Project Gutenberg
Book.
0000 - Gale Group | Sabin
Brittany D. Partain, Evelyn Bracho-Sanchez, Shaheen A. Farhadi, Elena G. Yarmola, Benjamin G. Keselowsky, Gregory A. Hudalla, Kyle D. Allen,
... 2,3-dioxygenase and galectin-3 fusion protein (IDO-Gal3), where IDO increases the production of local anti-inflammatory metabolites and Gal3 binds carbohydrates to extend IDO’s joint residence time. In this study, we evaluated IDO-Gal3’s ability to alter OA-associated inflammation ... and bioluminescence was tracked for 4 weeks. Next, IDO-Gal3s’s ability to modulate OA pain and ... via MCLT + MMT in male Lewis rats, with IDO-Gal3 or saline injected into OA-affected knees ... 0001). In OA-affected animals, both saline and IDO-Gal3 improved tactile sensitivity ( p = 0.008), but ...
Tópico(s): Osteoarthritis Treatment and Mechanisms
2023 - BioMed Central | Arthritis Research & Therapy
Directory of Open Access Journals (DOAJ)
Dan Jacobson, Derek Mahon, Denis Donoghue, David O'CONNOR, Angus Hall, Alisdair Fairley, Andrew Thomson, Erik De Mauny, Raymond Williams, Mark Girouard, Stuart Hood, Philip Elliott, Patricia Beer, Peter Campbell, John Carey, Kenneth Harris, Michael Rowland, Jim Biddulph, A. W. Friese-Greene, John Grigg, Christopher Serpell, Robert Kee, Mary Douglas, Frank Kermode, Bernard Bergonzi, Averell Harriman, Stephen Walsh, Caroline Blackwood, Ian Bellany, William Hardcastle, Ronald Stevenson, E. T. Dubois, Norman Moss, Alastair Hamilton, John Fuller, R. M. Pointon, David Caute, P. N. Furbank, Susanne Knowles, Valerie Goldberg, UtdtU, Murray Biggs, Priscilla Metcalf, Imogen Holst, Charles Tomlinson, Timothy O'KEEFFE, Krishnan Kumar, Gerard Mansell,
... 138 Wolsey Hall The Rapid Results College British Ido Society BBC Publications The Theosophical Society The Chappell ...
1971 - Gale Group | The Listener GDA
Jaehyun Park, Yunyoung Nah, Won Jong Kim,
Indoleamine 2,3-dioxygenase (IDO) has been studied as a promising target for cancer immunotherapy. IDO catalyzes the oxidation of tryptophan into kynurenine, which subsequently ... tissue. Due to its overexpression in tumor cells, IDO itself could be a tumor-specific stimulus for targeted cancer therapy. Toward this objective, we developed IDO-triggered swellable micelles for targeted cancer immunotherapy. The ... tryptophan as a hydrophobic block. The micelles exhibited IDO-responsive behavior via solubility conversion of the hydrophobic ...
Tópico(s): Cancer, Stress, Anesthesia, and Immune Response
2023 - Elsevier BV | Journal of Controlled Release
PubMed Central (PMC)
E.H. Burgess, A.F. Holford-Walker, W.A. Miller, John V. Hatch, G. Reichardt, Ian Thomson, Henry Meulen, J.B. Rees, A.M. Shapurian, Trevor Lloyd, Charles Dawes,
... Ecology Management Appointments The Economist Sir John Betjeman Ido Negative income tax Concorde Management Appointments Sterling Land ...
1972 - Gale Group | The Economist
Rahul Nandre, Vivek Verma, Pankaj Gaur, Veerupaxagouda Patil, Xing-Dong Yang, Zainab Ramlaoui, Nour Shobaki, Mads Hald Andersen, Ayako Wakatsuki Pedersen, Mai-Britt Zocca, Mikayel Mkrtichyan, Seema Gupta, Samir N. Khleif,
... TME is the indoleamine-pyrrole 2,3-dioxygenase (IDO) enzyme, produced mainly by cancer cells and suppressive immune cells of myeloid origin. In fact, IDO+ myeloid-derived suppressor cells (MDSC) and dendritic cells (DC) tend to be more suppressive than their IDO− counterparts. Hence, therapeutic approaches that would target the IDO+ cells in the TME, while sparing the antigen-presenting functions of IDO− myeloid populations, are needed. Using an IDO-specific peptide vaccine (IDO vaccine), we explored the ...
