Joern Linkner, Gregor Witte, Hongxia Zhao, Alexander Junemann, Benjamin Nordholz, Petra Runge-Wollmann, Pekka Lappalainen, Jan Faix,
... we analyzed the single I-BAR family member IBARa from D. discoideum. The X-ray structure of ... tubules. Immunofluorescence labelling further showed accumulation of endogenous IBARa at the tips of filopodia, the rim of ... prominently at the osmoregulatory contractile vacuole (CV). Consistently, IBARa-null mutants displayed defects in CV formation and ... whereas filopodia formation was not compromised. Of note, IBARa-null mutants were also strongly impaired in cell spreading. Together, these data suggest IBARa to constitute an important regulator of numerous cellular ...
Tópico(s): Microtubule and mitosis dynamics
2014 - The Company of Biologists | Journal of Cell Science
Douwe M. Veltman, Giulio Auciello, Heather J. Spence, Laura M. Machesky, Joshua Z. Rappoport, Robert H. Insall,
... where SH3 is Src homology 3) protein, called IBARa, along with homologues of proteins that interact with ... its cellular function. Disruption of the gene encoding IBARa leads to a mild defect in development, but ... and pseudopod dynamics are unaffected. Furthermore, ectopically expressed IBARa does not induce filopod formation and does not localize to filopods. Instead, IBARa associates with clathrin puncta immediately before they are ...
Tópico(s): Microtubule and mitosis dynamics
2011 - Portland Press | Biochemical Journal
Esther Nina Ontsira Ngoyi, Blaise Irénée Atipo Ibara, Rachelle Moyen, Philestine Clausina Ahoui Apendi, J. R. Ibara, O. Obengui, Roland Bienvenu Ossibi Ibara, Etienne Nguimbi, Rock Fabien Niama, J. M. Ouamba, F. Yala, Ange Antoine Abena, Jamuna Vadivelu, Khean‐Lee Goh, Armelle Ménard, Lucie Bénejat, Elodie Sifré, Philippe Lehours, Françis Mégraud,
Abstract Back ground Helicobacter pylori infection is involved in several gastroduodenal diseases which can be cured by antimicrobial treatment. The aim of this study was to determine the prevalence of H. pylori infection and its bacterial resistance to clarithromycin, fluoroquinolones, and tetracycline in Brazzaville, Congo, by using molecular methods. Material and Methods A cross‐ sectional study was carried out between September 2013 and April 2014. Biopsy specimens were obtained from patients ...
Tópico(s): Gastric Cancer Management and Outcomes
2015 - Wiley | Helicobacter
Yoshiyuki Koide, Koichi Tazaki, Hiroo Kagami,
Ibara dismembered ophiolite exposed in the western extension of the Maizuru Tectonic Belt is composed mainly of ... metamorphic age (270-290Ma), This suggests that the Ibara ophiolite was metamorphosed soon after solidification of the ...
Tópico(s): High-pressure geophysics and materials
1987 - Japan Association of Mineralogical Sciences | The Journal of the Japanese Association of Mineralogists Petrologists and Economic Geologists
Danielle Baptista, Liliana Moreira Teixeira, Clemens van Blitterswijk, Stefan Giselbrecht, Roman Truckenmüller,
... J. et al.The inverse BAR domain protein IBARa drives membrane remodeling to control osmoregulation, phagocytosis and ... J. et al.The inverse BAR domain protein IBARa drives membrane remodeling to control osmoregulation, phagocytosis and ...
Tópico(s): Silk-based biomaterials and applications
2019 - Elsevier BV | Trends in biotechnology
Adeoluwa Oluwaseyi Adeleye, O T Azeez, Olanrewaju Yusuff,
... housing quality by residents and non residents of Ibara housing estate, Abeokuta. Data for the study were ...
Tópico(s): Place Attachment and Urban Studies
2014 - | American Journal of Human Ecology
Rod Ibara-Okabande, Félix Koukouikila-Koussounda, Mathieu Ndounga, Christevy Vouvoungui, Vladimir Malonga, Prisca Nadine Casimiro, J. R. Ibara, Anissa Sidibé, Francine Ntoumi,
Abstract Background In this first study conducted after the introduction of artemisinin-combination therapy (ACT), the major objective was to evaluate Plasmodium falciparum genetic diversity and multiplicity of infection in isolates from Congolese children between one and nine years of age enrolled and followed up for one year. The secondary objective was to characterize the msp2 profiles of P. falciparum isolates collected from successive malaria episodes in ten children who had four or more clinical ...
