Directory of Open Access Journals (DOAJ)
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... Manager Jewellers in the Northwest Requires Full-Time… ICO Marshall Warburton Technology Armature Ltd Christopher Hamblyn Associates ... News International Newspapers Ltd C. V. Services Profiles ICO Multiple Display Advertising Items Institute of Directors Austin ...
1998 - Gale Group | Sunday Times HA GDA
Yi-pin Lv, Wenqing Tian, Yong‐sheng Teng, Pan Wang, Yongliang Zhao, Zhengyan Li, Shanhong Tang, Weisan Chen, Rui Xie, Muhan Lü, Yuan Zhuang,
... the mechanism of tumor-infiltrating mast cells stimulating ICOS+ regulatory T cells via the IL-33/IL- ... GC were conducted to examine mast cell counts, ICOS+ Tregs, and the levels of IL-33 or IL-2. Isolated ICOS+ Treg and CD8+ T cell were stimulated, cultured ... expression for the inducible T cell co-stimulator (ICOS). In vitro, IL-2 from IL to 33-stimulated mast cells induced increased numbers of ICOS+ Tregs with increased immunosuppressive activity against proliferation and effector function of CD8+ T cell. In vivo, ICOS+ Tregs were treated with anti-IL-2 neutralizing ...
Tópico(s): Mast cells and histamine
2023 - Elsevier BV | Journal of Advanced Research
Taki, Gerald Segal, Rezvani, Waldemar Januszczak, John Dugdale, Michael Prescott, Matthew Wall, Tony Wrigglesworth, Katherine Burke, George Burns, Tony Barrell, Philip Norman, Nicholas Rufford, Ruperts Steiner, John Peter, Pam Barrett, Amanda Ursell, Rufus olins, Lesley White, A S Byatt, Lawrie Madden, Victor Bockris, Ivo Tennant, Ferdinand Mount, Sam Gilpin, Sally Payne, Lucy Hughes-Hallett, David Smith, Donald Foreman, Nick Pitt, Andrew Sullivan, Uri Geller, Mary Wilson, Karen Robinson, Dr Roger Henderson, Chris Goodwin, Ajoy Bose, Tony Allen-Mills, Martin James, Robert Sandall, Steve Farrar, Irwin Stelzer, Waldemar Januszak, Peter Wilson, Roger Anderson, Rachel Cook, Charlotte Wolff, David Dougill, Robert Hewison, Patrick Wilson, Philip Kingsley, Philip Kerr, Auberon Waugh, David Hewson, Emperor Akihito, Harvey Porlock, Dr Steven White, Margaret Coles, Debble Hill, Hugh Canning, Ken Russell, Jeremy Clarkson, Peter Kemp, Edward Porter, Peter Conradi, Stewart Lee, Louise Taylor, Jennifer Miller, Jenny Shields, Michael Jones, Peter Millar, Peter Hadfield, George Perry, Helen Dunmore, Kristle Hamilton, Graham Otway, Nick Gardner, M Warson, Paul Nuki Consumer Affairs Correspondent, Kerr, Anna Blundy, Mike Laws, Stuart Wavell, Paul Donovan, John Dunlop, Kristle Hamilton City Editor, Frances Spalding, Sue Lawrence, Hugh McIlvanney, David Johnson, Paul Driver, Boris Schapiro, Garth Pearce, Nicholas Hellen, Ian Hawkey, Ian Chadband, Christopher Morgan, Ross Clark, Walter Grey, Nicola Fairbrother, Kirstie Hamilton, Tom Shone, Dalglish, Mark Edwards, Kilworth Cork, Rebeccaa Ianqueray, Mark Austin, David Lawrenson, Susan Clark, Malcolm Gloak, Winston Peterson President, Andy Goldberg, Phil Baker, Michael Riding, John Harlow Arts Correspondent, D Seguin, James Turrell, Francis Bennion, Richard Young, Sue Reid, Raymond Keene, Joanna Lumley, Paul Bew, Stanley Stewart, Albert French, Colin Smith, Diana Wright, Philip Flaxion, Debbie Hill, David Leopard, Elaine Showalter, May Sarton, David Hunt, Rebecca Tanqueray, Stephen Jones, Helen Hawkins, Richard Evans, Nick Cain, Michael Wright, Brian Deer, Richard Edton, Michael Bartlett, Andrew Smith, Paul Nuki, David Pleat, Andrew Grice, Margaret Tudeau-Clyton, Fiona Shaw, Steve Connor Science Correspondent, Martin Searby, Keith Wheatley, Ghulam Hasnain, Claire Oldfield, David Walsh, Peter Matthews, John Whittington, Martin Tyler, Trevor Lewis, Rasselas, Stephen Armstrong, Christopher Goodwin, Naoml Caine, Paul Kavanagh, Michael Larrers, Josh Salzmann, David Windle, Tony Strong, Garth Alexander, Roland White, Babara Hall, Maurice Chittenden, Kevin Pratt, Barrie Penrose, Smlta Talati, Graham Hind, Kristie Hamilton, Mark Franchetti, Brian Moore, Ray Hutton, Jon Ungoed-Thomas, R Moody, Peter Watts, Kevin McCarra, Jonathan Leake, Michael Sheridan, Christine Webb, David Starkey, Simon Callow, Matthew Lynn, Godfrey Smith, Bob Davis, Kate Thornton, Andrew Alderson, John Waples, John McManus, A A Gill, Andrew Malone, Matthew Campbell, Jane Lacraft, Julie Smyth, John Carey, Katharine Graham, Monte Carlo, David Hutcheon, Kirsty Lang, David Sumner Smith, Paul Ganz, Clarie Oldfield, Robert Johnston, Chrissy Iley, Stephen Pettitt, Kevin Goldstein-Jackson, Cherry Norton, Andrew Lorenz, Naomi Caine, Liam Clarke, David Wickers, Jane Hardy, Roger Dobson, Anne Esden, Mark Hodson, Nicholas Hellen Media Correspondent, Agenda Andrew Lorenz, Joe Lovejoy, Naoml Caine Deputy Money Editor, Rupert Steiner, Ali Stewart, Chris Lightbown, Rose Singel, Hugh Pearman, David Parsley, John Phillips, Susan d' Arcy, Noel Malcolm, Penny Perrick, Anthony Howard, Shelley von Strynckel, Glenys, Hugh Colver, Joanna Simon, Stephen Boyd, India Knight, Carol Shiekis, Pamela Coleman, Frank Whiford, Lord Sainsbury, Adam Parsons,
... Classified Advertising Items Seagram The Sunday Times Talisman ICO Multiple Display Advertising Items Multiple Classified Advertising Items ... Advertising Items Emirates British Airways Telstra Lasmo Mars ICO Multiple Classified Advertising Items BSA International Inc Multiple ...
