Olle M. de Bruin, Jagjit S. Ludu, Francis E. Nano,
... for humans while being highly virulent in mice. IglA is a 21 kDa protein encoded by a ... FPI).Bioinformatics analysis of the FPI suggests that IglA and IglB are components of a newly described ... secretion system. In this study, we showed that IglA regulation is controlled by the global regulators MglA and MglB. During intracellular growth IglA production reaches a maximum at about 10 hours post infection. Biochemical fractionation showed that IglA is a soluble cytoplasmic protein and immunoprecipitation experiments ...
Tópico(s): Yersinia bacterium, plague, ectoparasites research
2007 - BioMed Central | BMC Microbiology
Philip Raskin, Titus Gylvin, Wayne Weng, Louis Chaykin,
... safety of insulin detemir (IDet) and insulin glargine (IGla) in a basal‐bolus (insulin aspart) regimen in ... Methods 385 patients were randomized 2 : 1 (IDet : IGla). Non‐inferiority of IDet to IGla was determined by HbA 1c 95% CI upper limit <0.4. Results IDet and IGla showed similar efficacy in HbA 1c reduction at ... CI: 0.0149,0.3995). It appeared that IGla in some cases did better than IDet in ... 0.9% [LOCF], p < 0.001) and in IGla (−1.3% [26 weeks, LOCF], p < 0.001). ... 9% (26 weeks) and 7.0% (LOCF) in IGla. Final FPG were 130 mg/dL (26 weeks) ...
Tópico(s): Metabolism, Diabetes, and Cancer
2009 - Wiley | Diabetes/Metabolism Research and Reviews
Rasoul Nasiri Bezenjani, Victoria Pease, Martin J. Whitehouse, Mahmoud H. Shalaby, Khalid Kadi, Wiesław Kozdrój,
... in the Arabian-Nubian Shield (ANS). The Wadi Igla Formation in the Central Eastern Desert (CED) of ... indicate that the upper-part of the Wadi Igla Formation has a maximum depositional age of 628 ± ... clast from the upper-part of the Wadi Igla Formation gives a U–Pb age of 700 ± ... that the dominant rhyolitic clasts within the Wadi Igla Formation are not from the Dokhan Volcanics, as ... 635 ± 5 Ma, resembling that of the Wadi Igla Formation. Its middle part has a maximum age ... rocks that are overlain unconformably by the Wadi Igla Formation in the CED. The Wadi Igla basin ...
Tópico(s): Geochemistry and Geologic Mapping
2014 - Elsevier BV | Precambrian Research
James R. Fuller, Todd M. Kijek, Sharon Taft-Benz, Thomas H. Kawula,
... pH 5.5. A number of genes, including iglA , that are required for intracellular growth are regulated ... infection of host cells. We quantified ripA and iglA expression at different stages of intracellular growth and ... the similar intracellular expression patterns of ripA and iglA and that MglA and SspA are positive regulators of iglA we tested the impact of mglA and sspA deletions on ripA and iglA expression. In the deletion mutant strains iglA expression was reduced dramatically as expected, however ripA ...
Tópico(s): Bacterial Genetics and Biotechnology
2009 - BioMed Central | BMC Microbiology
Yoshiko Onda, Rimei Nishimura, Kiyotaka Ando, Hiroshi Takahashi, Daisuke Tsujino, Kazunori Utsunomiya,
... type 1 diabetes (T1D) treated with insulin glargine (IGla) versus insulin degludec (IDeg) using continuous glucose monitoring ( ... assigned to receive IDeg once-daily followed by IGla twice-daily or vice versa. They were evaluated ... significantly lower while taking IDeg than while taking IGla (mean [95% confidence interval] 0.72 [0.61– ... the patients while on IDeg versus while on IGla in 24-h mean glucose and SDs of ... but significantly different in the patients while taking IGla (P = 0.033). Conclusions The use of once- ...
Tópico(s): Pancreatic function and diabetes
2016 - Elsevier BV | Diabetes Research and Clinical Practice
Yunjiao Yang, Cong Long, Tongyi Li, Qiu Chen,
... determine whether insulin degludec (IDeg) or insulin glargine (IGla) was more beneficial for reducing glycemic fluctuations. Materials ... the efficacy of glucose variability between IDeg and IGla in diabetic patients were included. Results Fourteen trials ... and standard deviation (P = 0.03) compared to IGla in fasting blood glucose (FBG); in people with ... a lower coefficient of variation of FBG than IGla (P = 0.0254). For other indicators of glycemic ... no significant differences were identified between IDeg and IGla, regardless of T1DM or T2DM. Conclusions Based on ...
