygous state have been reported ...
Tópico(s): Genomics and Phylogenetic Studies
2021 - Multidisciplinary Digital Publishing Institute | Plants
National Bureau of Economic Research (NBER)
Wareeporn Disphanurat, Benjaporn Srisantithum,
... to treatments. A combination of isobutylamido thiazolyl resorcinol (ITR) and hyaluronic acid (HA) could increase melasma treatment ... compare the efficacy and safety of 0.15% ITR plus HA vs 0.15% ITR or HA alone in melasma treatment.Ninety-two patients received ITR 0.15% plus HA (n = 30), 0.15% ITR (n = 31), or HA (n = 31) along with ... water loss.Compared with the HA group, the ITR+HA group showed significantly reduced mMASI at weeks ... 0.015, and 0.001, respectively), whereas the ITR group showed a significant reduction at week 12 ( ...
Tópico(s): Acne and Rosacea Treatments and Effects
2021 - Wiley | Journal of Cosmetic Dermatology
National Bureau of Economic Research (NBER)
Vasanop Vachiramon, Chaninan Kositkuljorn, Kanchana Leerunyakul, Kumutnart Chanprapaph,
Abstract Background Isobutylamido thiazolyl resorcinol (ITR, Thiamidol ® ) has been proposed as a potent tyrosinase inhibitor. A formulation containing ITR has recently shown promising efficacy for the treatment ... aimed to evaluate the efficacy and safety of ITR in the prevention of ultraviolet (UV)‐induced hyperpigmentation ... One arm was randomly assigned to receive an ITR‐containing product for three weeks. Three hyperpigmented spots ... irradiation on both arms after 3 weeks of ITR application. Outcome evaluations included measuring mean lightness index (* ...
Tópico(s): Acne and Rosacea Treatments and Effects
2020 - Wiley | Journal of Cosmetic Dermatology
National Bureau of Economic Research (NBER)
Itraconazole (ITR) is a broad-spectrum antifungal drug, which has been shown to possess some promising anticancer, anti-proliferative, ... cancers of the lung, breast, and skin. However, ITR has some drawbacks, such as poor water solubility, ... activities in H1299 lung cancer cells. The prepared ITR nanoparticles showed a small particle size, narrow poly ... a controlled drug release profile. The cytotoxicity of ITR nanoparticles (NPs) on H1299 cancer cells after 24 ... of exposure was greater than that of the ITR solution. Apoptosis of cancer cells exposed to ITR ...
Tópico(s): Synthesis and biological activity
2019 - Multidisciplinary Digital Publishing Institute | Pharmaceutics
Jennifer Malik, Chengyu Li, Guillermo Maza, Alexander A. Farag, Jillian P. Krebs, Sam McGhee, Gabriela Zappitelli, Bhakthi Deshpande, Bradley A. Otto, Kai Zhao,
... remains highly controversial, with aggressive inferior turbinate reduction (ITR) or mucociliary dysfunction frequently implicated. However, the appropriate degree of ITR is highly debatable. Methods We applied individual computed ... dynamics (CFD) to 5 patients receiving relatively aggressive ITR but with no ENS symptoms, and compared them ... ENS patients who all had histories of aggressive ITRs, and 42 healthy controls. Patients’ surgical outcomes were ... 22‐item Sino‐Nasal Outcome Test (SNOT‐22) (ITR: 6.40 ± 4.56; ENS: 58.2 ± 15. ...
Tópico(s): Obstructive Sleep Apnea Research
2019 - Wiley | International Forum of Allergy & Rhinology
Thomas S. Lee, Parul Goyal, Chengyu Li, Kai Zhao,
Inferior turbinate reduction (ITR) is a commonly performed procedure for the treatment of nasal obstruction. Which portion of the inferior turbinates should be ... for each patient: 1 unaltered and 6 various ITRs, including 3 one-third ITRs (anterior, middle, and posterior one-third); 2 two-thirds ITRs (anterior and posterior two-thirds); and 1 full-length ITR model. Total airflow rate and nasal resistance was ... and nasal resistance for all 5 patients.Full ITR over the whole length was consistently most effective ...
Tópico(s): Obstructive Sleep Apnea Research
2018 - American Medical Association | JAMA Facial Plastic Surgery
Marcela Rosato, Inés Álvarez, Gonzalo Nieto Feliner, Josep A. Rosselló,
Interstitial telomeric repeat (ITR) sites, consisting of tandem repeats of telomeric motifs localized at intrachromosomal sites, have been reported in a few unrelated ... plants. However, the causes for the occurrence of ITRs outside of the chromosomal termini are not fully ... Anthemideae), the occurrence and patterns of variation of ITRs were explored in this genus with the aim ... telomeric sequence as a probe.Variable presence of ITR sites was detected in six out of nine ... chromosomal locations and a differential presence of the ITR site on homologous chromosome pairs. At the intraspecific ...