Tópico(s): Research on Leishmaniasis Studies
2012 - BioMed Central | Malaria Journal
... gusa kurusobe rw’miterere yabwo, harimo dorsum ifite ibara ry’cyatsi cyeru-rutse n’ruhu rubonerana rwo kunda, amagufwa afite ibara ry’bururu, n’tunodufatanijwe n’gahu, umutwe wenda ...
Tópico(s): Species Distribution and Climate Change
2012 - Q15088586 | Zootaxa
Produção Nacional
Revisado por pares
José Wellington de Oliveira Lima, Luciano Pamplona de Góes Cavalcanti, Ricardo José Soares Pontes, Jörg Heukelbach,
... et al. 1987; Conejo et al. 2000; Martinez-Ibara et al. 2002; Mohamed 2003). As the selection ... and cost reductions (Neng et al. 1987; Martinez-Ibara et al. 2002). We thank the technicians Roberto ...
Tópico(s): Malaria Research and Control
2010 - Wiley | Tropical Medicine & International Health
... has been reported that the metabasalts from the Ibara district belonging to the Maizuru Tectonic Belt show ... Yakuno district and metabasalts in both Yakuno and Ibara districts. Metagabbros and the related rocks in the ...
Tópico(s): Geochemistry and Elemental Analysis
1992 - Japan Association of Mineralogical Sciences | JOURNAL OF MINERALOGY PETROLOGY AND ECONOMIC GEOLOGY
Tomoyuki Kuroiwa, Aida K. Sarcon, Takuya Ibara, Eriku Yamada, Akiko Yamamoto, Kazuya Tsukamoto, Koji Fujita,
Artificial intelligence (AI) has gained tremendous popularity recently, especially the use of natural language processing (NLP). ChatGPT is a state-of-the-art chatbot capable of creating natural conversations using NLP. The use of AI in medicine can have a tremendous impact on health care delivery. Although some studies have evaluated ChatGPT's accuracy in self-diagnosis, there is no research regarding its precision and the degree to which it recommends medical consultations.
Tópico(s): Machine Learning in Healthcare
2023 - JMIR Publications | Journal of Medical Internet Research
Francesco De Pretis, Mark van Gils, Markus Forsberg,
... 20177483075Crossref Scopus (3) Google Scholar, 40.Beninger P. Ibara M.A. Pharmacovigilance and biomedical informatics: a model ...
Tópico(s): Pharmaceutical Economics and Policy
2022 - Elsevier BV | Trends in Pharmacological Sciences
Pembé Issamou Mayengué, Dezi Kouhounina Batsimba, Roch Fabien Niama, Reyna Ibara Ottia, Alida Malonga-Massanga, Grâce Petula Urielle Fila-Fila, Gabriel Ahombo, Simon Charles Kobawila, Henri Joseph Parra,
In the Republic of Congo, hot temperature and seasons distortions observed may impact the development of malaria parasites. We investigate the variation of malaria cases, parasite density and the multiplicity of Plasmodium falciparum infection throughout the year in Brazzaville.From May 2015 to May 2016, suspected patients with uncomplicated malaria were enrolled at the Hôpital de Mfilou, CSI « Maman Mboualé», and the Laboratoire National de Santé Publique. For each patient, thick blood was examined ...
Tópico(s): Mosquito-borne diseases and control
2020 - BioMed Central | BMC Infectious Diseases
Yuki Miyake, Eri Eguchi, Hiroshi Ito, Kazufumi Nakamura, Tatsuo Ito, Kenjiro Nagaoka, Noriyoshi Ogino, Keiki Ogino,
The purpose of this study was to investigate the relationship between occupational dysfunction and metabolic syndrome (MetS) and its component factors in community-dwelling Japanese adults (N = 1,514). Self-reported lifestyle behaviors, Classification and Assessment of Occupational Dysfunction (CAOD) scores, and metabolic traits were measured. CAOD levels were divided into tertiles (low, moderate, and high), and their associations with MetS and its components were evaluated through logistic regression ...