1998 - Gale Group | Sunday Times HA GDA
Vincent Panneton, Barbara C. Mindt, Yasser Bouklouch, Antoine Bouchard, Saba Mohammaei, Jinsam Chang, Nikoletta Diamantopoulos, Mariko Witalis, Joanna Li, Albert Stancescu, John Bradley, Troy D. Randall, Jörg H. Fritz, Woong‐Kyung Suh,
ICOS is a T-cell costimulatory receptor critical for Tfh cell generation and function. However, the role of ICOS in Tfr cell differentiation remains unclear. Using Foxp3-Cre–mediated ICOS knockout (ICOS FC) mice, we show that ICOS deficiency in Treg-lineage cells drastically reduces the ... early stage of the GC reaction suggests that ICOS normally inhibits Klf2 expression to promote follicular features including Bcl6 up-regulation. Furthermore, ICOS costimulation promotes nuclear localization of NFAT2, a known ...
Tópico(s): Immunotherapy and Immune Responses
2023 - | Life Science Alliance
Tom Jacobs, Phil Yates, Tunku Varadarajan, Jon Ashworth, Raymond Snoddy Media Editor, Helen Johnstone, Kathy Lipari, Sarah Potter, Magnus Linklater, Sean O'Callaghan, Richard Hobson, Raymond Snoddy, Media Editor, James Landale, Political Reporter, Philip Howard, Hilary Finch, Alber Hall, Jeremy Kingston, Joanna Bale, Clive Davis, Carl Mortished, Nick Nuttall, Environment Correspondent, Roger Maynard, Jeremy Whittle, Kevin Eason, Christine Buckley Industrial Correspondent, Geoff Brown, Robert Sheehan, Bridge Correspondent, Joe Joseph, Martin Fletcher, Pat Gibson, Jill Sherman, Chief Political Correspondent, Ruth Gledhill, Religion Correspondent, John O'leary Education Editor, A. E. Wright, John Bryant, Ian Linden, Executive Director, John Hopkins, Golf Correspondent, Benet Steinberg, I. G. Cross, Dominic Walsh, Shirley English, Hugh Canning, Carol Midgley, Media Correspondent, Raymond Keene Chess Correspondent, Leon Novik, Ross Dunn, Martin Barrow, Peter Ackroyd, Peter Waymark, Richard Shooter Chairman, Richard Ford Home Correspondent, Sarah Cunningham, Retail Correspondent, Stephen Farrell, Alan Hamilton, Ian Murray, Medical Correspondent, Jenny MacArthur, Robert Bruce, Michael Clark, Helen Dunmore, Phil Gordon, Jenny Borden, Acting Director, David Hands, Philip Webster and Martin Fletcher, Peter Barnard, Barry Millington and John Higgins, David Charter, I. A. McCoubrey, Victoria Fletcher, Jasper Gerard, Roger Scruton, Russell Kempson, M. P. Wyatt, Giles Whittell and Joanna Bale, Iain Kirkpatrick, Adam Lebor, Anthony Storr, Marit Hargie, Graham Dixon, John Hopkins, Barry Millington, Adam Jones, Raymond Keene, David Charter, Education Correspondent, John Grigg, Geoffrey Cooke, David Orr, Bronwen Maddox, Jill Sherman, Richard Owen, Roger Boyes, Sarah Cunningham, Stanley Blow, Ian Murray Medical Correspondent, Kathryn Knight and Arthur Leathley, Terence Bendixson, President, Richard Branson, Dom Young, Leslie Isaiah Thomas, Laura Brook and Emma Rolph, John Allison, William Rees-Mogg, Nick Szczepanik, Nick Nuttall, Technology Correspondent, Christopher Walker, James Pringle, Chris Parker, Jane Shilling, Paul Wilkinson and Kathryn Knight, Jason Nissé, Des Dearlove, Gerald Larner, Kevin McCarra, Matthew Parris, Chris McGrath, Moira Petty, Graeme Bell, Director, Peter Riddell, Christopher Hulse, Ian Brodie, Ben Macintyre, Alasdair Murray Economics Correspondent, Martin Scicluna, Graham Searjeant, Tim Jones, Michael Binyon, Diplomatic Editor, Mark Henderson, Martin Waller, Chris Ayres, Toby Litt, Ian Maiden, Nigel Hawkes Science Editor, Benedict Nightingale, Dr Thomas Stuttaford, Julian Muscat Tennis Correspondent, Sam Kiley, Alan Stewart, Susan MacDonald, David Maddock, Robert Whymant, Richard Miles Banking Correspondent, David Hands, Rugby Correspondent, Colin McQuillan, Alasdair Murray, Economics Correspondent, Christopher Irvine, John Rawlins,
... Pen Limited Arts Consultant CMR Head Chef Required ICO YMCA Sepro Hampshire Constabulary BT First Point International ... Littlewood The Yankee Group Europe University of Hertfordshire ICO BMW A Career in the City All Box ...