Tópico(s): Diabetes Treatment and Management
2022 - Frontiers Media | Frontiers in Endocrinology
Jeanette E. Bröms, Moa Lavander, Anders Sjöstedt,
... in several gram-negative bacteria. These genes include iglA and iglB encoding IglA and IglB, homologues of which are conserved in ... F. tularensis LVS. We identified a region of IglA, encompassing residues 33 to 132, necessary for efficient ... mutations within this domain caused modest defects in IglA-IglB binding in the yeast Saccharomyces cerevisiae but ... in severe attenuation of LVS in mice. Thus, IglA-IglB complex formation is clearly crucial for Francisella ... the notion of a conserved binding site. Thus, IglA-IglB complex formation is clearly crucial for Francisella ...
Tópico(s): Vibrio bacteria research studies
2009 - American Society for Microbiology | Journal of Bacteriology
Qingmei Jia, Richard A. Bowen, Bai‐Yu Lee, Barbara Jane Dillon, Saša Masleša‐Galić, Marcus A. Horwitz,
... various F. tularensis Francisella Pathogenicity Island (FPI) proteins - IglA, IglB and IglC, and a fusion protein (IglABC) comprising immunodominant epitopes of IglA, IglB, and IglC downstream of different Francisella promoters, ... bfr) promoter. We show that rLVS ΔcapB/bfr-iglA, iglB, iglC, and iglABC express more IglA, IglB, IglC or IglABC than parental LVS ΔcapB ... immunized mice. Mice immunized with rLVS ΔcapB/bfr-iglA, iglB, iglC or iglABC produce serum antibodies at ...
Tópico(s): Viral Infections and Outbreaks Research
2016 - Elsevier BV | Vaccine
Olle M. de Bruin, Barry N. Duplantis, Jagjit S. Ludu, Rebekah F. Hare, Eli B. Nix, Crystal L. Schmerk, Craig S. Robb, A.B. Boraston, Karsten Hueffer, Francis E. Nano,
... insoluble material showed that the FPI-encoded proteins IglA, IglB and IglC were found in multiple fractions, ... fraction. We interpreted these data to suggest that IglA, IglB and IglC are part of a macromolecular ... long nano-tubes. Thus the fractionation properties of IglA, IglB and IglC are consistent with the current model of the T6SS apparatus, which supposes that IglA and IglB homologues form an outer tube structure ...
Tópico(s): Vibrio bacteria research studies
2011 - Microbiology Society | Microbiology
Jun Suzuki, Tadashi Yamakawa, Mari S. Oba, Jo Nagakura, Erina Shigematsu, H. Tamura, Kenichiro Takahashi, Yoshihisa Okamoto, Rika Sakamoto, Minori Shinoda, Tatsuro Takano, Kazuaki Kadonosono, Yasuo Terauchi,
... We compared insulin IDeg and insulin glargine U100 (IGla) for glycemic control and glucose variability in hospitalized ... assigned to either the IDeg (36 patients) or IGla (38 patients) group and were administered with basal- ... 36) of the patients in the IDeg and IGla groups, respectively. The 6-point self-monitoring of ... larger in the IDeg group than in the IGla group. The incidence of hypoglycemia or glucose variability ... short-term efficacy and safety of IDeg and IGla in patients with type 2 diabetes during the ...
Tópico(s): Diabetes Treatment and Management
2019 - Japan Endocrine Society | Endocrine Journal
... Lira) and combinations of their aGLP-1 with iGla 100 U has been performed base on published ... Lira on 54,4 %) as their combinations with iGla 100 U (direct costs decreasing vs iGla 100 U + Exe on 23,8 %, vs iGla 100 U + Dula on 15,2 %). iGlaLixi decreased ...
