V. A. Ryabinin, Olga D. Zakharova, Ekaterina Y. Yurchenko, О. А. Тимофеева, Igor V. Martyanov, Andrei A. Tokarev, Eugeny F. Belanov, Н. И. Бормотов, Laura Tarrago‐Litvak, Marie Line Andreola, Simón Litvak, Georgy A. Nevinsky, A. N. Sinyakov,
A set of oligo-1,3-thiazolecarboxamide derivatives able to interact with the minor groove of nucleic acids was synthesized. These oligopeptides contained different numbers of thiazole units presenting dimethylaminopropyl or EDTA moieties on the C-terminus, and aminohexanoyl or EDTA moieties on the N-terminus. The inhibition of such compounds on HIV-1 reverse transcriptase activity was evaluated using different model template–primer duplexes: DNA·DNA, RNA·DNA, DNA·RNA and RNA·RNA. The biological ...
Tópico(s): HIV Research and Treatment
2000 - Elsevier BV | Bioorganic & Medicinal Chemistry