1998 - Gale Group | TDA
Manon Bouwmeester, Yu Tao, Susana Proença, Frank G. van Steenbeek, Roos‐Anne Samsom, Sandra M. Nijmeijer, Theo L. Sinnige, Luc J. W. van der Laan, Juliette Legler, Kerstin Schneeberger, Nynke I. Kramer, Bart Spee,
... safety assessment in drug development. Intrahepatic cholangiocyte organoids (ICOs) are described as a donor-derived in vitro ... Here, we explored the potential of hepatocyte-like ICOs (HL-ICOs) in in vitro toxicity testing by exploring the ... drug-induced toxicity, and the exposure of HL-ICOs to well-known hepatotoxicants. The current state of drug metabolism in HL-ICOs showed levels comparable to those of PHHs and ... levels. Additionally, EC50 values were determined in HL-ICOs for acetaminophen (24.0–26.8 mM), diclofenac ( ...
Tópico(s): Drug Transport and Resistance Mechanisms
2023 - Multidisciplinary Digital Publishing Institute | Molecules
Edith Cresson, Michael Binyon, Diplomatic Editor, and James Clark, Tunku Varadarajan, Barney Spender, Raymond Snoddy Media Editor, Andrew Pierce, Political Correspondent, Helen Johnstone, Mandy Stewart, Robert Cole, Rob Hughes, Sarah Potter, Magnus Linklater, Richard Ford and Frances Gibb, Gavin Lumsden, Philip Howard, Janet Bush Economics Editor, Hilary Finch, Ian Murray, George Sivell, Clare MacInnes, Carl Mortished, Peter Ryder, Robert Cogo-Fawcett, Simon Wilde, Tom Walker, Kevin Eason, Michael Wilks, Geoff Brown, Maggie Woolley, Jude Kelly, Charles J. Lewis, Robert Sheehan, Bridge Correspondent, Joe Joseph, Alastair Campbell, Carol Midgley, Michael Binyon and Roger Maynard, C. Holcombe, Jill Sherman, Chief Political Correspondent, Ruth Gledhill, Religion Correspondent, Pugh & Way, Thelma Holt, Chairman, Ruth Gledhill, Shirley English, Michael Attenborough, Mark Mazower, Paul Allen, Raymond Keene Chess Correspondent, Robert Maxtone Graham, Audrey Magee Ireland Correspondent, Peter Ackroyd, Matthew Parris Political Sketch, Paul Wilkinson and David Watts, Peter Waymark, Sarah Cunningham, Retail Correspondent, Stephen Farrell, Robin Young, Dom Young, Leslie Isaiah Thomas, Emma Rolph and Laura Brook, Rodney Milnes, Lucille McLauchlan, Robert Nye, Jenny MacArthur, Robert Bruce, Michael Clark, Gardner of Parkes, Michael Binyon and Graham Paterson, Charles Bremner, Philip Webster, Martin Fletcher and Audrey Magee, John Craven, Jill Sherman and Andrew Pierce, Jasper Gerard, Nicholas Watt Political Correspondent, Anne Karpf, Paul Durman, Helen Wallace, Sydney Friskin, Martin Fletcher, Chief Ireland Correspondent, Father Times, John Hopkins, David B. Cook, Barry Millington, Andrew Motion, David Watts, John Higgins, Dalya Alberge, Arts Correspondent, Raymond Keene, Alan Lee, Cricket Correspondent, Matt Dickinson, Bush Hartshorn, Peter Stothard, Alan Ayckbourn, Nigel Hawkes, Michael Wright, Carl Mortished, International Business Editor, Bronwen Maddox, Cathy Harris, Richard Owen, Sam Mendes, Damian Whitworth, Erica Wagner, Nigel Hawkes, Science Editor, John Stern, Oliver August, Andrew Pierce Political Correspondent, Nick Kelly, Robert Cole, City Correspondent, John Allison, Richard Duce, Christopher Thomas, Giles Whittell, Christopher Walker, Jason Nissé, Mel Webb, Des Dearlove, Michael Ratcliffe, Jenny Topper, Richard Evans Racing Correspondent, Russell Jenkins, Michael Austin, Peter Riddell, Ian Brodie, Menzies Campbell, Jason Cowley, Richard Miles, Graham Searjeant, Fraser Nelson, Barbara Matthews, Mark Henderson, Chris Ayres, Daniel Rosenthal, Benedict Nightingale, Alexandra Frean, Social Affairs Correspondent, Tom Rhodes, Sarah Cunningham Retail Correspondent, Dr Thomas Stuttaford, Frances Gibb Legal Correspondent, Russell Celyn Jones, David Powell, Frances Gibb, Sam Kiley, James Christopher, Haig, Michael Henderson, Susan MacDonald, Robin Lodge, Michael Evans, Roger Chapman, Frank Field, Roy Foster, David Hands, Rugby Correspondent, India Knight, Jatinder Verma, Frank Harding, Christopher Irvine, Michael Hornsby Agriculture Correspondent,
... Elestra TMP Worldwide Michael Page Sales & Marketing BT ICO Connaught AGAS The Open University CFS International Clsco ... Driver Required Multiple Classified Advertising Items Pedigree Petfoods ICO Andersen Consulting Wamnet 4 Sight MMi Conran Rest ...
