Rebecca Batorsky, R.A. Sergeev, Igor M. Rouzine,
Cytotoxic T lymphocytes (CTL) are a major factor in the control of HIV replication. CTL arise in acute infection, causing escape mutations to spread rapidly through the population of infected cells. As a result, the virus develops partial resistance to the immune response. The factors controlling the order of mutating epitope sites are currently unknown and would provide a valuable tool for predicting conserved epitopes. In this work, we adapt a well-established mathematical model of HIV evolution ...
Tópico(s): T-cell and B-cell Immunology
2014 - Public Library of Science | PLoS Computational Biology
Arkady Gonoskov, Sergei Bastrakov, E. S. Efimenko, Anton Ilderton, M. Marklund, Iosif Meyerov, A. A. Muraviev, A. Sergeev, Igor Surmin, Erik Wallin,
We review common extensions of particle-in-cell (PIC) schemes which account for strong field phenomena in laser-plasma interactions. After describing the physical processes of interest and their numerical implementation, we provide solutions for several associated methodological and algorithmic problems. We propose a modified event generator that precisely models the entire spectrum of incoherent particle emission without any low-energy cutoff, and which imposes close to the weakest possible demands ...
Tópico(s): Advanced Fiber Laser Technologies
2015 - American Physical Society | Physical Review E
Ruslan Masgutov, Galina Masgutova, Liliya Mukhametova, Ekaterina Garanina, Svetlana S. Arkhipova, Elena Zakirova, Yana Mukhamedshina, Zhuravleva Margarita, Zarema E. Gilazieva, Valeriia Syromiatnikova, Adelya Mullakhmetova, Gulnaz Kadyrova, Mariya Nigmetzyanova, Mikhail Sergeev, Igor Pankov, Ramil Yagudin, Albert A. Rizvanov,
We examined the effect of transplantation of allogenic adipose-derived stem cells (ADSCs) with properties of mesenchymal stem cells (MSCs) on posttraumatic sciatic nerve regeneration in rats. We suggested an approach to rat sciatic nerve reconstruction using the nerve from the other leg as a graft. The comparison was that of a critical 10 mm nerve defect repaired by means of autologous nerve grafting versus an identical lesion on the contralateral side. In this experimental model, the same animal ...
Tópico(s): Mesenchymal stem cell research
2018 - Frontiers Media | Frontiers in Pharmacology
Arkady Gonoskov, Sergei Bastrakov, E. S. Efimenko, Anton Ilderton, M. Marklund, Iosif Meyerov, A. A. Muraviev, Anton I. Sergeev, Igor Surmin, Erik Wallin,
Received 11 September 2015DOI:https://doi.org/10.1103/PhysRevE.92.039903©2015 American Physical Society
Tópico(s): Advanced Fiber Laser Technologies
2015 - American Physical Society | Physical Review E
Yana V. Tarakanchikova, Аlbert R. Muslimov, Igor S. Sergeev, Kirill V. Lepik, Nikita Yolshin, Alexander A. Goncharenko, Kirill Vasilyev, Igor E. Eliseev, Anton Bukatin, Vladislav S. Sergeev, S. I. Pavlov, Alexey Popov, Igor Meglinski, Boris Afanasiev, Bogdan V. Parakhonskiy, Gleb B. Sukhorukov, Dmitry A. Gorin,
The polyelectrolyte nanocarriers’ based on nanosized vaterite particles as a novel tool for genetic material delivery into the clinically relevant cell types and potential application of described technology in gene therapy approaches.
Tópico(s): Silk-based biomaterials and applications
2020 - Royal Society of Chemistry | Journal of Materials Chemistry B
R.A. Sergeev, Rebecca Batorsky, Igor M. Rouzine,
Tópico(s): T-cell and B-cell Immunology
2009 - Elsevier BV | Journal of Theoretical Biology
Н. В. Торопцова, Lydia I. Benevolenskaya, Alexander N. Karyakin, Igor L. Sergeev, Ш. Ф. Эрдес,
Study Design A representative sample of 18-to 65-years-old workers from a machine-building factory was studied using a standardized questionnaire. Objectives To study the prevalence of low back pain syndrome among workers at an industrial enterprise and to estimate the association between low back pain syndrome and certain factors. Methods This was a cross-sectional study of 800 workers (400 men and 400 women), who were invited to participate in the study. Seven-hundred-and-one (87.6%) persons took ...