Tópico(s): Immune cells in cancer
2022 - American Association for Cancer Research | Cancer Immunology Research
Angus Dalgleish, W.A. Miller, D.J. Lewis, Douglas Jay, M.B. Daniels, Patrick Hutber, Emanuel De Kadt, Christopher F. Foss, W.J. Igoe, C.A. Horn, Henry Meulen, Brian R. Roberts, Lucien Wigdor, E.J. Mishan, H.S. Axton,
... Economist Intelligence Unit The Economy Chile Graham Greene Ido Management Appointments International Appointments Property Dodwell On the ...
1973 - Gale Group | The Economist
Hada Buhe, Jixin Ma, Fang-zhou Ye, Chenyun Song, Xinyu Chen, Yang Liu, Huang Lin, Xu Han, Lixiang Ma, Hexige Saiyin,
... adenocarcinoma (PDAC) express indoleamine 2,3-dioxygenase 1 (IDO-1), an immunosuppressive enzyme. The metabolites of IDO-1 in cancers provide one-carbon units that ... immunosuppressive cells. In this study we investigated how IDO-1 affected the neoplastic cell behaviors in PDACs. ... 45-µm-thick tissue sections, we showed that IDO-1 expression was uniquely increased in the neoplastic ... basal domain, but decreased in lymph metastatic cells. IDO-1+ extruding neoplastic cells displayed increased vimentin expression ...
Tópico(s): Epigenetics and DNA Methylation
2022 - Springer Nature | Acta Pharmacologica Sinica
James Landale, Julia Llewellyn Smith, David Londin, Geoff Knight, David Adams, Edward Owen, Nick Nuttall, Andrew Pierce, Alain de Botton, Charles Bremner and Frances Gibb, Mark Skinner, Craig Lord, Swimming Correspondent, Jeremy Laurance, Tania Rice, Jill Sherman Political Correspondent, David Pryce-Jones, Mark Souster, Harvey Elliott, W. M. Ballantine, Philip Howard, Hilary Finch, J. K. Gore, Fitzroy MacLean, Jeremy Kingston, George Sivell, Peter Foster, Carl Mortished, Marianne Curphey and Jane O'callaghan, Nick Nuttall, Environment Correspondent, Philip Webster, Political Editor, and Charles Bremner, Stewart Tendler, Crime Correspondent, Colin Narbrough, World Trade Correspondent, Colin Narbrough, Geoff Brown, Michael Jopling, Robert Sheehan, Bridge Correspondent, Stuart Humby, Robert Miller, Giles Coren, Jonathan Prynn, Transport Correspondent, Martin Fletcher, Michael P. Christides, Darren Bailey, Steve Keenan, John Hopkins, Golf Correspondent, Patricia Tehan, Norman Hogg, Peter Ball, John O'leary, Education Editor, Graham Duffill, Raymond Keene Chess Correspondent, Rob Hughes Football Correspondent, Martin Barrow, Michael Evans, Defence Correspondent, Alan Hamilton, (Edward Owen), Daniel Johnson, Terry Waite and Patricia Cornwell, Jenny MacArthur, Robert Bruce, Michael Clark, Dr Thomas Stuffaford, Ian McIntyre, Peter Barnard, Philip Bassett, Industrial Editor, Michael Binyon Diplomatic Editor, Neil Addison, Patricia Tehan, Banking Correspondent, Ian F. Locke, Russell Kempson, Craig Lord and John Goodbody, Janet Daley, Sydney Friskin, Rachel Kelly Property Correspondent, Rachel Bridge, Raymond Keene, Adam Sage, Christine Buckley, Peter Davalle, Paul Wilkinson, P. H. S, Peter Bryan, David Nicholls, Janet Bush and Robert Miller, Richard