1998 - Gale Group | TDA
Xiashuang Zhao, Yongfeng Wang, Xianglai Jiang, Bangqian Mo, Chenyu Wang, Mingzheng Tang, Yao Rong, Guiqian Zhang, Ming Hu, Hui Cai,
... checkpoint known as Inducible T Cell Costimulatory Factor (ICOS, Cluster of Differentiation, CD278) is activated and expressed ... important for immunosuppression. Uncertainty surrounds the function of ICOS in tumor immunity. Methods Several bioinformatics techniques were ... thoroughly examine the expression and prognostic value of ICOS in 33 cancers based on data collected from TCGA and GTEx. In addition, ICOS was explored with pathological stage, tumor-infiltrating cells, ... TMB).In addition,To ascertain the level of ICOS expression in various cells, qRT-PCR was employed. ...
Tópico(s): Immune cells in cancer
2023 - BioMed Central | BMC Cancer
Andrew Robson, George Wedell (Secretary), Giles Tremlett, Noreen Taylor, Jullan Ryall, Oliver Holt Chief Sports Correspondent, Robert Cole, Oliver Wright and Alex O'Connell, Richard Ford and Tom Baldwin, Stephen Farrell and Robert Whymant, James Moore, Patricia Davies, Valerie Elliott and Steve Bird, Frances Gibb Legal Editor, Geoff Brow, Magnus Linklater, Derek Ezra, St Andrews diary, Richard Hobson, Fiona T. Saunderson, Robert Lefever, Ivo Tennant, Patricla Davies and John Hopkins, Philip Howard, Mark Rittner, James Bone, Elizabeth Judge, Lynne Truss, Carl Mortished, Gillian Harris Scotland Correspondent, Russell Kempson and George Caulkin, Barbara Ellen, Jeremy Whittle, Kevin Eason, Geoff Brown, Joe Joseph, Giles Coren, Peter Brown, Antonia Senior, David Arnold-Forster, Beryi Dixon, David Plowright, Chairman, Pat Gibson, Thrasy Petropoulos, Ben Cave, Melanie Tringham, Matt Wo, Dominic Walsh, Steve Bird, Ruth Gledhill, Cherrill Hicks, Michael Knipe, Michael Harvey, Dalya Alberge Arts Correspondent, Michael Mulvihill, Alan Hamilton, Mark Inglefield, E. W. Lighton, Robert Bruce, Andrew Bamji, John O'Leary, Anatole Kaletsky, Miranda Ingram, Valerie Elliott Consumer Editor, John Kavanagh, Norman Hammond Archaeology Correspondent, Peter Barnard, Caroline Merrell Banking Correspondent, James Doran City Correspondent, Angela Jameson, Stuart Kirkwood, Paul Armstrong, David Lister, David Duval, Marit Hargie, Louise Atkinson, Simon de Bruxelles, John Hopkins Golf Correspondent, Geoffrey Dean, Adam Jones, David Powell Athletics Correspondent, Raymond Keene, Graham Wallace, David Robinson, Larraine Nicholas, Clive Mathieson, Sean MacAulay, Philip Whiteley, Peta Bee, Jesper Parnevik, Nigel Hawkes, Paul J. Benfield, Chris Ayres Media Business Correspondent, Melissa Kite, Cathy Harris, Damian Whitworth, Ruth Taplin, Oliver August, Nick Hasell, Robert Whymant and Stephen Farrell, Adam Fresco, Tom Baldwin and Roland Watson, Richard Duce, Ruth Hilton, Philip Webster Political Editor, Mel Webb, Des Dearlove, Graham Searjeant Financial Editor, Anjana Ahuja, Chris McGrath, Melissa Kite Political Reporter, Rupert Barnes, Chairman, Russell Jenkins, Michael Austin, Peter Riddell, Ian Brodie, Allan Hall and John Phillips, Fraser Nelson, Martin Waller, Cella Brayfield, N. M. Greenwood, Nigel Hawkes Science Editor, Carl Mortished International Business Editor, Mark Baldwin, Giles Whittell and Michael Binyon, Christopher Warman, Roz Denny, Benedict Nightingale, Lesley O'Toole, Christopher Smallwood, Director, Jack Bailey, Richard Morrison, James Christopher, Alan Hamilton and Adam Fresco, Adam Sherwin, Darren Clarke, Susan MacDonald, Julian Ryall, Robert Whymant, Lea Paterson Economics Correspondent, Tom Baldwin and Andrew Pierce, Patience Wheatcroft, Arthur Leathley Transport Correspondent,
... Should Be Addressed to: Box… HW Capita RAS ICO Premier Executive ICO Bexley Council Whitehead Mann GKR Michael Page Whitehead ...