Tópico(s): Healthcare Systems and Public Health
1995 - Lippincott Williams & Wilkins | Spine
Alexander S. Timin, Аlbert R. Muslimov, Mikhail V. Zyuzin, Oleksii O. Peltek, Timofey E. Karpov, Igor S. Sergeev, Anna I. Dotsenko, Alexander A. Goncharenko, Nikita Yolshin, Artem D. Sinelnik, B. Krause, Tilo Baumbach, Maria A. Surmeneva, Roman V. Chernozem, Gleb B. Sukhorukov, Roman A. Surmenev,
The incorporation of bioactive compounds onto polymer fibrous scaffolds with further control of drug release kinetics is essential to improve the functionality of scaffolds for personalized drug therapy and regenerative medicine. In this study, polymer and hybrid microcapsules were prepared and used as drug carriers, which are further deposited onto polymer microfiber scaffolds [polycaprolactone (PCL), poly(3-hydroxybutyrate) (PHB), and PHB doping with the conductive polyaniline (PANi) of 2 wt % (PHB-PANi)]. ...
Tópico(s): 3D Printing in Biomedical Research
2018 - American Chemical Society | ACS Applied Materials & Interfaces
S. G. Lokhov, M. A. Podyminogin, Dmitry S. Sergeev, Vladimir N. Silnikov, Igor V. Kutyavin, G. V. Shishkin, Valentina Zarytova,
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and high stability of complementary complexes of N-(2-hydroxyethyl)phenazinium derivatives of oligonucleotidesS. G. Lokhov, M. A. Podyminogin, D. S. Sergeev, V. N. Sil'nikov, I. V. Kutyavin, G. V. Shishkin, and V. P. ZarytovaCite this: Bioconjugate Chem. 1992, 3, 5, 414–419Publication Date (Print):September 1, 1992Publication History Published online1 May 2002Published inissue 1 September 1992https://pubs.acs.org/doi/10.1021/bc00017a010https:// ...
Tópico(s): Click Chemistry and Applications
1992 - American Chemical Society | Bioconjugate Chemistry
Mikhail Kryuchkov, Vladimir L. Katanaev, Gennadiy A. Enin, Anton Sergeev, A. A. Timchenko, Igor N. Serdyuk,
Drosophila melanogaster is a model organism instrumental for numerous biological studies. The compound eye of this insect consists of some eight hundred individual ommatidia or facets, ca. 15 µm in cross-section. Each ommatidium contains eighteen cells including four cone cells secreting the lens material (cornea). High-resolution imaging of the cornea of different insects has demonstrated that each lens is covered by the nipple arrays - small outgrowths of ca. 200 nm in diameter. Here we for the first ...
Tópico(s): Heat shock proteins research
2011 - Public Library of Science | PLoS ONE
Kseniia A. Sergeeva, A. A. Sergeev, Oleg V. Minin, Igor V. Minin,
The photonic nanojet phenomenon is commonly used both to increase the resolution of optical microscopes and to trap nanoparticles. However, such photonic nanojets are not applicable to an entire class of objects. Here we present a new type of photonic nanojet in reflection mode with the possibility to control the modulation of the photonic nanojet by a standing wave. In contrast to the known kinds of reflective photonic nanojets, the reported one occurs when the aluminum oxide hemisphere is located ...