Tópico(s): Musculoskeletal pain and rehabilitation
2018 - Multidisciplinary Digital Publishing Institute | International Journal of Environmental Research and Public Health
Pembé Issamou Mayengué, Roch Fabien Niama, Dezi Kouhounina Batsimba, Alida Malonga-Massanga, Igor Louzolo, Nadia Claricelle Loukabou Bongolo, Lucette Macosso, Reyna Ibara Ottia, Ghyslain Kimbassa Ngoma, Louis Régis Dossou-Yovo, Brice Pembet Singana, Gabriel Ahombo, Géril Sekangue Obili, Simon Charles Kobawila, Henri Joseph Parra,
In the Republic of Congo, artemisinin-based combinations have been recommended for the treatment of uncomplicated malaria since 2006. However, the emergence of resistant parasites again these combinations in Southeast Asia is a threat for the control of this disease, especially in sub-Saharan Africa where the weight of the disease is important. Indeed, polymorphisms in Plasmodium falciparum K13-propeller gene have been involved in variations of drug sensitivity of Plasmodium falciparum to artemisinin- ...
Tópico(s): Drug-Induced Hepatotoxicity and Protection
2018 - BioMed Central | BMC Infectious Diseases
Hiroyuki Mochizuki, Satoshi Kusuda, Kenji Okada, Shigemi Yoshihara, Hiroyuki Furuya, Eric A. F. Simões, Hideomi Asanuma, Hiroshi Yoshida, Masahiko Katayose, Takashi Imamura, Hiroshi Suzumura, Youko Honma, Jichi Medical, Kenichi Maruyama, Yasushi Ohki, Koji Ozasa, Akiyoshi Nariai, Atsushi Uchiyama, Hideko Uryu, Shigeharu Hosono, Masatoshi Kondo, Yasuharu Kawase, Kazunari Ikeda, Kazunari Ikeda, Atsushi Naito, Yuki Minami, Tomohiko Nakamura, Atsushi Baba, Yoshihisa Nagayama, Hisashi Kaneda, Shigeru Ohki, Masami Shiraii, Yuto Henmi, Chizuko Suzuki, Kuniko Ieda, Taihei Tanaka, Yoshinori Kono, Kashiro Nisizawa, Fusako Niwa, Hisato Ito, Yasuyuki Tokunaga, Yoshinobu Takada, Yoshihide Nishikawa, Ikuo Nagata, Yasuhisa Kajino, Shinichi Watabe, Hiroyuki Yoshio, Nobumasa Takahashi, Nobutaka Sasaki, Michiko Hayashidani, Hiroshi Tateishi, Kenji Matsushita, Masatoshi Nakamura, Hideki Nakayama, Go Yamamoto, Noriaki Kanemitsu, T Takayanagi, Ayumi Sato, Satoshi Ibara,
Rationale: Respiratory syncytial virus (RSV) induces not only infantile recurrent wheezing but also potentially atopic asthma.Objectives: To test the effect of RSV infection on development of subsequent atopic asthma, we evaluated whether palivizumab, an anti-RSV monoclonal antibody, by preventing severe RSV disease in the first year of life, could impact subsequent recurrent wheezing and atopic asthma at 6 years of age.Methods: During the 2007 to 2008 RSV season, the decision to administer palivizumab ...
Tópico(s): Asthma and respiratory diseases
2017 - American Thoracic Society | American Journal of Respiratory and Critical Care Medicine
Paul Beninger, Michael A. Ibara,
PurposeThe discipline of pharmacovigilance is rooted in the aftermath of the thalidomide tragedy of 1961. It has evolved as a result of collaborative efforts by many individuals and organizations, including physicians, patients, Health Authorities, universities, industry, the World Health Organization, the Council for International Organizations of Medical Sciences, and the International Conference on Harmonisation. Biomedical informatics is rooted in technologically based methodologies and has ...