2000 - Gale Group | TDA
Siyi Wang, Xiaoqiang Cai, Lei Guan, Lianmin Zhang,
... logistics, and supply chain management. Initial coin offerings (ICOs), an emerging start-up fundraising method developed with ... public offering stage and market stage, the pre-ICO stage is an important phase for many ICO projects. In this paper, we establish an initial coin offering (ICO) model with network effects, a common phenomenon in ICOs, to study the effect of institutional investors’ participation in the pre-ICO stage of offerings made by cash-strapped entrepreneurs. ... is high. A higher issuance in the pre-ICO stage is thus a mixed blessing that can ...
Tópico(s): FinTech, Crowdfunding, Digital Finance
2022 - Elsevier BV | Transportation Research Part E Logistics and Transportation Review
By Our Social Services Correspondent, From Our Own Correspondent, From Ian McDonald, By Clifford Longley and Marcel Berlins, By Alan Hamilton Labour Staff, From Charles Hargrove, From Robert Fisk, By Our Political Staff, By Michael Hatfield Political Staff, By Geoffrey Wansell, By Paul Routledge, Labour Correspondent, By Geraldine Norman Sale Room Correspondent, By Pearce Wright Science Correspondent, By Our Labour Correspondent, By Hugh Noyes Parliamentary Correspondent, From Our Correspondent, By Tony Aldous Architectural Reporter, From Peter Evans Home Affairs Correspondent, By Peter Waymark, From Dan van der Vat, From Patrick Brogan, From Moshe Brilliant, From Michael Hornsby, From Richard Wigg Latin America Correspondent, From Dessa Trevisan, From Paul Martin, House of Commons, John Percival, Guy Brett, A.B., K.H., R. M., Irving Wardle, Charles Lewsen, Keith Horner, Leonard Buckley, By Jack Fingleton, By Neil Allen Boxing Correspondent, By Michael Phillips Racing Correspondent, From a Special Correspondent, by Moira Keenan, By Lewine Mair, Peter Evans Home Affairs Correspondent, Charles Douglas-Home, Louis Heren, PHS, HELEN GRANT, , PHILIP G. SHARP, , CHARLES L. RIGG, Warden., EDWARD TAYLOR, , SALLY OPPENHEIM, , RICHARD LUCE, , J. A. CROOK, , BRIAN THOMAS, Senior Lecturer in, KENNEDY WELLS, , PAUL SCOTT, , HERBERT van THAL, , MARTYN GOFF, , NICOLAS van den BRANDEN de REETH., L. G. MORGAN, , DAVID CLARK, , C. F. LEWIS., T. J. LENNARD, , GERALD CURTIS, , ALAN MacKICHAN, , MICHAEL COMAY, , L. E. ADDICOTT, , FELICITY PALMER, , JOHN JACOB, , R. A. OVENDEN., A friend, Laurence Irving, By David Wood Political Editor, From Frank Vogl, By Peter Jay, From R. W. Shakespeare Northern Industrial Correspondent, By Peter Jay Economics Editor, By Melvyn Westlake, By Maurice Barnfather, By Roger Vielvoye, By Guy Hawtin, By John Young, From Our US Economics Correspondent, By Peter Hill, Patricia Tisdall, BY THE FINANCIAL EDITOR, By Dennis Dwyer, C. G. SMYTH, , MARTIN SALTER, , J. F. PHILLIPS, , L. G. SCALES, , M. E. WALKER, , By Paul Routledge Labour Correspondent, KENNETH GRIFFITHS, , CLIVE DERBY, , G. S. PALM, , By Arthur Reed Air Correspondent, John Whitmore, Arthur Reed, Philip Dyer, by Pearce Wright Science Correspondent, by David Jones, by Patrick O'Leary, by Patricia Tisdall,
... Avoiding major crises, Uganda seeks $15m loan from ICO, Strict rules for Germans borrowing abroad, French group ...
1972 - Gale Group | TDA
Gujie Wu, Min He, Kuan Ren, Huiyun Ma, Qun Xue,
Background: Inducible co-stimulator (ICOS) is a cell-enhanced co-stimulatory receptor that has shown great potential in the regulation of innate and adaptive immunity. However, the role of ICOS in lung adenocarcinoma (LUAD) remains unclear. Methods: We ... to identify the expression and prognostic role of ICOS in LUAD. The results were validated using Gene ... survival of LUAD patients was constructed using fitted ICOS expression and other clinical parameters. We explored the biological function of ICOS. Subsequently, we further analysed and validated the effect ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2022 - Dove Medical Press | International Journal of General Medicine
By Henry Stanhope Defence Correspondent, By Michael Hatfield Political Reporter, From Michael Leapman, By Our Foreign Staff, By Diana Geddes Education Correspondent, From Patricia Clough, By a Staff Reporter, From Ian Murray, From Frank Vogl US Economics Correspondent, By Michael Baily Transport Correspondent, By Nicholas Timmins, By Arthur Reed Air Correspondent, From Our Correspondent, By Edward Townsend, By Craig Seton, By David Felton Labour Reporter, By Kenneth Gosling, By Lucy Hodges, By Christopher Warman Local Government Correspondent, Reports by John Winder, Philip Webster, Bernard Withers, Gordon Wellman and Derek Barnett of our Parliamentary Staff, By Peter Evans Home Affairs Correspondent, By Hugh Noyes, By Our Education Correspondent, From Richard Wigg, From Our Own Correspondent, From Harry Debelius, From Robert Fisk, By David Spanier Diplomatic Correspondent, By Nicholas Hirst, From Christopher Walker, From Patrick Brogan, From John Best, From Douglas Aiton, From Nicholas Ashford, From David Watts, By Lewine Mair, By Norman Fox Football Correspondent, By Sydney Friskin, By Michael Phillips