Tópico(s): Photonic Crystals and Applications
2021 - Multidisciplinary Digital Publishing Institute | Photonics
Daria Ryabchuk, Alexander Sergeev, Evgeny Burnashev, Viktor Khorikov, Igor Neevin, Olga Kovaleva, Leonid Budanov, Vladimir Zhamoida, Aleksandr Danchenkov,
The results of both onshore and offshore monitoring of the coastal zone in the Russian Baltic reveal the high intensity and recent acceleration of coastal dynamics caused by an increasing frequency of extreme hydrodynamic events and anthropogenic impacts on the diverse geology. Stable coasts dominate in the eastern Gulf of Finland, but the local rate of shoreline recession is up to 2.0 m a −1 , reaching 5 m in one extreme storm event. The coastal zone of the Kaliningrad area is diverse. The western ...
Tópico(s): Arctic and Antarctic ice dynamics
2020 - Geological Society of London | Quarterly Journal of Engineering Geology and Hydrogeology
Danil Ivanov, M Y Ovchinnikov, Oleg Aleksandrovich Pantsyrnyi, A. S. Selivanov, Artem Sergeev, Igor Fedorov, Oleg Evgen'evich Khromov, N. A. Yudanov,
Tópico(s): Aerospace Engineering and Control Systems
2019 - Pleiades Publishing | Cosmic Research
Sergey Barykin, Anna Strimovskaya, Sergey Mikhailovich Sergeev, L N Borisoglebskaya, Natalia Dedyukhina, Igor Yu. Sklyarov, Julia Sklyarova, Lilya Saychenko,
The development of modern logistics systems requires state-of-the-art solutions for simultaneously achieving sustainable development goals and ambitious business targets. On this issue, the challenge of implementing digital technologies in social life, in particular in smart cities, deserves special attention. The diversified application of Industry 4.0 doctrine and digital shadow penetration to all fields of socioeconomic systems highlights the gaps in the design, control, and efficiency assessment ...
Tópico(s): Transport and Logistics Innovations
2023 - Multidisciplinary Digital Publishing Institute | Sustainability
Musa Khaitov, Alexandra Nikonova, I.P. Shilovskiy, Ksenia V. Kozhikhova, И.А. Кофиади, Lyudmila Vishnyakova, А. А. Никольский, Pia Gattinger, V.I. Kovchina, Ekaterina Barvinskaia, Kirill Yumashev, Valeriy Smirnov, Artem Maerle, I.B. Kozlov, Artem Shatilov, Anastasiia V. Timofeeva, Sergey Andreev, О. О. Колоскова, Nadezhda A. Kuznetsova, Daria V. Vasina, Maria A. Nikiforova, Sergei D. Rybalkin, I.V. Sergeev, D. Yu. Trofimov, Alexander Martynov, Igor Berzin, Vladimir А. Gushchin, A. O. Kovalchuk, Sergei V. Borisevich, Rudolf Valenta, Rakhim M. Khaitov, В. В. Скворцова,
First vaccines for prevention of Coronavirus disease 2019 (COVID-19) are becoming available but there is a huge and unmet need for specific forms of treatment. In this study we aimed to evaluate the anti-SARS-CoV-2 effect of siRNA both in vitro and in vivo.To identify the most effective molecule out of a panel of 15 in silico designed siRNAs, an in vitro screening system based on vectors expressing SARS-CoV-2 genes fused with the firefly luciferase reporter gene and SARS-CoV-2-infected cells was ...
Tópico(s): SARS-CoV-2 and COVID-19 Research
2021 - Wiley | Allergy
... 2097620Sergey Evgenievich Barykin, Irina Vasilievna Kapustina, Sergey Mikhailovich Sergeev, Sara Mehrab Daniali, Lyudmila Anatolievna Kopteva, Galina Nikolaevna Semenova, Igor Petrovich Pryadko, Alexey Mikhaylov, Pavel Baboshkin, Polina Datsyuk, ...