Evans, Caroline Merrell, Sunjay Kakar, Eric Reguly, Oliver Holt, Christopher Walker and our Diplomatic Staff, Ross Leckie, Roger Boyes, Nigel Hawkes, Science Editor, J. H. Martin, Michael Hornsby, Agriculture Correspondent, Kate Alderson, Rodney Hobson, David Hands Rugby Correspondent, Julian Muscat, Nicholas Wood, Chief Political Correspondent, David Tang, Henry Hall, Sybil Sharpe, Christopher Thomas, Anne Ashworth, Nick Szczepanik, David Churchill, John Goodbody, Mary Ann Sieghart, Giles Whittell, Charles Bremner and Frances Gibb, Legal Correspondent, Chris Parker, Craig Lord, Susan Raven, Bruce Anderson, Richard Blake, Jonathan Clark, Anthony Loyd, Peter Riddell, David Walker, Simon Jenkins, Tim Jones, Kate Bassett, David Ford, Michael Horsnell, Michael Evans, Defence Correspondent, and Martin Fletcher, Christopher Irvine, Roy Jenkins, Patrick Browne, Tess Knighton, Benedict Nightingale, A. B. Goyder, Gerald Lang, Peter Walsh, David Powell, Ian Robertson, D. L. Dexter, Colin Campbell, Craig Lord and Dominic Kennedy, Kevin Eason, Motoring Editor, J. C. Tuck, Robert M. Barr,
... tales, says Ian Robertson Miele Impotence Laser sighted Ido-Air Danger claws I guess I'm soppy, ...
1995 - Gale Group | TDA
Carminia Maria Della Corte, Vincenza Ciaramella, Kavya Ramkumar, Giovanni Vicidomini, Alfonso Fiorelli, Valerio Nardone, Salvatore Cappabianca, Immacolata Cozzolino, Federica Zito Marino, Gaetano Di Guida, Qi Wang, Robert J. Cardnell, Carl M. Gay, Davide Ciardiello, Erika Martinelli, Teresa Troiani, Giulia Martini, Stefania Napolitano, Jing Wang, Lauren A. Byers, Fortunato Ciardiello, Floriana Morgillo,
... the expression of Indoleamine 2,3-dioxygenase-1 (Ido-1) gene expression demonstrated that Ido-1 resulted unaffected by the MEK inhibition and ... score; in parallel, we investigated the activation of Ido-1 pathway and modulation of immune cytokines productions ... L1 monoclonal antibody, the MEK inhibitor and the Ido-1 inhibitor. Results In NSCLC lung adenocarcinoma patient cohort (from TCGA) Ido-1 gene expression was significantly higher in samples ... NSCLC cell lines higher expression of MEK and Ido-1 related genes was detected in cells with ...
Tópico(s): Immune cells in cancer
2022 - BioMed Central | Journal of Translational Medicine
... Scripsit Fridericus Carolus Kraft. Ov Yáp New Toious Ido Àvépas Ovde Idwmat. Cum Effigie Illegenii Praefixa. Etc..
1839 - Gale Group | NCCO SciTechMed 2 of 2
Georgia Wells, Paul Kennedy, Lekh N. Dahal,
Background: The immunomodulatory enzyme, indoleamine 2,3-dioxygenase (IDO) facilitates tryptophan catabolism at the rate-limiting step of the kynurenine (Kyn) pathway. IDO expression and elevations in Kyn metabolites are associated ... progression. However, the extent of the role of IDO in acute myeloid leukemia (AML) is currently ill-defined. This study reviews the role of IDO-driven Treg function in AML and evaluates the current body of evidence implicating IDO in AML pathogenesis. Method: Studies related to IDO ...