Racing Correspondent, From Peter West Rugby Correspondent, by Graham Greene, Michael Ratcliffe, Caroline Moorehead, Philip Howard, Kay Dick, H. R. F. Keating, Philippa Toomey, Edited by Peter Davalle, David Wade, John Carter, Roy Hay, Leonard D. Court, Harry Golombek, Jeremy Flint, Tony Madigan, Fred Emery, Michael Coleman, P. SYKES, , M. A. GILLON, , G. M. THOMSON, , SEAN O'CONNOR, , PETER MURRISH, , BRIAN CROZIER, , T. M. HERON, , VERNON BARTLETT, , NICHOLAS MOSS, , GRAHAM ZELLICK, DAVID MATTHEW, , R. V. JONES, , NED THOMAS, , MARY RENAULT, , N. D. G. JAMES, , LEON SHIRLAW, , D. E. BARNES, , Ursula Fleming, By Geraldine Norman Sale Room Correspondent, By the Staff of Nature, From a Bridge Correspondent, Cyril Bainbridge, From Our Special Correspondent, By Pamela Macgregor-Morris, By Peter Hill Industrial Editor, By Our Industrial Staff, By Ronald Kershaw Northern Industrial Correspondent, Melvyn Westlake, By Philip Robinson, By Bill Johnstone, From John Earle, John Drummond, Peter Wainwright, John Whitmore, By ross, Robin Young, Sylvia Morris, Ronald Irving, , Tony Foreman,
... on the sidelines, New crop supplies will test ICO quotas, Economist on right road for Downing Street, ...
1980 - Gale Group | TDA
José Campino, Ana Brochado, Álvaro Rosa,
Recent literature has addressed initial coin offering (ICO) projects, which are an innovative form of venture financing through cryptocurrencies using blockchain technology. Many features of ICOs remain unexplored, leaving much room for additional research, including the success factors of ICO projects. We investigate the success of ICO projects, with our main purpose being to identify ... were collected, we used a database comprising 428 ICO projects in the banking/financial sector to regress ... an important determinant of the success of an ICO. We also confirm the strong dependency on cryptocurrency ...
Tópico(s): FinTech, Crowdfunding, Digital Finance
2022 - Springer Nature | Financial Innovation
Andrew Robson, Charles Scanlan, Jon Ashworth, Daniel Goldberg, Raymond Snoddy Media Editor, Anton Kachayev, Robert Cole, Andrew Pierce, James Moore, Philip Webster Political Editor and Adam Sage, Gillian Franklin, Robert Thicknesse, Anne Woodham, Mark Souster, Linda Tsang, Mary Ambrose, Michael Evans Defence Editor, Philip Howard, Carol Midgley, David Chater, A. H. Jarratt, Nic Hopkins, Michael Weston, Elizabeth Judge, Gillian Harris Scotland Correspondent, Patrick Barkham, John Burningham, Kevin Eason, Geoff Brown, Raymond Snoddy, Andrew Jameson, Sam Lister, Andrew Norfolk, Ben Webster Transport Correspondent, John Waterhouse, Joseph P. Kennedy, Robin Shepherd and Alice Lagnado and Richard Beeston Diplomatic Editor, Jennai Cox Fitness Editor, Rory Watson, Marian Nelsen, Tim Reid, David Taylor, Ruth Gledhill Religion Correspondent, Libby Purves, Roderick A. Smith, Richard Ford Home Correspondent, Mike Hume, Stephen Farrell, Oliver Wright, Oliver Wright Health Correspondent, James Delingpole, Alice Lagnado, James Bone and Melissa Kite, Anatole Kaletsky, Valerie Elliott Consumer Editor, Roland Watson, Richard Lloyd Parry, Charles Bremner, Richard Johnson, Stefanie Marsh, John Anderson, Alan Simpson, Mark Court, Caroline Merrell Banking Correspondent, Michael Byater, R. W. Mellor, Russell Kempson, Vanora Bennett, Tony Halpin Education Editor, David Charter and Alice Miles, Daniel McGrory, Oliver Kay, Edward Fennell, Barry Turner and Steane Marsh, Lisa Armstrong, Tom Baldwin, Jill Sherman Whitehall Editor, Gary Slapper, Gabriella Gamini, Paul Sexton, Ronald Forrest, John Hopkins Golf Correspondent, David La Chapelle, Laura Peek and David Brown, Dennis Murphy, Neil Harman Tennis Correspondent, Dan Sabbagh Telecoms Correspondent, Marcus Binney, Raymond Keene, John Brown, Jack Aspinall, James D. Zirin, Peter McGeown, Richard Ford and Stewart Tendler, Greg Hurst Parliamentary Correspondent, Trevor Grove, Bronwen Maddox, Graeme Holmes, Damian Whitworth, Christopher Martin-Jenkins Chief Cricket Correspondent, David Pannick QC, Alan Bussey, Veronica Cowan, Vaughan Williams and Philip Glass, Julian Muscat, Adam Fresco, Desmond Hartley, Barbara Esam, Nick Szczepanik, Philip Webster Political Editor, Christopher Walker, Ian Johns, George Caulkin, Glen Owen Education Correspondent, John Nandris, Keith Blackmore, Mark Court Health Industries Correspondent, Michael Gove, Ben Webster, Richard Beeston Diplomatic Editor, Ben Macintyre, David Charter Chief Political Correspondent, Michael Dynes, Richard Miles, Lewis Stuart, Martin Waller, Michael Horsnell, Julyan Drew, Rana Sabbagh-Gargour, Laura Peek, Ashling O'Connor, Christopher Andrew, Stephen Dalton, Gary Duncan and Caroline Merrell, Helen Studd and Clem Cecil, Richard Morrison, Frances Gibb, Abigail Rayner, Mark Venables, Alan Lee Racing Correspondent, Claire Fazan, Owen Slot, Richard Laming, Jenny Davey, Edward Gorman Sailing Correspondent, Tim Johnston, Sally Patten Retail Correspondent, Patience Wheatcroft, M. J. Oliver,
... next stop Wall Street weighs on early raily ICO Debate Impact of airport expansion Page 35 Anniversaries ...