Tópico(s): Corporate Taxation and Avoidance
1973 - University of Chicago Press | Journal of Political Economy
A.I. Borodulin, B.M. Desyatkov, Н. А. Лаптева, Sergeev An, Igor E. Agranovski,
Tópico(s): Bacillus and Francisella bacterial research
2006 - Elsevier BV | Atmospheric Environment
J. Fielding Hejtmancik, Xiaodong Jiao, Anren Li, Yuri V. Sergeev, Xiaoyan Ding, Anil K. Sharma, Chi‐Chao Chan, Igor Medina, Albert O. Edwards,
Snowflake vitreoretinal degeneration (SVD, MIM 193230) is a developmental and progressive hereditary eye disorder that affects multiple tissues within the eye. Diagnostic features of SVD include fibrillar degeneration of the vitreous humor, early-onset cataract, minute crystalline deposits in the neurosensory retina, and retinal detachment. A genome-wide scan previously localized the genetic locus for SVD to a 20 Mb region flanked by D2S2158 and D2S2202. This region contains 59 genes, of which 20 ...
Tópico(s): Retinal and Macular Surgery
2008 - Elsevier BV | The American Journal of Human Genetics
Kirill V. Lepik, Аlbert R. Muslimov, Alexander S. Timin, Vladislav S. Sergeev, D. S. Romanyuk, Ivan Moiseev, Elena V. Popova, Igor L. Radchenko, A. D. Vilesov, Oleg Galibin, Gleb B. Sukhorukov, Boris V. Afanasyev,
Mesenchymal stem cells (MSCs) are widely used in cell therapy due to their convenience, multiline differentiation potential, reproducible protocols, and biological properties. The potential of MSCs to impregnate magnetic microcapsules and their possible influence on cell function and ability to response to magnetic field have been explored. Interestingly, the cells suspended in media show much higher ability in internalization of microcapsules, then MSCs adhere into the surface. There is no significant ...
Tópico(s): Tissue Engineering and Regenerative Medicine
2016 - Wiley | Advanced Healthcare Materials
Sergey Barykin, Irina Kapustina, Sergey Mikhailovich Sergeev, Sara Mehrab Daniali, Lyudmila Kopteva, Galina N. Semenova, Igor Pryadko, Alexey Mikhaylov, Pavel Baboshkin, Polina Datsyuk, Tomonobu Senjyu,
Background: Some firms with good growth opportunities and additional funds could have difficulties accessing external finance. One possible way to enhance their financial inclusion could be an exciting approach to planning the money reserve collected on a firm’s account. Methods: This article aims to disclose the introduction of financial logistics as the new theoretical field of management science. The authors present, in this paper, the key findings on the development of logistical models of an optimum money ...
Tópico(s): Transport and Logistics Innovations
2022 - Faculty of 1000 | F1000Research
Igor M. Rouzine, R.A. Sergeev, A. I. Glushtsov,
The organization of the cytotoxic T lymphocyte (CTL) response at organismal level is poorly understood. We propose a mathematical model describing the interaction between HIV and its host that explains 20 quantitative observations made in HIV-infected individuals and simian immunodeficiency virus-infected monkeys, including acute infection and response to various antiretroviral therapy regimens. The model is built on two modes of CTL activation: direct activation by infected cells and indirect activation ...
Tópico(s): T-cell and B-cell Immunology
2006 - National Academy of Sciences | Proceedings of the National Academy of Sciences
A. V. Elzhov, N. S. Ginzburg, A. K. Kaminsky, S. V. Kuzikov, É. A. Perelstein, N. Yu. Peskov, M. I. Petelin, S. N. Sedykh, A. P. Sergeev, A. S. Sergeev, Igor Syratchev, N. I. Zaitsev,
Abstract Since 2001 an experimental test facility for investigation of lifetime of a copper material, with respect to multiple RF pulse actions, was set up on the basis of the JINR (Dubna) FEM oscillator, in collaboration with IAP RAS (Nizhny Novgorod). A high- Q copper cavity, which simulates the parameters of the accelerating structure of the collider CLIC at an operating frequency of 30 GHz, is used in the investigation. The experimental setup consists of a wavebeam injector—FEM oscillator (power ...