Tópico(s): Cancer-related cognitive impairment studies
2021 - Frontiers Media | Frontiers in Immunology
Gráinne Gilmore, Andrew Robson, Giles Smith, Matt Dickinson Chief Sports Correspondent, Amanda Andrews, Mike Theodoulou, Carol Lewis, David Brown, Caroline Slowik, Frances Gibb Legal Editor, Professor Brian Brinkworth, James Harding, Robert Lindsay, Mark Souster, Imam Mohammad Shahid Raza, Alexandra Frean Education Editor, Philip Howard, Carol Midgley, Camilla Cavendish, Christine Seib, David Chater, Rachel Campbell-Johnston, James Ducker, Murad Ahmed, Elizabeth Judge, Patrick Kidd, Matthew Hoggard, Will Pavia, Sam Marlowe, Wendy Ide, Kevin Eason, Martin Samuel Chief Football Correspondent, Joe Joseph, Andrew Norfolk, Robin Pagnamenta, Ben Webster Transport Correspondent, Jane MacArtney China Correspondent, Siobhan Kennedy, Tim Ensor, Jeremy Collingwood, Deborah Haynes, Tom Bawden, Dominic Walsh, Debra Craine, Peter Sergeant, Gary Jacob, Dr Marcus Braybrooke, Ken Russell, Tim Reid, Angela Jameson Industrial Correspondent, Dan Sabbagh, Libby Purves, Chris Riley, Richard Ford Home Correspondent, Anatole Kaletsky, Sir Sigmund Sternberg, Ron Lewis, Simon Bradley, Stephen Collins, Will Lawrence, Dr Ashok Sinha, Tim Teeman, Susan Thompson, Derwent May, Hugo Rifkind, Russell Kempson, Emma Young, Gary Duncan Economics Editor, Michael J. Hendrie Astronomy Correspondent, Gerard Baker, Oliver Kay, Sarah Vine, Mark Henderson Science Editor, James Harding Business Editor, Tom Baldwin, Jill Sherman Whitehall Editor, John Hopkins, Christopher Martin-Jenkins, Adrian Brodkin, Peter Sozou, Robert Low, Rob Wright, John Hopkins Golf Correspondent, Mark Hunter, Gabriel Rozenberg, Neil Harman Tennis Correspondent, Rebecca Newman, Chris Elliott, Raymond Keene, Adam Sage, Sean O'Neill Crime and Security Editor, Sarah Hiscock, Lewis Smith, Matthew Pryor, Matt Hughes, Kaveh Solhekol, Richard Lloyd Parry Asia Editor, Chris Campling, Fran Yeoman, Bronwen Maddox, Jill Sherman, Richard Owen, Sandra Parsons, Ian J. Hartill, Marcus Leroux, Richard Caborn, Roger Boyes, Gabriel Rozenberg Economics Reporter, Nick Hasell, Kevin Maher, Tom Dart, Paul Simons, Nick Szczepanik, Dominic Kennedy, Piers Corbyn, Thomas Catán, Emily Ford, Matthew Parris, Dana Moss, Sheila Keating, Alan Lee, Neil Fisher, Peter Riddell, Tony Dawe, Ben Webster, Richard Beeston Diplomatic Editor, Carly Chynoweth, David Sanderson, David Sinclair, Ben Webster Transport Editor, Professor Sabaratnam Arulkumaran President, Chris Ayres, Patrick Foster, Nigel Hawkes Health Editor, Sarah Butler, Benedict Nightingale, Dr Thomas Stuttaford, Stephen Dalton, Leo Lewis, Adrian Milledge, Tony Halpin, Stefan Simanowitz, Michael Evans, Clare Dight, Alan Lee Racing Correspondent, Olav Bjortomt, Meera Kishen President, Miles Costello, Fiona Hamilton, Caron Bell, Dr Miriam Stoppard, Jo Causon, Elizabeth Judge Telecoms Correspondent, Steve Hawkes Industry Reporter, Virginia Matthews,
... Kevin Maher his movie thrill of the week IDO The biggest bogeyman at the box office Screen ...