Tópico(s): Genetic diversity and population structure
2018 - Oxford University Press | Annals of Botany
National Bureau of Economic Research (NBER)
Chang Ho Shin, Doo Jae Lee, Won Joon Yoo, In Ho Choi, Tae‐Joon Cho,
... with removal. A dual interlocking telescopic rod (D-ITR), in which the sleeve and the obturator are ... problems.In this study, we compared the D-ITR with an older version of a single interlocking telescopic rod (S-ITR) based on (1) surgery-free survival and rod ... interlocking telescopic system.This article compares the D-ITR with the S-ITR using a historically controlled, single-surgeon, retrospective design ... Before August 2007, we exclusively used the S-ITR (n = 17 patients, 29 tibiae); from July 2008 until October 2014, we exclusively used the D-ITR (n = 17 patients, 26 tibiae). During the 1- ...
Tópico(s): Hip disorders and treatments
2018 - Lippincott Williams & Wilkins | Clinical Orthopaedics and Related Research
Adrien Savy, Yohann Dickx, Lucile Nauwynck, Delphine Bonnin, Otto‐Wilhelm Merten, Lionel Galibert,
Adeno-associated virus (AAV) inverted terminal repeats (ITRs) are key elements of AAV. These guanine-cytosine-rich structures are involved in the replication and encapsidation of the AAV genome, along with ... plasmids containing the gene of interest flanked by ITRs and used for rAAV production often present incomplete, truncated, or imperfect ITR sequences. For example, pSUB201 and its derivatives harbor ... nt missing on the external part of the ITR), flop-orientated ITR plus 46 bp of non-ITR viral DNA ...
Tópico(s): CRISPR and Genetic Engineering
2017 - Mary Ann Liebert, Inc. | Human Gene Therapy Methods
Víctor M. López-Álvarez, María Puigdomenech, Xavier Navarro, Stefano Cobianchi,
... characterizes the impact of increasing-intensity treadmill exercise (iTR) on noradrenergic (NE) and serotonergic (5HT) modulation of ... and thermal hyperalgesia that was partially prevented by iTR performed during the first 2weeks after injury. Marked ... horn was associated to SNTR and recovered by iTR, particularly in lamina II. iTR significantly increased 5HT2A in periaqueductal grey (PAG), raphe ... of serotonergic excitatory interconnections between PAG and DRN. iTR also increased the expression of α1A in locus ...
Tópico(s): Pharmacological Effects of Natural Compounds
2017 - Elsevier BV | Experimental Neurology
Xu Tao, Bojin Su, Chunhua Wang, Sumei Wang, He-Cheng Huang, Yunbao Pan, Donghui Wang, Weihong Wei, François X. Claret, Huiling Yang,
... markers between the short-term interval to recurrence (ITR) group (ITR <18 months) and long-term ITR group (ITR ≥18 months) were further analyzed. In Cox's regression analysis, the ITR was significantly associated as an independent‑negative prognostic ... p-Stat3 was increased in the short-term ITR group (ITR <18 months) and tended to be lower in the long-term ITR group (ITR ≥18 months). In the short-term ITR group, nuclear Akt expression was significantly increased in ...
Tópico(s): RNA Research and Splicing
2015 - Elsevier BV | Oncology Reports
Cameron Mroske, H Rivera, Taihra Ul-Hasan, Saswati Chatterjee, Kah Keng Wong,
Inverted terminal repeat (ITR) integrity is critical for the replication, packaging, and transduction of recombinant adeno-associated virus (rAAV), a promising gene therapy vector. Because AAV ITRs possess 70% GC content and are palindromic, they ... of this work was to develop a reliable ITR sequencing method. The ITRs of two molecular clones of AAV2, pTZAAV and ... ASM techniques yielded clear chromatograms, read through the ITR hairpin, and revealed hitherto unreported mutations in each ITR. pTZAAV and pAV2 possess identical mutations at the ...
Tópico(s): Viral Infectious Diseases and Gene Expression in Insects
2012 - Mary Ann Liebert, Inc. | Human Gene Therapy Methods
Victoria Hagens, Mark Dobrow, Roger Chafe,
Abstract Background This paper assesses interviewee transcript review (ITR) as a technique for improving the rigour of interview-based, qualitative research. ITR is a process whereby interviewees are provided with ... accuracy, correcting errors or inaccuracies and providing clarifications. ITR, in various forms, is widely used among qualitative ... the data, the interviewee or the researcher. Methods ITR was incorporated into a qualitative research study in ... mutually exclusive categories. Results The study found that ITR added little to the accuracy of the transcript ...
Tópico(s): Clinical practice guidelines implementation
2009 - BioMed Central | BMC Medical Research Methodology