Tópico(s): Particle accelerators and beam dynamics
2004 - Elsevier BV | Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment
M Y Ovchinnikov, Danil Ivanov, Oleg Pansyrnyi, Artem Sergeev, Igor Fedorov, A. S. Selivanov, Oleg Evgen'evich Khromov, N. A. Yudanov,
Tópico(s): Space exploration and regulation
2020 - Elsevier BV | Acta Astronautica
Nataliia Bakunina, Artyom Gil, Vitaly Polushkin, Boris I. Sergeev, Margarita Flores, Igor Toskin, Viktoriya Madyanova, R. A. Khalfin,
Abstract This narrative review was conducted to synthesize and summarize available up-to-date evidence on current health status, including both non-communicable diseases and infectious diseases, of migrants and refugees from the former Soviet Union countries in the Russian Federation. Epidemiological and sociological studies with one or more determinants of the health, as well as relevant qualitative studies characterizing risk factors, well-being indicators, and lifestyles of migrants and refugees ...
Tópico(s): Employment and Welfare Studies
2020 - BioMed Central | International Journal for Equity in Health
... the Defense Ministry had its leader, Defense Minister Igor Sergeev, replaced by Secretary of the National Security Council ...
Tópico(s): Global Energy Security and Policy
2002 - George Washington University | Demokratizatsiya The Journal of Post-Soviet Democratization
Anastasia Glebova, Igor S. Sergeev,
Tópico(s): Indigenous Studies and Ecology
2018 - Elsevier BV | Quaternary International
Anu Kaskela, Heta Rousi, Matti S Ronkainen, М. И. Орлова, A.V. Babin, George Gogoberidze, Kirsi Kostamo, Aarno Kotilainen, Igor Neevin, Daria Ryabchuk, Alexander Sergeev, Vladimir Zhamoida,
We analyzed hydrology, geology and benthic species composition to determine benthic habitat distribution patterns in a geologically complex area of the Gulf of Finland, Northern Baltic Sea. The analysis included several datasets describing coastal influence and geodiversity at multiple spatial scales. Geodiversity in this context refers to variation and/or patchiness of benthic substrates and seabed features. Multivariate statistical methods including BEST and LINKTREE routines were used to identify ...
Tópico(s): Marine and fisheries research
2017 - Elsevier BV | Continental Shelf Research
Igor E. Agranovski, А. С. Сафатов, Sergeev Aa, Oleg V. Pyankov, V. A. Petrishchenko, Maxim Mikheev, Sergeev An,
Tópico(s): Viral gastroenteritis research and epidemiology
2006 - Elsevier BV | Atmospheric Environment
Ivanov As, A. E. Medvedev, П. В. Ершов, A. A. Molnar, Yuri V. Mezentsev, Е.O. Yablokov, Leonid Kaluzhsky, O.V. Gnedenko, О.А. Бунеева, Irina Haidukevich, Gennadiy Sergeev, Aliaksandr Ya. Lushchyk, А. V. Yantsevich, Марина Владимировна Медведева, Sergey A. Kozin, Igor Popov, Светлана Новикова, Victor G. Zgoda, А. А. Гилеп, Sergey A. Usanov, А.В. Лисица, Alexander I. Archakov,
There is increasing evidence that proteins function in the cell as integrated stable or temporally formed protein complexes, interactomes. Previously, using model systems we demonstrated applicability of direct molecular fishing on paramagnetic particles for protein interactomics (Ershov et al. Proteomics , 2012, 12 , 3295). In the present study, we have used a combination of affinity‐based molecular fishing and subsequent MS for investigation of human liver proteins involved in interactions with immobilized ...
Tópico(s): Advanced Biosensing Techniques and Applications
2014 - Wiley | PROTEOMICS
Yuliya Troitskaya, Daniil Sergeev, O. A. Druzhinin, Alexander Kandaurov, Olga Ermakova, Ekaterina Ezhova, Igor Esau, Sergej Zilitinkevich,
Tópico(s): Aeolian processes and effects
2014 - Springer Science+Business Media | Ocean Dynamics