Produção Nacional
Revisado por pares
João Vitor Lana, Alexandre Rios, Renata Takeyama, Napoliane Santos, Luyddy Pires, Gabriel Silva Santos, Izair Jefthé Rodrigues, Madhan Jeyaraman, Joseph Purita, José Fábio Lana,
Glutathione (GSH), a tripeptide synthesized intracellularly, serves as a pivotal antioxidant, neutralizing reactive oxygen species (ROS) and reactive nitrogen species (RNS) while maintaining redox homeostasis and detoxifying xenobiotics. Its potent antioxidant properties, particularly attributed to the sulfhydryl group (-SH) in cysteine, are crucial for cellular health across various organelles. The glutathione-glutathione disulfide (GSH-GSSG) cycle is facilitated by enzymes like glutathione peroxidase ( ...
Tópico(s): Redox biology and oxidative stress
2024 - Multidisciplinary Digital Publishing Institute | Nutrients
Produção Nacional
Revisado por pares
José Fábio Lana, Annu Navani, Madhan Jeyaraman, Napoliane Santos, Luyddy Pires, Gabriel Silva Santos, Izair Jefthé Rodrigues, Douglas Santos, Tomas Mosaner, Gabriel Ohana Marques Azzini, Lucas Furtado da Fonseca, Alex Pontes de Macedo, Stephany Cares Huber, Daniel de Moraes Ferreira Jorge, Joseph Purita,
Spinal cord injury (SCI) represents a severe trauma to the nervous system, leading to significant neurological damage, chronic inflammation, and persistent neuropathic pain. Current treatments, including pharmacotherapy, immobilization, physical therapy, and surgical interventions, often fall short in fully addressing the underlying pathophysiology and resultant disabilities. Emerging research in the field of regenerative medicine has introduced innovative approaches such as autologous orthobiologic ...
Tópico(s): Spine and Intervertebral Disc Pathology
2024 - Multidisciplinary Digital Publishing Institute | Bioengineering
Produção Nacional
Revisado por pares
José Fábio Lana, Annu Navani, Madhan Jeyaraman, Napoliane Santos, Luyddy Pires, Gabriel Silva Santos, Izair Jefthé Rodrigues, Douglas Santos, Tomas Mosaner, Gabriel Ohana Marques Azzini, Lucas Furtado da Fonseca, Alex Pontes de Macedo, Stephany Cares Huber, Daniel de Moraes Ferreira Jorge, Joseph Purita,
In the original publication [...].
Tópico(s): Musculoskeletal pain and rehabilitation
2024 - Multidisciplinary Digital Publishing Institute | Bioengineering
Produção Nacional
Revisado por pares
Cezar Augusto Alves de Oliveira, Bernardo Scaldini Oliveira, Rafael Theodoro, J Wang, Gabriel Silva Santos, Bruno Lima Rodrigues, Izair Jefthé Rodrigues, Daniel de Moraes Ferreira Jorge, Madhan Jeyaraman, Peter A. Everts, Annu Navani, José Fábio Lana,
Degenerative disc disease (DDD) is a pervasive condition that limits quality of life and burdens economies worldwide. Conventional pharmacological treatments primarily aimed at slowing the progression of degeneration have demonstrated limited long-term efficacy and often do not address the underlying causes of the disease. On the other hand, orthobiologics are regenerative agents derived from the patient's own tissue and represent a promising emerging therapy for degenerative disc disease. This review ...
Tópico(s): Medical Imaging and Analysis
2024 - Multidisciplinary Digital Publishing Institute | Bioengineering
Andrei Fernandes Joaquim, Rodrigo Cavalcante, Izair J. Rodrigues, Marcelo Luís Mudo,
Introduction: Anomalies of the craniovertebral junction (CVJ) include a wide range of conditions, such as C1-2 chronic instability. Surgery is generally indicated in the context of neurological deficits, although the best surgical option to be chosen is controversy. Method: A 12-year-old girl with severe neurological deficits due to a chronic fixed C1-2 subluxation underwent to an occipito-C2 laminar screws fusion and posterior decompression, with significant neurological improvement after three ...
Tópico(s): Medical Imaging and Analysis
2018 - | JBNC - JORNAL BRASILEIRO DE NEUROCIRURGIA