2002 - Gale Group | TDA
Ian Stoppa, Casimiro Luca Gigliotti, Nausicaa Clemente, Deepika Pantham, Chiara Dianzani, Chiara Monge, Chiara Puricelli, Roberta Rolla, Salvatore Sutti, Filippo Renò, Renzo Boldorini, Elena Boggio, Umberto Dianzani,
ICOS and its ligand ICOSL are immune receptors whose interaction triggers bidirectional signals that modulate the immune ... the in vivo effects of ICOSL triggering by ICOS-Fc, a recombinant soluble form of ICOS, on skin wound healing.The effect of human ICOS-Fc on wound healing was assessed, in vitro, ... in vivo, by skin wound healing assay using ICOS-/- and ICOSL-/- knockout (KO) mice and NOD-SCID- ... show that, in wild type mice, treatment with ICOS-Fc improves wound healing, promotes angiogenesis, preceded by ...
Tópico(s): Neutrophil, Myeloperoxidase and Oxidative Mechanisms
2022 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
By Hugh Noyes Parliamentary Correspondent, From Robert Fisk, By George Clark Political Correspondent, From Peter Hazelhurst, From Tony Allaway, By Clifford Longley Religious Affairs Correspondent, By Fred Emery Political Editor, By John Young Planning Reporter, By Our Political Editor, By Richard Ford, From Paul Routledge Labour Editor, By Peter Bill Industrial Editor, By David Felton Labour Reporter, By Kenneth Gosling, By Our Political Reporter, By Our Labour Staff, By Arthur Reed Air Correspondent, By Lucy Hodges, By Our Health Services Correspondent, By Jacob Ecclestone, By Robin Mckie, By Martin Huckerby Music reporter, By Frances Gibb, By a Staff Reporter, From Annabel Ferriman Health Services Correspondent, From Diana Geddes Education Correspondent, By Peter Evans Home Affairs Correspondent, By Nicholas Timmins, From Our Correspondent, By Our Estates Correspondent, From Arthur Osman, From Patricia Clough, From Mario Modiano, By Our Diplomatic Correspondent, From Charles Hargrove, From Peter Nichols, From Peter Norman, From Michael Hornsby, From David Bonavia, From Michael Binyon, From Sue Masterman, From Denis Reinhardt, By Michael Coleman, From Our Own Correspondent, By Our Foreign Staff, From Michael Leapman, From Patrick Brogan, By Tony Samstag, By John Woodcock Cricket Correspondent, By John Blunsden, By Mitchell Platts, From Richard Streeton, By Michael Seely, By Pamela Macgregor-Morris, By John Watson, By Our Rifle Shooting Correspondent, By a Special Correspondent, John Greenhalgh, Irving Wardle, Stanley Sadie, Hilary Finch, John Percival, Judith Nagley, David Robinson, Michael Leapman, Edward Stairs, Hugh Clayton, Robert Fisk, Michael Binyon, Geoffrey Smith, PETER CADOGAN, , SHACKLETON, , JELLICOE, , RICHARD VENABLES, M. McEWEN CHARLISH, , ROTHSCHILD, , DAVID N. KING, , NORMAN L. WEBB, , FRANCIS BENNION, , PETER SCOTT, , RICHARD FITTER, , TIM CLARKE, , ALLAN THORNTON, , JOANNA GORDON CLARK, BILL JORDAN, , JANET BARBER, , DAVID BARNES, , R. J. MARTIN, , W. S. MITCHELL, , From Clive Cookson, By Geraldine Norman Sale Room Correspondent, From Our Special Correspondent, By Our Music Reporter, Susan Hill writes:, By Michael Prest, By Our Industrial Editor, By Our Industrial Staff, By Patricia Tisdall Management Correspondent, By Margaret Stone, By Edward Townsend, From Frank Vogl, Kenneth Owen, By Peter Hill, By Derek Harris Commercial Editor, JEREMY MITCHELL, , ELIZABETH STANTON, C. G. MAUGHAN, , PHILIP DIXON, , N. D. AMIS, , JOHN NEVINSON, , A. J. MARTIN, , RALPH D. GEE, , ROBERT S. BARNES, , DAVID L. SHAW, , KENNETH SPRING, , STEPHEN WEARNE, , P. REBOUL, , BY THE FINANCIAL EDITOR, Ross Davies, Clifford Webb, Tim Jones, By Our Financial Staff, Bryan Appleyard, Peter Waymark, Edited by Peter Davalle,
... figures, Briefly, Company liquidations 'at post war high', ICO meeting, Rubber headquarters, Ford dividend cut by 70 ...