Tópico(s): Academic integrity and plagiarism
2016 - Elsevier BV | Clinical Therapeutics
... 2016; 39 (2512–2513)Google Scholar, 5Beninger P. Ibara M. Pharmacovigilance and biomedical informatics: a model for ...
Tópico(s): Pharmaceutical Economics and Policy
2016 - Elsevier BV | Clinical Therapeutics
Mizuho Kadooka, Hiromi Kato, Akihiko Kato, Satoshi Ibara, Hisanori Minakami, Yuko Maruyama,
Fetomaternal hemorrhage (FMH) can cause severe morbidity. However, perinatal risk factors for long-term poor outcome due to FMH have not been extensively studied. To determine which FMH infants are likely to have neurological sequelae. A single-center retrospective observational study. Perinatal factors, including demographic characteristics, Kleihauer–Betke test, blood gas analysis, and neonatal blood hemoglobin concentration ([Hb]), were analyzed in association with long-term outcomes. All 18 neonates ...
Tópico(s): Fetal and Pediatric Neurological Disorders
2014 - Elsevier BV | Early Human Development
Takashi Yoshida, Hirofumi Miyaji, Kentaro Otani, Kana Inoue, Kazuyasu Nakane, Hitoshi Nishimura, Asako Ibara, Akira Shimada, Kosuke Ogawa, Eisuke Nishida, Tsutomu Sugaya, Ling Sun, Bunshi Fugetsu, M. Kawanami,
Beta-tricalcium phosphate (β-TCP), a bio-absorbable ceramic, facilitates bone conductivity. We constructed a highly porous three-dimensional scaffold, using β-TCP, for bone tissue engineering and coated it with co-poly lactic acid/glycolic acid (PLGA) to improve the mechanical strength and biological performance. The aim of this study was to examine the effect of implantation of the PLGA/β-TCP scaffold loaded with fibroblast growth factor-2 (FGF-2) on bone augmentation.The β-TCP scaffold was fabricated ...
Tópico(s): Dental Implant Techniques and Outcomes
2014 - Wiley | Journal of Periodontal Research
Hirofumi Miyaji, Izumi Kanayama, Hiroko Takita, Erika Nishida, Maiko Tsuji, Bunshi Fugetsu, Ling Sun, Kana Inoue, Asako Ibara, Tsukasa Akasaka, Tsutomu Sugaya, Masamitsu Kawanami,
Background: Graphene oxide (GO) is a single layer carbon sheet with a thickness of less than 1 nm. GO has good dispersibility due to surface modifications with numerous functional groups. Reduced graphene oxide (RGO) is produced via the reduction of GO, and has lower dispersibility. We examined the bioactivity of GO and RGO films, and collagen scaffolds coated with GO and RGO. Methods: GO and RGO films were fabricated on a culture dish. Some GO films were chemically reduced using either ascorbic acid ...
Tópico(s): Electrospun Nanofibers in Biomedical Applications
2014 - Dove Medical Press | International Journal of Nanomedicine
Masaya Anan, Koichi Shinkoda, Kentaro Suzuki, Masahide Yagi, Takuya Ibara, Nobuhiro Kito,
The sit-to-stand motion (STS) is a frequently executed activity that is affected by weakness in the quadriceps femoris muscle and knee joint pain in patients with knee osteoarthritis (OA). We investigated whether patients with knee OA can efficiently perform STS through mechanical energy transfer assessments. Participants were 20 women with knee OA and 17 age-matched asymptomatic controls. The center of mass (COM), segment angles, joint moments, and powers during STS were measured. The negative mechanical ...
Tópico(s): Sports injuries and prevention
2014 - Elsevier BV | Gait & Posture
A O Adeleye, Tajudeen Azeez, Olanrewaju Yusuff,
Tópico(s): Housing Market and Economics
2014 - | American Journal of Human Ecology
This paper examines clinical supervision approaches that have the potential to promote and implement effective teacher supervision in Nigeria. The various approaches have been analysed based on the conceptual framework of instructional supervisory behavior. The findings suggest that a clear distinction can be made between the prescriptive and collaborative clinical approaches of clinical supervision. The prescriptive clinical supervision is authoritative in nature while the collaborative approach ...