Tópico(s): Gastroesophageal reflux and treatments
2021 - | Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice
Produção Nacional
Revisado por pares
Chen Gilor, William T. N. Culp, Shruti Ghandi, J.A. do Carmo Emidio e Silva, A. Ladhar, Sean E. Hulsebosch,
Insulin glargine 300 U/mL (IGla-U300) and insulin degludec (IDeg) are synthetic insulin analogs designed as basal insulin formulations. In people, IGla-U300 is more predictable and longer acting compared ... would have longer duration of action compared with IGla-U300 in healthy purpose-bred cats. Seven cats ... 0.4 U/kg (subcutaneous) of IDeg and IGla-U300 on two different days, >1 wk apart. ... tests. There was no difference between IDeg and IGla-U300 in onset, peak action, or total metabolic ... On average, time to peak action (TPEAK) of IGla-U300 was 145 ± 114 min (95% confidence interval [ ...
Tópico(s): Diabetes and associated disorders
2019 - Elsevier BV | Domestic Animal Endocrinology
Yang Li, Torsten Christensen, Fengyu Sun, Jinghua Chang,
... term cost-effectiveness of switching from insulin glargine (IGla) to insulin detemir (IDet) in patients with type ... the results were robust.ResultsConversion to IDet from IGla was projected to improve patient life expectancy by ... converting to IDet.ConclusionsConversion to IDet from an IGla regimen improved life expectancy and was a cost- ...
Tópico(s): Diabetes Management and Education
2012 - Elsevier BV | Value in Health
M. A. Hassanen, Said A. El-Nisr, F.H. Mohamed,
... evolution of the Pan-African crust. The Gabal Igla Ahmar pluton comprises two magmatic suites: a calc- ... la croûte pan-africaine. Le pluton de Gabal Igla Ahmar comprend deux suites magmatiques: une suite calco- ...
Tópico(s): earthquake and tectonic studies
1996 - Elsevier BV | Journal of African Earth Sciences
Guido Linari, L. M. Fleeman, Chen Gilor, Lucia Giacomelli, Federico Fracassi,
... and safety of insulin glargine 300 U/ml (IGla-U300) in cats with variable duration of diabetes ... insulin efficacy evaluation. All cats were treated with IGla-U300 SC at a starting dosage of 0. ... achieve remission ( P = 0.02). Conclusions and relevance IGla-U300 seems effective and safe for the treatment ...
Tópico(s): Pancreatic function and diabetes
2021 - SAGE Publishing | Journal of Feline Medicine and Surgery
Mohamed M. Hamdy, Shaimaa A. El‐Shafei, Hamed Gamaleldien, Tamer Abu‐Alam,
... mantle remains a matter of investigation. The Wadi Igla serpentinite (southern Eastern Desert of Egypt) formed at ... subducting sediments-related CO2-rich fluid, the Wadi Igla serpentinite underwent metasomatism, producing chlorite (300 °C), antigorite, ... resulted from serpentinization-related hydrothermal alteration. The Wadi Igla serpentinite indicates silica cycled in a closed system, ...
Tópico(s): Paleontology and Stratigraphy of Fossils
2023 - Elsevier BV | Precambrian Research
... sediments (tuffites) is the main feature of the Igla Eliswid-Um Khariga metavolcanics. It contains both subaerial ...
Tópico(s): Geology and Paleoclimatology Research
1992 - Elsevier BV | Journal of African Earth Sciences (and the Middle East)
Yanbing Chen, Xiao Su, Zhenyu Wu, Xiling Deng, Yuling Zhang, Zhihao Zhao, Wei Zhong, Shiguo Sun,
... the peak current intensity of GLA and ISL (IGLA and IISL) also increased, while the peak current ... reference signal) remained relatively constant. The values of IGLA/IFc and IISL/IFc showed excellent linear relationships ...
Tópico(s): Conducting polymers and applications
2024 - Elsevier BV | Biosensors and Bioelectronics
Mohamed Zaki Khedr, Saif M. Abo Khashaba, Eiichi Takazawa, Safaa M. Hassan, Mokhles K. Azer, N. H. El-Shibiny, Kamal Abdelrahman, Yuji Ichiyama,
The Igla Ahmr region in the Central Eastern Desert (CED) of Egypt comprises mainly syenogranites and alkali feldspar granites, ... in origin. The rare metal mineralization in the Igla Ahmr granites is possibly attributed to: (1) essential ... metasomatism, leading to rare metal enrichment in the Igla Ahmr granites during the interaction between rocks and ...