1980 - Gale Group | TDA
Evgeny Lyandres, Berardino Palazzo, Daniel Rabetti,
... a comprehensive data set of initial coin offerings (ICOs) from 19 data sources including 11 ICO aggregators. We alleviate severe limitations of available ICO data by performing the first systematic analysis of ICO data quality. We use our data set to study determinants of ICO funding success as well as post-ICO operating performance and provide evidence on some novel determinants of initial and longer-term ICO success. Finally, we show that post-ICO operating performance is positively associated with contemporaneous token ...
Tópico(s): Market Dynamics and Volatility
2022 - Institute for Operations Research and the Management Sciences | Management Science
Giles Smith, Andrew Robson, Loretta Napoleoni, Andrew Pierce, DJM, Neelam Verjee, Brian Wood, John Vincent, Greg Hurst Political Correspondent, Frances Gibb Legal Editor, Gary Duncan, Adrian Waddingham (Chairman Association of Consulting Actuaries), Mark Henderson and Nigel Hawkes report, Akhmed Zakayev, Ivo Tennant, Gen Yuri Baluevsky, Philip Howard, Jeremy Hart and Kevin Eason, Christine Seib, Jeremy Page and Richard Beeston, Toney Dawe, Richard Hobson One-Day Cricket Correspondent, Shirley English and Sam Coates, Elizabeth Judge, Gabrielle Starkey, Tony Cockerill Professor of Applied Econimics, Wendy Ide, Tony Halpin and David Charter, Joe Joseph, Ivan James, Yulia Latynina, David McVay, Robin Wilson, Dominic Walsh, Erica Wagner Literary Editor, Mary Brown, Tom Bawden, Jill Dupleix, Tim Reid, Angela Jameson Industrial Correspondent, Richard Ford Home Correspondent, Robin Young, Anthony Browne Brussels Correspondent, Jenny MacArthur, Paul McGrath, John Young, Anatole Kaletsky, Phil Gordon, Don MacLean, Roland Watson, Richard Lloyd Parry, Charles Bremner, Ian MacKinnon, Matt Dickinson Chief Football Correspondent, Bronwen Maddox Foreign Editor's Briefing, Greg Hurst, Tom Baldwin and Peter Cardwell, Marcus Du Sautoy, Caroline Merrell Banking Correspondent, Russell Kempson, Daniel McGrory, Tony Halpin Education Editor, Oliver Kay, Barbara Rowlands, Peter Noble, David Lister, John Westerby, Patrick Hosking Investment Editor, Roger Fogden, Tom Baldwin, Mark Henderson Science Correspondent, Sam Coates, Joyce Glasser, Janine di Giovanni and Elaine Monaghan, Ann Treneman, Rob Wright, Peter A. Rushforth, Neil Harman Tennis Correspondent, Abigail Rayner and James Doran, Raymond Keene, Christine Buckley, Sean MacAulay, John Russell Taylor, Christine Buckley Industrial Editor, Sean O'Neill, Beryl Dixon, Peta Bee, Jeremy Page, Bronwen Maddox, Dec Downey, Mike Beaumont, Helen Nugent, Shane Warne, Alex Hawkes, Peter Dixon, Peter Nicholson, Carolyn Asome, Dalya Alberge, David Hands Rugby Correspondent, Julian Muscat, Nioc House, Mary Ann Sieghart, Philip Webster Political Editor, Ian Johns, George Caulkin, Ingrid Mansell, Alan Lee, Peter Riddell, Barry Ward, David Charter Chief Political Correspondent, Jack Malvern Arts Reporter, W. J. Harris, Gary Duncan Economics Correspondent, Martin Waller, Chris Ayres, Michael Horsnell, Benedict Nightingale, Angus Batey, Dr Thomas Stuttaford, Stephen Dalton, Brian Cane, James Christopher, Alice Miles, Terry Faulkner (Chairman National Association of Pension Funds), Nigel Hawkes and Alan Hamilton, Owen Slot, Conal Gregory, Jenny Davey, James Devitt, Peter Klinger, Sam Lister Health Correspondent, Patience Wheatcroft, Joe Bolger, Anthony Roberts,
... Metropolitan Film School Volkswagen Golf presents the Movie Ico Season Venice is Reborn as a Hollywood Neverland ...
2004 - Gale Group | TDA
Cindy Orvain, Anne Cauvet, Alexis Prudent, Christophe Guignabert, Raphaël Thuillet, Mina Ottaviani, Ly Tu, Fanny Duhalde, Carole Nicco, Frédéric Batteux, Jérôme Avouac, NingXin Wang, Michelle Seaberg, Stacey R. Dillon, Yannick Allanore,
... recent evidence supports a role of CD28 and ICOS in the development of fibrosis. We herein investigated the efficacy of acazicolcept (ALPN-101), a dual ICOS/CD28 antagonist, in two complementary SSc-related mouse ... disease, and pulmonary hypertension.Expression of circulating soluble ICOS and skin-expressed ICOS was investigated in SSc patients. Thereafter, acazicolcept was ... After 6 weeks, skin and lung were evaluated.ICOS was significantly increased in the sera from SSc ... acazicolcept was demonstrated by blockade of CD28 and ICOS detection by flow cytometry in treated mice.Our ...
Tópico(s): IL-33, ST2, and ILC Pathways
2022 - BioMed Central | Arthritis Research & Therapy