Tópico(s): Collaborative Teaching and Inclusion
2013 - Taylor & Francis | Africa Education Review
Asako Ibara, Hirofumi Miyaji, Bunshi Fugetsu, Erika Nishida, Hiroko Takita, Saori Tanaka, Tsutomu Sugaya, Masamitsu Kawanami,
Nanoparticle bioceramics have become anticipated for biomedical applications. Highly bioactive and biodegradable scaffolds would be developed using nanoparticles of β ‐tricalcium phosphate ( β ‐TCP). We prepared collagen scaffolds coated by nano‐ β ‐TCP and fibroblast growth factor 2 (FGF2) and evaluated the effects on new bone augmentation and biodegradation. The collagen sponge was coated with the nano‐TCP dispersion and freeze‐dried. Scaffold was characterized by SEM, TEM, XRD, compressive testing ...
Tópico(s): Electrospun Nanofibers in Biomedical Applications
2013 - Hindawi Publishing Corporation | Journal of Nanomaterials
Francine Ntoumi, Christevy Vouvoungui, Rod Ibara, M. L. Landry, Anissa Sidibé,
There have been few investigations evaluating the burden of malaria disease at district level in the Republic of Congo since the introduction of artemisinin-based combination therapies (ACTs). The main objective of this study was to document laboratory-confirmed cases of malaria using microscopy and/or rapid diagnostic tests (RDTs) in children and pregnant women attending selected health facilities in Brazzaville and Pointe Noire, the two main cities of the country. Secondly, P. falciparum genetic ...
Tópico(s): Parasites and Host Interactions
2013 - BioMed Central | BMC Public Health
Masahiro Hayakawa, Yushi Ito, Shigeru Saito, Nobuaki Mitsuda, Shigeharu Hosono, Hitoshi Yoda, Kazutoshi Cho, Katsufumi Otsuki, Satoshi Ibara, Katsuo Terui, Kouji Masumoto, Takeshi Murakoshi, Akihito Nakai, Mamoru Tanaka, Tomohiko Nakamura,
Hypoxic-ischemic encephalopathy (HIE) is one of the most critical pathologic conditions in neonatal medicine due to the potential for neurological deficits in later life. We investigated the incidence of term infants with moderate or severe HIE in Japan and identified prognostic risk factors for poor outcome in HIE.Data on 227 infants diagnosed with moderate or severe HIE and born between January and December 2008 were collected via nationwide surveys from 263 responding hospitals. Using logistic ...
Tópico(s): Neonatal Respiratory Health Research
2013 - Wiley | Pediatrics International
In this paper, we study the (group) strategy-proofness of deterministic mechanisms in the obnoxious facility game. In this game, given a set of strategic agents in a metric, we design a mechanism that outputs the location of a facility in the metric based on the locations of the agents reported by themselves. The benefit of an agent is the distance between her location and the facility and the social benefit is the total benefits of all agents. An agent may try to manipulate outputs by the mechanism ...
Tópico(s): Game Theory and Applications
2012 - Springer Science+Business Media | Lecture notes in computer science
Benjamin Longo‐Mbenza, Nkondi, Mokondjimobe, Gombet, Ibara, Bertrand Fikahem Ellenga Mbolla, Vangu, Mbungu,
Background: Helicobacter pylori is now incriminated in the pathogenesis of atherosclerosis. Objective: To examine the importance of H. pylori infection as a cardiovascular disease (CVD) risk factor. Methods: Two hundred five patients (128 with H. pylori infection [HP-seropositive] and 77 without) had a baseline assessment for other potential CVD risk factors and were followed prospectively for 10 years (1999–2008). They were assessed on a monthly basis for the outcomes of carotid plaque, angina pectoris, ...
Tópico(s): Eosinophilic Esophagitis
2012 - Dove Medical Press | Vascular Health and Risk Management
Rania Abubaker Bagabir, Farhatullah Syed, Riina Rautemaa, Duncan Angus McGrouther, Ralf Paus, Ardeshir Bayat,
... as chicken pox (Gathse et al., 2003Gathse A. Ibara J.R. Obengui P. et al.Gigantic keloïds ...
Tópico(s): Cutaneous Melanoma Detection and Management
2011 - Elsevier BV | Journal of Investigative Dermatology