2007 - Gale Group | TDA
Joshua Walker, Sean Richards, Stephen A. Whelan, Sung Bok Yoo, Teresa L. Russell, Nkiruka Arinze, Saran Lotfollahzadeh, Marc A. Napoleon, Mostafa Belghasem, Norman Lee, Laura M. Dember, Katya Ravid, Vipul C. Chitalia,
... the role of indoleamine 2,3-dioxygenase-1 (IDO-1), a key enzyme in kynurenine biogenesis, in ... genomic and pharmacological approaches, this study demonstrates that IDO-1 is a critical regulator of TF and ... vascular injury in CKD mice. Indoxyl sulfate upregulates IDO-1, creating a feedback-forward loop. IDO-1 activity was higher in patients with CKD, ... developed thrombosis after vascular interventions. This study identifies IDO-1 as a therapeutic target and uncovers crosstalk ... the role of indoleamine 2,3-dioxygenase-1 (IDO-1), a rate-limiting enzyme of kynurenine biogenesis, ...
Tópico(s): Tryptophan and brain disorders
2021 - American Society of Nephrology | Journal of the American Society of Nephrology
DAVID HANNAY., JOHN HUGHES, , BHUGWANDIN DUBE., A well-informed Correspondent writes:-, EBENEZER HOWARD., ARMAND POWLETT, , E. G. SELWYN., (Miss) MARGUERITE FEDDEN., HYTHE., T. S. LINDSAY., T. A. LACEY., M. R., O. W., A SMART UNION CLUB CREW., ALDERSHOT DAY., J. C. G.,
... Westminster., Language Fusion. Postal Workers On Esperanto And Ido., Civic Hospitality In St. Petersburg. Crowned Guests Of ...
1914 - Gale Group | TDA
Satu Salmi, Anton Lin, Benjamin Hirschovits-Gerz, Mari Valkonen, Niina Aaltonen, Reijo Sironen, Hanna Siiskonen, Sanna Pasonen‐Seppänen,
... T cells (Tregs) and indoleamine-2,3-dioxygenase (IDO) participate in the formation of an immunosuppressive tumor ... cutaneous melanoma (CM). Recent studies have reported that IDO expression correlates with poor prognosis and greater Breslow’ ... CM have been controversial. Furthermore, the correlation between IDO and Tregs has not been substantially studied in CM, although IDO is known to be an important regulator of ... Methods We investigated the associations of FoxP3+ Tregs, IDO+ tumor cells and IDO+ stromal immune cells with ...
Tópico(s): Immunotherapy and Immune Responses
2021 - BioMed Central | BMC Cancer
Rong Ji, Lixiang Ma, Xinyu Chen, Renqiang Sun, Li Zhang, Hexige Saiyin, Wenshi Wei,
Indoleamine 2,3-dioxygenase 1 (IDO-1) is an immunosuppressive enzyme expressed in the placenta, neoplastic cells, and macrophages to reject T cells by converting tryptophan into kynurenine. However, the role of IDO-1 in brain immunity, especially in the meninges, ... We aim to elucidate the distribution pattern of IDO-1+ macrophages/microglia in the human brain tissues, ... and explore the physiological and immunological roles of IDO-1+ macrophages/microglia. Here, we find that both ... and subarachnoid space and in glioblastoma (GBM) expressed IDO-1 but not macrophages/microglia of parenchyma. Using ...
Tópico(s): Stress Responses and Cortisol
2021 - Public Library of Science | PLoS ONE
Fahimeh Heidari, Mahboobeh Razmkhah, Vahid Razban, Nasrollah Erfani,
Indoleamine 2, 3-dioxygenase (IDO) catabolizes tryptophan, mediates immunomodulatory functions, and is released by stromal cells such as mesenchymal stem cells. The aims of this study were to investigate the effects of IDO silencing on immunosuppressive function of adipose-derived mesenchymal ... adipose tissues of healthy women were transfected with IDO-siRNA. Galectin-3, transforming growth factor-β1, hepatocyte ... evaluated in peripheral blood lymphocytes (PBLs) cocultured with IDO silenced-ASCs by flow cytometry and qRT-PCR, ...