Tópico(s): earthquake and tectonic studies
2024 - Multidisciplinary Digital Publishing Institute | Minerals
Florentino Carral San Laureano, Mariana Tomé Fernández-Ladreda, Ana Isabel Jiménez Millán, Concepción García Calzado, M Ortega,
... 18.7±12.3 years) using IDeg and IGla-300 ≥6 months to compare DIDR between groups. Patients using IGla-300 (n=187) were more frequently males (59% ... 8.1%±1.5%; p 8%. Patients using IGla-300 and IDeg used similar basal, prandial and ... DIDR was observed between patients with T1D using IGla-300 or IDeg during at least 6 months ...
Tópico(s): Pancreatic function and diabetes
2021 - SAGE Publishing | Journal of Investigative Medicine
Jie Guo, Xiaoke Wu, Mengzhen Li, Zhao Zexin, Xu Long,
... of line arresters with internal series air gap (IGLA) is chosen by this study, which is distinguished ... frequency electric field of this new kind of IGLA under polluted and icing situation, and making further ...
Tópico(s): Electrical Fault Detection and Protection
2018 - Institution of Engineering and Technology | The Journal of Engineering
Esteban Soto, Denise H. Fernandez, John P. Hawke,
... genes of the F. tularensis intracellular growth locus (iglA*, iglB*, iglC*, and iglD*) were identified from LADL ...
Tópico(s): Bacterial Genetics and Biotechnology
2009 - Wiley | Journal of Aquatic Animal Health
Hamdy M. Abdalla, Hossam A. Helba, Hiroharu Matsueda,
... W‐enriched, Li‐albite granite (e.g. Nuweibi, Igla and Abu Dabbab). The metasomatized granites are Nb>> ...
Tópico(s): High-pressure geophysics and materials
2009 - Wiley | Resource Geology
Pierre Freytet, F. Baltzer, Odette Conchon, Jean-Claudé Plaziat, B. H. Purser,
... Several sections across fluviatile formations and alluvial cones (Igla, Umm Gheig, Nahari, Khalilat el Bahari) and some ...
Tópico(s): Aeolian processes and effects
1994 - EDP Sciences | BSGF – Earth Sciences Bulletin
Amanda Read, Sigrid J. Vogl, Karsten Hueffer, Larry A. Gallagher, George M. Happ,
... replication in mammalian macrophages. The virulence factors MglA, IglA, IglB, IglC, and IglD as well as PdpA ...
Tópico(s): Viral gastroenteritis research and epidemiology
2008 - Oxford University Press | Journal of Medical Entomology
Amanda Read, Sigrid J. Vogl, Karsten Hueffer, Larry A. Gallagher, George M. Happ,
... replication in mammalian macrophages. The virulence factors MglA, IglA, IglB, IglC, and IglD as well as PdpA ...
Tópico(s): Yersinia bacterium, plague, ectoparasites research
2008 - Oxford University Press | Journal of Medical Entomology
Jagjit S. Ludu, Olle M. de Bruin, Barry N. Duplantis, Crystal L. Schmerk, Alicia Y. Chou, Karen L. Elkins, Francis E. Nano,
... affects the cellular distribution of FPI-encoded proteins IglA, IglB, and IglC. Finally, deletions of FPI genes ...
Tópico(s): Vibrio bacteria research studies
2008 - American Society for Microbiology | Journal of Bacteriology
S. L. Rajasekhar Karna, Xhavit Zogaj, Jeffrey R. Barker, J. Seshu, Simon L. Dove, Karl E. Klose,
... and Vibrio cholerae, known interactions between F. tularensis IglA and IglB and V. cholerae VipA and VipB ...
Tópico(s): Bacillus and Francisella bacterial research
2010 - Future Science Ltd | BioTechniques
Juraj LenÄo, Martin Hubálek, Pär Larsson, Alena FuÄÃková, Martin Brychta, AleÅ¡ Macela, JiÅà StulÃk,
... island I (FPI). Of these, the IglC and IglA proteins were previously reported to be necessary for ...
Tópico(s): Bacterial Genetics and Biotechnology
2007 - Oxford University Press | FEMS Microbiology Letters
... Pomaken Bulgariens; Yulian Konstantinov, Gulbrand Alhaug and Birgit Igla, ‘Names of the Bulgarian Pomaks’, Nordlyd: Tromsø University ...
Tópico(s): European and International Law Studies
2007 - Taylor & Francis | The Journal of Communist Studies and Transition Politics