P Fehling, Kai Buckenmaier, Sergey A. Dobrynin, Denis A. Morozov, Yuliya F. Polienko, Yulia V. Khoroshunova, Yulia Borozdina, Philipp Mayer, Jörn Engelmann, Klaus Scheffler, Goran Angelovski, Igor A. Kirilyuk,
The efficacy in 1H Overhauser dynamic nuclear polarization in liquids at ultralow magnetic field (ULF, B0 = 92 ± 0.8 µT) and polarization field (Bp = 1-10 mT) was studied for a broad variety of 26 different spin probes. Among others, piperidine, pyrrolidine, and pyrroline radicals specifically synthesized for this study, along with some well-established commercially available nitroxides, were investigated. Isotope-substituted variants, some sterically shielded reduction-resistant nitroxides, and some biradicals ...
Tópico(s): Magnetism in coordination complexes
2021 - American Institute of Physics | The Journal of Chemical Physics
Sergey A. Dobrynin, Sergei Kutseikin, Denis A. Morozov, Olesya A. Krumkacheva, Anna Spitsyna, Yu. V. Gatilov, Vladimir N. Silnikov, Goran Angelovski, Michael K. Bowman, Igor A. Kirilyuk, Alexey S. Chubarov,
Four albumin-nitroxide conjugates were prepared and tested as metal-free organic radical contrast agents (ORCAs) for magnetic resonance imaging (MRI). Each human serum albumin (HSA) carrier bears multiple nitroxides conjugated via homocysteine thiolactones. These molecular conjugates retain important physical and biological properties of their HSA component, and the resistance of their nitroxide groups to bioreduction was retained or enhanced. The relaxivities are similar for these four conjugates ...
Tópico(s): Magnetism in coordination complexes
2020 - Multidisciplinary Digital Publishing Institute | Molecules
Igor Opsenica, Nataša Terzić, Dejan Opsenica, Goran Angelovski, M. Lehnig, Peter Eilbracht, Bernard Tinant, Zorica D. Juranić, Kirsten S. Smith, Young Soon Yang, Damaris Diaz, Philip L. Smith, Wilbur K. Milhous, D. Đoković, Bogdan A. Šolaja,
Mixed tetraoxanes 5a and 13 synthesized from cholic acid and 4-oxocyclohexanecarboxylic acid were as active as artemisinin against chloroquine-susceptible, chloroquine-resistant, and multidrug-resistant Plasmodium falciparum strains (IC50, IC90). Most active 13 is metabolically stable in in vitro metabolism studies. In vivo studies on tetraoxanes with a C(4' ') methyl group afforded compound 15, which cured 4/5 mice at 600 and 200 mg·kg-1·day-1, and 2/5 mice at 50 mg·kg-1·day-1, showing no toxic effects. ...
Tópico(s): Insect and Pesticide Research
2006 - American Chemical Society | Journal of Medicinal Chemistry
P Fehling, Kai Buckenmaier, Sergey A. Dobrynin, Denis A. Morozov, Yuliya F. Polienko, Yulia V. Khoroshunova, Yulia Borozdina, Philipp Mayer, Jörn Engelmann, Klaus Scheffler, Goran Angelovski, Igor A. Kirilyuk,
First Page
Tópico(s): Atomic and Subatomic Physics Research
2022 - American Institute of Physics | The Journal of Chemical Physics
Igor Esmerov, Branko Atanasov, Aleksandra Angelevska, Radmila Chrcheva, Ljupco Mickov, Ljupco Angelovski, Slavica Josifovska, Nikolaj Markov, Nikola Adamov,
Abstract The aim of this study was to construct two plasmid-specific shRNA transcripts of the bcl-2 gene in order to prepare for reverse of cell apoptosis. The plasmid was designed according to a previously published sequence of interfering RNA following an appropriate reference, using appropriate software. By annulling complementary oligonucleotides, double-stranded inserts were formed. Recombinant shRNA-encoding plasmids were constructed by digestion of psiRNA-x7SKGFPzeo plasmid (psiRNA-x7SKGFPzeo, ...
Tópico(s): Molecular Biology Techniques and Applications
2022 - Ss.Cyril and Methodius University, Skopje | Macedonian Veterinary Review