Tópico(s): Immune cells in cancer
2021 - Wiley | Cell Biology International
Lijie Zhai, April Bell, Erik Ladomersky, Kristen L. Lauing, Lakshmi Reddy Bollu, Brenda Nguyen, Matthew Genet, Miri Kim, Peiwen Chen, Xinlei Mi, Jennifer D. Wu, Matthew J. Schipma, Brian Wray, John R. Griffiths, Richard D. Unwin, Simon J. Clark, Rajesh Acharya, Riyue Bao, Craig Horbinski, Rimas V. Lukas, Gary E. Schiltz, Derek A. Wainwright,
... Trp) metabolic enzyme, indoleamine 2,3-dioxygenase 1 (IDO). This observation supported the historical hypothesis that IDO suppresses the antitumor immune response solely through a ... led us to investigate the alternative hypothesis that IDO suppresses the anti-GBM immune response independent of its association with Trp metabolism.IDO-deficient GBM cell lines reconstituted with IDO wild-type or IDO enzyme-null cDNA were created and validated in ... analysis was conducted to search for genes that IDO regulates, followed by the analysis of human GBM ...
Tópico(s): Glioma Diagnosis and Treatment
2021 - American Association for Cancer Research | Clinical Cancer Research
Vienna Ludovini, Fortunato Bianconi, Annamaria Siggillino, Jacopo Vannucci, Sara Baglivo, Valeria Berti, Francesca Romana Tofanetti, Maria Sole Reda, Guido Bellezza, Martina Mandarano, Maria Laura Belladonna, Giulio Metro, Rita Chiari, Angelo Sidoni, Francesco Puma, Vincenzo Minotti, Fausto Roila,
... related genes PD-1, PD-L1, PD-L2, IDO-1, IDO-2 and INFγ in tumor tissue of surgically ... PCR Arrays (Qiagen). PD-1, PD-L2 and IDO-2 gene expression levels were significantly higher in ... 0.001; respectively). PD-1, PD-L1 and IDO-2 gene expression levels were significantly higher in ... with higher levels of both genes (PD-L1/IDO-2) or (PD-L2/IDO-1) were associated with a worse OS (HR ... and higher levels of both genes (PD-L1/IDO-2) and (PD-L2/IDO-1) with worse OS (HR 1.98, p = ...
Tópico(s): Immune cells in cancer
2021 - Multidisciplinary Digital Publishing Institute | Genes
Nattawut Wongpraparut, Ploy Pengchata, Sudarat Piyophirapong, P Panchavinnin, Rungtiwa Pongakasira, Noppadol Arechep, Kanda Kasetsinsombat, Kittipong Maneechotesuwan,
Abstract Background Indoleamine 2,3 dioxygenase (IDO), the rate-limiting enzyme in the kynurenine (Kyn) pathway of tryptophan (Trp) degradation, is modulated by inflammation, and is regarded as a ... immunotolerance and immunosuppressive mechanisms. Little is known about IDO activity in patients with active coronary artery disease ( ... were scheduled to undergo coronary angiography. Measurement of IDO, high-sensitivity troponin T (hs-TnT), and high- ... hs-CRP) levels was performed at baseline, and IDO activity was monitored at the 6-month follow- ...
Tópico(s): Stress Responses and Cortisol
2021 - BioMed Central | BMC Cardiovascular Disorders
Shane Babcock, John Beverley, Lindsay G. Cowell, Barry Smith,
... principles are exemplified by the Infectious Disease Ontology (IDO), a suite of interoperable ontology modules aiming to ... the infectious disease domain. At its center is IDO Core, a disease- and pathogen-neutral ontology covering ... relations that are relevant to infectious diseases generally. IDO Core is extended by disease and pathogen-specific ... more generally, we have recently developed three new IDO extensions: IDO Virus (VIDO); the Coronavirus Infectious Disease Ontology (CIDO); ... an extension of CIDO focusing on COVID-19 (IDO-COVID-19). Reflecting the fact that viruses lack ...
Tópico(s): Tuberculosis Research and Epidemiology
2021 - BioMed Central | Journal of Biomedical Semantics
Qiaoping Zheng, Guifang Gan, Xianfu Gao, Qingqiong Luo, Fuxiang Chen,
Indolamine 2,3-dioxygenase (IDO) is the rate limiting enzyme of tryptophan degradation and is a negative prognostic factor in oral squamous cell carcinoma (OSCC) ... remains unclear. This research aimed to explore the IDO expression and its biological functions in OSCC.IDO expression was analyzed by qPCR, Western blots, and ... Meier survival analyses were used to identify the IDO expression and its correlation with OSCC prognosis. Cell ... assays were used to assess the effect of IDO inhibition on OSCC growth either by shRNA or ...
Tópico(s): Genomics, phytochemicals, and oxidative stress
2021 - Dove Medical Press | OncoTargets and Therapy
Xin Zhang, Xiuting Liu, Wei Zhou, Qianming Du, Mengdi Yang, Yang Ding, Rong Hu,
... a metabolite catalyzed by indoleamine 2,3-dioxygenase (IDO), was required for IDO-mediated T cell function, and adaptive immunity indeed ... sulfate (DSS)–induced CRC model was established in IDO–/–, Rag1–/–, and wild-type mice, and tumor-associated ... AhR and Foxp3 promoter. Additionally, compared WT mice, IDO–/– mice treated with AOM/DSS exhibited fewer and ... role in CRC.ConclusionsWe demonstrated that inhibition of IDO diminished Kyn/AhR-mediated Treg differentiation and could ... a metabolite catalyzed by indoleamine 2,3-dioxygenase (IDO), was required for IDO-mediated T cell function, ...
Tópico(s): Gut microbiota and health
2021 - Elsevier BV | Cellular and Molecular Gastroenterology and Hepatology
Yan Zhang, Han Shi, Ge Yang, Yongfeng Yang, Wenqiang Li, Meng Song, Minglong Shao, Xi Su, Luxian Lv,
Abstract The indoleamine 2,3-dioxygenase (IDO) enzyme is the first rate-limiting enzyme of the tryptophan degradation pathway in which dysfunction of neuroactive metabolites has been implicated in ... pro-inflammatory cytokines could enhance the activity of IDO. There are few studies on the expression of IDO levels and its correlation with levels of inflammatory ... or placebo combined with risperidone. Serum levels of IDO and six inflammatory cytokines (IL-1β, IL-6, ... healthy subjects, patients had significantly elevated levels of IDO and six cytokines at baseline. Over the 6- ...
Tópico(s): Stress Responses and Cortisol
2021 - Springer Nature | Translational Psychiatry
Hong-Lan Huang, Hui‐Li Yang, Zhen‐Zhen Lai, Shao‐Liang Yang, Ming‐Qing Li, Da‐Jin Li,
Indoleamine 2, 3-dioxygenase (IDO), a tryptophan-catabolizing enzyme, is essential in physiological immunoregulation. The present research was conducted to elucidate the expression and roles of IDO in decidual macrophages (dMφ) during early pregnancy. Here, we observed a remarkable decrease of IDO+ dMφ from patients with unexplained recurrent spontaneous abortion (URSA). IDO+ dMφ displayed M2 phenotype with higher CD206, CD209 ... with 1-methyl-d-tryptophan (1-MT, an IDO pathway inhibitor) led to the M1 bias of ...
Tópico(s): Maternal Mental Health During Pregnancy and Postpartum
2021 - Elsevier BV | Journal of Reproductive Immunology
Daniel J. Lin, James Ng, Lei Huang, Max Robinson, James O’Hara, J. A. Wilson, Andrew L. Mellor,
... activity. The intracellular enzyme indoleamine 2,3‐dioxygenase (IDO) is a critical regulator of the tumour microenvironment ( ... via tryptophan metabolism. The potential immunotherapeutic role of IDO in head and neck squamous cell carcinoma (HNSCC) ... exploration. We aim to assess the evidence on IDO in HNSCC. Methods A systematic review of literature ... cell lines: eight assessed tumour immunohistochemistry: ten measured IDO gene transcription: 15 reported on clinical trials. Increased cell line IDO expression was postulated to adversely affect tumour metabolism ...
Tópico(s): Cancer, Stress, Anesthesia, and Immune Response
2021 - Wiley | Clinical Otolaryngology